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Primary rectal mucosa-associated lymphoid tissue lymphoma treated with only endoscopic submucosal dissection:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3362-3368页

作者： Wan-Sik Lee Myung-Giun Noh Young-Eun Joo Department of Internal Medicine Chonnam National University Medical SchoolHwasun-eup 58128South Korea Department of Pathology Chonnam National University Medical SchoolHwasun-eup 58128South Korea

BACKGROUND Mucosa-associated lymphoid tissue(MALT)lymphoma is a distinct subtype of non-Hodgkin B cell lymphoma that mostly involves the gastrointestinal *** stomach is the most commonly affected site whereas colorectal involvement occurs very *** its rarity,the management and clinical outcome of colorectal MALT lymphoma are not well established *** SUMMARY From the superficial capillary bed in the lower *** ultrasonography showed homogenous hypoechoic lesions in the deep mucosal *** submucosal dissection(ESD)was done for accurate histologic diagnosis and treatment and both the rectal lesions were completely removed en bloc and subsequently diagnosed as primary rectal MALT ***,we report a case of primary rectal MALT lymphoma in a 68-year-old woman that was treated by only ESD,and the 12-month follow-up revealed no tumour *** These results of our case and previous reports suggest that endoscopic resection alone may be a feasible and safe treatment for primary colorectal MALT lymphoma and allows organ preservation.

关键词： Rectum Mucosa-associated lymphoid tissue lymphoma Endoscopic submucosal dissection

Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites

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World Journal of Gastroenterology 2008年第24期14卷 3884-3890页

作者： Soong Lee Seung-Cheol Son Moon-Jong Han Woo-Jin Kim Soo-Hyun Kim Hye-Ran Kim Woo-Kyu Jeon Ki-Hong Park Myung-Geun Shin Department of Internal Medicine College of MedicineSeonam University and Seonam University Hospital Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National University Hwasun Hospital Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National University Medical School Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Korea Polymer Testing & Research Institute Ltd.

AIM： To determine intestinal permeability, the serum tumor necrosis factor （TNF）-α level and urine nitric oxide （NO） metabolites are altered in liver cirrhosis （LC） with or without ascites. METHODS： Fifty-three patients with LC and 26 healthy control subjects were enrolled in the study. The intestinal permeability value is expressed as the percentage of polyethylene glycol （PEG） 400 and 3350 retrieval in 8-h urine samples as determined by high performance liquid chromatography. Serum TNF-α concentrations and urine NO metabolites were determined using an enzyme-linked immunosorbent assay （ELISA） and Greiss reaction method, respectively. RESULTS： The intestinal permeability index wassignificantly higher in patients with LC with ascites than in healthy control subjects or patients with LC without ascites （0.88 ± 0.12 vs 0.52 ± 0.05 or 0.53 ± 0.03, P 〈 0.05） and correlated with urine nitrite excretion （r = 0.98）. Interestingly, the serum TNF-α concentration was significantly higher in LC without ascites than in control subjects or in LC with ascites （198.9 ± 55.8 pg/mL vs 40.9 ± 12.3 pg/mL or 32.1 ± 13.3 pg/mL, P 〈 0.05）. Urine nitrite excretion was significantly higher in LC with ascites than in the control subjects or in LC without ascites（ 1170.9± 28.7 μmol/L vs 903.1 ± 55.1 μmol/L or 956.7 ± 47.7 μmol/L, P 〈 0.05）. COMCLUSIOM： Increased intestinal macromolecular permeability and NO is probably of importance in the pathophysiology and progression of LC with ascites, but the serum TNF-α concentration was not related to LC with ascites.

关键词： Intestinal permeability Tumor necrosisfactor-R Nitric oxide Liver cirrhosis Ascites

Expanded natural killer cells augment the antimyeloma effect of daratumumab, bortezomib, and dexamethasone in a mouse model

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Cellular & Molecular Immunology 2021年第7期18卷 1652-1661页

