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Acta Geochimica 2024年第3期43卷 441-458页

作者： Qing-Qing Zhang You-Wei Chen Jian-Feng Gao State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of chinese Academy of Sciences Beijing 100049China

The Xingluokeng deposit is the largest gran-ite-related tungsten deposit within the Wuyi metallogenic belt in South *** Xingluokeng intrusion primarily consists of porphyritic biotite granite,biotite granite,andfine-grained *** deposit is represented by veinlet-disseminated mineralization with K-feldspathization and biotitization,alongside quartz-vein mineralization with gre-isenization and *** study investigates in-situ analyses of quartz compositions from both the intrusion and hydrothermal veinlets and *** element correlations indicate that trivalent Al^(3+)and Fe^(3+)replace Si^(4+)within the quartz lattice,with monovalent cations(such as Li^(+),Na^(+),and K^(+))primarily serving as charge *** Ge/Al ratios(association with tungsten *** contents in quartz from quartz veins indicate Qz-Ⅰformed at temperatures above 400°C,while Qz-Ⅱto Qz-Ⅴformed at temperatures below 350°*** in different generations of quartz,as indicated by Al content and(Al+Fe)/(Li+Na+K)ratio,suggest that Qz-Ⅰprecipi-tated from a less acidicfluid with a stable pH,whereas Qz-Ⅱto Qz-Ⅴoriginated from a more acidicfluid with notable pH ***,alkaline alteration and acidic alteration supplied the essential Ca and Fe for the precipita-tion of scheelite and wolframite,respectively,highlighting a critical mechanism in tungsten mineralization at the Xin-gluokeng deposit.

关键词： Quartz Xingluokeng Tungsten deposit Trace elements South China

Negligible normal fluid in superconducting state of heavily overdoped Bi_(2)Sr_(2)CaCu_(2)O_(8+δ) detected by ultra-low temperature angle-resolved photoemission spectroscopy

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chinese Physics B 2024年第7期33卷 562-567页

作者：殷超辉汪清泓解于洋陈逸雯刘俊豪杨鉴刚贾俊杰张杏吕文凯闫宏涛戎洪涛张申金王志敏宗楠刘丽娟李如康王晓洋张丰丰杨峰彭钦军许祖彦刘国东毛寒青赵林李昕彤周兴江 National Laboratory for Superconductivity Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China University of chinese Academy of Sciences Beijing 100049China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

In high temperature cuprate superconductors,it was found that the superfluid density decreases with the increase of hole *** natural question is whether there exists normal fluid in the superconducting state in the overdoped *** this paper,we have carried out high-resolution ultra-low temperature laser-based angle-resolved photoemission measurements on a heavily overdoped Bi2212 sample with a T_(c) of 48 *** find that this heavily overdoped Bi2212 remains in the strong coupling regime with 2Δ_(0)/(k_(B)T_(c))=*** single-particle scattering rate is very small along the nodal direction(~5 meV) and increases as the momentum moves from the nodal to the antinodal regions.A hard superconducting gap opening is observed near the antinodal region with the spectral weight at the Fermi level fully suppressed to *** normal fluid is found to be negligibly small in the superconducting state of this heavily overdoped *** results provide key information to understand the high T_(c) mechanism in the cuprate superconductors.

关键词： cuprate superconductor angle-resolved photoemission spectroscopy electronic structure

Multi-prior physics-enhanced neural network enables pixel super-resolution and twin-imagefree phase retrieval from single-shot hologram

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Opto-Electronic Advances 2024年第9期7卷 22-38页

作者： Xuan Tian Runze Li Tong Peng Yuge Xue Junwei Min Xing Li Chen Bai Baoli Yao State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China University of chinese Academy of Sciences Beijing 100049China.

Digital in-line holographic microscopy(DIHM)is a widely used interference technique for real-time reconstruction of living cells’morphological information with large space-bandwidth product and compact ***,the need for a larger pixel size of detector to improve imaging photosensitivity,field-of-view,and signal-to-noise ratio often leads to the loss of sub-pixel information and limited pixel ***,the twin-image appearing in the reconstruction severely degrades the quality of the reconstructed *** deep learning(DL)approach has emerged as a powerful tool for phase retrieval in DIHM,effectively addressing these ***,most DL-based strategies are datadriven or end-to-end net approaches,suffering from excessive data dependency and limited generalization ***,a novel multi-prior physics-enhanced neural network with pixel super-resolution(MPPN-PSR)for phase retrieval of DIHM is *** encapsulates the physical model prior,sparsity prior and deep image prior in an untrained deep neural *** effectiveness and feasibility of MPPN-PSR are demonstrated by comparing it with other traditional and learning-based phase retrieval *** the capabilities of pixel super-resolution,twin-image elimination and high-throughput jointly from a single-shot intensity measurement,the proposed DIHM approach is expected to be widely adopted in biomedical workflow and industrial measurement.

