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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen Xu Feng Yuan Shi Xin-Lin Li Zheng-Rong Shi Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

Taming of trinitromethyl-oxadiazole to access high density and high oxygen balance via a dual modulation strategy

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Defence Technology(防务技术) 2025年第1期43卷 142-149页

作者： Jinya Zhang Teng Fei Jingwei Meng Jinxiong Cai Lei Zhang Siping Pang Chunlin He School of Materials science&Engineering Beijing Institute of TechnologyBeijing 100081China Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China hongqing Innovation Center Beijing Institute of TechnologyChongqing 401120China

Energetic compounds bearing the trinitromethyl group are garnering broad attraction as potential candidates for a new generation of high energy dense *** this work,an effective dual modulation strategy involving both molecular isomerization and crystal morphology control was employed to design and optimize trinitromethyl-oxadiazole with improved comprehensive *** this dual strategy,3,5-bis(trinitromethyl)-1,2,4-oxadiazole(3)was synthesized,resulting in the formation of two distinct crystal morphologies(needle and sheet)corresponding to two crystal forms(3-a and3-b).Encouragingly,while maintaining ultra-high oxygen balance(21.73%),3 achieves impressive densities(1.97-1.98 g/cm^(3)).To our knowledge,the density of 1.98 g/cm^(3)for 3-a sets a new record among that of nitrogen-rich monocyclic ***,practical crystal morphology prediction was creatively introduced to guide the experimental crystallization conditions of 3,increasing the impact sensitivity and friction sensitivity from 1 J to 80 N(3-a)to 10 J and 240 N(3-b),***,the crystal structural analyses and theoretical calculations were conducted to elucidate the reasons of differences between 3-a and 3-b in density and *** work provides an efficient strategy to enhance performance of trinitromethyl derivatives,broadening the path and expanding the toolbox for energetic materials.

关键词： Energetic materials High oxygen balance High density Dual modulation Trinitromethyl group

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Long non-coding RNAs as promising targets for controlling disease vector mosquitoes

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Insect science 2025年第1期32卷 24-41页

作者： Yujiao Han Qian Pu Ting Fan Tianqi Wei Yankun Xu Lu Zhao Shiping Liu State Key Laboratory of Resource Insects Southwest UniversityChongqing400716 China

Hematophagous female mosquitoes are important vectors of numerous devastating human diseases,posing a major public health *** prevention and control of mosquito-borne diseases rely considerably on progress in understanding the molecular mechanisms of various life activities,and accordingly,the molecules that regulate the various life activities of mosquitoes are potential targets for implementing future vector control *** long non-coding RNAs(lncRNAs)have been identified in mosquitoes and significant progress has been made in determining their ***,we present a comprehensive overview of the research advances on mosquito lncRNAs,including their molecular identification,function,and interaction with other non-coding RNAs,as well as their synergistic regulatory roles in mosquito life *** also highlight the potential roles of competitive endogenous RNAs in mosquito growth and development,as well as in insecticide resistance and virus–host *** into the biological functions and mechanisms of lncRNAs in mosquito life activities,viral replication,pathogenesis,and transmission will contribute to the development of novel drugs and safe vaccines.

关键词： competitive endogenous RNAs(ceRNAs) insecticide resistance long noncoding RNA(lncRNA) mosquito mosquito-borne diseases pathogen-host interaction

Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-Rong Wu Xiao-Hong He Yong-Fang Xie School of Life Health Information science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

Dual-Task Contrastive Meta-Learning for Few-Shot Cross-Domain Emotion Recognition

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Computers, Materials & Continua 2025年第2期82卷 2331-2352页

作者： Yujiao Tang Yadong Wu Yuanmei He Jilin Liu Weihan Zhang School of Computer science and Engineering Sichuan University of Science and EngineeringYibin644002China School of Mechanical and Power Engineering Chongqing University of Science and TechnologyChongqing401331China

Emotion recognition plays a crucial role in various fields and is a key task in natural language processing (NLP). The objective is to identify and interpret emotional expressions in text. However, traditional emotion recognition approaches often struggle in few-shot cross-domain scenarios due to their limited capacity to generalize semantic features across different domains. Additionally, these methods face challenges in accurately capturing complex emotional states, particularly those that are subtle or implicit. To overcome these limitations, we introduce a novel approach called Dual-Task Contrastive Meta-Learning (DTCML). This method combines meta-learning and contrastive learning to improve emotion recognition. Meta-learning enhances the model’s ability to generalize to new emotional tasks, while instance contrastive learning further refines the model by distinguishing unique features within each category, enabling it to better differentiate complex emotional expressions. Prototype contrastive learning, in turn, helps the model address the semantic complexity of emotions across different domains, enabling the model to learn fine-grained emotions expression. By leveraging dual tasks, DTCML learns from two domains simultaneously, the model is encouraged to learn more diverse and generalizable emotions features, thereby improving its cross-domain adaptability and robustness, and enhancing its generalization ability. We evaluated the performance of DTCML across four cross-domain settings, and the results show that our method outperforms the best baseline by 5.88%, 12.04%, 8.49%, and 8.40% in terms of accuracy.

关键词： Contrastive learning emotion recognition cross-domain learning dual-task meta-learning

Convergence of a New Bregman Projection Method with a Self-adaptive Stepsize for Solving Monotone Inclusion Problems and Variational Inequality Problems in Reflexive Banach Spaces

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数学进展 2025年第1期54卷 141-163页

作者： CHEN Lulu CAI Gang School of Mathematical sciences Chongqing Normal UniversityChongqing401331P.R.China

The purpose of this article is to introduce a new method with a self-adaptive stepsize for approximating a common solution of monotone inclusion problems and variational inequality problems in reflexive Banach *** strong convergence result for our method is established under some standard assumptions without any requirement of the knowledge of the Lipschitz constant of the *** numerical experiments are provided to verify the advantages and efficiency of proposed algorithms.

