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Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome

World Journal of Gastroenterology 2023年第28期29卷 4451-4465页

作者： christopher J Martoni shalini srivastava Anders Damholt Gregory J Leyer Clinical Development Human HealthChr.Hansen A/SHoersholm 2970Denmark Clinical Development Vedic LifesciencesMumbai 400053India scientific Affairs Human HealthChr.Hansen A/SHoersholm 2970Denmark

BACKGROUND Probiotics have shown promise in alleviating symptoms of diarrhea-predominant irritable bowel syndrome(IBs-D);however,the certainty of evidence is *** randomized controlled dose-ranging trials are warranted on promising single-strain *** To investigate the clinical efficacy of Lactiplantibacillus plantarum(***)Lpla33(DsM34428)in adults with *** This is a randomized,double-blind,placebo-controlled,multi-center,and doseranging *** hundred and seven adults,18-70 years of age,with IBs-D,according to Rome IV criteria,were allocated(1:1:1)to receive placebo or *** Lpla33 at 1×10^(9)(1B)or 1×10^(10)(10B)colony-forming units/d over an 8-wk intervention *** primary outcome was the change in IBs severity scoring system(IBs-sss)total score after 8 wk,while secondary and exploratory outcomes included abdominal pain severity,IBs related quality of life,stool and microbial profile,and perceived *** IBs-sss was significantly reduced,after 8 wk,in participants receiving *** 1B(-128.45±83.30;Pse-ranging effect was observed,with a greater absolute reduction in the *** 10B group(Psub-scores related to abdominal pain,abdominal distension,bowel habits,and quality of life was observed in both *** groups compared to placebo(Ps administered *** 1B and 10B,respectively,were classified as stool consistency responders based on a reduction in diarrheal stool form,as compared to 26.3%in the placebo group(Pst,no significant shifts were observed in microbial *** *** Lpla33(DsM34428)is well tolerated and improves IBs symptom severity with a dose-ranging effect and a corresponding normalization of bowel habits in adults with IBs-D.

关键词： Randomized clinical trial Diarrhea-predominant irritable bowel syndrome Microbiome Probiotic Lactiplantibacillus plantarum

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Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli

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Journal of Animal science and Biotechnology 2019年第4期10卷 969-980页

作者： Kwangwook Kim Yijie He Xia Xiong Amy Ehrlich Xunde Li Helen Raybould Edward R.Atwill Elizabeth A.Maga Jens JΦrgensen Yanhong Liu Department of Animal science University of CaliforniaDavisCA 95616USA school of Veterinary Medicine University of CaliforniaDavisCA 95616USA chr.hansen a/s HoersholmDenmark

Background: There is growing evidence to support the beneficial effects of supplementing direct-fed microbials(DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary supplementation of Bacillus subtilis(DsM 25841) on growth performance, diarrhea, gut permeability and immunity of weaned pigs experimentally infected with a pathogenic F-18 Escherichia coli(E. coli).Results: The F18 E. coli infection reduced(P stinal villi height, whereas increased(P scellular and paracellular permeability in the jejunum compared with non-challenged control. supplementation of Bacillus subtilis linearly enhanced average daily gain of E. coli infected pigs from d 0 to 5 post-inoculation(PI)(P supplementation of high dose of Bacillus subtilis reduced(P scellular and paracellular permeability on d 5 and d11 PI compared with the E. coli infected pigs fed with control diet. E. coli infection up-regulated(P ssion of sLC5 A10(soluble carrier family 5 member 10) and MUC2(mucin 2) on d 5 PI, but down-regulated(P ssion of sLC5 A10, MUC2, and CLDN1 on d 11 PI in jejunal mucosa when pigs were fed with the control diet. supplementation of Bacillus subtilis linearly up-regulated(P ssion of CFTR and ZO1 on d 5 PI and sLC5 A10 and MUC2 on d 11 PI in jejunal mucosa of E. coli infected pigs. In addition, E. coli infection increased(P ssion of several immune genes(IL1 A, IL1 B, and IL7 on d 5 PI, and IL1 B, IL6, IL7, and TNF on d 11 PI) in the ileal mucosa of weaned pigs. Inclusion of Bacillus subtilis to control diet linearly down-regulated gene expression of IL1 A on d 5 PI(P = 0.07) and IL6 on d 11 PI(P sa of E. coli infected ***: supplementation of Bacillus subtilis(DsM 25841) enhanced growth r

关键词： Bacillus subtilis Growth rate Gut barrier function Intestinal inflammation Pathogenic Escherichia coli Weaned pigs

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发酵乳制品

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中国乳品工业 1982年第4期 65-69页

作者： R.L.sellars 顾仁童 chr.hansen's Laboratory Inc.