关键词： optical microscopy quantitative phase imaging digital holographic microscopy deep learning super-resolution

Salivary metabolites are promising noninvasive biomarkers of druginduced liver injury

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World Journal of Gastroenterology 2024年第18期30卷 2454-2466页

作者： Si-Miao Yu Hao-Cheng Zheng Si-Ci Wang Wen-Ya Rong Ping Li Jing Jing Ting-Ting He Jia-Hui Li Xia Ding Rui-Lin Wang School of Traditional chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Traditional chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology of Traditional chinese Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China The First Clinical Medical College Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND Drug-induced liver injury(DILI)is one of the most common adverse events of medication use,and its incidence is ***,early detection of DILI is a crucial challenge due to a lack of biomarkers and noninvasive *** To identify salivary metabolic biomarkers of DILI for the future development of noninvasive diagnostic *** Saliva samples from 31 DILI patients and 35 healthy controls(HCs)were subjected to untargeted metabolomics using ultrahigh-pressure liquid chromatography coupled with tandem mass *** analyses,including partial least squares-discriminant analysis modeling,t tests and weighted metabolite coexpression network analysis(WMCNA),were conducted to identify key differentially expressed metabolites(DEMs)and metabolite *** we utilized least absolute shrinkage and selection operato and random fores analyses for biomarker *** use of each metabolite and metabolite set to detect DILI was evaluated with area under the receiver operating characteristic *** We found 247 differentially expressed salivary metabolites between the DILI group and the HC *** WMCNA,we identified a set of 8 DEMs closely related to liver injury for further prediction ***,the distinct separation of DILI patients and HCs was achieved with five metabolites,namely,12-hydroxydodecanoic acid,3-hydroxydecanoic acid,tetradecanedioic acid,hypoxanthine,and inosine(area under the curve:0.733-1).CONCLUSION Salivary metabolomics revealed previously unreported metabolic alterations and diagnostic biomarkers in the saliva of DILI *** study may provide a potentially feasible and noninvasive diagnostic method for DILI,but further validation is needed.

关键词： Drug-Induced liver injury Salivary Metabolomics Biomarker Weighted metabolite Coexpression network analysis Machine learning Noninvasive Diagnostic method Metabolites

Amino acids in piglet diarrhea: Effects, mechanisms and insights

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Animal Nutrition 2024年第1期16卷 267-274页

作者： Xihong Zhou Jing Liang Xia Xiong Yulong Yin Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture The Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences

Piglet diarrhea is among one of the most serious health problems faced by the pig industry, resulting in significant economic losses. Diarrheal disease in piglets has a multifactorial etiology that is affected by physiology, environment, and management strategy. Diarrhea is the most apparent symptom of intestinal dysfunction. As a key class of essential nutrients in the piglet diet, amino acids confer a variety of beneficial effects on piglets in addition to being used as a substrate for protein synthesis, including maintaining appropriate intestinal integrity, permeability and epithelial renewal, and alleviating morphological damage and inflammatory and oxidative stress. Thus, provision of appropriate levels of amino acids could alleviate piglet diarrhea. Most amino acid effects are mediated by metabolites, gut microbes, and related signaling pathways. In this review, we summarize the current understanding of dietary amino acid effects on gut health and diarrhea incidence in piglets, and reveal the mechanisms involved. We also provide ideas for using amino acid blends and emphasize the importance of amino acid balance in the diet to prevent diarrhea in piglets.