关键词： Bregman distance variational inequality monotone inclusion maximal operator reflexive Banach space

Status analysis on sputtering and erosion evaluation methods of ion optic systems

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Chinese Journal of Aeronautics 2025年第1期38卷 254-270页

作者： Long MIAO Tongxun YANG Zhengxi ZHU Chang LU Zhiwen WU Ningfei WANG School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China chongqing Innovation Center Beijing Institute of TechnologyChongqing 404100China Advanced Aerospace Power and Energy Research Center Beijing Institute of TechnologyZhuhai 519088China

In the past few decades,ion engines have been widely used in deep-space propulsion and satellite *** aim of extending the thruster lifetime is still one of the most important parts during the design stage of ion *** one of the core components of ion engine,the grid assembly of ion optic systems may experience long-term ion sputtering in extreme electro-thermal environments,which will eventually lead to its structural and electron-backstreaming *** this paper,the current studies of the grid assembly erosion process are systematically analyzed from the aspects of sputtering damage process of grid materials,numerical simulations,and measurements of erosion characteristics of grid *** advantages and disadvantages of various erosion prediction models are highlighted,and the key factors and processes affecting the prediction accuracy of grid assembly erosion patterns are *** different types of experimental methods of grid assembly erosion patterns are *** analysis in this paper is of great importance for selecting the sputter-resistant grid materials,as well as establishing the erosion models and measurement methods to accurately determine the erosion rate and failure modes of grid ***,the working conditions and structure parameters of ion optic systems could be optimized based on erosion models to promote the ion engine lifetime.

关键词： Electric propulsion Ion optic systems Sputtering yield Erosion characteristics Erosion pattern measurement Lifetime evaluation

Experimental Study for Effect of Multi-Site Spark Ignition on Dedicated Hybrid Engine Performance under High Dilution Condition

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Journal of Thermal science 2025年第1期34卷 254-267页

作者： YAN Bowen WATERS Benjamin HAINES Andrew MCGHEE Mike HU Tiegang DENG Wei PU Yongxian MA Tianyu Powertrain Engineering R&D Center Chongqing Changan Automobile Co.Ltd.Chongqing 400000China Changan UK R&D Centre Limited Birmingham B377YGUnited Kingdom

In this study,a triple spark ignition scheme was first designed on a three-cylinder 1.5-L dedicated hybrid engine(DHE).On this basis,the effect of different ignition modes on engine combustion and emission characteristics was studied,especially under high dilution *** results tested at 2000 r/min and 0.8 MPa BMEP(brake mean effective pressure)show that with highly increased in-cylinder flow intensity,using only passive prechamber(PPC)has a lower lean limit than that with single central spark plug(CSP),thereby leading to slightly higher minimum fuel consumption and nitrogen oxides(NO_(x))*** side spark plugs(SSP)based on PPC can result in improved capability of lean limit extension and engine performance than ***,the improvement level is lower than that with triple spark plugs(TSP).As the excess air ratio λ increases,the advantage of PPC and PPC with SSP in improving the combustion phasing compared with CSP gradually ***,the increasing tendency of their ignition delay and combustion duration is more *** added SSP based on PPC can effectively shorten the ignition delay of leaner mixture,but the combustion duration can be only slightly *** a result,under extremely lean condition,the advantage of PPC and PPC with SSP in terms of combustion characteristics over CSP becomes much *** contrast,the TSP ignition can achieve much shorter ignition delay and combustion duration simultaneously under this *** to the highest available dilution level,the TSP ignition achieves the lowest raw NO_(x)***,it can also reduce the raw carbon monoxide(CO)and hydrocarbons(HC)emissions compared to CSP due to a more thorough combustion of the end gas *** on the excellent performance of TSP,the highest engine brake thermal efficiency(BTE)was further *** results show that with normal RON 92 fuel,the engine finally achieved 43.69% and 45.02% BTE under stochiometric mode with exhaus

关键词： dedicated hybrid engine triple spark plug scheme passive prechamber high dilution condition thermal efficiency NO_(x)emissions

Angiotensin-converting enzyme 2 and hepatic SARS-CoV-2 infection:Regulation,association,and therapeutic implications

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World Journal of Gastroenterology 2025年第6期31卷 8-13页

作者： Yu-Wei Luo Ai-Long Huang Kai-Fu Tang Key Laboratory of Molecular Biology on Infectious Disease Ministry of EducationChongqing Medical UniversityChongqing 400016China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)enters host cells via the angiotensin-converting enzyme 2(ACE2)*** evidence has indicated the presence of hepatic SARS-CoV-2 infection and liver injury in pa-tients with coronavirus disease 2019(COVID-19).Understanding the mechanisms of hepatic SARS-CoV-2 infection is crucial for addressing COVID-19–related liver pathology and developing targeted *** editorial discusses the signi-ficance of ACE2 in hepatic SARS-CoV-2 infection,drawing on the research by Jacobs et *** findings indicate that hepatic ACE2 expression,frequency of hepatic SARS-CoV-2 infection,and severity of liver injury are elevated in patients with pre-existing chronic liver *** data suggest that hepatic ACE2 could be a promising therapeutic target for COVID-19.

关键词： Hepatic angiotensin-converting enzyme 2 SARS-CoV-2 Liver infection Chronic liver diseases COVID-19 treatment