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A Dietary Source of High Level of Fluoroquinolone Tolerance in mcr-Carrying Gram-Negative Bacteria

research 2024年第3期2023卷 105-121页

作者： Tianqi Xu Dan Fang Fulei Li Zhiqiang Wang Yuan Liu Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses College of Veterinary MedicineYangzhou UniversityYangzhou 225009China. Joint international research Laboratory of Agriculture and Agri-Product Safety the Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China. institute of comparative Medicine Yangzhou UniversityYangzhou 225009China.

The emergence of antibiotic tolerance,characterized by the prolonged survival of bacteria following antibiotic exposure,in natural bacterial populations,especially in pathogens carrying antibiotic resistance genes,has been an increasing threat to public ***,the major causes contributing to the formation of antibiotic tolerance and underlying molecular mechanisms are yet poorly ***,we show that potassium sorbate(PS),a widely used food additive,triggers a high level of fluoroquinolone tolerance in bacteria carrying mobile colistin resistance gene *** studies demonstrate that PS treatment results in the accumulation of intracellular fumarate,which activates bacterial two-component system and decreases the expression level of outer membrane protein OmpF,thereby reducing the uptake of *** addition,the supplementation of PS inhibits aerobic respiration,reduces reactive oxygen species production and alleviates DNA damage caused by bactericidal ***,we demonstrate that succinate,an intermediate product of the tricarboxylic acid cycle,overcomes PS-mediated ciprofloxacin *** multiple animal models,ciprofloxacin treatment displays failure outcomes in PS preadministrated animals,including comparable survival and bacterial loads with the vehicle *** together,our works offer novel mechanistic insights into the development of antibiotic tolerance and uncover potential risks associated with PS use.

关键词： overcome thereby additive

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Exploring Paths of Students'Academic Burden Reduction in the East Asian educational Circle:An Analysis of Learning Time Investment and Efficiency Based on PISA 2022

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Frontiers of education in china 2024年第3期19卷 235-250页

作者： XU Jinjie LU Jing Lab for educational Big Data and Policymaking under the Ministry of education of the People's Republic of china Shanghai 200234China Shanghai Academy of educational Sciences Shanghai 200032China china research institute for international comparative education Shanghai Normal UniversityShanghai 200234China

By comparing the changes from the Organization for Economic Co-operation and Development's results of Programme for international Student Assessment(PISA)2018 and 2022,it is found that 15-year-old students in East Asian countries and economies maintain a commanding lead in reading,mathematics,and *** students from regions such as Singapore,Japan,the Republic of Korea,Hong Kong(china),Macao(china),and Chinese Taipei not only sustain their academic excellence but also experience improvements in learning efficiency and their sense of belonging at *** on the PISA 2022 data,this study analyzes students'learning time investment,out-of-school-hours(OsH)services,and their relationship with student academic *** results show that the above countries and economies have achieved encouraging results in academic burden reduction by decreasing learning time in regular school lessons,controlling homework time,and providing OsH *** distinctive policy interventions can serve as valuable reference points for the Chinese Mainland's ongoing implementation of the"double reduction"policy while facilitating an informed judgment of potential risks.

关键词： Programme for international Student Assessment(PISA)2022 East Asian educational circle academic burden reduction learning time

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Continuous preparation of strong and tough PVA nanocomposite fibers by mechanical stretching-assisted salting-out treatment

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Nano research 2024年第4期17卷 3156-3163页

作者： Hang Chen Guangze Yang Yingzhi Sun Yichao Xu Mingjie Liu Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of education School of ChemistryBeihang UniversityBeijing 100191China research institute for Frontier Science Beihang UniversityBeijing 100191China international research institute for Multidisciplinary Science Beihang UniversityBeijing 100191China

Polymer composite fibers with superior properties such as excellent combined strength and toughness and biocompatibility can be used in high-tech applications of braided protective devices and smart wearable,however the research of high-performance polymer composite fiber remains in the infant *** we present a strategy to produce strong and tough anisotropic polymer nanocomposite fibers with orientedly aligned salt rods using mechanical stretching-assisted salting-out *** prepared nanocomposite fibers have a tensile strength of up to 786±2.7 MPa and an elongation at break of 81%,and the anisotropic fibers exhibit good transmission of mechanical vibration in the longitudinal direction with high *** the fabrication process,the salt builds up into oriented rods during the directional salting process,and the polymer is confined to the 150 nm domain between the rods after the solvent is completely evaporated,giving the nanocomposite fibers superior mechanical *** presented strategy can be applied to the continuous mass production of nanocomposite fibers and is also generalizable to other polymer nanocomposites,which could extend the applicability of nanocomposite fibers to conditions involving more demanding mechanical loading and mechanical vibration transmission.