关键词： Piglet Amino acid Diarrhea Gut microbe Immune

Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 36-51页

作者： Yingqian Wang Yujia Li Yangling Qiu Min Shen Ling Wang Jiangjuan Shao Feng Zhang Xuefen Xu Zili Zhang Mei Guo Shizhong Zheng Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of chinese Materia Medica Nanjing University of Chinese MedicineNanjingJiangsuChina Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhouJiangsuChina Jiangsu Key Laboratory of Therapeutic Material of chinese Medicine Nanjing University of Chinese MedicineNanjingJiangsu China

Background and Aims:Development of fibrosis in chronic liver disease requires activation of hepatic stellate cells(HSCs)and leads to a poor ***(Art)is an ester derivative of artemisinin that can induce ferroptosis in HSCs,and activated transcriptional factor 3(ATF3)is an ATF/CREB transcription factor that is induced in response to *** this study,we examined the role of the Rho-associated protein kinase 1(ROCK1)/ATF3 axis in Art-induced ferroptosis in ***:HSC activation and ferroptosis were studied in vitro by western blotting,polymerase chain reaction,immunofluorescence,and other ***3 electrophoretic mobility and ROCK1 protein stability were assayed by western *** was used to detect the interaction of ROCK1 and ATF3,as well as ATF3 phosphorylation.A ubiquitination assay was used to verify ROCK1 ***3-interfering and Rock1-overexpressing mice were constructed to validate the anti-hepatic fibrosis activity of Art in ***:Art induced ferroptosis in HSCs following glutathione-dependent antioxidant system inactivation resulting from nuclear accumulation of unphosphorylated ATF3 mediated by ROCK1-ubiquitination in *** also decreased carbon tetrachloride-induced liver fibrosis in mice,which was reversed by interfering with Atf3 or overexpressing ***:The ROCK1/ATF3 axis was involved in liver fibrosis and regulation of ferroptosis,which provides an experimental basis for further study of Art for the treatment of liver fibrosis.

关键词： Ferroptosis Liver fibrosis Antioxidant system ATF3 ROCK1

Structural and Chemical Characterization of the Ediacaran Embryo-Like Fossils via the Combination of 3D-XRM and FIB-SEM Approaches

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Journal of Earth Science 2024年第4期35卷 1204-1214页

作者： Qian Chen Weichen Sun Suping Wu Zongjun Yin State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing210008China University of chinese Academy of Sciences Nanjing211135China

The three-dimensional(3D)morphology,anatomy,and in-situ chemical composition analysis of fossils are crucial for systematic paleontology and determining their phylogenetic *** electron microscopy(SEM)coupled with energy-dispersive X-ray spectroscopy(EDS),offers valuable structural and chemical information for the analysis of ***,its primary limitation is the restriction to two-dimensional surface data,which limits the exploration of fossils’3D ***,3D X-ray microscopy(3D-XRM),also known as a novel form of micro-computed tomography(micro-CT)facilitates the non-destructive 3D reconstruction of fossil ***,it lacks the capability to provide in-situ compositional *** the constraints inherent in these individual techniques,and in response to the evolving requirements of paleontological research,this study introduces an integrated approach that combines 3D-XRM with EDS-coupled focused ion beam scanning electron microscopy(FIB-SEM).This innovative strategy is designed to synergize the advantages of both techniques,thereby addressing challenges that conventional methods *** enables the rapid identification of regions of interest(ROI)within fossil specimens at micrometer ***,this method collects detailed data on both 3D structures and chemical compositions at the nanometer scale for the identified *** integrated approach represents a significant advancement in paleontological and geological research methodologies,promising to meet the increasing demands of these fields.

关键词： Embryo-like microfossils structural and chemical characterization 3D-XRM FIB-SEM 3D reconstruction

Outlier Robust Feature Correspondence by Learning Based Matching Process

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Journal of Systems Science & Complexity 2024年第4期37卷 1351-1367页

作者： YANG Xu ZENG Shaofeng LIU Zhiyong State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation of Chinese Academy of SciencesBeijing 100190China University of chinese Academy of Sciences Beijing 100190China

Feature correspondence is a crucial aspect of various computer vision and robot vision *** traditional optimization-based matching techniques,researchers have recently adopted a learning-based approach for matching,but these methods face challenges in dealing with outlier *** paper presents an outlier robust feature correspondence method that employs a pruned attentional graph neural network and a matching layer to address the outlier ***,the authors introduce a modified cross-entropy matching loss to handle the outlier *** a result,the proposed method significantly enhances the performance of learning-based matching algorithms in the presence of outlier *** experiments confirm the effectiveness of the proposed approach.