前言发酵或经过培养的乳制品为人类社会提供了具有特殊营养价值、对身体健康有益的食品。幸而有了牛乳这种天然卫生的、有益于健康的食物,因而乳品工业能较容易地和廉价地将它转变为高级优质的营养食品。作为牛乳副产品转化和保存之用... 详细信息

前言发酵或经过培养的乳制品为人类社会提供了具有特殊营养价值、对身体健康有益的食品。幸而有了牛乳这种天然卫生的、有益于健康的食物,因而乳品工业能较容易地和廉价地将它转变为高级优质的营养食品。作为牛乳副产品转化和保存之用的乳酸菌纯培养物中的微生物是极好的生物能量转

关键词：发酵乳制品销售量发酵剂凝块脱脂乳农家干酪稀奶油酸凝乳发酵酪乳人工酪乳

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Feeding Bacillus-based probiotics to gestating and lactating sows is an efficient method for improving immunity,gut functional status and biofilm formation by probiotic bacteria in piglets at weaning

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Animal Nutrition 2023年第2期13卷 361-372页

作者： PawełKonieczka Karolina Ferenc Jens NJørgensen Lea HBhansen Romuald Zabielski Jarosław Olszewski Zdzisław Gajewski Magdalena Mazur-Kusnirek Dominika szkopek Natalia szyrynska Krzysztof Lipinski Department of Poultry science University of Warmia and Mazury in OlsztynOlsztynPoland Department of Animal Nutrition The Kielanowski Institute of Animal Physiology and Nutrition Polish Academy of SciencesJabłonnaPoland Center for Translational Medicine Warsaw University of Life SciencesWarszawaPoland chr.hansen a/s Animal Health and NutritionHoersholmDenmark Department of Animal Nutrition and Feed science University of Warmia and Mazury in OlsztynOlsztynPoland Department of Histology and Embryology Faculty of Veterinary MedicineUniversity of Warmia and Mazury in OlsztynOlsztynPoland

The effects of dietary probiotic supplementation with viable Bacillus subtilis and Bacillus amyloliquefaciens spores on sow performance,immunity,gut functional status and biofilm formation by probiotic bacteria in piglets at weaning were ***-six sows reared in a continuous farrowing system for one full cycle were fed gestation diets during the first 90 d of pregnancy and lactation diets until the end of *** sows were fed a basal diet without probiotics(control;n=48)or a diet supplemented with viable spores(1.1×10^(9)CFU/kg of feed)(probiotic;n=48).At 7 d of age,sucking piglets(n=12/group)were provided prestarter creep feed until weaning at 28 d of *** piglets in the probiotic group were supplemented with the same probiotic and dosage as their *** and colostrum collected from sows and ileal tissues collected from piglets on the day of weaning were used for *** increased the weight of piglets(P=0.077),improved the weaning weight(P=0.039)and increased both the total creep feed consumption(P=0.027)and litter gain(P=0.011).Probiotics also improved the faecal score in the second(P=0.013)week of *** immunoglobulin G(IgG)concentrations in sow blood at farrowing and the IgM concentrations in piglet blood at weaning were higher in the probiotic group than in the control group(P=0.046).The piglets from the probiotic-treated sows showed a higher IgM concentration in the ileal mucosa(P=0.050)and a lower IgG concentration in the ileal mucosa(P=0.021)compared with the piglets from control *** probiotic-treated piglets had a thicker ileal mucosa(P=0.012)due to the presence of longer villi and larger Peyer's patches(Ps but not the control piglets;these bacteria were present in the digesta and villus structures and formed structures resembling ***,Bacillus-based probiotic supplementation improves the health indices of sows

关键词： Probiotic Gut function Immune status Biofilm Piglet sow

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乳酸菌在肉制品中的生物防腐作用

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中国食品工业 1998年第3期 28-29页

作者： Lone Anderson chr.hansen a/s公司

肉制品是人们喜爱的食物,并具备丰富的营养。它不但能补充人体所需,促进人体健康,亦是各种自然细菌滋长的良好基质,能提供理想的细菌繁殖和生长条件,导致产品易腐败,甚至使人生病。所以,肉制品的质量在很大程度上受细菌群落的种类影响;... 详细信息

