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Meta-analysis of the efficacy and safety of sodium fusidate ointment and mupirocin ointment in the treatment of bacteria-infected skin disease

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TMR Clinical Research 2020年第2期3卷 53-62页

作者： Yuan Qin Qian Yi Department of Neurology Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China

Objective:To evaluate the efficacy and safety of sodium fusidate ointment and mupirocin ointment in the treatment of bacteria-infected skin ***:The search terms“sodium fusidate ointment”,“mupirocin ointment”,“bacterial infection”,*** searched in the database of PubMed,EMbase,Cochrane,Web of Science,Wanfang,VIP,and *** search time was from inception to November *** controlled trials of sodium fusidate ointment and mupirocin ointment for the treatment of bacteria-infected skin disease were *** studies independently performed literature screening,data extraction,and literature quality *** analysis was performed using RevMan 5.3 ***:A total of 14 literature were included,involving 1,825 patients,916 in the experimental group,and 909 in the control *** analysis results showed that the total clinical effective rate of the experimental group(RR=1.12,95%CI(1.06,1.19),P<0.0001),degree of improvement in pruritus score(MD=−1.21,95%CI(−1.78,−0.64),P<0.0001),degree of improvement of eczema area and severity index score(MD=−2.47,95%CI(−3.92,−1.02),P=0.0008),and sensitivity rate of drug sensitivity test(RR=1.35,95%CI(1.24,1.46),P<0.00001)were better than those of control *** incidence of adverse reactions(RR=0.18,95%CI(0.09,0.39),P<0.00001)was significantly smaller than that of control *** the bacterial clearance rate(RR=1.22,95%CI(0.98,1.52),P=0.08)compared with the control group,the difference was not statistically ***:Sodium fusidate ointment is better than mupirocin ointment in the treatment of bacteria-infected skin disease,and it helps to improve the severity of disease and itching,and has good safety,which is worthy of clinical promotion.

关键词： Sodium fusidate ointment Mupirocin ointment Bacterial infection Meta analysis

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Correction to:NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3967-3968页

作者： Tengfei Fan Xiaoning Wang Sheng Zhang Ping Deng Yi Jiang Yidan Liang Sheng Jie Qing Wang Chuwen Li Guocai Tian Zhen Zhang Zhenhu Ren Bo Li Yanrong Chen Zhijing He Yan Luo Mingliang Chen Hanjiang Wu Zhengping Yu Huifeng Pi Zhou Zhou Zhiyuan Zhang Shanghai Ninth People’s hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical Sciences Department of Oral and Maxillofacial-Head Neck Oncology Shanghai China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293) Zhang Zhiyuan Academician Workstation Hainan Western Central Hospital Shanghai Ninth People’s Hospital Department of Oral and Maxillofacial Surgery Danzhou China (GRID:grid.412523.3) (ISNI:0000 0004 0386 9086) The Second Xiangya hospital of Central South university Department of Oral and Maxillofacial Surgery Changsha China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208) Shanghai Ninth People’s hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical Sciences Department of Oral and Maxillofacial-Head Neck Oncology Shanghai China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293) Shanghai Ninth People’s hospital Shanghai Jiao Tong University School of Medicine Department of Oral Pathology Shanghai China (GRID:grid.16821.3c) (ISNI:0000 0004 0368 8293) The Second Xiangya hospital of Central South university Department of Oral and Maxillofacial Surgery Changsha China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208) Third Military Medical university Department of Occupational Health Chongqing China (GRID:grid.410570.7) (ISNI:0000 0004 1760 6682) The Second Xiangya hospital of Central South university Department of Pathology Changsha China (GRID:grid.452708.c) (ISNI:0000 0004 1803 0208) Guangxi university School of Medicine Nanning China (GRID:grid.256609.e) (I

In the process of checking the raw data1,the authors noticed several inadvertent mistakes occurring in Fig.5a,b,c,d,f that need to be corrected after online publication of the *** the preparation of Fig.5,the representative image showing TFE3 overexpression antagonized the NUPR1 KD-induced inhibition of OSCC cell proliferation and metastasis,were pasted and placed by *** correct results should be as shown *** authors apologize for these oversights and declare that these corrections do not affect the description,interpretation,or conclusions detailed in the original manuscript.

