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Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image

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Journal of Innovative Optical Health sciences 2024年第3期17卷 105-113页

作者： Yiwei Chen Yi He Hong Ye Lina Xing Xin Zhang Guohua Shi jiangsu key laboratory of medical optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163P.R.China School of biomedical engineering(suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of China Hefei 230026P.R.China Center for Excellence in Brain Science and Intelligence technology Chinese Academy of SciencesShanghai 200031P.R.China

The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image *** comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from *** many deep learning models are available,a single model can only perform one or two of these prediction *** accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial *** three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test *** comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our *** high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error.

关键词： Fundus fluorescein angiography image fundus structure image image translation unified deep learning model generative adversarial networks

Ensemble Attention Guided Multi-SEANet Trained with Curriculum Learning for Noninvasive Prediction of Gleason Grade Groups from MRI

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Journal of Shanghai Jiaotong university(Science) 2024年第1期29卷 109-119页

作者：沈傲胡冀苏金鹏飞周志勇钱旭升郑毅包婕王希明戴亚康 School of Computer Science and technology Changchun University of Science and TechnologyChangchun 130022China suzhou institute of biomedical engineering and technology Chinese Academy of SciencesSuzhou 215163JiangsuChina School of biomedical engineering(SooChow) University of Science and Technology of ChinaSuzhou 215163JiangsuChina Department of Radiology The First Afiliated Hospital of Soochow UniversitySuzhou 215006JiangsuChina

The Gleason grade group(GG)is an important basis for assessing the malignancy of prostate can-cer,but it requires invasive biopsy to obtain *** noninvasively evaluate GG,an automatic prediction method is proposed based on multi-scale convolutional neural network of the ensemble attention module trained with curriculum ***,a lesion-attention map based on the image of the region of interest is proposed in combination with the bottleneck attention module to make the network more focus on the lesion ***,the feature pyramid network is combined to make the network better learn the multi-scale information of the lesion ***,in the network training,a curriculum based on the consistency gap between the visual evaluation and the pathological grade is proposed,which further improves the prediction performance of the ***-perimental results show that the proposed method is better than the traditional network model in predicting GG *** quadratic weighted Kappa is 0.4711 and the positive predictive value for predicting clinically significant cancer is 0.9369.

关键词： prostate cancer Gleason grade groups(GGs) bi-parametric magnetic resonance imaging deep learn-ing curriculum learning

D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-Ⅱ fluorescence imaging-guided through-skull photodynamic therapy of gliomas

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Aggregate 2024年第1期5卷 185-195页

作者： Xuelu He Yuan Luo Yanying Li Yuanbo Pan Ryan T.K.Kwok Lulu He Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li Ningbo key laboratory of biomedical Imaging Probe Materials and technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Guangdong key laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology(HKUST)KowloonP.R.China School of Science and engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenP.R.China

Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in ***-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)***,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor *** this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion *** theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting *** the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in *** results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.

关键词： aggregation-induced emission D-type neuropeptide glioma photodynamic therapy rare-earth doping nanoparticles

Tumor-targeted self-assembled micelles reducing PD-L1 expression combined with ICIs to enhance chemo-immunotherapy of TNBC

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chinese Chemical Letters 2024年第2期35卷 305-310页

作者： Hongda Zhu Kai Ma Rui Ruan Chaobo Yang Aqin Yan Jing Li Qi Yu Hongmei Sun Mingxing Liu Hongmei Zheng Jing Gao Xiaofang Guan Zhu Dai Yao Sun Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province) Key Laboratory of Fermentation Engineering (Ministry of Education)National “111” Center for Cellular Regulation and Molecular PharmaceuticsSchool of Food and Biological EngineeringHubei University of TechnologyWuhan 430068China Hubei Cancer Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079China National key laboratory of Green Pesticide College of ChemistryCentral China Normal UniversityWuhan 430079China key laboratory of medical optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China key laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science Ministry of EducationQingdao University of Science and TechnologyQingdao 266000China

Immune checkpoint inhibitors(ICIs)therapy targeting programmed cell death ligand 1(PD-L1)and programmed death protein 1(PD-1)had exhibited significant clinical benefits for cancer treatment such as triple negative breast cancer(TNBC).However,the relatively low anti-tumor immune response rate and ICIs drug resistance highlight the necessity of developing ICIs combination therapy strategies to improve the anti-tumor effect of ***,the immunomodulator epigallocatechin gallate palmitate(PEGCG)and the immunoadjuvant metformin(MET)self-assembled into tumor-targeted micelles via hydrogen bond and electrostatic interaction,which encapsulated the therapeutic agents doxorubicin(DOX)-loaded PEGCG-MET micelles(PMD)and combined with ICIs(anti-PD-1 antibody)as therapeutic strategy to reduce the endogenous expression of PD-L1 and improve the tumor immunosuppressive *** results presented that PMD integrated chemotherapy and immunotherapy to enhance antitumor efficacy in vitro and in vivo,compared with DOX or anti-PD-1 antibody for the therapy of *** micelles might be a potential candidate,which could remedy the shortcomings of antibody-based ICIs and provide synergistic effect to enhance the antitumor effects of ICIs in tumor therapy.

