检索结果-南通市图书馆

Targeting miRNA by CRISPR/Cas in cancer:advantages and challenges

Military Medical Research 2024年第3期11卷 345-373页

作者： Bashdar Mahmud Hussen Mohammed Fatih Rasul Snur Rasool Abdullah Hazha Jamal Hidayat Goran Sedeeq Hama Faraj Fattma Abodi Ali Abbas Salihi Aria Baniahmad Soudeh Ghafouri-Fard Milladur Rahman Mark C.Glassy Wojciech Branicki Mohammad Taheri Department of Biomedical Sciences Cihan University-ErbilErbilKurdistan Region 44001Iraq Department of Clinical Analysis College of PharmacyHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Pharmaceutical Basic Science Faculty of PharmacyTishk International UniversityErbilKurdistan Region 44001Iraq Medical Laboratory Science Lebanese French UniversityErbilKurdistan Region 44001Iraq Department of Biology College of EducationSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Department of Medical Laboratory Science Komar University of Science and TechnologySulaymaniyah 46001Iraq Department of Medical Microbiology College of Health SciencesHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Biology College of ScienceSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Center of Research and Strategic Studies Lebanese French UniversityErbil 44001Iraq Institute of Human Genetics Jena University Hospital07747 JenaGermany Department of Medical Genetics School of MedicineShahid Beheshti University of Medical SciencesTehran 374-37515Iran Department of Clinical Sciences MalmöSection for SurgeryLund University22100 MalmöSweden Translational Neuro-Oncology Laboratory San Diego(UCSD)Moores Cancer CenterUniversity of CaliforniaSan DiegoCA 94720USA Faculty of Biology Institute of Zoology and Biomedical ResearchJagiellonian University31-007 KrakówPoland Urology and Nephrology Research Center Shahid Beheshti University of Medical SciencesTehran 374-37515Iran

Clustered regulatory interspaced short palindromic repeats(CRISPR)has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last *** the study of cancer,the CRISPR/CRISPR-associated protein(Cas)system opens new avenues into issues that were once unknown in our knowledge of the non-coding genome,tumor heterogeneity,and precision ***/Cas-based geneediting technology now allows for the precise and permanent targeting of mutations and provides an opportunity to target small non-coding RNAs such as microRNAs(miRNAs).However,the development of effective and safe cancer gene editing therapy is highly dependent on proper design to be innocuous to normal cells and prevent introducing other *** study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer ***,we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them.

关键词： CRISPR CRISPR/Cas9 CRISPR/Cas12 Gene editing miRNAs Cancer therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Examining the Use of Scott’s Formula and Link Expiration Time Metric for Vehicular Clustering

引用

Computer Modeling in Engineering & Sciences 2024年第3期138卷 2421-2444页

作者： Fady Samann Shavan Askar Department of Energy Engineering Technical College of EngineeringDuhok Polytechnic UniversityDuhok42001Iraq Department of Information System Engineering Technical College of EngineeringErbil Polytechnic UniversityErbil44001Iraq

Implementing machine learning algorithms in the non-conducive environment of the vehicular network requires some adaptations due to the high computational complexity of these algorithms.K-clustering algorithms are simplistic,with fast performance and relative ***,their implementation depends on the initial selection of clusters number(K),the initial clusters’centers,and the clustering *** paper investigated using Scott’s histogram formula to estimate the K number and the Link Expiration Time(LET)as a clustering *** traffic flows were considered for three maps,namely Highway,Traffic Light junction,and Roundabout junction,to study the effect of road layout on estimating the K number.A fast version of the PAM algorithm was used for clustering with a modification to reduce time *** Affinity propagation algorithm sets the baseline for the estimated K number,and the Medoid Silhouette method is used to quantify the ***++,Veins,and SUMO were used to simulate the traffic,while the related algorithms were implemented in *** Scott’s formula estimation of the K number only matched the baseline when the road layout was ***,the clustering algorithm required one iteration on average to converge when used with LET.

关键词： Clustering vehicular network Scott’s formula FastPAM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Groundwater vulnerability assessment using a GIS-based DRASTIC method in the erbil Dumpsite area (Kani Qirzhala), Central erbil Basin, North Iraq

引用

Journal of Groundwater Science and Engineering 2024年第1期12卷 16-33页

作者： Masoud H Hamed Rebwar N Dara Marios C Kirlas Department of Earth Sciences and Petroleum College of ScienceSalahaddin University-ErbilErbilIraq Department of Petroleum Engineering College of EngineeringKnowledge UniversityErbilIraq Department of Agriculture Faculty of AgricultureForestry and Natural EnvironmentAristotle University of Thessaloniki

