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Actively tunable electromagnetically induced transparency in hybrid Dirac-VO_(2) metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI Ke XIE Meng XIA Huarong CHENG Anyu LIU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and TelecommunicationsChongqing 400065China chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and TelecommunicationsChongqing 400065China Department of Automation Chongqing University of Post and TelecommunicationsChongqing 400065China

In this paper,we present a metamaterial structure of Dirac and vanadium dioxide(VO_(2))and investigate its optical properties using the finite-difference time-domain(FDTD)*** the phase transition feature of VO_(2),the design can realize active tuning of the plasmon induced transparency(PIT)effect at terahertz frequency,thereby converting from a single PIT to a *** VO_(2) is in the insulating state,the structure is symmetric to obtain a single-band PIT *** VO_(2) is in the metallic state,the structure turns asymmetric to realize a dual-band PIT *** design provides a reference direction for the design of actively tunable ***,it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear *** addition,the structure achieves superior refractive index sensitivity in the terahertz band,surpassing 1 THz/***,the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： tunable tuning transparency

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

Efficient implementation of quantum permutation algorithm using a polar SrO molecule in pendular states

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Communications in Theoretical Physics 2025年第2期77卷 41-53页

作者： Jie-Ru Hu Zuo-Yuan Zhang Jin-Ming Liu State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University School of Physical science and Technology Yangzhou University chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal University

Quantum algorithms offer more enhanced computational efficiency in comparison to their classical counterparts when solving specific tasks. In this study, we implement the quantum permutation algorithm utilizing a polar molecule within an external electric field. The selection of the molecular qutrit involves the utilization of field-dressed states generated through the pendular modes of SrO. Through the application of multi-target optimal control theory, we strategically design microwave pulses to execute logical operations, including Fourier transform,oracle Ufoperation, and inverse Fourier transform within a three-level molecular qutrit *** observed high fidelity of our outcomes is intricately linked to the concept of the quantum speed limit, which quantifies the maximum speed of quantum state manipulation. Subsequently,we design the optimized pulse sequence to successfully simulate the quantum permutation algorithm on a single SrO molecule, achieving remarkable fidelity. Consequently, a quantum circuit comprising a single qutrit suffices to determine permutation parity with just a single function evaluation. Therefore, our results indicate that the optimal control theory can be well applied to the quantum computation of polar molecular systems.

关键词： polar molecule optimal control quantum permutation algorithm pendular states

Spatio-temporal variations in air/ground freezing–thawing indices along the China–Nepal Highway during 1987–2017

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Journal of Mountain science 2025年第2期22卷 521-536页

作者： ZHANG Tianqi LUO Tao ZHANG Chonglei YU Wenbing PEI Wansheng Shaanxi Key Laboratory of Safety and Durability of Concrete Structures Xijing UniversityXi’an 710123China State Key Laboratory of Mountain Hazards and Engineering Resilience Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China Institute of Future Civil Engineering science and Technology Chongqing Jiaotong UniversityChongqing 400074China Key Laboratory of Cryospheric science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Freezing–thawing indices serve as a comprehensive indicator of both the duration of the freezing/thawing periods and the degree of cold and heat in a given ***-depth analysis of the freezing-thawing indices not only enables the prediction of permafrost distribution and its dynamic changes,but also facilitates the assessment of damage risk to infrastructure under freeze-thaw *** this paper,the air/ground freezing–thawing indices from 1987 to 2017,based on daily temperature observations from meteorological stations along the China–Nepal Highway(CNH),were calculated,and their spatial and temporal variation patterns were *** results showed that:(1)Both mean annual air temperature and mean annual ground surface temperature along the CNH fluctuated upward,with climate tendency rates of 0.43 and 0.52.C·(10a)~(-1),respectively;(2)The number of days with negative air temperature and ground temperature showed fluctuated downward,with change rates of-8.6 and-8.3 d·(10a)~(-1),respectively;(3)The ranges of air freezing index,air thawing index,ground freezing index,and ground thawing index over the years were 157.05-458.88°C·d,2034.20-2560.73°C·d,108.78-396.83°C·d,and 3515.25-4288.67°C·d,*** climate tendency rates were-5.42,10.22,-6.79,and 12.14.C·d·a-1,respectively,showing a general warming trend;(4)The air freezing index,ground freezing index,and ground thawing index changed abruptly in 1999,2000,and 2002,respectively,evincing significant changes after *** research results can provide a basis for the risk assessment of freezing–thawing erosion and the prevention and control of permafrost engineering diseases along the CNH.

关键词： China–Nepal Transportation Corridor China–Nepal Highway Freezing–thawing indices Spatio–temporal change

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

CSF multi-omics of intracerebral hemorrhage from onset to reperfusion underscores lipid metabolism in functional outcome

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science Bulletin 2025年第2期70卷 162-166页

作者： Yibin Jiang Sin Man Lam Shuixian Zhang Huan Miao Yong Zhou Qian Zhang Tengyuan Zhou Hui Feng Ning Ding Haomiao Wang Ran Luo Yi Yin Hua Feng Guanghou Shui Rong Hu Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China chongqing Key Laboratory on Big Data for Bio Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China Clinical Medical Research Center Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China

Constituting 6.5%to 19.6%of all stroke cases worldwide,non-traumatic intracerebral hemorrhage(ICH)represents the most devastating form of stroke,with aging,male gender,and hypertension being important risk factors that predispose individuals to ICH[1,2].Injuries following episodes of ICH can be classified into two forms,namely(1)primary injury arising from mechanical pressure exerted by the hematoma on adjacent tissues,(2)secondary injury resulting from oxidative stress and inflammation mediated by blood cell degradation products and coagulation factors[3].

