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A Novel Poly(3-hexylthiophene) Engineered Interface for Electrochemical Monitoring of Ascorbic Acid During the Occurrence of Glutamate-Induced Brain Cytotoxic Edemas

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Research 2024年第1期2023卷 301-313页

作者： Zexuan Meng Yuchan Zhang Lu Yang Shuang Zhao Qiang Zhou Jiajia Chen Jiuxi Sui Jian Wang Lizhong Guo Luyue Chang Jialing He Guixue Wang Guangchao Zang Institute of Life Science and Laboratory of Tissue and Cell BiologyLab Teaching and Management CenterChongqing Medical UniversityChongqing 400016China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing 400030China Jinfeng Laboratory Chongqing 401329China Department of Pathophysiology Chongqing Medical UniversityChongqingChina

Although neuroelectrochemical sensing technology offers unique benefits for neuroscience research,its application is limited by substantial interference in complex brain environments while ensuring biosafety *** this study,we introduced poly(3-hexylthiophene)(P3HT)and nitrogen-doped multiwalled carbon nanotubes(N-MWCNTs)to construct a composite membrane-modified carbon fiber microelectrode(CFME/P3HT-N-MWCNTs)for ascorbic acid(AA)*** microelectrode presented good linearity,selectivity,stability,antifouling,and biocompatibility and exhibited great performance for application in neuroelectrochemical ***,we applied CFME/P3HT-N-MWCNTs to monitor AA release from in vitro nerve cells,ex vivo brain slices,and in vivo living rat brains and determined that glutamate can induce cell edema and AA *** also found that glutamate activated the N-methyl-d-aspartic acid receptor,which enhanced Na^(+) and Cl^(−) inflow to induce osmotic stress,resulting in cytotoxic edema and ultimately AA *** study is the first to observe the process of glutamate-induced brain cytotoxic edema with AA release and to reveal the *** work can benefit the application of P3HT in in vivo implant microelectrode construction to monitor neurochemicals,understand the molecular basis of nervous system diseases,and discover certain biomarkers of brain diseases.

关键词： release microelectrode Engine

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Physics-informed optimization for a data-driven approach in landslide susceptibility evaluation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3192-3205页

作者： Songlin Liu Luqi Wang Wengang Zhang Weixin Sun Yunhao Wang Jianping Liu School of Civil Engineering Chongqing UniversityChongqing400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityMinistry of EducationChongqing400045China National Joint Engineering Research center of Geohazards Prevention in the Reservoir Areas Chongqing UniversityChongqing400045China chongqing Field Scientific Observation Station for Landslide Hazards in Three Gorges Reservoir Area Chongqing UniversityChongqing400045China chongqing Mingfeng Construction Engineering Co. LtdChongqing405800China

Landslide susceptibility mapping is an integral part of geological hazard ***,the emphasis of many studies has been on data-driven models,notably those derived from machine learning,owing to their aptitude for tackling complex non-linear ***,the prevailing models often disregard qualitative research,leading to limited interpretability and mistakes in extracting negative samples,*** non-landslide *** this study,Scoops 3D(a three-dimensional slope stability analysis tool)was utilized to conduct a qualitative assessment of slope stability in the Yunyang section of the Three Gorges Reservoir *** depth of the bedrock was predicted utilizing a Convolutional Neural Network(CNN),incorporating local boreholes and building on the insights from prior *** Random Forest(RF)algorithm was subsequently used to execute a data-driven landslide susceptibility *** proposed methodology demonstrated a notable increase of 29.25%in the evaluation metric,the area under the receiver operating characteristic curve(ROC-AUC),outperforming the prevailing benchmark ***,the landslide susceptibility map generated by the proposed model demonstrated superior *** result not only validates the effectiveness of amalgamating mathematical and mechanistic insights for such analyses,but it also carries substantial academic and practical implications.

