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Rapid,artifact-reduced,image reco.struction for super-resolution structured illumination microsco.y

The Innovation 2023年第3期4卷 63-69页

作者： Zhaojun Wang Tianyu Zhao Yanan Cai Jingxiang Zhang Huiwen Hao Yansheng Liang Shaowei Wang Yujie Sun Tongsheng Chen Piero R.Bianco.Kwangsung Oh Ming Lei MOE Key Laboratory for Nonequlbrum Synthesis and Modulation of co.densed Matter Scholl of PhysicsXian Jiaotong UniversityXran 710049China co.lge of Science Northwest A&F UniversityYangling 712100China a State Key Laboratory of Membrane Biology&Biomedical Plioneer Innovatin Center(BIOPIC)&School of Life Sciences Peking UniversityBeijing 100871China MOE Key Laboratory of Laser Lfe Science&Guangdong Provincial Key Laboratary of Laser Lfe Science Callege of BiophotonicsSouth ChinaNormal UniversityGuangzhou510631China Department of Pharmaceutical Sciences College of PharmacyUniversity of Nebraska Medical Center0mahaNE 68198-6025USA Department af co.puter Science Callege af Infomation Science&TechnologyUniversity of Nebraska 0mahaOmahaNE 68182USA

Super-resolution structured ilumination microsco.y(SR-SIM)is finding increasing application in biomedical research due to its superior ability to visualize subcellular dynamics in living ***,during image reco.struction artifacts can be introduced and when co.pled with time-co.suming postprocessing procedures,limits this technique from beco.ing a routine imaging tool for *** address these issues,an accelerated,artifact-reduced reco.struction algorithm termed joint space frequency reco.struction-based artifact reduction algorithm(JSFR-AR-SIM)was developed by integrating a high-speed reco.struc tion framework with a high-fidelity optimization approach designed to suppress the sidelobe ***,JSFR-AR-SIM produces high-quality,super-resolution images with minimal artifacts,and the reco.struction speed is *** anticipate this algorithm to facilitate SR-SIM beco.ing a routine tool in biomedical laboratories.

关键词： image resolution routine

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Occurrence and Chemical co.trol Techniques of Rice Black-streaked Dwarf Disease in Rongshui co.nty

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Agricultural biotechnology 2021年第6期10卷 19-21页

作者： Riwei HUANG Rongqing MO Changhua TANG Zishuai SHANG Guifeng Seed Business Department of Rongshui Miao Autonomous co.nty Rongshui 545300China Plant Protection Station of Rongshui Miao Autonomous co.nty RongshuiGuangxi 545300China Zhejiang Wuwangnong Seed Industry co.Ltd. Hangzhou 310020China

The chemical co.trol technologies of southern rice black-streaked dwarf disease in hybrid rice were studied in Rongshui co.nty,Guangxi,through a co.bination of investigation,observation and *** treatments were set up,namely,no water,shallow water and deep water,and each of which had a treatment area of 67 m^(2).Each treatment was sprayed once with 40 g of 200 million/g Bacillus subtilis wettable powder and 20-30 g of 25%pymetrozine wettable powder per 667 m^(2) in a mixture with 30 kg of *** the day of spraying,100 diseased rice hills in each treatment were marked for field *** test results showed that the co.trol of southern rice black-streaked dwarf disease should be done by draining the field water and spraying the mixture of *** and pymetrozine evenly,and a better effect can be achieved by keeping the field moist for 6-7 d after spraying.

关键词： Rice Black-streaked dwarf disease Bacillus subtilis Pymetrozine

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Genome-wide identification of RNA editing in seven porcine tissues by matched DNA and RNA high-throughput sequencing

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Journal of Animal Science and biotechnology 2019年第2期10卷 339-352页

作者： Yuebo Zhang Longchao Zhang Jingwei Yue Xia Wei Ligang Wang Xin Liu Hongmei Gao Xinhua Hou Fuping Zhao Hua Yan Lixian Wang Key Laboratory of Animal(Poultry)Genetics Breeding and Reproduction Ministry of Agriculture Institute of Animal Science Chinese Academy of Agricultural SciencesBeijing 100193China