Groundwater vulnerability assessment is a crucial step in the efficient management of groundwater resources,especially in areas with intensive anthropogenic activities and groundwater *** the present study,the DRASTIC method was applied using Geographic Information System(GIS)to delineate groundwater vulnerability zones in the erbil Dumpsite area,Central erbil Basin,North *** showed that the area was classified into four vulnerability classes:Very low(16.97%),low(27.67%),moderate(36.55%)and high(18.81%).The southern,south-eastern and northern parts of the study area exhibited the highest vulnerability potential,while the central-northern,northern and north-western regions displayed the lowest vulnerability ***,results of the single-parameter sensitivity analysis indicated that amongst the seven DRASTIC parameters,the unsaturated zone and the aquifer media were the most influencing *** conclustion,the correlation of 25 nitrate concentration values with the final vulnerability map,assessed using the Pearson correlation coefficient,yielded a satisfactory result of R=0.72.

关键词： DRASTIC erbil Iraq Groundwater vulnerability assessment Nitrate Pollution Sensitivity analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Developing three-dimensional groundwater flow modeling for the erbil Basin using Groundwater Modeling System (GMS)

引用

Journal of Groundwater Science and Engineering 2024年第2期12卷 178-189页

作者： Jwan Sabah Mustafa Dana Khider Mawlood Department of Civil College of EngineeringUniversity of SalahaddinErbil 00044Iraq Vice President in university.of Kurdistan-Hawler(UKH) ErbilIraq

This study presents the development of a comprehensive three-dimensional groundwater flow model for the erbil Basin utilizing the Groundwater Modeling System(GMS).The erbil Basin,situated in the Kurdistan Region of Iraq,is a vital water resource area facing increasing water demands and environ-mental *** three-dimensional nature of the groundwater flow system is crucial for accurately understanding and managing water resources in the *** modeling process involved data collection,geological and hydrogeological characterization,conceptual model development,and numerical simulation using GMS software MODFLOW 2000 *** parameters such as hydraulic conductivity,recharge rates,and boundary conditions were integrated into the model to represent the complex hydrogeo-logical conditions of the *** calibration was performed by comparing simulated groundwater levels with observed data from monitoring wells across the basin,using the automatic calibration method of automated Parameter Estimation(PEST).Pilot points were applied to adjust the hydraulic conductivity in the model area *** analysis was conducted to assess the influence of key parameters on model predictions and to identify areas of *** developed three-dimensional groundwater flow model provides valuable insights into the dynamics of groundwater flow,recharge-discharge mechanisms,and potential impacts of future scenarios such as climate change and water resource management *** serves as a useful tool for decision-makers,water resource managers,and researchers to evaluate differ-ent management scenarios and formulate sustainable groundwater management policies for the erbil *** conclusion,this study demonstrates the effectiveness of using GMS for developing three-dimensional groundwater flow models in complex hydrogeological settings like the erbil Basin,contributing to improved understanding and management of groundwater resources in the

关键词： Aquifer System erbil Basin Groundwater Management GMS MODFLOW

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improving Heat Transfer Performance of Flat Plate Water Solar Collectors Using Nanofluids

引用

Journal of Harbin Institute of Technology(New series) 2024年

作者： Barhm Mohamad Department of Petroleum Technology Koya Technical Institute erbil Polytechnic university

This study delves into both experimental and analytical examinations of heat exchange in a straight channel， where Al2O3-water nanofluids are utilized， spanning the Reynolds number spectrum from 100 to 1800. Diverse volume fractions （1%， 2%， and 3%） of Al2O3-water nanofluids are meticulously prepared and analyzed. The essential physical properties of these nanofluids， critical for evaluating their thermal and flow characteristics， have been comprehensively assessed. From a quantitative perspective， numerical simulations are employed to predict the Nusselt number （Nu） and friction factor （f）. The empirical findings reveal intriguing trends: the friction factor experiences an upward trend with diminishing velocity， attributed to heightened molecular cohesion. Conversely， the friction factor demonstrates a decline with diminishing volume fractions， a consequence of reduced particle size. Both the nanofluid’s viscosity and heat transfer coefficient exhibit a rise in tandem with augmented volume flow rate and concentration gradient. Notably， the simulation results harmonize remarkably well with experimental data. Rigorous validation against prior studies underscores the robust consistency of these outcomes. In the pursuit of augmenting heat transfer， a volume fraction of 3% emerges as particularly influential， yielding an impressive 53.8% enhancement. Minor increments in the friction factor， while present， prove negligible and can be safely overlooked.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Thermodynamic Analysis and Optimization of Flat Plate Solar Collector Using TiO_(2)/Water Nanofluid

引用

Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 61-73页

作者： Firas F.Qader Falah Z.Mohammed Barhm Mohamad Technical Engineering College-Kirkuk Northern Technical UniversityKirkuk 36001Iraq Medical Device Technology Engineering AL-Qalam University CollegeKirkuk 36001Iraq Department of Petroleum Technology Koya Technical InstituteErbil Polytechnic UniversityErbil 44001Iraq