关键词： Physics-informed Machine learning Bedrock depth Scoops 3D Landslide susceptibility

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Accelerated design of high-performance Mg-Mn-based magnesium alloys based on novel bayesian optimization

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Journal of Magnesium and Alloys 2024年第2期12卷 750-766页

作者： Xiaoxi Mi Lili Dai Xuerui Jing Jia She Bjørn Holmedal Aitao Tang Fusheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Southwest Technology and Engineering Research Institute Chongqing 400039China National Engineering Research center for Magnesium Alloys Chongqing UniversityChongqing 400044China Department of Materials Science and Engineering Norwegian University of Science and Technology(NTNU)Trondheim 7051Norway

Magnesium(Mg),being the lightest structural metal,holds immense potential for widespread applications in various *** development of high-performance and cost-effective Mg alloys is crucial to further advancing their commercial *** the rapid advancement of machine learning(ML)technology in recent years,the“data-driven''approach for alloy design has provided new perspectives and opportunities for enhancing the performance of Mg *** paper introduces a novel regression-based Bayesian optimization active learning model(RBOALM)for the development of high-performance Mg-Mn-based wrought *** employs active learning to automatically explore optimal alloy compositions and process parameters within predefined ranges,facilitating the discovery of superior alloy *** model further integrates pre-established regression models as surrogate functions in Bayesian optimization,significantly enhancing the precision of the design *** RBOALM,several new high-performance alloys have been successfully designed and ***,after mechanical property testing of the designed alloys,the Mg-2.1Zn-2.0Mn-0.5Sn-0.1Ca alloy demonstrates exceptional mechanical properties,including an ultimate tensile strength of 406 MPa,a yield strength of 287 MPa,and a 23%fracture ***,the Mg-2.7Mn-0.5Al-0.1Ca alloy exhibits an ultimate tensile strength of 211 MPa,coupled with a remarkable 41%fracture elongation.

关键词： Mg-Mn-based alloys High-performance Alloy design Machine learning Bayesian optimization

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A new type of lipophilic hydrophobic self-repairing cellulose insulating paper developed with ST-110/FAS/PTFE ternary system as coating substrate

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High Voltage 2024年第2期9卷 474-483页

作者： Zhenglin Zeng Jinshan Qin Zuhao Wang Weimin Tan Chao Tang College of Engineering and Technology Southwest UniversityChongqingChina International R&D center for New Technologies of Smart Grid and Equipment ChongqingChina

The moisture generated by the ageing of the oil-paper insulating system can easily lead to the deterioration of the performance of the insulating *** order to alleviate the impact of moisture on the performance of the insulating paper,we developed a kind of lipophilic hydrophobic self-repairing cellulose insulating paper(new insulating paper)based on the ternary system of polytetrafluoroethylene,fluorocarbon surfactant and fluorinated alkyl silane,and accelerated thermal ageing test for 45 days at 130°C was carried *** experimental results show that the new insulating paper with excellent lipophilic property can realise hydrophobic self-repairing through heat treatment after physical *** tensile strength and elongation at break of the new insulating paper increased by 5%–8%and 6.25%–27%respectively compared with the original cellulose insulating *** the end of ageing,the relative dielectric constant and dielectric loss factor of new insulating paper are 10.4%and 9.9%lower than that of the original cel-lulose insulating paper,while the breakdown voltage is 6.8%*** acid and moisture content produced during the ageing process of the insulating oil impregnated with new insulating paper are also less,indicating that the coating can delay the ageing of the insulating paper.

关键词： coating moisture cellulose

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Alleviating limit cycling in training GANs with an optimization technique

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Science China Mathematics 2024年第6期67卷 1287-1316页

作者： Keke Li Liping Tang Xinmin Yang National center for Applied Mathematics in chongqing Chongqing Normal UniversityChongqing401331China School of Mathematical Sciences University of Electronic Science and Technology of ChinaChengdu611731China

In this paper,we undertake further investigation to alleviate the issue of limit cycling behavior in training generative adversarial networks(GANs)through the proposed predictive centripetal acceleration algorithm(PCAA).Specifically,we first derive the upper and lower complexity bounds of PCAA for a general bilinear game,with the last-iterate convergence rate notably improving upon previous ***,we combine PCAA with the adaptive moment estimation algorithm(Adam)to propose PCAA-Adam,for practical training of GANs to enhance their generalization ***,we validate the effectiveness of the proposed algorithm through experiments conducted on bilinear games,multivariate Gaussian distributions,and the CelebA dataset,respectively.

