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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen Chang Cheng Yu-Han Wang Wen-Chao Cheng De-Zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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Preparation and combustion properties of laminated sticks of B-CuO and B-Bi_(2)O_(3)

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Defence Technology（防务技术） 2024年第8期38卷 67-74页

作者： Haoyu Song Chenyang Li Fubing Gao Chongwei An Shijiao Li Xuan Zhan Jianchen He School of Environment and Safety Engineering North University of ChinaTaiyuan 030051China chongqing military agency of the army Chongqing 400060China

To explore the composite process of B-CuO and B-Bi_(2)O_(3) two-component laminated sticks,obtain the corresponding sticks with good printing effect,and explore the energy release *** this study,boron,copper oxide,and bismuth trioxide powders were dispersed in the dispersed phase (DMF) using F_(2602) as a binder,and the construction of two-component B-CuO,B-Bi_(2)O_(3),three-component microcomposite,and three-component macro-composite sticks were realized with the help of double nozzle direct ink writing (DIW) technique *** resulting sticks were ignited by a nichrome wire energized with a direct current,and a high-speed camera system was used to record the combustion behavior of the sticks,mark the flame position,and calculate the rate of *** results showed that the B-CuO stick burning rate (42.11 mm·s^(-1)) was much higher than that of B-Bi_(2)O_(3)(17.84 mm·s^(-1)).The formulation with the highest CuO content (ω_(CuO)=58.7%) in the microscale composite of the sticks also had the fastest burning rate of 60.59 mm·s^(-1),as the CuO content decreased (ω_(CuO)=43.5%,29.3%),its burning rate decreased to 34.78 mm·s^(-1),37.97 mm·s^(-1).The stick with the highest copper oxide content(ω_(CuO)=60%) also possessed the highest burning rate (48.84 mm·s^(-1)) in the macro-composite sticks,and the burning rates of the macro-composite sticks with component spacing of 0.1 mm,0.2 mm,and 0.5 mm were 43.34 mm·s^(-1),48.84 mm·s^(-1),and 40.76 mm·s^(-1).

关键词： Boron-based thermite Direct ink writing Linear burning rate Multi-component composite

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Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo

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military Medical Research 2022年第3期9卷 331-350页

作者： Ying He Xun-Hu Dong Qiong Zhu Ya-Li Xu Ming-Liang Chen Zheng Liu Department of Ultrasound Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing400037China Department of Chemical Defense Medicine School of Military Preventive MedicineThird Military Medical University(Army Medical University)Chongqing400038China Institute of Toxicology School of Military Preventive MedicineThird Military Medical University(Army Medical University)Chongqing400038China Institute of Pathology and Southwest Cancer Centre Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China

Background:Ultrasound-triggered microbubble destruction(UTMD) is a widely used noninvasive technology in both military and civilian medicine,which could enhance radiosensitivity of various ***,little information is available regarding the effects of UTMD on radiotherapy for glioblastoma or the underlying *** study aimed to delineate the effect of UTMD on the radiosensitivity of glioblastoma and the potential involvement of ***:GL261,U251 cells and orthotopic glioblastoma-bearing mice were treated with ionizing radiation(IR) or IR plus *** was observed by confocal microscopy and transmission electron *** blotting and immunofluorescence analysis were used to detect progesterone receptor membrane component 1(PGRMC1),light chain 3 beta 2(LC3B2) and sequestosome 1(SQSTM1/p62) *** vectors or siRNAs transfection,and fluorescent probes staining were used to explore the underlying ***:UTMD enhanced the radiosensitivity of glioblastoma in vitro and in vivo(P0.05).Furthermore,UTMD inhibited PGRMC1expression and binding with LC3B2 in IR-exposed glioblastoma cells(P<0.01).PGRMC1 inhibitor AG-205 or PGRMC1siRNA pretreatment enhanced UTMD-induced LC3B2 and p62 accumulation in IR-exposed glioblastoma cells,thereby promoting UTMD-mediated radiosensitization(P<0.05).Moreover,PGRMC1 overexpression abolished UTMD-caused blockade of autophagic degradation,subsequently inhibiting UTMD-induced radiosensitization of glioblastoma ***,compared with IR plus UTMD group

关键词： Ultrasound-triggered microbubble destruction Radiosensitization Progesterone receptor membrane component 1 Autophagy Glioblastoma

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EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

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Signal Transduction and Targeted Therapy 2022年第3期7卷 746-757页

作者： Qu-Jing Gai Zhen Fu Jiang He Min Mao Xiao-Xue Yao Yan Qin Xi Lan Lin Zhang Jing-Ya Miao Yan-Xia Wang Jiang Zhu Fei-Cheng Yang Hui-Min Lu Ze-Xuan Yan Fang-Lin Chen Yu Shi Yi-Fang Ping You-Hong Cui Xia Zhang Xindong Liu Xiao-Hong Yao Sheng-Qing Lv Xiu-Wu Bian Yan Wang Institute of Pathology and Southwest Cancer Center Southwest HospitalArmy Medical University(Third Military Medical University)ChongqingChina Biobank of Institute of Pathology Southwest HospitalArmy Medical University(Third Military Medical University)ChongqingChina Institute of Cancer Xinqiao HospitalArmy Medical University(Third Military Medical University)ChongqingChina Department of Neurosurgery Xinqiao HospitalArmy Medical University(Third Military Medical University)ChongqingChina