关键词： metastasis correction paste

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Missed diagnosis of early gastric cancer or high-grade intraepithelial neoplasia

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World Journal of Gastroenterology 2013年第13期19卷 2092-2096页

作者： Wei Ren Jin Yu Zhi-Mei Zhang Yuan-Kun Song Yi-Hui Li Lei Wang Department of Gastroenterology Xin Qiao HospitalThe Third Military Medical University

AIM: To investigate the causes of missed diagnosis of early gastric cancer (EGC) or high-grade intraepithelial neoplasia (HGIN) in chongqing, China. METHODS: The present study summarizes 103 cases of EGC/HGIN detected by esophagogastroduodenos-copy (EGD) and pathological analysis from January 2010 to December 2011. Dimethyl silicone oil was administrated orally 15 min before the EGD procedures. The stomach was cleaned by repeated washing with saline when the gastroscope entered the stomach cavity. Suspected EGC lesions were subject to conventional biopsy sampling and pathological examinations. The correlation between lesion locations, endoscopic morphology of cancerous sites, training level of the examiners, pathological biopsies, and missed diagnosis was analyzed. RESULTS: Twenty-three cases were missed among the 103 cases (22.23%) of EGC/HGIN. The rate of missed EGC in the gastroesophageal junction (8/19, 42.1%) was significantly higher than at other sites (15/84, 17.86%) (χ2 = 5.253, P = 0.022). In contrast, the rate of missed EGC in the lower stomach body (2/14, 14.29%) was lower than at other sites (21/89,23.6%), but there were no significant differences (χ2 = 0.289, P = 0.591). The rate of missed EGC in the gastric antrum (5/33, 15.15%) was lower than at other sites (18/70, 25.71%), but there were no significant differences (χ2 = 1.443, P = 0.230). Endoscopists from less prestigious hospitals were more prone to not diagnosing EGC than those from more prestigious hospitals (χ2 = 4.261, P = 0.039). When the number of biopsies was 4 biopsies (3/23, 13.04%) (P < 0.001). In addition, there was no significant difference in the rate of missed diagnosis in patients with 1-3 biopsy specimens (χ2 = 0.141, P = 0.932). CONCLUSION: Endoscopists should have a clear understanding of the anatomical characteristics of the esophagus/stomach, and endoscopic identification of early lesions inc

关键词： Missed diagnosis Early gastric cancer High-grade intraepithelial neoplasia Endoscopic diagnosis Biopsies

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Neuron-glial antigen 2 overexpression in hepatocellular carcinoma predicts poor prognosis

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World Journal of Gastroenterology 2015年第21期21卷 6649-6659页

作者： Le-Le Lu Jing Sun Jie-Juan Lai Yan Jiang Lian-Hua Bai Lei-Da Zhang Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University

AIM:To investigate whether neuron-glial antigen 2(NG2) could be an effective prognostic marker in hepatocellular carcinoma(HCC).METHODS:NG2 expression was semi-quantitatively scored from the immunohistochemistry(IHC) data based on the number of positive cells and the staining intensity.A total of 132 HCC specimens and 96 adjacent noncancerous tissue samples were analyzed by IHC for NG2 protein *** confirm the NG2 expression levels observed by IHC,we measured NG2 expression in 30 randomly selected tumor and adjacent noncancerous tissue samples by quantitative real-time polymerase chain reaction and Western *** correlations between NG2 protein expression and the clinicopathological features of HCC patients were analyzed using the χ2 *** assess the prognostic value of NG2 for HCC,the association between NG2 expression and survival was analyzed using the KaplanMeier method with the log-rank *** further evaluate the prognostic value of NG2 expression,a Cox multivariate proportional hazards regression analysis was performed with all the variables to derive risk estimates related to disease-free and overall survival and to control for ***:High NG2 expression was observed in significantly more primary tumor samples(63.6%; 84/132) compared with the adjacent noncancerous tissue samples(28.1%; 27/96)(P < 0.0001).Moreover,high NG2 protein expression was closely associated with tumor differentiation(χ2 = 9.436,P = 0.0089),recurrence(χ2 = 5.769,P = 0.0163),tumor-nodemetastasis(TNM) stage(χ2 = 8.976,P = 0.0027),and invasion(χ2 = 5.476,P = 0.0193).However,no significant relationship was observed between NG2 protein expression in HCC and other parameters,such as age,sex,tumor size,serum alpha fetoprotein(AFP),tumor number,or tumor *** log-rank test indicated a significant difference in the overall survival of HCC patients with high NG2 expression compared with those with low NG2 expression(29.2% vs 9.5%,P < 0.001).Moreover,NG2 expressio