作者： Jaya Lakshmi Thangaraj Seo-Yeon Ahn Sung-Hoon Jung Manh-Cuong Vo Tan-Huy Chu Minh-Trang Thi Phan Minsuk Kwon Kyung-Hwa Lee Mihee Kim Ga-Young Song Deok-Hwan Yang Jae-Sook Ahn Hyeoung-Joon Kim Duck Cho Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun Hospital and Chonnam National University Medical SchoolGwangjuKorea Department of Hematology-Oncology Chonnam National University Hwasun Hospital and Chonnam National University Medical SchoolGwangjuKorea Department of Molecular Medicine Chonnam National UniversityGwangjuKorea Stem Cell&Regenerative Medicine Institute Samsung Medical CenterSeoulKorea View author publications Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Pathology Chonnam National University Medical SchoolGwangjuKorea Department of Health Sciences and Technology SAIHSTSungkyunkwan UniversitySeoulKorea Department of Laboratory Medicine and Genetics Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea

The use of natural killer(NK)cells is a promising and safe immunotherapeutic approach in the field of cancer ***,combination treatments are required to enhance the effector functions and therapeutic efficacy of NK *** this study,we investigated the potential of daratumumab(Dara),bortezomib,and dexamethasone(Dvd)to augment the antitumor effects of NK cells in a multiple myeloma(MM)xenograft mouse *** cells were expanded and activated using the K562-OX40 ligand and membrane-bound IL-18 and IL-21 in the presence of IL-2 and IL-15 from peripheral blood mononuclear cells from MM patients.A human MM xenograft model was established using human RPMI8226-RFP-FLuc cells in NOD/SCID IL-2Rγnull(NSG)***-bearing mice were divided into six treatment groups:no treatment,expanded NK cells(eNKs),Dara,Dara+eNKs,Dvd,and Dvd+*** treatment strongly enhanced the cytotoxicity of eNKs by upregulating expression of NK cell activation ligands,downregulating expression of NK cell inhibitory ligands,and promoting antibody-dependent cellular *** combination of eNKs with Dvd significantly prolonged mouse survival and reduced the tumor burden and serum M-protein ***,Dvd pretreatment significantly increased eNK persistence and homing to MM *** findings suggest that Dvd treatment potentiates the antimyeloma effects of NK cells expanded and activated ex vivo by modulating immune responses in MM-bearing mice.

关键词： Multiple myeloma Natural killer cell Chemotherapy

Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists

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Cellular & Molecular Immunology 2011年第4期8卷 341-347页

作者： Thanh-Nhan Nguyen-Pham Mi-Seon Lim Truc Anh Thi Nguyen Youn-Kyung Lee Chun-Ji Jin Hyun Ju Lee Cheol Yi Hong Jae-Sook Ahn Deok-Hwan Yang Yeo-Kyeoung Kim Ik-Joo Chung Byoung Chul Park Hyeoung-Joon Kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National UniversityGwangjuKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea Vaxcell-Bio Therapeutics JeollanamdoKorea Korea Research Institute of Bioscience and Biotechnology(KRIBB) DaejeonKorea

The major limitation for the maturation of dendritic cells(DCs)using Toll-like receptor(TLR)agonists is their decreased ability to migrate into lymph nodes compared with conventional ***38 can be used as a multifunctional marker to modulate migration,survival and Th1 responses of ***74 has been shown to negatively regulate DC *** goal of this study was to investigate the combinations of TLR agonists and interferons(IFNs)that most effectively regulate CD38 and CD74 expression on *** TLR agonist stimulation in combination with IFN-a and IFN-c was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of *** in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability,similar to that observed in cells expressing CD38,CD74 and *** results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production.

关键词： CD38 CD74 dendritic cells interferon Toll-like receptor

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World Journal of Clinical Cases 2020年第21期8卷 5341-5346页

作者： Eun-A Jang Tae-Young Kim Eu-Gene Jung Seongtae Jeong Hong-Beom Bae Seongheon Lee Department of Anesthesiology and Pain Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469South Korea

