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SeisResoDiff: Seismic resolution enhancement based on a diffusion model

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petroleum Science 2024年第5期21卷 3166-3188页

作者： Hao-Ran Zhang Yang Liu Yu-Hang Sun Gui Chen State Key Laboratory of petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China CNPC Key Laboratory of Geophysical Prospecting China University of Petroleum(Beijing)Beijing102249China School of petroleum China University of Petroleum(Beijing)at KaramayKaramay834000XinjiangChina Northeast petroleum university Daqing163318HeilongjiangChina

High resolution of post-stack seismic data assists in better interpretation of subsurface structures as well as high accuracy of impedance inversion. Therefore, geophysicists consistently strive to acquire higher resolution seismic images in petroleum exploration. Although there have been successful applications of conventional signal processing and machine learning for post-stack seismic resolution enhancement,there is limited reference to the seismic applications of the recent emergence and rapid development of generative artificial intelligence. Hence, we propose to apply diffusion models, among the most popular generative models, to enhance seismic resolution. Specifically, we apply the classic diffusion model—denoising diffusion probabilistic model(DDPM), conditioned on the seismic data in low resolution, to reconstruct corresponding high-resolution images. Herein the entire scheme is referred to as SeisResoDiff. To provide a comprehensive and clear understanding of SeisResoDiff, we introduce the basic theories of diffusion models and detail the optimization objective's derivation with the aid of diagrams and algorithms. For implementation, we first propose a practical workflow to acquire abundant training data based on the generated pseudo-wells. Subsequently, we apply the trained model to both synthetic and field datasets, evaluating the results in three aspects: the appearance of seismic sections and slices in the time domain, frequency spectra, and comparisons with the synthetic data using real well-logging data at the well locations. The results demonstrate not only effective seismic resolution enhancement,but also additional denoising by the diffusion model. Experimental comparisons indicate that training the model on noisy data, which are more realistic, outperforms training on clean data. The proposed scheme demonstrates superiority over some conventional methods in high-resolution reconstruction and denoising ability, yielding more competitive results

关键词： Seismic resolution enhancement Diffusion model High resolution Reservoir characterization Deep learning Seismic data processing

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

DETERMINATION OF ROCK-BREAKING PERFORMANCE OF HIGH-PRESSURE SUPERCRITICAL CARBON DIOXIDE JET

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Journal of Hydrodynamics 2012年第4期24卷 554-560页

作者： DU Yu-kun WANG Rui-he NI Hong-jian LI Mu-kun SONG Wei-qiang SONG Hui-fang College of petroleum Engineering China University of Petroleum(East China)Qingdao 266580China

In this study, a well-designed experimental setup is used to determine the rock-breaking performance of a high-pressure supercritical carbon dioxide （SC-CO2） jet. Its rock-breaking performance is first compared with that of a high-pressure water jet under the same operation conditions. The effects of five major factors that affect the rock-breaking performance of the high-pressure SC-CO2 jet, i.e., the nozzle diameter, the standoff distance, the jet pressure, the rock compressive strength and the jet temperature are experimentally determined. The experimental results indicate that the rock-breaking performance of the SC-CO2 jet is significantly improved over the high-pressure water jet. It is also found that the rock-breaking performance of the SC-CO2 jet is improved with the increase of the nozzle diameter or the standoff distance, until the nozzle diameter or the standoff distance reaches a certain critical value and after that it begins to deteriorate. The rock-breaking performance of the SC-CO2 jet improves monotonically with the increase of the jet pressure, while it shows a monotonic deterioration with the increase of the rock compressive strength. In addition, it is found that, under the same working conditions, the SC-CO2 jet can always provide a better rock-breaking performance than the subcritical liquid CO2 jet.

关键词： supercritical carbon dioxide drilling engineering rock-breaking performance

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo Li Fu Tang Jingkai Zhang Yuetong Kang Hean Zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

Permeability measurement of the fracture-matrix system with 3D embedded discrete fracture model

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petroleum Science 2022年第4期19卷 1757-1765页

作者： Bao Jia Cheng-Gang Xian State Key Laboratory of petroleum Resources and Prospecting China University of Petroleum(Bejing)Beijing 102249China Unconventional petroleum Research Institute China University of Petroleum(Bejing)Bejing 102249China

In this work, we performed the pulse-decay experiment on a fractured shale core and applied the 3 D embedded discrete fracture model(EDFM) to simulate the experiment process. The irregularly rough fracture surface was depicted in detail using a 3 D scanner. Then the fracture surface profile was imported in the discrete fracture network model to simulate the flow process in the fracture-matrix system realistically. History matching was efficiently performed to simultaneously obtain porosity and permeability for the matrix and fracture. Gas properties after applying nanopore confinement were obtained by modifying Sutton's viscosity correlation with sensitivity analysis on the pore diameter ranging from 2 to50 nm. Nanopore confinement results in low matched permeability due to viscosity reduction in the matrix-only porous media. The fracture-matrix system complicates the interpretation of nanopore confinement impact on flow behavior in shale reservoirs. Different scenarios of the highly fractured and matrix-dominated systems were discussed in detail by constructing the digital twin model.