关键词： Immunotherapy Tumor-targeted Self-assembled micelles Metformin Reducing PD-L1 expression TNBC

Polyoxometalates for continuous power generation by atmospheric humidity

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Nano Research 2024年第3期17卷 1875-1885页

作者： Tuo Ji Weilin Chen Zhenhui Kang Liming Zhang key laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Northeast Normal UniversityChangchun 130024China institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices DepartmentSoochow UniversitySuzhou 215123China Macao institute of Materials Science and engineering Macao University of Science and TechnologyTaipaMacao 999078China institute of Functional State key laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

Atmospheric humidity is a sustainable low-value energy widely existing in natural environment,which is a promising candidate to solve the noncontinuous and low efficiency of low-value energy power *** the mono-substituted Dawson-type polyoxometalates are constructed to be highly dispersed organic ammonium-polyoxoanion clusters and are assembled into thin films power generators with micropores,working in atmospheric *** optimal polyoxometalates generator with the thickness of 7.2μm and the area of 0.36 cm^(2) produces a voltage of 0.68 V and a current density of 19.5μA·cm^(-2) under simulated natural environment,and works continuously and stably under almost all-natural environments(humidity 10%–90%).The highly dispersed polyoxometalate nanoclusters can form microporous in polyoxometalate films to effectively absorb atmospheric humidity and spontaneously form distribution gradient of water,which is the structural basis of power *** continuous power generation may be maintained by the effective adsorption and utilization of H_(2)O,the huge electrostatic field of organic ammonium-polyoxoanion clusters,and the reasonably designed polyoxometalates containing inorganic small ions with high *** is the first humidity generator designed with polyoxometalates,which may provide a new research direction for polyoxometalates in sustainable utilization of low-value energy.

关键词： atmospheric humidity continuous power generations nanomaterials polyoxoanions polyoxometalates

Thiol-Disulfide Exchange Coordinates the Release of Nitric Oxide and Dexamethasone for Synergistic Regulation of Intestinal Microenvironment in Colitis

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Research 2024年第2期6卷 285-300页

作者： Junna Lu Tongfei Shi Chengxin Shi Fangman Chen Chao Yang Xiaochun Xie Zheng Wang He Shen Jiaqi Xu Kam W.Leong Dan Shao School of biomedical sciences and engineering South China University of TechnologyGuangzhou International CampusGuangzhouGuangdong 510006China National engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangdong 510006China Department of Plastic and Aesthetic Center The First Affliated Hospital of Zhejiang UniversityHangzhou 310000China Department of biomedical engineering Columbia UniversityNew YorkNY 10027USA School of Medicine South China University of TechnologyGuangzhouGuangdong 510006China CAS key laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and NanoBionicsChinese Academy of SciencesSuzhou 215123China CAS key laboratory for biomedical Efects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Guangdong Provincial key laboratory of biomedical engineering South China University of TechnologyGuangzhou 510006China key laboratory of biomedical Materials and engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China

The cell-specific functions of nitric oxide(NO)in the intestinal microenvironment orchestrate its therapeutic effects in ulcerative *** most biomaterials show promise by eliciting the characteristics of NO,the insufficient storage,burst release,and pro-inflammatory side effects of NO remain as ***,we report the development of thiol-disulfide hybrid mesoporous organosilica nanoparticles(MONs)that improve the storage and sustained release of NO,broadening the therapeutic window of NO-based therapy against *** tailored NO-storing nanomaterials coordinated the release of NO and the immunoregulator dexamethasone(Dex)in the intestinal microenvironment,specifically integrating the alleviation of oxidative stress in enterocytes and the reversal of NO-exacerbated macrophage ***,such a synchronous operation was achieved by a self-motivated process wherein the thiyl radicals produced by NO release cleaved the disulfide bonds to degrade the matrix and release Dex via thiol-disulfide ***,the MON-mediated combination of NO and Dex greatly ameliorated intractable colitis compared with 5-aminosalicylic acid,even after delayed ***,our results reveal a key contribution of synergistic modulation of the intestinal microenvironment in NO-based colitis therapy and introduce thiol-disulfide hybrid nanotherapeutics for the management of inflammatory diseases and cancer.

