检索结果-南通市图书馆

SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2024年第2期15卷 79-82页

作者： Ping Liu Junjie Hui Lei Wang national Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

Disruption of epigenetic regulation in host cells is a common evasion strategy used by viruses(Ozturkler and Kalkan 2021).Recently,Kee et al.(2022)reported that accessory protein ORF8 of SARS-CoV-2 can diffuse into the cell nucleus and mimic histone H3 through the ARKS motif,thereby interfering with H3 post-translational modifications(PTMs),disrupting gene transcription,and diminishing the antiviral response.

关键词： mimic thereby function

RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun Li Fang-Zhou Sun Chun-Xiao Li Hong-Nan Mo Yan-Tong Zhou Dan Lv Jing-Tong Zhai Hai-Li Qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor prognosis.As the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment strategies.Recent evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully elucidated.Methods Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of TNBC.We investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo studies.Key signaling pathway components were evaluated using multi-omics approaches.Lipidomics were performed to elucidate the regulation of lipid metabolic reprogramming of RARRES2.Results We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic reprogramming.Mechanistically,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain microenvironment.Conclusions Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of BrM.RARRES2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

Time-lagged Effects of the Spring Atmospheric Heat Source over the Tibetan Plateau on Summer Precipitation in Northeast China during 1961–2020:Role of Soil Moisture

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第8期41卷 1527-1538页

作者： Yizhe HAN Dabang JIANG Dong SI Yaoming MA Weiqiang MA Institute of Atmospheric Physics Chinese Academy of Sciences State Key Laboratory of Tibetan Plateau Earth System Environment and Resources (TPESER)Institute of Tibetan Plateau Research Chinese Academy of Sciences national Institute of Natural Hazards Ministry of Emergency Management of China University of chinese academy of Sciences College of Atmospheric Sciences Lanzhou University national Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Kathmandu Center of Research and Education Chinese Academy of Sciences China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of Sciences

The spring atmospheric heat source(AHS) over the Tibetan Plateau(TP) has been suggested to affect the Asian summer monsoon and summer precipitation over South China. However, its influence on the summer precipitation in Northeast China(NEC) remains unknown. The connection between spring TP AHS and subsequent summer precipitation over NEC from 1961 to 2020 is analyzed in this study. Results illustrate that stronger spring TP AHS can enhance subsequent summer NEC precipitation, and higher soil moisture in the Yellow River Valley-North China region(YRVNC)acts as a bridge. During spring, the strong TP AHS could strengthen the transportation of water vapor to East China and lead to excessive rainfall in the YRVNC. Thus, soil moisture increases, which regulates local thermal conditions by decreasing local surface skin temperature and sensible heat. Owing to the memory of soil moisture, the lower spring sensible heat over the YRVNC can last until mid-summer, decrease the land–sea thermal contrast, and weaken the southerly winds over the East Asia–western Pacific region and convective activities over the South China Sea and tropical western Pacific. This modulates the East Asia–Pacific teleconnection pattern, which leads to a cyclonic anomaly and excessive summer precipitation over NEC.

关键词： atmospheric heat source Northeast China soil moisture summer precipitation Tibetan Plateau

Several whitefly genome assemblies and an integrated whitefly gene search platform

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2024年第1期31卷 299-306页

作者： Xingnuo Li Peng Liang Mingyue Wu Shaoli Wang Qingjun Wu Wen Xie Youjun Zhang State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijingChina Sanya academy of Troprical Agricultural Sciense SanyaHainanChina national Research Institute of Breeding in Hainan Chinese Academy of Agricultural SciencesSanyaHainanChina

Dear Editor,The characteristics and importance of the whitefly Bemisia tabaci as an economic pest seem to continually get more and more attention.Among the whiteflies B.tabaci including,at least 11 genetic groups and 36 morphologically indistinguishable cryptic species,invasive MEAMl(Middle East-Asia Minor 1,"B"type)and MED(the Mediterranean,"Q"type)are the 2 most destructive cryptic species of the B.

关键词： Middle white East

Understanding Human and Machine Interaction from Decision Perspective: An Empirical Study Based on the Game of Go

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第2期37卷 647-667页

作者： ZHAO Ping LI Xuerong WANG Shouyang academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

The authors aim to interpret human and AI interactions from the decision perspective.The authors decompose the interaction analysis into the following main components in the context of interactions:Individual behavior patterns,interaction relationships,and comprehensive analysis.The authors interpret intertemporal decisions from a physical perspective and employ cross-discipline concepts and methodologies to extract the behavior characteristics of players in the empirical case study.About the individual behavior patterns,the authors find that human players prefer short-term periods to AI in decision-making.The interaction relationship analysis reveals a dynamic relationship between possible short-term co-movement and nearly counter-movement in the long run.The authors apply principal component analysis to descriptive indicators and discover a regular decision hierarchy.The main behavior pattern of players in the game of Go is switching between careful and daring behaviors.The differences in the decision hierarchies imply a discrepancy of patience between humans and AI.