关键词： Neuron-glial antigen 2 Hepatocellularcarcinoma Survival analysis Poor prognosis Prognosticmarker

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three gorges Dam: friend or foe of riverine greenhouse gases?

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National Science Review 2022年第6期9卷 81-89页

作者： Jinren Ni Haizhen Wang Tao Ma Rong Huang Philippe Ciais Zhe Li Yao Yue Jinfeng Chen Bin Li Yuchun Wang Maosheng Zheng Ting Wang Alistair G.L.Borthwick Key Laboratory for Water and Sediment Sciences Ministry of Education College of Environmental Sciences and Engineering Peking University State Environmental Protection Key Laboratory of All Materials Fluxes in River Ecosystems Ministry of Ecology and Environment Laboratoire des Sciences du Climat et de l'Environnement Institut Pierre Simon LaplaceCommissariat à l' énergie Atomique et aux énergies AlternativesCNRS Université de Versailles Saint-Quentinen-Yvelines Key Laboratory of Reservoir Environment Chongqing Institute of Green and Intelligent TechnologyChinese Academy of Sciences State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Department of Water Environment China Institute of Water Resources and Hydropower Research MOE Key Laboratory of Regional Energy Systems Optimization Resources and Environmental Research AcademyNorth China Electric Power University School of Engineering The University of Edinburgh

Dams are often regarded as greenhouse gas(GHG) emitters. However, our study indicated that the world’s largest dam, the three gorges Dam(TGD), has caused significant drops in annual average emissions of CO2, CH4and N2O over 4300 km along the Yangtze River, accompanied by remarkable reductions in the annual export of CO2(79%), CH4(50%) and N2O(9%) to the sea. Since the commencement of its operation in 2003, the TGD has altered the carbonate equilibrium in the reservoir area, enhanced methanogenesis in the upstream, and restrained methanogenesis and denitrification via modifying anoxic habitats through long-distance scouring in the downstream. These findings suggest that ‘large-dam effects’ are far beyond our previous understanding spatiotemporally, which highlights the fundamental importance of whole-system budgeting of GHGs under the profound impacts of huge dams.

关键词： three gorges Dam greenhouse gas spatiotemporal variation equilibrium Yangtze River whole system analysis

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How to improve the COVID-19 health education strategy in impoverished regions:a pilot study

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Infectious Diseases of Poverty 2022年第2期11卷 90-91页

作者： Huimin Wang Rujun Liao Xin Chen Jie Yu Tianyu Zhu Qiang Liao Tao Zhang Department of Epidemiology and Health Statistics West China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuanChina 不详 Liangshan Prefecture Center for Disease Control and Prevention XichangSichuanChina