关键词： metabolism hemorrhage intracerebral

A seaweed-inspired separator for high performance Zn metal batteries:Boosting kinetics and confining side-reactions

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Journal of Energy Chemistry 2025年第2期101卷 191-200页

作者： Qianzhi Gou Horan Luo Long Qu Feilin Yu Kaixin Wang Sida Zhang Ziga Luogu Ben Zhang Yujie Zheng Bingye Song John Wang Meng Li National Innovation Center for Industry-Education Integration of Energy Storage MOE Key Laboratory of Low-grade Energy Utilization Technologies and SystemsCQU-NUS Renewable Energy Materials & Devices Joint Laboratory College of Energy & Power Engineering Chongqing University School of Building Services science and Engineering Xi'an University of Architecture and Technology School of Chemistry and Chemical Engineering Chongqing University of Science and Technology Southwest Technology and Engineering Research Institute National University of Singapore (chongqing) Research Institute

Uncontrolled dendrite growth,sluggish reaction kinetics,and drastic side reactions on the anodeelectrolyte interface are the main obstacles that restrict the application prospect of aqueous zinc-ion *** glass fiber（GF） separator with chemical inertness is almost ineffective in restricting these ***,inspired by the ionic enrichment behavior of seaweed plants,a facile biomass species,anionic sodium alginate（SA）,is purposely decorated on the commercial GF separator to tackle these issues towards Zn *** from the abundant zincophilic functional groups and superior mechanical strength properties,the as-obtained SA@GF separator could act as ion pump to boost the Zn2+transference number（0.68）,reduce the de-solvation energy barrier of hydrated Zn2+,and eliminate the undesired concentration polarization effect,which are verified by experimental tests,theoretical calculations,and finite element simulation,*** on these efficient modulation mechanisms,the SA@GF separator can synchronously achieve well-aligned Zn deposition and the suppression of parasitic ***,the Zn‖Zn coin cell integrated with SA@GF separator could yield a prolonged calendar lifespan over 1230 h(1 mA cm-2and 1 mAh cm-2),exhibiting favorable competitiveness with previously reported separator modification ***,the Zn-MnO2full and pouch cell assembled with the SA@GF separator also delivered superior cycling stability and rate performance,further verifying its practical application *** work provides a new design philosophy to stabilize the Zn anode from the aspect of separator.

关键词： Aqueous zinc-ion batteries Dendrite-free Interfacial reaction kinetics Separator modification Sodium alginate

Primordial black holes and scalar induced density perturbations: the effects of probability density functions

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Chinese Physics C 2025年第02期 206-212页

作者：周敬之况宇庭常哲张旭坤朱庆华 Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin University Institute of High Energy Physics Chinese Academy of Sciences University of Chinese academy of sciences College of Physics and Information Engineering Shanxi Normal University Department of Physics and chongqing Key Laboratory for Strongly Coupled Physics Chongqing University

We investigate the second order energy density perturbation δ（2）induced by small-scale Gaussian and local-type non-Gaussian primordial curvature *** relative abundance of primordial black holes（PBHs） is calculated in terms of the probability density functions（PDFs） of the total energy density perturbation δr=δ（1）+1/2δ（2）.The effects of the second order density perturbation greatly reduce the upper bounds of small-scale power spectra of primordial curvature perturbations by one to two orders of *** a log-normal primordial power spectrum,its amplitude Aζis constrained to be approximately Aζ～3×10-3,and for the local-type non-Gaussianity with fNL=10,the upper bound of Aζis approximately 2.5×10-4.

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Estimated Ultimate Recovery and Productivity of Deep Shale Gas Horizontal Wells

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Fluid Dynamics & Materials Processing 2025年第1期21卷 221-232页

作者： Haijie Zhang Haifeng Zhao Ming Jiang Junwei Pu Yuanping Luo Weiming Chen Tongtong Luo Zhiqiang Li Xinan Yu Exploration and Development Department Chongqing Shale Gas Exploration and Development Co.Ltd.Chongqing401120China Oil&Gas Technology Research Institute Changqing Oilfield CompanyXi’an710018China Exploration and Development Research Institute Zhejiang Oilfield CompanyHangzhou310023China Geological Exploration and Development Research Institute Chuanqing Drilling Engineering Co.Ltd.Chengdu610056China School of Petroleum and Natural Gas Engineering Chongqing University of Science and TechnologyChongqing401331China Technology Department Chongqing University of Science and TechnologyChongqing401331China

Pressure control in deep shale gas horizontal wells can reduce the stress sensitivity of hydraulic fractures and improve the estimated ultimate recovery(EUR).In this study,a hydraulic fracture stress sensitivity model is proposed to characterize the effect of pressure drop rate on fracture ***,a production prediction model is introduced accounting for a non-uniform hydraulic fracture conductivity *** results reveal that increasing the fracture conductivity leads to a rapid daily production increase in the early ***,above 0.50 D·cm,a further increase in the fracture conductivity has a limited effect on shale gas production *** initial production is lower under pressure-controlled conditions than that under *** extended pressure control durations,the cumulative production initially increases and then *** a fracture conductivity of 0.10 D·cm,the increase in production output under controlled-pressure conditions is~35%.For representative deep shale gas wells(Southern Sichuan,China),if the pressure drop rate under controlled-pressure conditions is reduced from 0.19 to 0.04 MPa/d,the EUR increase for 5 years of pressure-controlled production is 41.0 million,with an increase percentage of~29%.

关键词： Deep shale gas fracture stress sensitivity pressure-controlled production production prediction