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Subretinal fibrosis seco.dary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is co.plex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its co.plications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular co.stituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of co.plement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,co.nective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the disco.ery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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The behaviors of ultra-low-gold-loaded catalysts （Au/ Ce02） for co.oxidation in the presence of water on the catalysts

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Nano Research 2015年第9期8卷 3075-3084页

作者： Qiaoling Li Wei Xie Guoqin Chen Yuefeng Li Yanjun Huang Xiaodong Chen Technology Center of china tobacco Fujian industrial co. Ltd Xiamen 361022 China Department of Chemical and Biochemical Engineering College of Chemistry and Chemical Engineering Xiamen University Xiamen 360015 China

The catalytic behavior of ultra-low-gold-loaded Au/CeO2 during co.oxidation was studied using HRTEM, TGA, in-situ FTIR, co.-TPD, O2-TPD, and O2-TPO. Herein, water, which facilitates co.oxidation, is present on the catalyst rather than obtained from the reactant gas. The experimental results show that the presence of water on the catalyst enhances the adsorption and activation of 02 to produce Oact on the catalyst surface, resulting in excellent catalytic activity. Different reaction pathways for co.oxidation over Au/CeO2 may be present; however, the dominant pathway is influenced by the species on the catalyst surface.

关键词： ultra-low-gold catalysts,water addition on thecatalysts,hydroxyl and carbonate-like species,reaction pathways

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Sesquiterpenes from the leaves of Nico.iana tabacum and their anti-tobacco mosaic virus activity

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Chinese Chemical Letters 2016年第5期27卷 753-756页

作者： Qin-Peng Shen Xing-Meng Xu Lan Li Wei Zhao Neng-Jun Xiang Guang-Yu Yang Yong-Kuan Chen Ming-Ming Miao Chun-Bo Liu Zhi-Hua Liu Key Laboratory of tobacco Chemistry of Yunnan Province China Tobacco Yunnan Industrial Co. Ltd. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmaco.ogy for Nature Products Kunming Medical University

In searching for more bioactive co.pounds, phytochemical investigations on the acetone extract of the leaves ofNico.iana tabacurn resulted in the isolation of two new sesquiterpenes, nico.esquiterpene A and B （1 and 2）, along with four known sesquiterpene derivatives （3-6）. Structural elucidation of I and 2 was performed by spectral methods, such as HRMS, IR, UV, 1D and 2D NMR spectrosco.y. co.pounds 1 and 2 are the first naturally occurring pterosin-type sesquiterpene bearing an isopropyl moiety. co.pounds 1-6 were also evaluated for their anti-tobacco mosaic virus （anti-TMV） activity. The results showed that co.pounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 36.7% and 45.6%, respectively, which is higher than that of positive co.trol. The other co.pounds also showed potential activity with inhibition rates in the range of 22.7%-29.2%.

关键词： Sesquiterpenes Anti-tobacco mosaic virus activity (AntiTMV) Nico.iana tabacum Structural elucidation Ningnanmycin

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Gas flow and filter ventilation of an unlit cigarette: model building,numerical solution and experimental validation

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烟草科技 2018年第A1期51卷 62-70页

作者： WANG Le CUI Xiaomeng YOU Min YI Bin XIE Guoyong LU Duanfeng DENG Nan ZHANG Ke ZHANG Mingjian LI Bin WANG Bing Zhengzhou tobacco Research Institute of CNTC No.2 Street Zhengzhou 450001 China Ningbo Cigarette Factory China Tobacco Zhejiang Industrial Co. Ltd.No. 102 Shuguang RoadNingbo 315500 ZhejiangChina Huaiyin Cigarette Factory China Tobacco Jiangsu Industrial Co. Ltd.No.32 Yipinmei RoadHuai'an 223002 Jiangsu China china tobacco Yunnan industrial co. Ltd.No.367 Hongjin Road Kunming 650231China Technology Center China Tobacctt Hunan Industrial Co. Ltd. No.426 Laodong Road Changsha 410007 China

Understanding the fundamcntal relationship betwecn gas dilution rate of a cigarette and key cigarette design parameters is important in the overall co.trol of smoke *** this work,an equation was derived to express the total gas dilution with the cigarette rod length,cigarette paper air permeability,and the filter ventilation *** relationship was validated using experimental *** accuracy of the developed model was dependent on the regression method used,i.e.,linear or a *** expression provides a quantitative description of the interactions between filter ventilation level,cigarette length,cigarette circumference and cigarette paper air permeability and the total air dilution at the cigarette's mouth end.

关键词： Cigarette paper permeability Filter ventilation Gas flow dilution Total ventilation rate Cigarette design Non-linear fitting

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Effect of Ga addition on the magnetic properties and microstructure of nanocrystalline Nd_(12.3)Fe_(81.7)B_(6.0) ribbons

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Rare Metals 2011年第5期30卷 447-452页

作者： BAO Xiaoqian GUO Xiaoyan GUO Jianchun GAO Xuexu State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China shandong Jinma industrial Group co. Ltd. Rizhao 276826 China

Nd 12.3 Fe 81.7 x Ga x B 6.0 （x = 0-1.8） ribbons were prepared by melt spinning at 22 m/s and subsequent annealing treatment. The influences of Ga addition and annealing co.ditions on the magnetic properties and microstructure of the nanocrystalline alloys were systematically investigated. After being annealed at 620℃ for 20 min, the J r and H ci increased from 0.85 T and 582.6 kA/m for Ga-free sample to 0.97 T and 734.6 kA/m for the x = 0.9 sample, respectively. The （BH） max for the x = 0.9 sample increased by about 40% from 96.3 to 135.5 kJ/m 3 co.pared with that of the Ga-free one. The significant improvement of magnetic properties originated from the refinement of grains in the samples by introducing Ga, which led to a stronger exchange co.pling between the neighboring grains in co.parison with that in Ga-free samples. The microstructure and magnetic properties of the samples depended strongly on annealing parameters, while the sensitivity of micro-structure to annealing co.ditions co.ld be significantly suppressed by the addition of Ga element.

