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A Stable Open-Shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-Ⅱ Photo-Immunotherapy of Metastatic Tumor

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Nano-Micro Letters 2024年第2期16卷 1-14页

作者： Yijian Gao Ying Liu Xiliang Li Hui Wang Yuliang Yang Yu Luo Yingpeng Wan Chun‑sing Lee Shengliang Li Xiao‑hong Zhang College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Center of Super‑Diamond and Advanced Films(COSDAF)&Department of Chemistry City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARPeople’s Republic of China

Massive efforts have been concentrated on the advance of eminent near-infrared(NIR) photothermal materials(PTMs) in the NIR-Ⅱ window(1000–1700 nm), especially organic PTMs because of their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-Ⅱresponsive organic PTMs was explored, and their photothermal conversion efficiencies(PCEs) still remain relatively low. Herein, donor–acceptor conjugated diradical polymers with open-shell characteristics are explored for synergistically photothermal immunotherapy of metastatic tumors in the NIR-Ⅱ window. By employing side-chain regulation, the conjugated diradical polymer TTB-2 with obvious NIR-Ⅱ absorption was developed, and its nanoparticles realize a record-breaking PCE of 87.7% upon NIR-Ⅱ light illustration. In vitro and in vivo experiments demonstrate that TTB-2 nanoparticles show good tumor photoablation with navigation of photoacoustic imaging in the NIR-Ⅱ window, without any side-effect. Moreover, by combining with PD-1 antibody,the pulmonary metastasis of breast cancer is high-effectively prevented by the efficient photo-immunity effect. Thus, this study explores superior PTMs for cancer metastasis theranostics in the NIR-Ⅱ window, offering a new horizon in developing radical-characteristic NIR-Ⅱ photothermal materials.

关键词： NIR-Ⅱconjugated polymer Photothermal Radical Nanoparticles Cancer therapy

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Lithium-induced graphene layer containing Li_(3)P alloy phase to achieve ultra-stable electrode interface for lithium metal anode

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Rare Metals 2024年第2期43卷 562-574页

作者： Jia-Xin Chen Guo-Qiang Zhang Xian-Ying Qin Kui Lin Zi-Jin Yang Ge-Meng Liang Yue Xia Guo-Bin Zhang Hai-Kun Wu Qiu-Chan Cai Hai Lin Bao-Hua Li Shenzhen Key Laboratory on Power Battery Safety Research and Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolShenzhen518055China Shenzhen Graphene Innovation Center Co. Ltd.Shenzhen518107China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA5005Australia Department of Chemistry City University of Hong KongHong Kong990077China

Uncontrolled growth of lithium dendrite will lead to low Coulombic efficiency and poor cycle stability,which hinders the commercialization of lithium metal ***,a novel modified lithium anode with reduced graphene oxide conductive network containing trace lithiophilic phosphorus(P-rGO/Cu)is prepared by electrospraying technique combined with heat treatment *** rGO layer has a concave and undulating conductive structure,which can significantly improve the effective electrical contact between lithium metal and the current collector,speed up the kinetics of interfacial electron transport and reaction,and improve the resistance of the negative electrode to the internal stress caused by volume change of the lithium,which is advantageous for the stability of the SEI *** extremely small and uniformly distributed red phosphorus element avoids the volume change caused by lithiation to the maximum *** two-phase compound Li_(3)P obtained by alloying P with Li can directionally induce the homogeneous nucleation and dense deposition of lithium metal,address the issue of lithium dendrites and extend the cycle life of the *** obtained P-rGO/Cu exhibits excellent electrochemical performance with an average Coulombic efficiency(CE)of 98%at a current density of 1 mA·cm^(−2) for 400 cycles,and the capacity retention rate of the full cell matched with lithium iron phosphate(LFP)is 83%after 400 cycles at 1C.