Platelet-derived growth subunit A(PDGFA)plays critical roles in development of glioblastoma(GBM)with substantial evidence from TCGA database analyses and in vivo mouse *** far,only platelet-derived growth receptor a(PDGFRA)has been identified as receptor for ***,PDGFA and PDGFRA are categorized into different molecular subtypes of GBM in TCGA_GBM database.

关键词： PDGFRA Platelet glioblastoma

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Sex-based differences in the prevalence of acute mountain sickness: a meta-analysis

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military Medical Research 2020年第2期7卷 228-238页

作者： Yun-Peng Hou Jia-Lin Wu Chao Tan Yu Chen Rui Guo Yong-Jun Luo Department of military Medical Geography Army Medical Service Training BaseArmy Medical UniversityChongqing 400038China

Background:When lowlanders rapidly ascend to altitudes>2500 m,they may develop acute mountain sickness(AMS).The individual susceptibility,ascending velocity,time spent at altitude,activity levels and altitude reached are considered risk factors for ***,it is not clear whether sex is a risk *** results have been *** conducted a meta-analysis to test whether there were sex-based differences in the prevalence of AMS using Lake Louise Scoring ***:Systematic searches were performed in August 2019 in EMBASE,PubMed,and Web of Science for prospective studies with AMS data for men and *** titles and abstracts were independently checked in the primary screening step,and the selected full-text articles were independently assessed in the secondary screening step by the two authors(YPH and JLW)based on pre-defined inclusion *** meta-analysis was performed using by the STATA 14.1 software program.A random-effects model was ***:Eighteen eligible prospective studies were included.A total of 7669 participants(2639[34.4%]women)were *** results showed that there was a statistically significant higher prevalence rate of AMS in women than in men(RR=1.24,95%CI 1.09–1.41),regardless of age or ***,the heterogeneity was significant in the analysis(Tau2=0.0403,Chi2=50.15,df=17;I2=66.1%,P=0.000),it was main caused by different numbers of subjects among the studies(coefficient=–2.17,P=0.049).Besides,the results showed that there was no evidence of significant publication bias in the combined studies on the basis of Egger’s test(bias coefficient=1.48,P=0.052)and Begg’s test(P=0.130).Conclusions:According to this study,the statistically significant finding emerging from this study was that women have a higher prevalence of ***,the authors could not exclude studies where patients were on *** analysis provided a direction for future studies of the relationship of sex and the risk of AMS,such as

关键词： Prevalence Sex differences Acute mountain sickness Risk factors

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Gastroduodenal artery disconnection during liver transplantation decreases non-anastomotic stricture incidence

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 28-33页

作者： Bi Pan Wei Liu Yan-Jiao Ou Yan-Qi Zhang Di Jiang Yuan-Cheng Li Zhi-Yu Chen Lei-Da Zhang Cheng-Cheng Zhang Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Health Statistics College of Military Preventive MedicineThird Military Medical University(Army Medical University)Chongqing 400038China

Background:The hepatic artery is the only blood source nourishing the biliary duct and associated with biliary complication after liver transplantation(LT).Gastroduodenal artery(GDA)disconnection increased proper hepatic artery *** this procedure attenuates biliary non-anastomotic stricture(NAS)is not ***:A total of 241 patients with LT were retrospectively *** patients were divided into the GDA disconnection(GDA-)and GDA preservation(GDA+)*** score matching(PSM)was administrated to reduce *** regression was conducted to analyze risk factors for biliary NAS before and after *** complications were ***-Meier survival analysis and log-rank tests were performed to compare overall ***:In all,99 patients(41.1%)underwent GDA disconnection,and 49(20.3%)developed *** logistic regression revealed that GDA preservation(OR=2.24,95%CI:1.11-4.53;P=0.025)and model for end-stage liver disease(MELD)score>15(OR=2.14,95%CI:1.12-4.11;P=0.022)were risk factors for biliary *** provided 66 pairs using 1:2 matching method,including 66 GDA disconnection and 99 GDA preservation *** logistic regression after PSM also showed that GDA preservation(OR=3.15,95%CI:1.26-7.89;P=0.014)and MELD score>15(OR=2.41,95%CI:1.08-5.36;P=0.031)were risk factors for *** comparing complications between the two groups,GDA preservation was associated with a higher incidence of biliary NAS before and after PSM(P=0.031 and 0.017,respectively).In contrast,other complications including early allograft dysfunction(P=0.620),small-for-size graft syndrome(P=0.441),abdominal hemorrhage(P=1.000),major complications(Clavien-Dindo grade≥3,P=0.318),and overall survival(P=0.088)were not significantly different between the two ***:GDA disconnection during LT ameliorates biliary NAS incidence and may be recommended for application in clinical practice.