关键词： poly(vinyl alcohol)(PVA)nanofibers oriented structure ultrastrong and stiff mechanical vibration transmission salting out continuous production

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Large-area ultrastrong and stiff aramid nanofiber based layered nanocomposite films

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Nano research 2024年第2期17卷 829-835页

作者： Zhidong Nie Yingzhi Sun Tianxu Zhou Shengwen Kong Linxing Liu Chuangqi Zhao Mingjie Liu Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of education School of ChemistryBeihang UniversityBeijing 100191China University of Science and Technology of china Hefei 230026China Suzhou institute for Advanced research University of Science and Technology of ChinaSuzhou 215123China international research institute for Multidisciplinary Science Beihang UniversityBeijing 100191China

One-dimensional(1D)aramid nanofiber(ANF)based nanocomposite films have drawn increasing attentions in various applications due to their excellent mechanical properties and impressive chemical and thermal ***,the large-area fabrication of aramid nanocomposite films with ultrastrong mechanical properties under mild conditions remains a great *** we present a facile superspreading-assisted strategy to produce aramid nanofiber based oriented layered nanocomposites using phase inversion process that occurs at the fully swollen hydrogel *** nanocomposite films based on ANF,carboxylation carbon tube(CNT–COOH),poly(vinyl alcohol)(PVA),and MXene nanosheet exhibit a tensile strength of up to 870.8±85 MPa,a Young’s modulus of 21.8±2.2 GPa,and outstanding toughness(up to 43.2±4.6 MJ/m^(3)),which are much better than those conventional aramid nanofiber based *** conductivity of our nanocomposite films reaches the maximum of about 1100 S/*** fabulous mechanical properties combination and continuous production capability render our strategy representing a promising direction for the development of high-performance nanocomposites.

关键词： aramid nanofibers MXene nanosheets nanocomposites ultrastrong and stiff superspreading large-area production

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Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway

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Science china(Life Sciences) 2024年第4期67卷 663-679页

作者： Yanfang Liu Yan Wang Bing Liu Wenzhong Liu Yuanyuan Ma Yiren Cao Shi Yan Panpan Zhang Lixin Zhou Qimin Zhan Nan Wu Key Laboratory of Carcinogenesis and Translational research(Ministry of education/Beijing) Department of Thoracic Surgery IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational research(Ministry of education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational research(Ministry of education/Beijing) Department of Thoracic Oncology IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational research(Ministry of education) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China Peking University international Cancer institute Beijing 100191China institute of Cancer research Shenzhen Bay LaboratoryShenzhen 518132China

Chemoresistance is a significant barrier to effective cancer *** mechanisms for chemoresistance include reactive oxygen species(ROS)accumulation and expression of chemoresistance-promoting ***,we report a novel function of lncRNA16 in the inhibition of ROS generation and the progression of *** analyzing the serum levels of lncRNA16 in a cohort of 35 patients with non-small cell lung cancer(NSCLC)and paired serum samples pre-and post-treatment from 10 NSCLC patients receiving neoadjuvant platinum-based chemotherapy,performing immunohistochemistry(IHC)assays on 188 NSCLC tumor samples,using comprehensive identification of RNA-binding proteins by mass spectrometry(ChIRP-MS)assays,as well as RNA immunoprecipitation(RIP)and RNA pull-down analyses,we discovered that patients with increased serum levels of lncRNA16 exhibited a poor response to platinum-based *** expression of hemoglobin subunit beta(HBB)and NDUFAF5 significantly increases with the development of ***16 binds to HBB and promotes HBB accumulation by inhibiting ***16 can also inhibit ROS generation via the HBB/NDUFAF5 axis and function as a scaffold to facilitate the colocalization of HBB and NDUFAF5 in the ***,preclinical studies in mouse models of chemo-resistant NSCLC have suggested that lncRNA16 targeting by trivalent N-acetylgalactosamine(GalNAc)-conjugated siRNA restores chemosensitivity and results in tumor growth inhibition with no detectable toxicity in ***,lncRNA16 is a promising therapeutic target for overcoming chemoresistance,and the combination of first-line platinum-based chemotherapy with lncRNA16 intervention can substantially enhance anti-tumor efficacy.