关键词： Lithium anode Dendrite-free Lithiophilicity Induced nucleation deposition

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Acceptor-planarized typeⅠphotosensitizer for lipid droplet-targeted two-photon photodynamic therapy by ferroptosis

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Science China Chemistry 2024年第7期67卷 2392-2402页

作者： Jie Sha Weimin Liu Jiasheng Wu Yanping Wang Xuewei Li Haohui Ren Zhi Pang Wenjun Zhang Chun-Sing Lee Pengfei Wang Key Laboratory of Photochemical Conversion and Optoelectronic Materials CityU-CAS Joint Laboratory of Functional Materials and DevicesTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China Center of Super-Diamond and Advanced Films&Department of Materials Science and Engineering City University of Hong KongHong KongChina

Two-photon photodynamic therapy(TP-PDT)has garnered significant attention because of its excellent depth of tissue penetration and high spatiotemporal ***,the limited targeting ability and oxygen dependency of photosensitizers(PSs)significantly hinder the effectiveness of photodynamic therapy in hypoxic tumor ***,we designed and synthesized two lipid droplet(LD)-targeted two-photon PSs(TBPCP and TBCP)by reducing benzene rings to achieve“acceptor planarization”.Notably,acceptor planarization not only enhanced the intramolecular charge transfer but also transferred the photochemical reaction from typeⅡ(TBPCP)to typeⅠ(TBCP).Under the irradiation of 940 nm femtosecond pulsed laser,TBPCP and TBCP showed bright two-photon-excited fluorescence and excellent LD targeting in living *** TBPCP(typeⅡPS),the outstanding TP-PDT efficacy of TBCP(typeⅠPS)under hypoxic conditions could be obtained in both cellular experiments and multicellular tumor spheroids(MCTS)***,both TBPCP and TBCP could induce the lipid peroxidation in the typeⅠor typeⅡPDT due to the location of LD,depleting GSH and inactivating GPX4 to induce nonprogrammed ferroptosis in cells.

关键词： two-photon photodynamic therapy lipid droplet targeting acceptor planarization hypoxia tumor ferroptosis

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A novel deep generative model for mRNA vaccine development: Designing 5′ UTRs with N1-methyl-pseudouridine modification

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1814-1826页

作者： Xiaoshan Tang Miaozhe Huo Yuting Chen Hai Huang Shugang Qin Jiaqi Luo Zeyi Qin Xin Jiang Yongmei Liu Xing Duan Ruohan Wang Lingxi Chen Hao Li Na Fan Zhongshan He Xi He Bairong Shen Shuai Cheng Li Xiangrong Song Institute of Systems Genetics Department of Critical Care MedicineFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610000China Department of Computer Science City University of Hong KongHong Kong 99907China Department of Biology Brandeis UniversityBostonMA 02453USA

Efficient translation mediated by the 5'untranslated region(5'UTR)is essential for the robust efficacy of mRNA ***,the N1-methyl-pseudouridine(m1)modification of mRNA can impact the translation efficiency of the 5'*** discovered that the optimal 5'UTR for m1y-modified mRNA(m1y-5'UTR)differs significantly from its unmodified counterpart,high-lighting the need for a specialized tool for designing mly-5'UTRs rather than directly utilizing high-expression endogenous gene 5'*** response,we developed a novel machine learning-based tool,Smart5UTR,which employs a deep generative model to identify superior m1y-5'UTRs in *** tailored loss function and network architecture enable Smart5UTR to overcome limitations inherent in existing *** a result,Smart5UTR can successfully design superior 5'UTRs,greatly benefiting mRNA vaccine ***,Smart5UTR-designed superior 5'UTRs significantly enhanced antibody titers induced by COVID-19 mRNA vaccines against the Delta and Omicron variants of SARS-CoV-2,surpassing the performance of vaccines using high-expression endogenous gene 5'UTRs.

关键词： mRNA vaccine Machine learning 5'UTR mRNA design Sequence design N1-Methyl-pseudouridine COVID-19 SARS-CoV-2

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Interface Engineering on Constructing Physical and Chemical Stable Solid-State Electrolyte Toward Practical Lithium Batteries

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Energy & Environmental Materials 2024年第4期7卷 28-47页

作者： honggang He Litong Wang Malek Al-Abbasi Chunyan Cao Heng Li Zhu Xu Shi Chen Wei Zhang Ruiqing Li Yuekun Lai Yuxin Tang Mingzheng Ge School of Textile and Clothing Nantong University School of Science Qingdao University of Technology Department of Biomedical Sciences City University of Hong Kong Institute of Applied Physics and Materials Engineering University of Macau College of Chemical Engineering Fuzhou University

Solid-state lithium batteries (SSLBs) with high safety have emerged to meet the increasing energy density demands of electric vehicles,hybrid electric vehicles,and portable electronic ***,the dendrite formation,high interfacial resistance,and deleterious interfacial reactions caused by solid-solid contact between electrode and electrolyte have hindered the commercialization of SSLBs.