关键词： Liver transplantation Biliary complication Gastroduodenal artery disconnection Hepatic artery hyperperfusion

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Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4/Cxcl10 axis in adipose tissue macrophages

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Signal Transduction and Targeted Therapy 2020年第1期5卷 457-469页

作者： Wei Xiang Rongchen Shi Dapeng Zhang Xia Kang Lili Zhang Jing Yuan Xuan Zhang Hongming Miao Department of Biochemistry and Molecular Biology Third Military Medical University(Army Medical University)400038 ChongqingChina Department of Oncology Southwest HospitalThird Military Medical University(Army Medical University)400038 ChongqingChina

Peritoneal carcinomatosis(PC)of colorectal cancer(CRC)is a terminal phase of malignancy with no effective strategies for the prevention of this *** we established PC models in mice by intraperitoneal engraftment of CRC cells and revealed an unexpected role for a high-fat diet(HFD)in preventing metastatic seeding in the visceral ***,the HFD stimulated the activation of adipose tissue macrophages(ATMs)toward an M1-like phenotype and enhanced ATM tumor phagocytosis in a TLR4-dependent ***,the TLR4–Cxcl10 axis in ATMs promoted T cell recruitment,and M1-like macrophages stimulated T cell activation in tumor-seeded *** inhibitory effect of the HFD on tumor seeding was abolished with the ablation of macrophages,inactivation of T cells,or blockade of the TLR4–Cxcl10 axis in ***,we showed that a HFD and conventional chemotherapeutic agents(oxaliplatin or 5-fluorouracil)synergistically improved the survival of tumor-seeded ***,our findings demonstrate that peritoneal seeding of CRC can be suppressed by short-term treatment with a HFD in the early phase,providing a novel concept for the management of these patients in the clinic.

关键词： peritoneal colorectal TLR4

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Circular RNA vaccine in disease prevention and treatment

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4574-4596页

作者： Dun Niu Yaran Wu Jiqin Lian Department of Clinical Laboratory Medicine Southwest HospitalArmy Medical University(Third Military Medical University)400038 ChongqingChina Department of Clinical Biochemistry Army Medical University(Third Military Medical University)400038 ChongqingChina

CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail *** the decades since its initial discovery,their biogenesis,regulation,and function have rapidly disclosed,permitting a better understa... 详细信息

关键词： prevention vaccine treatment

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Long noncoding RNA HAND2-AS1 re duce d the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 567-574页

作者： Hua-Qiang Bi Zhong-Hui Li Hui Zhang Department of Hepatobiliary Surgery First Affiliated Hospital of Third Military Medical University(Army Medical University)Chongqing 400038China Department of Radiology First Affiliated Hospital of Third Military Medical University(Army Medical University)Chongqing 400038China Department of Vascular Surgery First Affiliated Hospital of Third Military Medical University(Army Medical University)Chongqing 400038China

Background:Hepatocellular carcinoma(HCC)is one of the most prevalent human cancers with high *** non-coding RNA heart and neural crest derivatives expressed 2 anti-sense 1(HAND2-AS1)is down-regulated in several cancers including HCC,yet the precise mechanisms how HAND2-AS1 regulates cell survival in HCC remains poorly ***:The expression levels of HAND2-AS1 and miR-300 were measured using quantitative real-time *** protein levels of suppressor of cytokine signaling 5(SOCS5),Bcl-2,Bax and cleaved caspase-3 were determined by Western *** viability and cell proliferation were assessed using cell counting kit-8 and clone formation assay,*** apoptosis was detected using flow *** interactions between HAND2-AS1 and miR-300,miR-300 and SOCS5 were validated using luciferase reporter ***:HAND2-AS1 was down-regulated in HCC tissues and cell lines,and the expression level of HAND2-AS1 was positively correlated to patient ***2-AS1 over-expression reduced viability and proliferation in HCC *** HAND2-AS1 level induced apoptosis in HCC cells,accompanied with increased Bax and cleaved caspase-3 levels and decreased Bcl-2 *** also validated that HAND2-AS1 acted as a sponge of miR-300,and there was a negative correlation between expression levels of HAND2-AS1 and miR-300 in HCC ***,we found that SOCS5 was a downstream target of *** addition,miR-300 mimics abolished HAND2-AS1-mediated inhibition of cell viability and ***-300 mimics also reversed the HAND2-AS1-induced apoptosis in HCC ***:lncRNA HAND2-AS1 inhibits proliferation in HCC through regulating miR-300/SOCS5 axis.

关键词： Hepatocellular carcinoma Cell survival Heart and neural crest derivatives expressed 2 anti-sense 1 microRNA-300 Suppressor of cytokine signaling 5

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