To research solar energy's efficiency and environmental benefits,the thermal efficiency,exergy,and entropy of solar collectors were *** experiment involved two glass-topped collectors,fluid transfer tubes,and aluminum heat-absorbing *** wool insulation minimized heat loss.A 0.5% TiO_(2)/Water nanofluid was created using a mechanical and ultrasonic *** showed that solar radiation increased thermal efficiency until midday,reaching 48.48% for water and 51.23% for the *** increasing mass flow rates from 0.0045 kg/s to 0.02 kg/s,thermal efficiency improved from 16.26% to 47.37% for water and from 20.65% to 48.76% for the *** water provided 380 W and 395 W of energy in March and April,while the nanofluid increased it to 395 W and 415 W during these *** flow generated energy,and the Reynolds number raised *** noon exergy efficiency for nanofluids was 50%-55%,compared to 30% for *** noon,the broken exergy measured 877.53 W for the nanofluid and 880.12 W for *** Kirkuk,Iraq,the 0.5% TiO_(2)/Water nanofluid outperformed water in solar collectors.

关键词： energy exergy entropy generation nanofluid flat plate solar collector

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of primary percutaneous coronary intervention on ST-segment elevation myocardial infarction patients:A comprehensive analysis

引用

World Journal of Experimental Medicine 2024年第1期14卷 58-69页

作者： Eza Nawzad Saeed Abdulsatar Kamil Faeq Department of Medicine Hawler Medical UniversityErbil 44001KurdistanIraq

BACKGROUND Myocardial infarction,particularly ST-segment elevation myocardial infarction(STEMI),is a key global mortality *** study investigated predictors of mortality in 96 STEMI patients undergoing primary percutaneous coronary intervention at erbil Cardiac *** factors were identified influencing in-hospital ***,time from symptom onset to hospital arrival emerged as a decisive ***,our study hypothesis is:"Reducing time from symptom onset to hospital arrival significantly improves STEMI prognosis."AIM To determine the key factors influencing mortality rates in STEMI *** We studied 96 consecutive STEMI patients undergoing primary percutaneous coronary intervention(PPCI)at the erbil Cardiac *** clinical histories were compiled,and coronary evaluations were performed via angiography on *** included comorbid conditions,onset of cardiogenic shock,complications during PPCI,and ***-discharge,one-month follow-up assessments were *** significance was set at P<*** Our results unearthed several significant *** in-hospital and 30-d mortality rates among the 96 STEMI patients were 11.2%and 2.3%*** the investigation of independent predictors of in-hospital mortality,we identified atypical presentation,onset of cardiogenic shock,presence of chronic kidney disease,Thrombolysis In Myocardial Infarction grades 0/1/2,triple vessel disease,ventricular tachycardia/ventricular fibrillation,coronary dissection,and the no-reflow ***,the recorded average time from symptom onset to hospital arrival amongst patients who did not survive was significantly longer(6.92±3.86 h)compared to those who survived(3.61±1.67 h),P<*** findings underscore the critical role of timely intervention in improving the survival outcomes of STEMI *** Our results affirm that early hospital arrival after symptom onset significantly i

关键词： Percutaneous coronary intervention Impact analysis,Segment elevation erbil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Scour hole reduction at a diversion channel junction using different entrance edge shapes

引用

International Journal of Sediment Research 2023年第6期38卷 811-820页

作者： Ahmed Yahya Abdulhafedh Nashwan Kamalaldeen Alomari Ahmed Mohammed Sami Al-Janabi Department of Dams and Water Resources Engineering College of Engineering university.of Mosul Department of Civil Engineering cihan university.erbil

In the current study,the effect of the entrance edge shape on the scour hole in the diversion junction region was experimentally *** investigation has considered three entrance modelsrounded edge shapes on one or both sides of the diversion channel entrance-with five different inlet edge radius ratios(rr) of 25%,37.5%,50%,62.5%,and 75% and five different diversion discharge ratios(Qr)of 7.5%,12.5%,17.5%,22.5%,and 30%.The results have found the direct relation between Qrand the scour depth to the diversion channel water depth ratio(ds/yb).Moreover,the use of a rounded edge shape on one or both sides of the diversion channel entrance instead of a sharp shape results in a reduction in scour depth to diversion channel water depth ratio(ds/yb) when the Qris greater than 20%.The results also indicated that the largest decrease in the scour coefficient(Kds) for the model with a rounded downstream edge compared with the sharp edge diversion channel entrance shape was 22% at a discharge ratio of 22.5% and an edge radius ratio of 37.5%.In addition,the entrance shape model with a rounded edge at the upstream outperformed other models in scour reduction with an average of all experiments of 5.77%.Finally,empirical relations for estimating scour depth for different rounded edge models in terms of the effective dimensionless parameters were established with coefficients of determination(R2) of not less than 0.853.