BACKGROUND Donepezil is an acetylcholinesterase inhibitor used to improve cognition and delay disease progression in dementia patients by increasing acetylcholine *** drug may potentially interact with neuromuscular blocking agents(NMBAs)that act on muscular acetylcholine receptors during general ***,we present a case of inadequate neuromuscular blockade with rocuronium,a nondepolarizing NMBA,in a dementia patient who had taken *** SUMMARY A 71-year-old man was scheduled for laparoscopic *** had been taking donepezil 5 mg for *** anesthesia was induced with propofol and *** depth of neuromuscular blockade was monitored by train-of-four(TOF)*** the administration of rocuronium,the TOF ratio decreased at an unusually slow rate,and a TOF count of 0 was detected 7 min *** intubation,a TOF count of 1 was detected within 1 min,and a TOF ratio of 12%was detected within 2 *** TOF count remained at 4 even with an additional bolus and continuous infusion of rocuronium,suggesting resistance to this *** of propofol,an inhalation anesthetic was administered alongside another NMBA(cisatracurium).Then,the quality of neuromuscular blockade improved,and the TOF count remained at 0-1 for the next 70 *** further problems were encountered with respect to surgery or *** Donepezil may be responsible for inadequate neuromuscular blockade during anesthesia,especially when total intravenous anesthesia is used.

关键词： Donepezil Dementia General anesthesia Rocuronium Neuromuscular blocking agents Case report

Septic shock due to Granulicatella adiacens after endoscopic ultrasound-guided biopsy of a splenic mass:A case report

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World Journal of Gastroenterology 2021年第8期27卷 751-759页

作者： Seo-Yeon Cho Eunae Cho Chang-Hwan Park Hee-Joon Kim Joo-Yeon Koo Division of Gastroenterology Department of Internal MedicineChonnam National University HospitalGwangju 61469South Korea Department of Surgery Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Endoscopic ultrasound-guided fine needle aspiration or biopsy(EUS-FNA or FNB)has become a popular method for diagnosing various lesions of the gastrointestinal tract and surrounding tissue due to the accuracy and *** the best of our knowledge,no case report of severe infection after EUS-FNB of a solid lesion in the spleen has been ***,we report a rare case of septic shock after EUS-FNB of a splenic *** SUMMARY A 45-year-old male patient presented to the outpatient clinic due to an incidentally detected splenic mass.A definitive diagnosis could not be established based on the abdominal magnetic resonance *** of the spleen showed a 6 cm-sized,relatively well-demarcated,heterogeneous mass,and EUS-FNB with a 22G needle was *** days after the procedure patient developed septic shock and a splenic abscess was *** culture revealed growth of Granulicatella *** the treatment with antibiotics the patient underwent surgical resection,and the pathological examination showed diffuse large B-cell *** patient received chemotherapy and he is in complete *** Infection of a splenic mass after EUS-FNB is a rare complication and prophylactic antibiotics might be considered.

关键词： Endoscopic ultrasound Endoscopic ultrasound-guided fine needle biopsy Splenic neoplasms Lymphoma Septic shock Case report

Different intraoperative decisions for undiagnosed paraganglioma:Two case reports

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World Journal of Clinical Cases 2022年第30期10卷 11059-11065页

作者： Dongho Kang Bo-eun Kim Minjae Hong Joungmin Kim Seongtae Jeong Seongheon Lee Department of Anesthesiology and Pain Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469South Korea

BACKGROUND Paragangliomas may be preoperatively misdiagnosed as non-functioning retroperitoneal tumors and are sometimes suspected only at the time of intraoperative *** preoperative alpha blockade preparation,a hypertensive crisis during tumor manipulation and hypotension after tumor removal may result in critical ***,primary consideration should be given to the continuation or discontinuation of surgery on the basis of the possibility of gentle surgical manipulation and hemodynamic *** report two cases of paragangliomas detected *** SUMMARY A 65-year-woman underwent laparoscopic small-bowel wedge resection.A hypertensive crisis occurred during manipulation of the mass,and an unrecognized catecholamine-producing paraganglioma was *** surgeon and anesthesiologists believed that tumor excision could be performed with minimal manipulation of the tumor because the tumor was in a favorable *** hemodynamic instability did not occur with aggressive use of vasoactive drugs.A week later,a 54-year-man underwent open resection of a 3-cm-sized retroperitoneal mass and showed the same findings during mass *** this patient,continuous manipulation of the mass seemed inevitable due to adhesion between the right adrenal gland and the mass in a narrow surgical *** surgeon and anesthesiologists decided to cancel the surgical procedure and planned to perform a reoperation after alpha blockade *** weeks later,the tumor was uneventfully removed with small doses of vasoactive *** When an undiagnosed paraganglioma is suspected intraoperatively,reoperation after adequate preparation should be considered as an option to avoid fatal outcomes.