关键词： Permeability Fracture Pulse-decay Shale Viscosity

A THREE-SEGMENT HYDRAULIC MODEL FOR ANNULAR CUTTINGS TRANSPORT WITH FOAM IN HORIZONTAL DRILLING

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Journal of Hydrodynamics 2008年第1期20卷 67-73页

作者： CHENG Rong-chao WANG Rui-he College of petroleum Engineering China University of Petroleum（East China） Dongying 257061 China

Through mechanical analysis, an improved hydraulic model for annular cuttings transport with foam was established for horizontal drilling. Based on the two critical inclination angles, the entire well was divided into three segments. The Bagnold stress, generalized power law rheological model and modified hindered particle settling velocity in foam fluid were adopted in the model to improve the simulation accuracy. The proposed model allows more precise prediction of cuttings transport property in the whole range of well inclination angle. Model performance was examined via case study and experimental data. Simulation results given by the propulsion iteration and trial-and-error method agree well with in-situ horizontal well drilling practice for the case study, and the comparison between the model prediction and Capo’s experimental data shows satisfactory agreement.

关键词： horizontal well foam fluid drilled cuttings hydraulic model well inclination angle

Enhancing output performance of triboelectric nanogenerator by increasing charge storage capacity of electrodes

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Nano Research 2025年第1期18卷 395-403页

作者： Congcong Hao Zekun Wang Mingzhe Cai Shuaining Cheng Zhongxin Wang Cong Zhai Juan Cui Yongqiu Zheng Chenyang Xue Key Laboratory of Instrumentation Science and Dynamic Measurement Ministry of Education North University of ChinaTaiyuan 030051China

ABSTRACT:The practical application of rotating triboelectric nanogenerators is often limited by the wear of high-friction surface materials and low surface charge *** addition to the charge pump replenishment strategy,suppressing charge decay is also crucial for increasing surface charge ***,we present a high performance rotary triboelectric nanogenerator(HPR-TENG)based on a coplanar charge pumping strategy and polyvinyl chloride(PVC)*** has been demonstrated that applying PVC film to the surface of the storage electrode of the main TENG(M-TENG)significantly enhances the M-TENG’s output ***,the HPR-TENG with three layers of PVC film pasted achieved the best output performance,with a peak-topeak output voltage of 2828 V,a peak-to-peak output current of 327μA and a charge transfer of 0.81μC at 500 *** addition,the output improvement effects of different materials are *** TENG with 3 layers of PVC film pasted on it has a maximum output power of 748 mW at a load resistance of 4×10^(6)Ω.HPR-TENG’s output performance remains consistent after 100,000 cycles,which shows excellent *** excellent electrical performance of the HPR-TENG can be used as the energy supply for the tip high-voltage breakdown sensor system,which can achieve 14 breakdowns in 10 *** to its extraordinary electrical performance,HPRTENG can not only serve as an energy supply for cutting-edge high-voltage breakdown sensor systems,but also has the potential to serve as an energy supply for high-pressure sterilization,high-pressure vacuum and water electrolysis.

关键词： triboelectric nanogenerator coplanar charge pump enhancing charge density suppressing charge decay polyvinyl chloride(PVC)film

Revolutionizing photothermal CO_(2)hydrogenation with ceria-based catalysts

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Nano Research 2025年第1期18卷 30-49页

作者： Zhaorui Zhang Xiao Han Junhong Zhang Yunyun Dong Jinsheng Zhao Qian Xu ingqiang Zhang School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252059China Institute for Catalysis Hokkaido UniversityN-21W-10Sapporo 001-0021Japan National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China

In the context of achieving carbon neutrality,CO_(2)catalytic conversion technologies are effective in reducing atmospheric CO_(2)concentrations while simultaneously producing renewable *** approach is seen as a viable method for constructing a new carbon cycle,thereby effectively addressing the issue of global *** CO_(2)conversion has recently emerged as a promising research focus due to its high energy utilization efficiency,superior CO_(2)conversion,excellent product selectivity,mild operating conditions,low energy consumption and minimal operating *** oxide(CeO_(2))has been widely used in photothermal catalysis due to its unique chemical properties,particularly when used as a support material with supported metals,creating distinctive interfacial sites for catalytic *** an emerging star support in photothermal CO_(2)conversion,its contributions are equally significant and should not be ***,to our knowledge,there has been no comprehensive review of CeO_(2)applications in catalytic hydrogenation of CO_(2).In this paper,we summarize and discuss CeO_(2)-based materials for photothermal CO_(2)conversion to value-added *** research particularly focuses on the synthesis methods of CeO_(2)-supported catalysts,the history of CeO_(2)in photothermal catalysis,types of photothermal catalytic reactors,unique characterization methods for the photothermal catalysts and the photothermal CO_(2)hydrogenation reactions by CeO_(2)-based *** related to further challenges and future directions for photothermal CO_(2)hydrogenation are also provided.

关键词： CO_(2)neutrality hydrogenation photothermal catalysis ceria C1 chemistry