关键词： dendrite formation high energy density interface instability interfacial resistance solid-state electrolyte

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Riding towards a sustainable future:an evaluation of bike sharing’s environmental benefits in Xiamen Island,China

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Geography and Sustainability 2024年第2期5卷 276-288页

作者： Jianxiao Liu Meilian Wang Pengfei Chen Chaoxiang Wen Yue Yu KW Chau Department of Real Estate and Construction Faculty of ArchitectureThe University of Hong KongPokfulamHong Kong 999077China Department of Land Surveying and Geo-informatics The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China School of Geospatial Engineering and Science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Department of Urban Planning School of Architecture and Civil EngineeringXiamen UniversityXiamen 550002China Ronald Coase Centre for Property Rights Research HKUrbanLabThe University of Hong KongPokfulamHong Kong 999077China

In the pursuit of sustainable urbanization,Bike-Sharing Services(BSS)emerge as a pivotal instrument for promoting green,low-carbon *** BSS is often commended for its environmental benefits,we offer a more nuanced analysis that elucidates previously neglected *** the Dominant Travel Distance Model(DTDM),we evaluate the potential of BSS to replace other transportation modes for specific journey based on travel *** multiscale geographically weighted regression(MGWR),we illuminate the relationship between BSS’s environmental benefits and built-environment *** life cycle analysis(LCA)quantifies greenhouse gas(GHG)emissions from production to operation,providing a deeper understanding of BSS’s environmental ***,our study focuses on Xiamen Island,a Chinese“Type Ⅱ large-sized city”(1–3 million population),contrasting with the predominantly studied“super large-sized cities”(over 10 million population).Our findings highlight:(1)A single BSS trip in Xiamen Island reduces GHG emissions by an average of 19.97 g CO_(2)-eq,accumulating monthly savings of 144.477 t CO_(2)-eq.(2)Areas in the southwest,northeast,and southeast of Xiamen Island,characterized by high population densities,register significant BSS environmental benefits.(3)At a global level,the stepwise regression model identifies five key built environment factors influencing BSS’s GHG mitigation.(4)Regionally,MGWR enhances model precision,indicating that these five factors function at diverse spatial scales,affecting BSS’s environmental benefits variably.

关键词： Greenhouse gases Shared mobility Carbon emission Multiscale geographically weighted regression Travel behavior Urban mobility

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A Survey on Model Predictive Control of DFIGs in Wind Energy Conversion Systems

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1085-1104页

作者： Shuo Yan Junyu Chen Minghao Wang Yongheng Yang Jose M.Rodriguez STEM College RMIT UniversityMelbourneAustralia hong kong Polytechnic university Hong KongChina State Key Laboratory of Internet of Things for Smart city(UM) Department of Electrical and Computer EngineeringUniversity of MacaoMacaoChina College of Electrical Engineering Zhejiang UniversityHangzhou 310027China universidad San Sebastin Campus BellavistaSantiago de ChileCLSantiago de Chile 000000Chile IEEE

This paper presents a comprehensive study on the model predictive control(MPC)of doubly fed induction generators(DFIG)in wind energy conversion systems(WECS);in particular the MPC of the rotor side *** general principle of prevalent MPC strategies is discussed to introduce the theoretical framework in the first ***,mainstream and high-performance MPC methods of DFIGs have been identified as model predictive current control(MPCC),model predictive torque control(MPTC),and model predictive power control(MPPC).Starting from analyzing dynamic models,these MPC strategies are investigated in terms of operating principles and technical *** paper further investigates implementation of MPC strategies in unbalanced *** on the quantitative and qualitative analysis of several case studies,performance of various MPC schemes is compared and their special features are *** for designing MPC strategies of DFIGs in WECS are provided.

关键词： Doubly fed induction generator(DFIG) model predictive control(MPC) wind energy

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Biomechanical analysis of bone mesoscopic structure and mechanical properties of vertebral endplates of degenerated intervertebral discs in rabbits

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Medicine in Novel Technology and Devices 2024年第2期22卷 59-72页

作者： Bingying Zhao Yuan Guo Xushu Zhang Yibo Zhao Bin Zhao Ming Zhang College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan030024China The Second Hospital of Shanxi Medical university Taiyuan City030001China Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong999077China