关键词： nanocrystalline alloys exchange co.pling microstructure magnetic properties gallium

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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng co.lege of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are co.monly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver co.ld represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder

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World Journal of Clinical Cases 2025年第2期13卷 5-9页

作者： Wei Zhu Shanghai XiRong Information Science and Technology co. LtdNational Science and Technology ParkSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 ***/hyperactivity disorder(ADHD)is co.sidered a neurodevelopment and psychiatric disorder in *** characteristics and clinical presentation co.ld play an important role in the diagnosis of Sotos syndrome and *** resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and *** images process is co.sidered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more co.plete information in single image in this *** the future,genetic mechanisms and artificial intelligence related to medical images co.ld be used in the clinical diagnosis of Sotos syndrome and ADHD.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Genetic mutation Magnetic resonance imaging Wavelet fusion

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A new method for identifying flow pattern of spouted fluidized bed by co.pling Hilbert-Huang transform characteristics of differential pressure signals in different zones

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Particuology 2024年第6期89卷 67-78页

作者： Yongzhi Mei Yang Wang Lihui Zhang Feng Duan School of Energy and Environment Anhui University of TechnologyMaanshan243002China Wuhu Technology and Innovation Research Institute Wuhu241000China Wuhu Cigarette Factory of china tobacco Anhui industrial co. Ldt.Wuhu241002China

On a co.d spouted fluidized bed,this study co.pares the characteristic differences in intrinsic mode function(IMF)energy and Hilbert–Huang spectrum between the spout zone and annulus zone under different co.binations of spouted gas and fluidized gas flow rates for five typical flow *** energy distribution characteristics under different flow patterns are also *** Hilbert–Huang spectrum and IMF energy of pressure difference signals exhibit distinct variations in different zones as the flow pattern ***,there exists a co.relation between the energy in the middle-frequency range and the flow *** the K-means algorithm,the middle-frequency range energy of IMFs in the spout zone and annulus zone is subjected to clustering analysis,leading to the identification of partition boundaries for each flow *** on this,a flow pattern identification method of spouted fluidized bed co.pled with middle-frequency range energy in spout zone and annulus zone is proposed,which has very high identification accuracy.

关键词： Spouted fluidized bed Flow pattern Zoning signal Flow pattern transition Hilbert-Huang transform

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Regularized least-squares migration of simultaneous-source seismic data with adaptive singular spectrum analysis

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Petroleum Science 2017年第1期14卷 61-74页

作者： Chuang Li Jian-Ping Huang Zhen-Chun Li Rong-Rong Wang School of Geosciences China University of PetroleumQingdao 266580 Shandong China Hisense (shandong) Refrigerator co. Ltd HisenseQingdao 266580 Shandong China

Simultaneous-source acquisition has been reco.- nized as an eco.omic and efficient acquisition method, but the direct imaging of the simultaneous-source data produces migration artifacts because of the interference of adjacent sources. To overco.e this problem, we propose the regularized least-squares reverse time migration method （RLSRTM） using the singular spectrum analysis technique that imposes sparseness co.straints on the inverted model. Additionally, the difference spectrum theory of singular values is presented so that RLSRTM can be implemented adaptively to eliminate the migration artifacts. With numerical tests on a fiat layer model and a Marmousi model, we validate the superior imaging quality, efficiency and co.vergence of RLSRTM co.pared with LSRTM when dealing with simultaneoussource data, inco.plete data and noisy data.

关键词： Least-squares migration Adaptive singularspectrum analysis Regularization Blended data

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Design optimization of guide vane for mitigating elbow erosion using co.putational fluid dynamics and response surface methodology

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Particuology 2022年第4期20卷 83-94页

作者： Anjun Li Zhenbo Wang Liyun Zhu Zengli Wang Jingyuan Shi Wensan Yang School of New Energy China University of Petroleum(East China)266580 ShandongChina CNPC East china Design Institute co. Ltd.266071 ShandongChina

A90°elbow equipped with guide vanes was developed with the intent of reducing elbow *** models were formed to predict the maximum erosion rate of elbow and Face-1,and the response surface methodology was used to study the relationship between the erosion rate and structural parameters of guide vane.A seco.d-order response surface model was established to determine the relationship between R and variables,and a reduced cubic(RC)polynomial model was obtained to reveal the relation-ship between R2 and the three *** numerical results show that the low-speed region is expended and the maximum discrete particle matter(DPM)co.centration is reduced after installing the guide *** internal co.ponent provides a shelter for the elbow from the direct impact of high-speed solids.

关键词： Elbow Particle erosion Guide vane Response surface methodology

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