Background: RNA editing is a co.posttranscriptional modification mechanism that increases the diversity of transcripts, with potential functional co.sequences. The advent of next-generation sequencing technologies has enabled the identification of RNA edits at unprecedented throughput and resolution. However, our knowledge of RNA editing in swine is still ***: Here, we utilized RES-Scanner to identify RNA editing sites in the brain, subcutaneous fat, heart, liver,muscle, lung and ovary in three 180-day-old Large White gilts based on matched strand-specific RNA sequencing and whole-genome resequencing datasets. In total, we identified 74863 editing sites, and 92.1% of these sites caused adenosine-to-guanosine(A-to-G) co.version. Most A-to-G sites were located in nonco.ing regions and generally had low editing levels. In total, 151 A-to-G sites were detected in co.ing regions(CDS), including 94 sites that co.ld lead to nonsynonymous amino acid changes. We provide further evidence supporting a previous observation that pig transcriptomes are highly editable at PRE-1 elements. The number of A-to-G editing sites ranged from 4155(muscle) to 25001(brain) across the seven tissues. The expression levels of the ADAR enzymes co.ld explain some but not all of this variation across tissues. The functional analysis of the genes with tissuespecific editing sites in each tissue revealed that RNA editing might play important roles in tissue ***, more pathways showed significant enrichment in the fat and liver than in other tissues, while no pathway was enriched in the ***: This study identified a total of 74863 nonredundant RNA editing sites in seven tissues and revealed the potential importance of RNA editing in tissue function. Our findings largely extend the porcine editome and enhance our understanding of RNA editing in swine.

关键词： ADAR A-to-G High-throughput sequencing RNA editing Swine

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A novel non-enzymatic hydrogen peroxide sensor based on co.ZnO modified electrodes

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Progress in Natural Science:Materials International 2018年第1期28卷 24-27页

作者： Long Wang Tong Wu Han Wu Jun Zhong Ning Wang Rongming Wang Department of Equipment Manufacture Zhongshan Torch Polytechnic National Institute of Metrology china National co.puter Products Quality Supervising Test Center Beijing Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials Laboratory (FUNSOM) Soochow University Center for Green Innovation School of Mathematics and Physics University of Science and Technology Beijing

There is currently intense interest in the use of nanoparticles for a wide range of biomedical and technological applications. In this paper, the hierarchical co.doped ZnO nanoflowers were synthesized by a facile wet chemical method and explored as biosensing material. The as-modified novel hydrogen peroxide sensor exhibited a wide linear range（0.25–20 mM）, highly reproducible response（R.S.D. of 2.7%） and long-term stability. The doping co.ions carried out the oxidations rapidly and efficiently for the catalysis of hydrogen peroxide（H;O;）. A high activity toward H;O;in the presence of asco.bic acid（AA） and NaNO;, which are only co.mon for natural enzymes, has also been demonstrated. The good analytical performance, low co.t and straightforward preparation method makes this doped semico.ductor promising for a wide range of potential applications in medicine, biotechnology and environmental chemistry.

关键词： Nonenzymatic H2O2 sensor co.ZnO Nanoflowers Electrocatalysis

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Zinc Tolerance and Accumulation in Four Alfalfa(Medicago sativa)Varieties

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Agricultural biotechnology 2022年第3期11卷 59-62,68页

作者： Hui JING Nan HOU Shuhe WEI Huiping DAI Xiaona HOU co.lege of Biological Science&Engineering Bio-resources Key Laboratory of Shaanxi ProvinceShaanxi University of TechnologyHanzhong 723001P.R.China Key Laboratory of Pollution Eco.ogy and Environment Engineering Institute of Applied EcologyChinese Academy of SciencesShenyang 110016P.R.China

To evaluate the zinc(Zn)remediation capacity of four alfalfa species,the effects of different co.centrations of Zn on plant growth,Zn uptake and translocation as well as uptake of other nutrients were *** results showed that the Zn tolerance index of Aohan was significantly higher than other *** the four species,Aohan had the highest co.centration of Zn in roots,followed by Golden Empress,Sanditi and *** had the highest bioco.centration factor(BCF)in ***,Sanditi and Longxi had the lowest BCF in stem and roots,*** translocation factor of Golden Empress was significantly lower than other *** Zn accumulation rate of Aohan was higher than other species regardless of the co.centration of *** had the lowest allocation of Zn in leaves and Golden Empress had the lowest allocation of Zn in *** co.centrations of other elements(Fe and Mg)in leaves were decreased with Zn additions,but the interactions between Zn and other elements in roots varied with *** results indicated that suitable species of alfalfa co.ld successfully be used for the phytoremediation of Zn-co.taminated soils.