关键词： chemoresistance lncRNARNA interference ROs chemosensitizer

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Quantifying quantum entanglement via machine learning models

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Communications in Theoretical Physics 2024年第7期76卷 52-56页

作者： Changchun Feng Lin Chen LMIB(Beihang University) Ministry of EducationBeijing 100191China School of Mathematical Sciences Beihang UniversityBeijing 100191China international research institute for Multidisciplinary Science Beihang UniversityBeijing 00191China

Quantifying entanglement measures for quantum states with unknown density matrices is a challenging *** learning offers a new perspective to address this *** training machine learning models using experimentally measurable data,we can predict the target entanglement *** this study,we compare various machine learning models and find that the linear regression and stack models perform better than *** investigate the model's impact on quantum states across different dimensions and find that higher-dimensional quantum states yield better ***,we investigate which measurable data has better predictive power for target entanglement *** correlation analysis and principal component analysis,we demonstrate that quantum moments exhibit a stronger correlation with coherent information among these data features.

关键词： quantum information entanglement predict machine learning coherence

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Two-dimensional and absolutely entanglement-breaking subspaces

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Communications in Theoretical Physics 2024年第9期76卷 21-26页

作者： Jian Yan Lin Chen LMIB(Beihang University) Ministry of Educationand School of Mathematical SciencesBeihang UniversityBeijing 100191China international research institute for Multidisciplinary Science Beihang UniversityBeijing 100191China

Entanglement-breaking(EB)subspaces determine the additivity of entanglement of formation(EOF),which is a long-standing issue in quantum *** explicitly construct the twodimensional EB subspaces of any bipartite system,when system dimensions are equal,and we apply the subspaces to construct EB spaces of arbitrary *** also present partial construction when system dimensions are ***,we present the notion and properties of EB subspaces for some systems,and in particular the absolute EB *** construct some examples of absolute EB subspaces,as well as EB subspaces for some systems by using multiqubit Dicke states.

关键词： entanglement-breaking subspaces entanglement of formation absolutely EB subspaces entanglement cost additivity

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AKT2^(S128)/CCTα^(S315/319/323)-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs)

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Signal Transduction and Targeted Therapy 2024年第2期9卷 782-796页

作者： Jie Chen Lingyuan Zhang Yuheng Zhu Di Zhao Jing Zhang Yanmeng Zhu Jingyuan Pang Yuanfan Xiao Qingnan Wu Yan Wang Qimin Zhan Key Laboratory of Carcinogenesis and Translational research(Ministry of education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&Institute100142 BeijingChina Peking University international Cancer institute Peking University100191 BeijingChina research Unit of Molecular Cancer research Chinese Academy of Medical SciencesBeijingChina Soochow University Cancer institute Suzhou 215000China institute of Cancer research Shenzhen Bay LaboratoryShenzhen 518107China

Abnormal metabolism is regarded as an oncogenic hallmark related to tumor progression and therapeutic *** study employed multi-omics,including phosphoproteomics,untargeted metabolomics and lipidomics,to demonstrate that the pAKT2 Ser128 and pCCTαSer315/319/323-positive cancer-associated fibroblasts(CAFs)substantially release phosphatidylcholines(PCs),contributing to the resistance of focal adhesion kinase(FAK)inhibitors in esophageal squamous cell carcinoma(ESCC)***,we observed extremely low levels of FAK Tyr397 expression in CAFs,potentially offering no available target for FAK inhibitors playing their anti-growth role in ***,FAK inhibitor increased the intracellular concentration of Ca2+in CAFs,promoting the formation of AKT2/CCTαcomplex,leading to phosphorylation of CCTαSer315/319/323 sites and eventually enhancing stromal PC *** activation could stimulate the intratumoral Janus kinase 2(JAK2)/Signal transducer and activator of transcription 3(STAT3)pathway,triggering resistance to FAK *** of clinical samples demonstrated that stromal pAKT2 Ser128 and pCCTαSer315/319/323 are related to the tumor malignancy and reduced patient ***-targeted lipidomics and further validation cohort quantitatively showed that plasma PCs enable to distinguish the malignant extent of ESCC *** conclusion,inhibition of stroma-derived PCs and related pathway could be possible therapeutic strategies for tumor therapy.