关键词： Coherence analysis decision hierarchy machine behaviour multitaper spectral analysis

Neuronal conversion from glia to replenish the lost neurons

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第7期19卷 1446-1453页

作者： Shiyu Liang Jing Zhou Xiaolin Yu Shuai Lu Ruitian Liu national Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijingChina School of Chemical Engineering University of Chinese Academy of SciencesBeijingChina Department of Geriatric Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Neuronal injury,aging,and cerebrovascular and neurodegenerative diseases such as cerebral infarction,Alzheimer’s disease,Parkinson’s disease,frontotemporal dementia,amyotrophic lateral sclerosis,and Huntington’s disease are characte rized by significant neuronal loss.Unfo rtunately,the neurons of most mammals including humans do not possess the ability to self-regenerate.Replenishment of lost neurons becomes an appealing therapeutic strategy to reve rse the disease phenotype.Transplantation of pluripotent neural stem cells can supplement the missing neurons in the brain,but it carries the risk of causing gene mutation,tumorigenesis,severe inflammation,and obstructive hydrocephalus induced by brain edema.Conversion of neural or non-neural lineage cells into functional neurons is a promising strategy for the diseases involving neuron loss,which may overcome the above-mentioned disadvantages of neural stem cell therapy.Thus far,many strategies to transfo rm astrocytes,fibroblasts,microglia,Muller glia,NG2 cells,and other glial cells to mature and functional neurons,or for the conversion between neuronal subtypes have been developed thro ugh the regulation of transcription factors,polypyrimidine tra ct binding protein 1(PTBP1),and small chemical molecules or are based on a combination of several factors and the location in the central nervous system.However,some recent papers did not obtain expected results,and discrepancies exist.Therefore,in this review,we discuss the history of neuronal transdifferentiation,summarize the strategies for neuronal replenishment and conversion from glia,especially astrocytes,and point out that biosafety,new strategies,and the accurate origin of the truly co nverted neurons in vivo should be focused upon in future studies.It also arises the attention of replenishing the lost neurons from glia by gene therapies such as up-regulation of some transc ription factors or downregulation of PTBP1 or drug interfe rence therapies.

关键词： astrocytes neural stem cells neurodegenerative diseases neuron polypyrimidine tract binding protein 1 repair reprogramming small molecule transcription factor transdifferentiation

Linear mathematical model for the unique solution of 3D ptychographic iterative engine

在线全文

学校读者我要写书评

暂无评论

chinese Optics Letters 2024年第5期22卷 1-7页

作者：吴丽青齐乃杰昌成成陶华何小亮刘诚朱健强 Key Laboratory of High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China national Laboratory on High Power Laser and Physics China Academy of Engineering PhysicsChinese Academy of SciencesShanghai 201800China University of chinese academy of Sciences Beijing 100049China

Diffraction intensities of the 3D ptychographic iterative engine(3PIE)were written as a set of linear equations of the selfcorrelations of Fourier components of all sample slices,and an effective computing method was developed to solve these linear equations for the transmission functions of all sample slices analytically.With both theoretical analysis and numerical simulations,this study revealed the underlying physics and mathematics of 3PIE and demonstrated for the first time,to our knowledge,that 3PIE can generate mathematically unique reconstruction even with noisy data.

关键词： 3D imaging 3D ptychographic iterative engine linear equation group unique solution

Photostability of colloidal single photon emitter in near-infrared regime at room temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Physics B 2024年第3期33卷 515-520页

作者：靳思玥许兴胜 Key Laboratory of Optoelectronic Materials and Devices Chinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Hefei national Laboratory Hefei 230088China

The photostability of a colloidal single photon emitter in near-infrared regime at room temperature is investigated.The fluorescence lifetime,blinking phenomenon,and anti-bunching effect of a single CdTeSe/ZnS quantum dot with an emission wavelength of 800 nm at room temperature are studied.The second-order correlation function at zero delay time is much smaller than 0.1,which proves that the emission from single quantum dots at 800 nm is a highly pure single-photon source.The effects of the irradiation duration on the fluorescence from single quantum dots are analyzed.The experimental results can be explained by a recombination model including a multi-nonradiative recombination center model and a multi-charged model.

关键词： colloidal quantum dots single photon source blinking

Density peak clustering using tensor network

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第3期67卷 321-322页

作者： Xiao SHI Yun SHANG Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences national Center for Mathematics and Interdisciplinary Sciences Key Laboratory of ManagementDecision and Information SystemsAcademy of Mathematics and Systems ScienceChinese Academy of Sciences

Tensor networks have been a powerful tool in simulating many-body physics and have recently gained recognition in the machine learning community due to their remarkable representation capabilities. However, using tens... 详细信息

关键词： Tensors