关键词： GANs general bilinear game predictive centripetal acceleration algorithm lower and upper complexity bounds PCAA-Adam

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Crystallinity-defect matching relationship of g-C_(3)N_(4): Experimental and theoretical perspectives

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Green Energy & Environment 2024年第4期9卷 623-658页

作者： Yuhan Li Ziteng Ren Zhengjiang He Ping Ouyang Youyu Duan Wendong Zhang Kangle Lv Fan Dong Engineering Research center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and Business UniversityChongqing400067China Nanchang Institute of Technology Nanchang33044China Key Laboratory of Resources Conversion and Pollution Control of the State Ethnic Affairs Commission College of Resources and Environmental ScienceSouth-Central Minzu UniversityWuhan430074China College of Physics and center of Quantum Materials and Devices Chongqing UniversityChongqing401331China chongqing Key Laboratory of Green Synthesis and Application Chongqing Normal UniversityChongqing401331China

Good crystallinity can reduce the charge recombination centers caused by defects,whilst structures with strong polycondensation have high charge mobility,leading to more charge transfer to the material surface for *** effort has been put into the preparation of a highly efficient g-C_(3)N_(4) with defects to improve its application potential under the premise in high ***,this review paper emphasizes the importance to balance the defect and crystallinity of g-C_(3)N_(4).In addition,detailed discussion on the relationship between defects and activity of g-C_(3)N_(4) was carried out based on its applications in environmental purification(e.g.,VOCs oxidation,NO_(x) oxidation,H_(2)O_(2) evolution,sterilization,pesticide oxidation)and energy conversion(H_(2) evolution,N_(2) fixation and CO_(2) reduction).Lastly,the challenge in developing more efficient defective g-C_(3)N_(4) photocatalytic materials is summarized.

关键词： Photocatalysis Defect G-C_(3)N_(4) Crystallinity Application

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SsdchA is a novel secretory cellobiohydrolase driving pathogenicity in Sclerotinia sclerotiorum

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The Crop Journal 2024年第2期12卷 493-502页

作者： Yangui Chen Yijuan Ding Siqi Zhao Nan Yang Zhaohui Wu Ping Zhang Hongmei Liao Mengquan Dong Yang Yu Huafang Wan Wei Qian Integrative Science center of Germplasm Creation in Western China(chongqing)Science City College of Agronomy and BiotechnologySouthwest UniversityChongqing 400715China Academy of Agricultural Sciences Southwest UniversityChongqing 400715China Engineering Research center of South Upland Agriculture Ministry of EducationChongqing 400715China College of Plant Protection Southwest UniversityChongqing 400715China

The necrotrophic fungus, Sclerotinia sclerotiorum, employs an array of cell wall-degrading enzymes(CWDEs), including cellulase, to dismantle host cell walls. However, the molecular mechanisms through which S. sclerotiorum degrades cellulose remain elusive. Here, we unveil a novel secretory cellobiohydrolase, SsdchA, characterized by a signal peptide and a Glyco_hydro_7(GH7) domain. SsdchA exhibits a robust expression of during early infection stages. Interestingly, colony morphology and growth rates remain unaffected across the wild-type, SsdchA deletion strains and SsdchA overexpression strains on potato dextrose agar(PDA) medium. Nevertheless, the pathogenicity and cellobiohydrolase activity decreased in the SsdchA deletion strains, but enhanced in the SsdchA overexpression strains. Moreover,the heterologous expression of SsdchA in Arabidopsis thaliana leads to reduced cellulose content and heightened susceptibility to S. sclerotiorum. Collectively, our data underscore the pivotal role of the novel cellobiohydrolase SsdchA in the pathogenicity of S. sclerotiorum.

关键词： Cellobiohydrolase Cellulose Pathogenicity Sclerotinia sclerotiorum Secretory protein SsdchA

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A First-principles Study on the Adhesion Strength,Interfacial Stability,and Electronic Properties of Mg/Mg_(2)Y Interface

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 537-550页

作者： Yunxuan Zhou Wenjun Tian Quan Dong Hailian Wang Jun Tan Xianhua Chen Kaihong Zheng Fusheng Pan College of Materials Science and Engineering National Engineering Research Center for Magnesium AlloysChongqing UniversityChongqing 400044China State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400044China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China