关键词： Open channel Diversion flow Entrance edge shape Scour Channel junctions

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Efficient Communication in Wireless Sensor Networks Using Optimized Energy Efficient Engroove Leach Clustering Protocol

引用

Tsinghua Science and Technology 2024年第4期29卷 985-1001页

作者： N.Meenakshi Sultan Ahmad A.V.Prabu J.Nageswara Rao Nashwan Adnan Othman Hikmat A.M.Abdeljaber R.Sekar Jabeen Nazeer SRM Institute of Science and Technology KattankulathurChennai 603203India Department of Computer Science College of Computer Engineering and SciencesPrince Sattam Bin Abdulaziz UniversityAlkharj 11942Saudi Arabia university.Center for Research and Development(UCRD) Department of Computer Science and EngineeringChandigarh UniversityGharuanMohali 140413India Department of ECE Koneru Lakshmaiah Education FoundationVaddeswaramGuntur 522502India Department of Computer Science and Engineering Lakireddy Balireddy College of Engineering(A)NTR District 521230India Department of Computer Engineering College of EngineeringKnowledge UniversityErbil 44001Iraq Department of Computer Science Faculty of Information TechnologyApplied Science Private UniversityAmman 11937Jordan Department of Electronics and Communication Engineering(ECE) School of EngineeringPresidency UniversityBangalore 834001India

The Wireless Sensor Network(WSN)is a network that is constructed in regions that are inaccessible to human *** widespread deployment of wireless micro sensors will make it possible to conduct accurate environmental monitoring for a use in both civil and military *** make use of these data to monitor and keep track of the physical data of the surrounding environment in order to ensure the sustainability of the *** data have to be picked up by the sensor,and then sent to the sink node where they may be *** nodes of the WSNs are powered by batteries,therefore they eventually run out of *** energy restriction has an effect on the network life span and environmental *** objective of this study is to further improve the Engroove Leach(EL)protocol’s energy efficiency so that the network can operate for a very long time while consuming the least amount of *** lifespan of WSNs is being extended often using clustering and routing *** Meta Inspired Hawks Fragment Optimization(MIHFO)system,which is based on passive clustering,is used in this study to do *** cluster head is chosen based on the nodes’residual energy,distance to neighbors,distance to base station,node degree,and node *** on distance,residual energy,and node degree,an algorithm known as Heuristic Wing Antfly Optimization(HWAFO)selects the optimum path between the cluster head and Base Station(BS).They examine the number of nodes that are active,their energy consumption,and the number of data packets that the BS *** overall experimentation is carried out under the MATLAB *** the analysis,it has been discovered that the suggested approach yields noticeably superior outcomes in terms of throughput,packet delivery and drop ratio,and average energy consumption.

关键词： wireless sensor networks energy efficient engroove leach protocol meta inspired Hawks fragment optimization heuristic wing antfly optimization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Introduction to the Special Issue on Computational Intelligent Systems for Solving Complex Engineering Problems: Principles and Applications

引用

Computer Modeling in Engineering & Sciences 2024年第3期138卷 2023-2027页

作者： Danial Jahed Armaghani Ahmed SalihMohammed Ramesh Murlidhar Bhatawdekar Pouyan Fakharian Ashutosh Kainthola Wael Imad Mahmood School of Civil and Environmental Engineering University of Technology SydneyUltimoNSW 2007Australia College of Engineering University of SulaimaniKurdistan46001Iraq Engineering Department American University of IraqSulaimaniKurdistan46001Iraq Centre of Tropical Geoengineering(GEOTROPIK) Institute of Smart Infrastructure and Innovative Engineering(ISIIC)Faculty of Civil EngineeringUniversiti Teknologi MalaysiaJohor Bahru81310Malaysia Faculty of Civil Engineering Semnan UniversitySemnanIran Geo-Engineering and Computing Laboratory Banaras Hindu UniversityVaranasi221005India Scientific Research Centre Soran UniversitySoranErbilKurdistan-Region44008Iraq

Computational Intelligent(CI)systems represent a pivotal intersection of cutting-edge technologies and complex engineering challenges aimed at solving real-world *** comprehensive body of work delves into the realm of CI,which is designed to tackle intricate and multifaceted engineering problems through advanced computational *** history of CI systems is a fascinating journey that spans several decades and has its roots in the development of artificial intelligence and machine learning *** a wide array of practical examples and case studies,this special issue bridges the gap between theoretical concepts and practical implementation,shedding light on how CI systems can optimize processes,design solutions,and inform decisions in complex engineering *** compilation stands as an essential resource for both novice learners and seasoned practitioners,offering a holistic perspective on the potential of CI in reshaping the future of engineering problem-solving.

关键词： offering bridges landscape

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：