肉制品是人们喜爱的食物,并具备丰富的营养。它不但能补充人体所需,促进人体健康,亦是各种自然细菌滋长的良好基质,能提供理想的细菌繁殖和生长条件,导致产品易腐败,甚至使人生病。所以,肉制品的质量在很大程度上受细菌群落的种类影响;至于肉制品中细菌群落的种类,则取决于原料肉的质量、加工过程中原料肉的处理方法,以及运输和贮存时的温度。在中国,目前经加工处理后出售的肉制品,只占肉类总产量的5～10％。

关键词：乳酸菌肉制品生物防腐

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提高商品生长-肥育猪日粮中生物可以用糖的含量

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国外畜牧学（猪与禽） 2016年第5期36卷 58-61页

作者：王晶晶张涛 Jack Egelund Madsen 丹麦chr.hansen a/s公司

在现代家畜管理中,饲料添加剂在动物营养上发挥着重要的作用。它们有助于改善饲料中营养物质的利用率,从而可提高动物的生产性能和盈利能力。饲料成本约占生猪生产总成本的70%。然而,饲料利用率并不理想。猪对饲料中15%-25%的成分不能... 详细信息

在现代家畜管理中,饲料添加剂在动物营养上发挥着重要的作用。它们有助于改善饲料中营养物质的利用率,从而可提高动物的生产性能和盈利能力。饲料成本约占生猪生产总成本的70%。然而,饲料利用率并不理想。猪对饲料中15%-25%的成分不能消化利用,

关键词：肥育猪饲料利用率生产总成本动物营养家畜管理饲料添加剂盈利能力生产性能营养物质消化率

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Bacillus sp. probiotic supplementation diminish the Escherichia coli F4ac infection in susceptible weaned pigs by influencing the intestinal immune response, intestinal microbiota and blood metabolomics

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Journal of Animal science and Biotechnology 2020年第1期11卷 95-110页

作者： Diana Luise Micol Bertocchi Vincenzo Motta Chiara salvarani Paolo Bosi Andrea Luppi Flaminia Fanelli Maurizio Mazzoni Ivonne Archetti Giuseppe Maiorano Bea K.K.Nielsen Paolo Trevisi Department of Agricultural and Food sciences University of BolognaViale G.Fanin 4640127 BolognaItaly Department of Agricultural Environmental and Food SciencesUniversity of MoliseVia F.De SanctisCampobassoItaly Istituto Zooprofilattico sperimentale della Lombardia e dell’Emilia Romagna Bruno Ubertini V.Bianchi 925124 BresciaItaly Endocrinology Unit and Center for Applied Biomedical Research Department of Medical and Surgical SciencesUniversity of Bologna–S.Orsola-Malpighi Hospitalvia Massarenti 940138 BolognaItaly Department of Veterinary Medical sciences University of BolognaVia.Tolara di Sopra 5040064 Ozzano EmiliaItaly chr.hansen a/s Boege Allé10-122970 HoersholmDenmark

Background:Probiosis is considered a potential strategy to reduce antibiotics use and prevent postweaning diarrhea(PWD).This study investigated the effect of Bacillus amyloliquefaciens DsM25840 or Bacillus subtilis DsM25841 supplementation on growth,health,immunity,intestinal functionality and microbial profile of post-weaning pigs after enterotoxigenic ***(ETEC)F4 ***:sixty-four post-weaning piglets(7748 g±643 g)were randomly al ocated to four groups:control basal diet(CO);CO+1.28×10~6 CFU/g of ***(BAA);CO+1.28×10~6 CFU/g feed of ***(BAs);CO+1 g colistin/kg of feed(AB).At day(d)7,animals were chal enged with 10~5 CFU/m L of ETEC F4 ac O149 and then fol owed for fecal score and performance until d *** was col ected at d 6,d 12 and d 21 for immunoglobulins,at d 8 for acute phase proteins,at d 8 and d 21 for metabolomics *** was sampled for morphometry,quantification of apoptosis,cel proliferation,neutral and acid mucine and Ig A secretory cel s,and microarray analysis at d *** and cecum contents were col ected for microbiota at d ***:AB and BAs reduced the fecal score impairment compared to CO(Ps groups and *** improved BW at d 7,d 14 and d 21,ADWG ADFI and G:F from d 0 to d 7(Psma arginine,lysine,ornithine,glycine,serine and threonine than other groups,and higher haptoglobin than AB(Ps apoptosis and mucins did not *** and AB increased the vil us mitotic *** profile of BAs and AB were more similar than *** sets related to adaptive immune response were enriched in BAA,BAs and *** had enriched gene set for nuclear structure and RNA *** had a trend of higher Enterobacteriaceae in cecum than the oth