In previous studies of disc degeneration,the structural and mechanical properties of the endplate were often *** this paper,the station legislation was used to construct an animal model of minor trauma disc degeneration,and the mechanism of disc degeneration was further investigated by observing the changes of mesoscopic structure and developing the mechanical properties of endplate ***-eight 6-month-old Japanese white rabbits were divided into two groups:control group and experimental *** animal model of intervertebral disc degeneration was established by upright experiment in the experimental *** bone mesoscopic structures in different areas of each endplate were observed by histological and imaging methods,and the mechanical properties of the endplates were measured by indentation *** two groups of data were compared by one-way *** the experimental animals stood for 17 weeks,The experimental group showed the characteristics of early disc *** microstructure of the degenerative group showed that the end plate mineralization degree was higher,the bone mass was larger,and the number and thickness of bone trabeculae were *** results of indentation test showed that the mechanical properties of the degeneration group were enhanced,and the lower endplate was obviously *** successfully established a model of human disc degeneration with non invasive trauma and more consistent with the process of human disc degeneration through the standing *** the experimental group,the internal structure of the endplate was dense and pore distance was *** change of bone mesoscopic structure further affects the endplate,resulting in the enhancement of the mechanical properties of the endplate after intervertebral disc *** reduction of the pore distance and the narrowing of the internal channel structure of the endplate also hinder the nutrition supply of the intervertebral disc,which ma

关键词： Vertebral endplate Biomechanics Intervertebral disc degeneration model Mechanical properties Mesoscopic structure

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Piezoionics:Mechanical-to-ionic transduction for sensing,biointerface,and energy harvesting

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Aggregate 2024年第1期5卷 85-94页

作者： kongqi Chen Derek Ho Department of Materials Science and Engineering City University of Hong KongHong KongChina hong kong Center for Cerebro-Cardiovascular Health Engineering Hong KongChina

Piezoionic materials consisting of a polymer matrix and mobile ions can produce an electrical output upon an applied pressure inducing an ion concentration *** from charges generated by the piezoelectric or triboelectric effects,the use of generated mobile ions to carry a signal closely resembles many ionic biological *** to this similarity to biology,the piezoionic effect has great potential to enable seamless integration with biological systems,which accelerates the advancement of medical devices and personalized *** this review,a comprehensive description of the piezoionic mechanism,methods,and applications are presented,with the aim to facilitate a dialogue among relevant scientific ***,the piezoionic effect is briefly introduced,then the development of mechanistic understanding over time is ***,different types of piezoionic materials are reviewed and methods to enhance the piezoionic output via materials properties,electrode interfaces,and device architectures are ***,applications,challenges,and outlooks are *** its novel properties,piezoionics is expected to play a key role in the overcoming of grand challenges in the areas of sensing,biointerfaces,and energy harvesting.

关键词： flexible electronics intelligent soft matter ionic hydrogel iontronics mechanical energy harvesting

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Correlating dynamic relaxation and viscoelasticity in metallic glasses

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 81-90页

作者： GuangHui Xing Qi Hao Fan Zhu Yun-Jiang Wang Yong Yang Hidemi Kato Eloi Pineda Si Lan JiChao Qiao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Department of Mechanical Engineering College of EngineeringCity University of Hong KongHong Kong 999077China Department of Materials Science and Engineering College of EngineeringCity University of Hong KongHong Kong 999077China Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Department of Physics Institute of Energy TechnologiesUniversitat Politècnica de CatalunyaBarceona 9Spain School of Material Science and Engineering Herbert Gleiter Institute of NanoscienceNanjing University of Science and Technology.Nanjing 210094China State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment Northwestern Polytechnical UniversityXi'an 710072China

Relaxation dynamics,essential for the structural evolution of non-equilibrium systems like glassy materials,remain ***,we explore relaxation dynamics and viscoelastic properties in three types of metallic glasses with distinctβrelaxation *** systems with significantβrelaxation,stress relaxation and creep experiments reveal a transition from two-step to one-step relaxation with rising ***,such a phenomenon is absent in systems with weakerβ*** model the two-step relaxation process using a double Kohlrausch-Williams-Watts equation,and the obtained relaxation times elegantly adhere to the Arrhenius *** combining fitted activation energies with theoretical analysis,we conclusively attribute these relaxation processes toβrelaxation andαrelaxation,***,we analyze the relaxation time spectra of two processes and establish a comprehensive picture linking dynamic relaxation with *** study provides new strategies for probing the complex relaxation behaviors of glasses from the perspective of viscoelasticity.

关键词： creep relaxation glasses

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