关键词： sustained release disulfide

Long distance all-optical logic operations through a single multimode fiber empowered by wavefront shaping

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Photonics Research 2024年第3期12卷 587-597页

作者： ZHIPENG YU TIANTING ZHONG HUANHAO LI HAORAN LI CHI MAN WOO SHENGFU CHENG SHUMING JIAO HONGLIN LIU CHAO LU PUXIANG LAI Department of biomedical engineering The Hong Kong Polytechnic UniversityHong Kong SARChina Hong Kong Polytechnic University Shenzhen Research institute Shenzhen 518000China Peng Cheng laboratory Shenzhen 518055China key laboratory for Quantum optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Department of Electronic and Information engineering The Hong Kong Polytechnic UniversityHong Kong SARChina Photonics Research institute The Hong Kong Polytechnic UniversityHong Kong SARChina

Multimode fibers(MMFs)are a promising solution for high-throughput signal transmission in the time ***,crosstalk among different optical modes within the MMF scrambles input information and creates seemingly random speckle patterns at the *** characterize this process,a transmission matrix(TM)can be used to relate input and output *** innovations use TMs to manipulate the output field by shaping the input wavefront for exciting advances in deep-brain imaging,neuron stimulation,quantum networks,and analog ***,these approaches consider input/output segments as independent,limiting their use for separate signal processing,such as logic *** proposed method,which makes input/output segments as interdependent,adjusts the phase of corresponding output fields using phase bias maps superimposed on input *** superposition enables signal logic operations through a 15-m-long *** experiments,a single optical logic gate containing three basic logic functions and cascading multiple logic gates to handle binary operands is *** operations are performed for multi-bit logic operations,and multiple optical logic gates are reconstructed simultaneously in a single logic gate with polarization *** proposed method may open new avenues for long-range logic signal processing and transmission via MMFs.

关键词： optical polarization fiber

Scalable synthesis of lipid nanoparticles for nucleic acid drug delivery using an isometric channel-size enlarging strategy

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Nano Research 2024年第4期17卷 2899-2907页

作者： Zesen Ma Haiyang Tong Sijin Lin Li Zhou Demeng Sun Baoqing Li Changlin Tian Jiaru Chu Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230027China key laboratory of Precision Scientific Instrumentation of Anhui Higher Education institutes University of Science and Technology of ChinaHefei 230027China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China Anhui Provincial key laboratory of High Field Magnetic Resonance Imaging High Magnetic Field LaboratoryHefei Institute of Physical ScienceChinese Academy of SciencesHefei 230031China Anhui Provincial engineering laboratory of Peptide Drugs University of Science and Technology of ChinaHefei 230027China School of biomedical engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaSuzhou 215127China

Lipid nanoparticles(LNPs)have emerged as highly effective delivery systems for nucleic acid-based ***,the broad clinical translation of LNP-based drugs is hampered by the lack of robust and scalable synthesis techniques that can consistently produce formulations from early development to clinical *** this work,we proposed a method to achieve scalable synthesis of LNPs by scaling inertial microfluidic mixers isometrically in three ***,a theoretical predictive method,which controls the mixing time to be equal across different chips,is developed to ensure consistent particle size and size distribution of the synthesized *** loaded with small interfering RNA(siRNA)were synthesized at different flow rates,exhibiting consistent physical properties,including particle size,size distribution and encapsulation *** work provides a practical approach for scalable synthesis of LNPs consistently,offering the potential to accelerate the transition of nucleic acid drug development into clinical application.

关键词： lipid nanoparticles nucleic acid delivery microfluidics scalable synthesis consistent particle size

αExtractor: a system for automatic extraction of chemical information from biomedical literature

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Science China(Life sciences) 2024年第3期67卷 618-621页

作者： Jiacheng Xiong Xiaohong Liu Zhaojun Li Hongzhong Xiao Guangchao Wang Zhenjiang Niu Chaoyuan Fei Feisheng Zhong Gang Wang Wei Zhang Zunyun Fu Zhiguo Liu Kaixian Chen Hualiang Jiang Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of chinese academy of sciences Beijing 100049China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215125China College of Computer and Information engineering Dezhou UniversityDezhou 253023China

Dear Editor,Great progress has been made using artificial intelligence(AI) techniques in learning knowledge from biomedical databases in recent years, revolutionizing the study of many fields, such as protein structure prediction and protein design(Madani et al., 2023). However, there is massive biomedical knowledge not curated in the form of structured data but hidden in primary scientific literature.

关键词： has such knowledge