Background:It is of great challenge to raise the public coronavirus disease 2019(COVID-19)related health literacy(CRHL)in impoverished regions due to the limits of poor infrastructure,large proportion of vulnerable groups,***,those limits cannot be solved in the short ***,this study chose Liangshan Yi Autonomous Prefecture,one of the poorest areas in China,as a pilot,to reveal the quantitative relationships among diferent dimensions under the COVID-19 health education framework,clarify the key points for health promotion,and provide specifc suggestions for COVID-19 health education strategy in impoverished ***:A cross-sectional questionnaire survey was conducted in fve regions of Liangshan Yi Autonomous Prefecture in *** were 2,100 individuals sampled by multi-stage *** survey mainly measured the four dimensions:CRHL,COVID-19 related tense psychological reactions(CRTPR),COVID-19 related information report acquisition(CRIRA),and general health literacy(GHL).The multivariate logistic regression was used to explore the infuence of demographic characteristics on each ***,to quantify the relationships among different dimensions,this study employed the structural equation model(SEM),and analyzed the mediating efects of CRHL and CRIRA as well as the moderating efects of regional characteristic ***:The CRHL played an important role in promoting COVID-19 health education,reaching 52.5%in Liangshan Yi Autonomous *** GHL(β=0.336)and age(β=0.136)had statistically positive impacts on *** CRHL afected CRTPR negatively(β=−0.198)and CRIRA positively(β=0.052).The CRHL played signifcant mediating roles among the four dimensions(P<0.05).Efectiveness of government prevention and control as well as the ethnicity moderated not only the relationships between CRHL and other dimensions,but also the mediating efect of CRHL(P<0.05).People with lower income and education levels had lower GHL(β=0.286,1

关键词： COVID-19 Health education strategy Impoverished region Health literacy Structural equation model Mediating efect Moderating efect

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Studies on the antinociception effect of melatonin and its mechanism in the rat

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中国药理通讯 2005年第4期22卷 52-52页

作者： Li Shu - hui Hu De - yao Li Xiao - hui Wang Zheng - guo Research Institute of Surgery Daping Hospital Third Military Medical University Chongqing 400042 People＇s Republic of China Faculty of Basic Medicine Third Military Medical University Chongqing 40003

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Study on biocompatibility of PDLLA/HA/DBM with co-cultured human osteoblasts in vitro

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Journal of Medical Colleges of PLA(China) 2003年第5期18卷 277-282页

作者：郭乔楠赵建华卢佳友 Institute of Pathology Southwest HospitalThird Military Medical UniversityChongqing 400038China Department of Orthopaedics Daping HospitalThird Military Medical UniversityChongqing 400042China Institute of Pathology Southwest HospitalThird Military Medical UniversityChongqing 400038Chinabjective: To evaluate the osteocompatibility of D L-polylactic/hydroxyapatite/decalcifying bone matrix (PDLLA/HA/DBM) and compare with PDLLA and DBM. Methods: Human primary osteoblasts isolated from the femoral head of patients were inoculated onto PDLLA/HA/DBM PLA and DBM respectively. The proliferation rate and collagen Ⅰexpression were detected. The interface between biomaterial and osteoblasts was investigated with phase contrast microscopy and electron scanning microscopy. Results: Best proliferation rate was observed with the PDLLA/HA/DBM and followed by DBM and PLA suggesting that PDLLA/HA/DBM satisfying most requirements for the cultivation of human osteoblasts. Scanning electron microscopy showed the morphology of osteoblasts was correlated with the proliferation data. The cells well spread and flattened were attached closely on the surface of biomaterial with an arched structure and had normal morphology. The extracellular collagenous matrixs covered the surface of biomaterial and packed the granules of biomaterial. Conclusion: PDLLA/HA/DBM can form osteointerface early and have a good biocompability.

Objective: To evaluate the osteocompatibility of D, L-polylactic/hydroxyapatite/decalcifying bone matrix (PDLLA/HA/DBM), and compare with PDLLA and DBM. Methods: Human primary osteoblasts isolated from the femoral head of patients were inoculated onto PDLLA/HA/DBM, PLA and DBM respectively. The proliferation rate and collagen Ⅰ expression were detected. The interface between biomaterial and osteoblasts was investigated with phase contrast microscopy and electron scanning microscopy. Results: Best proliferation rate was observed with the PDLLA/HA/DBM and followed by DBM and PLA, suggesting that PDLLA/HA/DBM satisfying most requirements for the cultivation of human osteoblasts. Scanning electron microscopy showed the morphology of osteoblasts was correlated with the proliferation data. The cells, well spread and flattened, were attached closely on the surface of biomaterial with an arched structure and had normal morphology. The extracellular collagenous matrixs covered the surface of biomaterial and packed the granules of biomaterial. Conclusion: PDLLA/HA/DBM can form osteointerface early and have a good biocompability.