关键词： CAFs metabolism resistance

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comparative analysis between single-train passing and double-train intersection in a tunnel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 429-442页

作者： Jianming DU Qian FANG Xuan ZHANG Hualao WANG Bridge and Tunnel research Center Research Institute of Highway Ministry of TransportBeijing 100088China Tunnel and Underground Engineering research Center of Ministry of education Beijing Jiaotong UniversityBeijing 00044China

Aerodynamic pressure significantly impacts the scientific evaluation of tunnel service *** aerodynamic pressure of two trains running in a double-track tunnel is considerably more complicated than that of a single *** used the numerical method to investigate the difference in aerodynamic pressure between a single train and two trains running in a double-track ***,the numerical method was verified by comparing the results of numerical simulation and on-site ***,the characteristics of aerodynamic pressure were ***,the influence of various train-tunnel factors on the characteristics of aerodynamic pressure was *** results show that the aerodynamic pressure variation can be divided into stage I:irregular pressure fluctuations before the train tail leaves the tunnel exit,and stage II:periodic pressure declines after the train tail leaves the tunnel *** addition,the aerodynamic pressure simultaneously jumps positively or drops negatively for a single train or two trains running in double-track tunnel *** pressure amplitude in the two-train case is higher than that for a single *** maximum positive peak pressure difference(P_(STP))and maximum negative peak pressure difference(P_(STN))increase as train speed rises to the power from 2.256 to 2.930 in stage *** P_(STP) and P_(STN) first increase and then decrease with the increase of tunnel length in stage *** P_(STP) and P_(STN) increase as the blockage ratio rises to the power from 2.032 to 2.798 in stages I and II.

关键词： Railway tunnel Aerodynamic effect Pressure characteristic Train speed Tunnel length Blockage ratio

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Geobacter sulfurreducens promoted the biosynthesis of reduced graphene oxide and coupled it for nitrobenzene reduction

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Journal of Environmental Sciences 2024年第4期138卷 458-469页

作者： Shoujuan Zhang Qi Liu Linrui Zhong Jianhong Jiang Xiaozhe Luo Xingxin Hu Qian Liu Yue Lu College of Environmental Science and Engineering Hunan UniversityChangsha 410082China Shenzhen research institute Hunan UniversityShenzhen 510082China Key Laboratory of Environment Biology and Pollution Control Hunan UniversityMinistry of EducationChangsha 410082China china Machinery international Engineering Design&research institute Co. LtdChangsha 410007China Hunan Engineering research Center for Water Treatment Process&Equipment Changsha 410007China

In order to explore an efficient and green method to deal with nitrobenzene(NB)pollutant,reduced graphene oxide(r GO)as an electron shuttle was applied to enhance the extracellular electron transfer(EET)process of Geobacter sulfurreducens,which was a typical electrochemically active bacteria(EAB).In this study,r GO biosynthesis was achieved via the reduction of graphene oxide(GO)by *** PCA within 3 ***,the r GOPCA combining system completely reduced 50-200μmol/L of NB to aniline as end product within one *** characterization revealed that PCA cells were partly wrapped by rGO,and therefore the distance of electron transfer between strain PCA and r GO material was ***,the ID/IGof GO,r GO,and r GO-PCA combining system were 0.990,1.293 and 1.31,***,highest currents were observed in r GO-PCA-NB as 12.950μA/-12.560μA at -408 m V/156 m V,attributing to the faster electron transfer efficiency in EET ***,the NB reduction was mainly due to:(I)direct EET process from *** PCA to NB;(II)r GO served as electron shuttle and accelerated electron transfer to NB,which was the main degradation ***,the biosynthesis of r GO via GO reduction by Geobacter promoted the NB removal process,which provided a facile strategy to alleviate the problematic nitroaromatic pollution in the environment.

关键词： Reduced graphene oxide Geobacter Nitrobenzene Removal Extracellular electron transfer

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