The interfacial microstructures and configurations directly affect the comprehensive properties of the composites,but their interfacial adhesion mechanism is complicated to expound by experimental *** this work,based on the stacking sequence of the Mg/Mg_(2)Y interface models,nine different Mg/Mg_(2)Y interface configurations with top site,bridge site,and hollow site(HCP)under Mg1,Mg_(2),and Y terminations were successfully constructed and systematically explored by first-principles *** results showed that the Mg_(2)Y(0001)surface with Y termination is the most stable when the yttrium chemical potential()is less than-1.09 eV;otherwise,Mg_(2)Y(0001)surface with Mg1 termination is the most *** seven-layer Mg(0001)and eleven-layer Mg_(2)Y(0001)slabs are employed to reflect the bulk-like interior ***,the Mg(0001)/Mg_(2)Y(0001)with the Y-HCP stacking has the largest interface thermodynamic stability with the value of 2.383 J/m^(2) in all interface configurations owing to its largest work of *** addition,the interfacial energy of Y-HCP stacking is significantly smaller than those of Mg1-HCP when is approximately less than-0.55 eV,showing that it is more *** thermodynamic stability of Mg/Mg_(2)Y with Y-HCP is due to Mg-Y chemical bonds formed between Mg and Y ***,the Mg/Mg_(2)Y interfaces are strong interfaces based on the Griffith fracture theory.

关键词： Mg/Mg_(2)Y interface Interface stability Work of adhesion Electronic structure First-principles calculations

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Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

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Genes & Diseases 2024年第2期11卷 1066-1081页

作者： Junyan Yan Lu Xiao Di Feng Baolin Chen Ting Yang Bei Tong Ruifang Luo Yuting Wang Jie Chen Children Nutrition Research center Children's Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Child Nutrition and HealthMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing 401122China Department of Gastroenterology Children's Hospital of Chongqing Medical UniversityChongqing 401122China

Vitamin A (VA) plays an essential role in modulating both the gut microbiota and gut barrier ***-chain fatty acids (SCFAs),as metabolites of the gut microbiota,protect the physiological intestinal barrier;however,they are compromised when VA is ***,there is an urgent need to understand how and which SCFAs modulate colonic epithelial barrier integrity in VA deficiency (VAD).Herein,compared with normal VA rats (VAN),at the beginning of pregnancy,we confirmed that the colonic desmosome junction was impaired in the VAD group,and the amounts of acetate,propionate,and butyrate declined because of the decreased abundance of SCFA-producing bacteria (Romboutsia ,Collinsella ,and Allobaculum ).The differentially expressed genes correlated with the gut barrier and the histone deacetylase complex between the VAD and VAN groups were enriched by RNA *** the VAD group,the expression levels of colonic CEA cell adhesion molecule 1 (CEACAM1) were down-regulated,and the levels of histone deacetylase 1 (HDAC1) and HDAC3 were ***,the above changes in the VAD groups were rescued by VA supplementation in the early postnatal *** study indicated that in Caco-2 cells,butyrate treatment significantly repressed the enrichment of HDAC3 on the promoter of the CEACAM1 gene to induce its *** findings support that butyrate intervention can alleviate the impairment of colonic barrier function caused by VAD,and timely postnatal VA intervention may reverse the damage caused by VAD on gut barrier integrity during pregnancy.

关键词： CEACAM1 Colonic epithelial barrier HDAC3 Short-chain fatty acids Vitamin A deficiency

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Research on a fiber sensing system for metal ion detection based on SPF-PCF-SPF structure and coated LPFG

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Optoelectronics Letters 2024年第4期20卷 211-215页

作者： GUO Junqi ZHOU Yanfang ZHENG Wenyue XU Qianwen LIU Yu LI Renpu chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Post and TelecommunicationsChongqing 400065China chongqing Engineering Research center of Intelligent Sensing Technology and Microsystem Chongqing University of Posts and TelecommunicationsChongqing 400065China

In order to provide a method for accurately detecting the concentration and types of heavy metal ions in water,a fluid ion detection system is *** consists of a side-polished fiber-assisted fluid structure and a long-period fiber grating(LPFG)coated with a metal chelating agent *** this study,both theoretical and experimental investigations are conducted to examine the sensing characteristics of the system towards copper ion and iron ion *** results demonstrate that under the premise of ensuring solution flow,the system can achieve specific identification of different types of heavy metal ***,it exhibits concentration sensing sensitivities of 9.23×10^(4) mL·nm/mol and 7.13×10^(4) mL·nm/mol for copper sulfate(CuSO_(4))and ferric chloride(FeCl_(3))solutions,***,this sensing system offers the potential for real-time detection of metal ions.

关键词： system fiber structure

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