关键词： Bacil us amyloliquefaciens Bacil us subtilis Diarrhea ETEC Gut microbiota Post-weaning Transcriptomics

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关注仔猪早期的生产性能对成功至关重要

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国外畜牧学（猪与禽） 2018年第10期38卷 21-24页

作者：高和坤(译) 柳丽(译) 王晶晶(校) 邵建忠(审) 靳文广(制图) 无江苏省连云港市农业科学院不详丹麦chr.hansen公司技术团队

母猪舍梦寐以求的目标是在不影响仔猪存活力的情况下最大限度地提高母猪的繁殖性能.养猪行业正在朝这个方向迈进,在过去的10年里,丹麦的高产母猪品种的窝产仔数增加到了18头左右。

关键词：生产性能仔猪早期繁殖性能窝产仔数母猪舍存活力猪品种

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IsLAND COTTAGE ON LAKE sUPERIOR

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Journal of Green Building 2014年第2期9卷 62-83页

作者： christine L.Albertsson Albertsson hansen Architecture Ltd.MinneapolisMN 55408

Built on Madeline Island in Lake superior in northwestern Wisconsin,this cottage is an experiment:an attempt to create the feeling of a modern-day settler’s *** built for the harsh climate of northern Wisconsin,the cottage appears lightly put *** this illusion of rudimentary shelter,one feels more closely connected to the project’s powerful natural *** owner and architect were intrigued with the possibility of performance combined with relaxed *** formed the conceptual framework for the creation of these little *** embody the values of efficiency and conservation,with a belief in simple amenities.

关键词： small space simple materials scale and proportion thermal envelope isothermal insulation solar panels aging-in-place

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Malaria epidemiology and stratification of incidence in the malaria elimination setting in Harari Region,Eastern Ethiopia

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Infectious Diseases of Poverty 2020年第6期9卷 102-103页

作者： Endashaw Esayas Asefa Tufa Fekadu Massebo Abdulhamid Ahemed Ibssa Ibrahim Dereje Dillu Eyuel Asemahegn Bogale solomon Yared Kebede Deribe 不详 Malaria and Neglected Tropical Diseases Research Directorate Armauer Hansen Research InstituteAddis AbabaEthiopia

Background: Ethiopia has shown notable progress in reducing the burden of malaria over the past two *** of this progress,the country has shifted efforts from control to elimination of *** study was conducted to analyse the malaria epidemiology and stratification of incidence in the malaria elimination setting in eastern ***:: A retrospective study was conducted to analyse the epidemiology of malaria by reviewing the district health office data from 2013 to 2019 in Harari *** addition,three years of sub-district level malaria data were used to stratify the malaria transmission *** interventions(Long-lasting insecticidal nets[LLIN]and indoor residual spraying[IRs])employed were reviewed to analyse the intervention coverage at the Regional *** statistics were used to show the malaria transmission in terms of years,season and species of the malaria *** rate per 1000 population and death rate per 1000000 population at risk were computed using the total population of each ***: In the Harari Region,malaria incidence showed a more pronounced declining trend from 2017 to *** falciparum,*** and mixed infections accounted for 69.2%,30.6%and 0.2%of the cases,*** was an increment in malaria intervention coverage and improved malaria *** the year 2019 the coverage of LLIN and IRs in the Region were 93.4%and 85.1%*** annual malaria incidence rate dropped from 42.9 cases per 1000 population in 2013 to 6.7 cases per 1000 population in ***-related deaths decreased from 4.7 deaths per 1000000 people annually in 2013 to zero,and there have been no deaths reported since *** malaria risk appears to be heterogeneous and varies between districts.A higher number of malaria cases were recorded in Erer and Jenella districts,which constitute 62%of the cases in the *** to the sub-district level malaria stratification,there wa

关键词： Malaria elimination Epidemiology Incidence Harari region Ethiopia Interventions sub-district stratification

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