关键词： Paraganglioma Undiagnosed diseases Hypertensive crisis Preoperative alpha blockade Surgery cancellation Neuroendocrine tumors Case report

The EPHX1 rs1051740 Polymorphism Is Associated with Childhood Acute Lymphoblastic Leukemia in a Korean Population

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Advances in Bioscience and Biotechnology 2014年第7期5卷 678-684页

作者： Hee Nam Kim Nan Young Kim Li Yu Il-Kwon Lee Min-Ho Shin Hee Jo Baek Hoon Kook Hyeoung-Joon Kim Center for Creative Biomedical Scientists Chonnam National University Gwangju Korea Department of Hematology/Oncology Chonnam National University Hwasun Hospital Hwasun Korea Environmental Health Center for Childhood Leukemia and Cancer Chonnam National University Hwasun Hospital Hwasun Korea

Microsomal epoxide hydrolase (EPHX1) is involved in the activation and detoxification of exogenous chemicals. Genetic polymorphisms in EPHX1 have been associated with the development of leukemia. To investigate an association between single-nucleotide polymorphisms (SNPs) of EPHX1 and risk factors for childhood acute lymphoblastic leukemia (ALL) in Korean children, we genotyped two SNPs, Tyr113His (rs1051740) and His139Arg (rs2234922) in 185 childhood ALL cases and 536 healthy controls. Genotyping for these two SNPs was performed by simplex pyrosequencing assay and high-resolution melt analysis, respectively. We found that the Tyr113His genotype was associated with a decreased risk of childhood ALL (odds ratio, OR = 0.64, 95% confidence interval, CI = 0.43 - 0.93;p = 0.02). There was no association between His139Arg and the combined genotypes and the risk of childhood ALL. These results suggest that the EPHX1 113TyrHis genotype may protect against leukemogenesis in childhood.

关键词： EPHX1 Polymorphism Association Childhood ALL

Transplantation of human adipose tissue-derived stem cells for repair of injured spiral ganglion neurons in deaf guinea pigs

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Neural Regeneration Research 2016年第6期11卷 994-1000页

作者： Sujeong Jang Hyong-Ho Cho Song-Hee Kim Kyung-Hwa Lee Yong-Bum Cho Jong-Seong Park Han-Seong Jeong Department of Physiology Chonnam National University Medical School Department of Otolaryngology Chonnam National University Medical School Department of Pathology Chonnam National University Medical School

Excessive noise, ototoxic drugs, infections, autoimmune diseases, and aging can cause loss of spiral ganglion neurons, leading to permanent sensorineural hearing loss in mammals. Stem cells have been confirmed to be able to differentiate into spiral ganglion neurons. Little has been reported on adipose tissue-derived stem cells（ADSCs） for repair of injured spiral ganglion neurons. In this study, we hypothesized that transplantation of neural induced-human ADSCs（NI-h ADSCs） can repair the injured spiral ganglion neurons in guinea pigs with neomycin-induced sensorineural hearing loss. NI-h ADSCs were induced with culture medium containing basic fibroblast growth factor and forskolin and then injected to the injured cochleae. Guinea pigs that received injection of Hanks＇ balanced salt solution into the cochleae were used as controls. Hematoxylin-eosin staining showed that at 8 weeks after cell transplantation, the number of surviving spiral ganglion neurons in the cell transplantation group was significantly increased than that in the control group. Also at 8 weeks after cell transplantation, immunohistochemical staining showed that a greater number of NI-h ADSCs in the spiral ganglions were detected in the cell transplantation group than in the control group, and these NI-h ADSCs expressed neuronal markers neurofilament protein and microtubule-associated protein 2. Within 8 weeks after cell transplantation, the guinea pigs in the cell transplantation group had a gradually decreased auditory brainstem response threshold, while those in the control group had almost no response to 80 d B of clicks or pure tone burst. These findings suggest that a large amount of NI-h ADSCs migrated to the spiral ganglions, survived for a period of time, repaired the injured spiral ganglion cells, and thereby contributed to the recovery of sensorineural hearing loss in guinea pigs.

关键词： guinea ganglion repair hearing adipose injured brainstem auditory neuronal cochlear