关键词： Feature correspondence graph neural network optimal transport problem pointmatching

Geometry and 3D seismic characterisation of post-rift normal faults in the Pearl River Mouth Basin,northern South China Sea

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Acta Oceanologica Sinica 2024年第4期43卷 25-39页

作者： Yuanhang Liu Jinwei Gao Wanli Chen Jiliang Wang Umair Khan Laboratory of Marine Geophysics and Georesources Institute of Deep-sea Science and EngineeringChinese Academy of SciencesSanya 572000China University of chinese Academy of Sciences Beijing 100049China

Based on high-resolution 3D seismic data acquired in the Pearl(Zhujiang)River Mouth Basin of the northern South China Sea,this study investigated the geometry,spatial extension,and throw distribution of the post-rift normal fault through detailed seismic interpretation and fault modeling.A total of 289 post-rift normal faults were identified in the study area and can be classified into four types:(1)isolated normal faults above the carbonate platform;(2)isolated normal faults cutting through the carbonate platform;(3)conjugate normal faults,and(4)connecting normal *** distribution analysis on the fault planes show that the vertical throw profiles of most normal fault exhibit flat-topped *** normal faults above the carbonate platform exhibit roughly concentric ellipses with maximum throw zones in the central section whereas the normal faults cutting through the carbonate platform miss the lowermost section due to the chaotic seismic reflections in the interior of the carbonate *** vertical throws of conjugate normal faults anomalously decrease toward their intersection region on the fault plane whereas the connecting normal faults present two maximum throw zones in the central section of the fault *** to the symmetric elliptical distribution model of fault throw,an estimation was made indicating that normal faults cutting through the carbonate platform extended downward between-1308 s and-1780 s(two-way travel time)in depth and may not penetrate the entire Liuhua carbonate ***,it is observed that the distribution of karst caves on the top of the carbonate platform disaccord with those of hydrocarbon reservoirs and the post-rift normal faults cutting through the carbonate platform in the study *** propose that these karst caves formed most probably by corrosive fluids derived from magmatic activities during the Dongsha event,rather than pore waters or hydrocarbons.

关键词： Post-rift normal faults fault throw Karst caves Corrosive fluids Pearl River Mouth Basin South China Sea

Efficacy and safety of traditional chinese medicine external interventions in juvenile myopia: A systematic review and meta-analysis

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 96-107页

作者： Xinyan Zou Xinfu Zou Yuan Wu Hanqing Zhao College of Traditional chinese Medicine Hebei UniversityBaoding 071000HebeiChina The First Clinical College Shandong University of Traditional Chinese MedicineJinan 250014ShandongChina China association of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China

Background:Myopia is a common refractive error that is increasingly prevalent amongst young *** and controlling myopia is crucial due to its association with several complications such as myopic macular degeneration,glaucoma,and retinal ***:The aim of this study is to systematically evaluate the efficacy of external chinese medicine therapies in the treatment of adolescent ***:We performed a systematic search of the chinese National Knowledge Infrastructure(CNKI),PubMed,the Cochrane Library,Science Direct,WanFang,the Weipu Database(VIP),China Biology Medicine(CMB),Web of Science(WOS),Medline,Clinical Trials,the chinese Science Citation Database(CSCD),and the Bailian Yun Library databases from January 2012 to December 2022 to identify the randomized control trials(RCTs)that compared traditional chinese medicine(TCM)external therapies with conventional therapies for the treatment of juvenile *** independent reviewers conducted the screening process,data extraction,and quality assessment.A meta-analysis was then ***:A total of 1735 relevant articles were *** included 38 RCTs involving 3680 patients and 7250 eyes that used TCM external therapies for the intervention of juvenile *** results of the metaanalysis showed that the efficacy of TCM external therapies in preventing and controlling myopia was statistically significant compared with conventional therapies[odds ratio(OR)=3.72,95%CI(2.87,4.83),P<0.01],and a funnel plot showed the basic *** meta-analysis results showed that compared with conventional therapies,TCM external therapies had statistically significant effects on the spherical equivalent[weighted mean difference(WMD)=0.22,95%CI(0.16,0.27),P<0.01],visual acuity[WMD=0.09,95%CI(0.07,0.12),P<0.01],and axial length[standardized mean difference(SMD)=0.19,95%CI(0.07,0.31),P<0.01].Conclusion:Results showed that TCM external therapies can be an effective intervention in prev

关键词： Juvenile myopia Traditioanl chinese medicine Traditional chinese medicine external therapy Acupuncture Meta-analysis