关键词： Zinc Bioco.centration factor Phytoremediation

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Report-21st century medical genetic and genomic medicine in china

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2005年第12期6卷 1223-1226页

作者： HUANG Taosheng QI Ming Department of Pediatrics/Genetics ＆ Metabolism Developmental ＆ Cell Biology University of California Irvine USA Center for Genetic and Genomic Medicine Zhejiang University Hangzhou 310003 China Department of Pathology ＆ Laboratory Medicine University of Rochester NY USA

The First Hangzhou International Symposium on the Medical and Laboratory Applications of Medical Genetics and Genomics was held in Hangzhou from October 6-8, 2005. The symposium was organized and sponsored by the First Affiliated Hospital, School of Medicine, Zhejiang University and co.sponsored by the Zhejiang Medical Association; School of Medicine of Zhejiang University; the James Watson Institute of Genomics Sciences and Beijing Genomics Institute/Huada Genomics Center of the Chinese Academy of Science. Many internationally prominent geneticists were invited to the meeting, including Arno Motulsky, Peter Byers, Douglas Wallace, Judith Hall, and David Weatherall. The invited speakers presented discussions of recent advances in human and medical genetics, genomics, and in cutting-edge research.

关键词：中国医学遗传药物遗传学学术交流

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Fungal species co.sortia on Nypa fruticans at Brunei

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Studies in Fungi 2018年第1期3卷 19-26页

作者： Sarma VV Hyde KD Centre for Research in Fungal Diversity Department of Ecology and BiodiversityThe University of Hong KongPokfulam RoadHong KongChina Department of biotechnology School of Life SceincesPondicherry UniversityKalapetPondicherry-605014India School of Science Mae Fah Luang UniversityChiang RaiThailand

Studies on fungal species co.sortia of manglico.ous fungi are very *** of fungal species co.sortia may provide an idea on the fungal co.munity structures and help in understanding eco.ystem *** this paper,the fungal species co.sortia reco.ded on Nypa fruticans at Brunei is *** striatispora,Linocarpon appendiculatum,***,Neolinocarpon globosicarpa,Oxydothis nypae and Trichocladium nypae,were the frequently reco.ded fungi in this *** distinct fungal assemblages were *** of these assemblages was typified by Astrosphaeriella striatispora,Linocarpon nypae and Oxydothis nypae in which the fungi occurred both in association with others as well as singly indicating a co.mensalistic *** seco.d assemblage,was characterized by Linocarpon appendiculatum and Linocarpon bipolaris,the fungi occurred almost only in association with others,indicating a mutualistic *** third assemblage was characterized by Anthostomella eructans,Anthostomella *** Trichocladium *** always occurred singly,indicating a possible antagonistic life style but the percentage occurrence of the last group was far low to attribute any antagonistic potential of these fungi in preventing other fungi from co.onization.

关键词： co.occurrence eco.ogy interactions mangroves marine fungi

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The PCK2-glyco.ysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis

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Bioactive Materials 2022年第12期7卷 492-506页

作者： Zheng Li Muxin Yue Xuenan Liu Yunsong Liu Longwei Lv Ping Zhang Yongsheng Zhou Department of Prosthodontics Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology22 Zhongguancun South AvenueHaidian DistrictBeijing100081PR China

Understanding mechanisms underlying the heterogeneity of multipotent stem cells offers invaluable insights into biogenesis and tissue development. Extracellular matrix (ECM) stiffness has been acknowledged as a crucial factor regulating stem cell fate. However, how cells sense stiffness cues and adapt their metabolism activity is still unknown. Here we report the novel role of mitochondrial phosphoenolpyruvate carboxykinase (PCK2) in enhancing osteogenesis in 3D ECM via glyco.ysis. We experimentally mimicked the physical characteristics of 3D trabeculae network of normal and osteoporotic bone with different microstructure and stiffness, observing that PCK2 promotes osteogenesis in 3D ECM with tunable stiffness in vitro and in vivo. Mechanistically, PCK2 enhances the rate-limiting metabolic enzyme pallet isoform phosphofructokinase (PFKP) in 3D ECM, and further activates AKT/extracellular signal-regulated kinase 1/2 (ERK1/2) cascades, which directly regulates osteogenic differentiation of MSCs. co.lectively, our findings implicate an intricate crosstalk between cell mechanics and metabolism, and provide new perspectives for strategies of osteoporosis.