关键词： biomaterial osteoblasts biocompatibility cell culture D, L-polylactic/hydroxyapatite/decalcifying bone matrix(PDLLA/HA/DBM)

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Research on clinical application of manual therapy to tumor-related adverse reactions

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Journal of Acupuncture and Tuina Science 2022年第4期20卷 321-328页

作者： YAO Chongjie LU Zhizhen ZHANG Shuaipan KONG Lingjun ZHU Qingguang CHENG Yanbin FANG Min ZHANG Kaiwei Yueyang hospital of Integrated Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Tuina Shanghai Academy of Traditional Chinese MedicineShanghai 200437China College of Acupuncture-moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai 201203China 不详

Objective To analyze the clinical application of manual therapy(MT)to tumor-related adverse reactions via summarizing the research at home and abroad,in order to provide more theoretical evidence for the clinical promotion of *** We searched 7 Chinese and English databases,including China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),chongqing VIP Database(CQVIP),PubMed,Excerpta Medica Database(EMBASE),Ovid and *** publication date was between the establishment date of the database and December 31,*** screened the literature according to the inclusion and exclusion criteria,and then sorted and analyzed the selected *** A total of 46 papers were *** studies focused on the adverse reactions in breast cancer *** interventions demonstrated the best efficacy for fatigue,followed by pain,depression and *** different MT interventions,Tuina(Chinese therapeutic massage)was mainly adopted for fatigue,pain,anxiety,depression,and limb *** pressing was mainly adopted for gastrointestinal and psychological problems such as abdominal bloating,insomnia,depression and *** application of reflexotherapy was similar to that of *** MT can alleviate various adverse reactions by effectively relieving patients’somatic symptoms and improving their psychological states and overall *** can be popularized as a significant non-drug ***,however,the clinical application of MT is neither extensive nor has sufficient basic ***,we should attach importance to this application.

关键词： Manual Therapies Tuina Massage Acupoint Pressure Therapy Reflexotherapy Tumor Adverse Reaction Literature

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多媒体式用药宣教在小儿呼吸科住院患者的应用

多媒体式用药宣教在小儿呼吸科住院患者的应用

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第二十九届全国儿科药学学术年会暨第十届全国儿科药学中青年药师论文报告会

作者：周艳赵智华 HUANG Ying JIA Yun-tao GU Rong 重庆医科大学附属儿童医院药学部重庆医科大学附属儿童医院呼吸科 Department of Respiration Children’s Hospital of Chongqing Medical University Dept.of Pharmacy Children’s Hospital of Chongqing Medical University

目的:掌握儿科呼吸系统常见疾病及常用药物的作用机制、作用特点及用药监护要点,药师向住院患儿家长做用药宣教,提高患者用药正确率。方法:每周药师对呼吸科住院患者集中授课,以幻灯片讲解的形式进行用药宣教,家属于宣教前后分别填写《... 详细信息

目的:掌握儿科呼吸系统常见疾病及常用药物的作用机制、作用特点及用药监护要点,药师向住院患儿家长做用药宣教,提高患者用药正确率。方法:每周药师对呼吸科住院患者集中授课,以幻灯片讲解的形式进行用药宣教,家属于宣教前后分别填写《呼吸科常用药物宣教认知考核表》,并收集及回答家属的用药疑问。结果:共收集有效答卷364份,宣教提高率为25.7%,通过药师的用药宣教,家长基本可以掌握常用药物的药理作用及使用方法

关键词：药师儿科呼吸科宣教

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