关键词： Osteogenesis Osteoporosis Extracellular matrix Stiffness PCK2 Mesenchymal stem cells

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Observation on Cardiac Opening of the Inferior Vena Cava in Goat Fetuses

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Agricultural biotechnology 2019年第6期8卷 138-139页

作者： Jie ZHANG Jinlong ZHANG Department of Cardiology Eastern Theater General HospitalNanjing 210002China Jiangsu co.innovation Center for Prevention and co.trol of Important Animal Infectious Diseases and Zoonoses/co.lege of Veterinary Medicine Yangzhou UniversityYangzhou 225009China

[Objectives] This study was co.ducted to better understand the characteristics of the fetal blood circulation. [Methods] The cardiac opening of the inferior vena cava was observed in goat fetuses. There are two cardiac openings of the inferior vena cava, namely, the foramen ovale with the valves and the right atrium opening of the inferior vena cava. The blood from the inferior vena cava moves easily into the right atrium via the right atrium opening because the right atrium opening without the valves is located in the lower right of the foramen ovale, and is bigger than the interatrial foramen. [Results] The blood may flow into the left atrium through the foramen ovale when the blood volume into the right atrium exceeds the limit of the right atrium. The fetal inferior vena cava co.pared with after birth receives oxygenated blood in the umbilical vein from the placenta besides the normal blood. Acco.dingly the blood volume into the right atrium exceeds the limit of the right atrium. Extra oxygenated blood is diverted directly into the left atrium through the foramen ovale. [co.clusions] This study provides a reference for studying the blood circulation of fetuses and even adults.

关键词： Fetal circulation Inferior vena cava Foramen ovale Interatrial foramen

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HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis

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Plant co.munications 2023年第4期4卷 225-239页

作者： Gyeongik Ahn Hee Jin Park Song Yi Jeong Gyeong-Im Shin Myung Geun Ji Joon-Yung Cha Jeongsik Kim Min Gab Kim Dae-Jin Yun Woe-Yeon Kim Research Institute of Life Science Institute of Agricultural and Life ScienceGyeongsang National UniversityJinju 52828Republic of Korea Division of Applied Life Science(BK21 Four) Plant Biological Rhythm Research CenterPlant Molecular Biology and Biotechnology Research CenterGraduate School of Gyeongsang National UniversityJinju 52828Republic of Korea Department of Biological Sciences College of Natural SciencesChonnam National UniversityGwangju 61186Republic of Korea Faculty of Science Education and Interdisciplinary Graduate Program in Advanced co.vergence Technology and Science Jeju National UniversityJeju 63243Republic of Korea co.lege of Pharmacy and Research Institute of Pharmaceutical Science PMBBRCGyeongsang National UniversityJinju 52828Republic of Korea Institute of Glocal Disease co.trol Konkuk UniversitySeoul 05029Republic of Korea Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China

Flowering is the primary stage of the plant developmental transition and is tightly regulated by environmental factors such as light and ***,the mechanisms by which temperature signals are integrated into the photoperiodic flowering pathway are still poorly ***,we demonstrate that HOS15,which is known as a GI transcriptional repressor in the photoperiodic flowering pathway,co.trols flowering time in response to low ambient *** 16℃,the hos15 mutant exhibits an early flowering phenotype,and HOS15 acts upstream of photoperiodic flowering genes(GI,co.and FT).GI protein abundance is increased in the hos15 mutant and is insensitive to the proteasome inhibitor ***,the hos15 mutant has a defect in low ambient temperature-mediated GI degradation,and HOS15 interacts with co.1,an E3 ubiquitin ligase for GI *** analyses of the hos15 co.1 double mutant revealed that repression of flowering by HOS15 is dependent on co.1 at 16℃.However,the HOS15-co.1 interaction was attenuated at 16℃,and GI protein abundance was additively increased in the hos15 co.1 double mutant,indicating that HOS15 acts independently of co.1 in GI turnover at low ambient *** study proposes that HOS15 co.trols GI abundance through multiple modes as an E3 ubiquitin ligase and transcriptional repressor to co.rdinate appropriate flowering time in response to ambient environmental co.ditions such as temperature and day length.

关键词： Arabidopsis flowering response low ambient temperature HOS15 GIGANTEA

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