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chinese medical Journal 2024年第8期137卷 883-886页

作者： Xiaoshuang Wang Jing Wang Tao Cheng Institute of Basic medical sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

The Institute of Basic medical sciences(IBMS)is a global leader in biomedical research and advanced medical *** year(2023)marks the 65^(th)anniversary of its foundation at the chinese academy of medical sciences(CAMS)and School of Basic Medicine(SBM)of the Peking Union medical College(PUMC).In the beginning,the IBMS and SBM incorporated the premedical departments of the PUMC,which was established by the Rockefeller Foundation in *** then,these departments have been committed to undertakingrstrate medical science research in china.

关键词： Basic IBMS foundation

A Brief Overview of the Development and Significance of Modern Scientific Medicine in china:Take chinese academy of medical Science and Peking Union medical College as an Example

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chinese medical sciences Journal 2024年第2期39卷 140-143页

作者： Pu-An Cui Zhe-Xi Gong Zhong He School of Humanities and Social sciences Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China

Since the early 20th century,china has gradually established a clinical,educational,and research system centered around modern scientific medicine,which has now become the dominant force in china's medical and health system and services,with the construction and development of the chinese academy of medical sciences and Peking Union medical College as the most prominent *** scientific medicine in the new era requires close cooperation across multiple disciplines and fields to build a high-quality and efficient medical and health service *** also involves combining the excellent traditional chinese culture with Western medicine to explore a unique path of modern scientific medicine with chinese characteristics.

关键词： modern scientific medicine cultural confidence multiple view

Evaluating the historical,clinical,and cultural value of the Tian Hui Yi Jian

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Journal of Traditional chinese Medicine 2024年第1期44卷 220-221页

作者： YU Linyong GU Man china academy of chinese medical sciences Beijing 100700China Institute for History of Medicine and medical Literature China Academy of Chinese Medical SciencesBeijing 100700China

Tian Hui Yi Jian was compiled by the Tianhui medical Manuscripts Compilation Group,which includes scholars from the Institute for History of Medicine and medical Literature of the china academy of chinese medical sciences(CACMS),Chengdu University of Traditional chinese Medicine,Chengdu Institute of Cultural Relics and Archaeology,and Jingzhou Cultural Relics Protection *** was published by the Cultural Relics Press in November *** volume includes images of eight medical manuscripts,along with the Team's annotations,and photographs of a lacquered figurine with meridian-channels and words on its surface.

关键词： surface Chengdu Tian

A survey on facial image deblurring

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Computational Visual Media 2024年第1期10卷 3-25页

作者： Bingnan Wang Fanjiang Xu Quan Zheng Institute of Software Chinese Academy of SciencesBeijing100190China University of chinese academy of sciences Beijing100049China

When a facial image is blurred,it significantly affects high-level vision tasks such as face *** purpose of facial image deblurring is to recover a clear image from a blurry input image,which can improve the recognition accuracy,***,general deblurring methods do not perform well on facial ***,some face deblurring methods have been proposed to improve performance by adding semantic or structural information as specific priors according to the characteristics of the facial *** this paper,we survey and summarize recently published methods for facial image deblurring,most of which are based on deep ***,we provide a brief introduction to the modeling of image ***,we summarize face deblurring methods into two categories:model-based methods and deep learning-based ***,we summarize the datasets,loss functions,and performance evaluation metrics commonly used in the neural network training *** show the performance of classical methods on these datasets and metrics and provide a brief discussion on the differences between model-based and learning-based ***,we discuss the current challenges and possible future research directions.

关键词： facial image deblurring model-based deep learning-based semantic or structural prior

Comprehensive reutilization of herbal waste:Coproduction of magnolol,honokiol,and β-amyrin from Magnolia officinalis residue

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Green Energy & Environment 2024年第2期9卷 403-412页

作者： Lukun Xiao Anyi Zhao Jie Qiu An Liu Sha Chen Jinzhu Jiang Jun Zhang Cong Guo Jipeng Di Jintang Cheng Chang Chen Kangxin Hou Aiping Zhang Yan Liu Caixia Wang Institute of chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China School of Pharmacy Shanxi Medical UniversityTaiyuan030001China

Herbal extraction residues(HERs)cause serious environmental pollution and resource *** this study,a novel green route was designed for the comprehensive reutilization of all components in HERs,taking Magnolia officinalis residues(MOR)as an *** reluctant structure of MOR was first destroyed by alkali pretreatment to release the functional ingredients(magnolol and honokiol)originally remaining in MOR and to make MOR more accessible for hydrolysis.A metal–organic frame material MIL-101(Cr)with a maximum absorption capacity of 255.64 mg g^(-1)was synthesized to absorb the released honokiol and magnolol from the pretreated MOR solutions,and 40 g L^(-1)reducing sugars were obtained with 81.8%enzymatic hydrolysis rate at 10%MOR solid ***,382 mg L-1β-amyrin was produced from MOR hydrolysates by an engineered yeast *** total,1 kg honokiol,8 kg magnolol,and 7.64 kg β-amyrin could produce from 1 ton MOR by this cleaner process with a total economic output of 170,700 RMB.

关键词： Magnolia officinalis residues(MOR) Comprehensive utilization Metal-organic frame material Biosynthesis

Understanding Human and Machine Interaction from Decision Perspective: An Empirical Study Based on the Game of Go

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Journal of Systems Science & Complexity 2024年第2期37卷 647-667页

作者： ZHAO Ping LI Xuerong WANG Shouyang academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematical sciences University of Chinese Academy of SciencesBeijing 100190China

The authors aim to interpret human and AI interactions from the decision *** authors decompose the interaction analysis into the following main components in the context of interactions:Individual behavior patterns,interaction relationships,and comprehensive *** authors interpret intertemporal decisions from a physical perspective and employ cross-discipline concepts and methodologies to extract the behavior characteristics of players in the empirical case *** the individual behavior patterns,the authors find that human players prefer short-term periods to AI in *** interaction relationship analysis reveals a dynamic relationship between possible short-term co-movement and nearly counter-movement in the long *** authors apply principal component analysis to descriptive indicators and discover a regular decision *** main behavior pattern of players in the game of Go is switching between careful and daring *** differences in the decision hierarchies imply a discrepancy of patience between humans and AI.

关键词： Coherence analysis decision hierarchy machine behaviour multitaper spectral analysis

Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional chinese medicine JinMaiTong

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Journal of Pharmaceutical Analysis 2024年第2期14卷 225-243页

作者： Bingjia Zhao Qian Zhang Yiqian He Weifang Cao Wei Song Xiaochun Liang Department of Traditional chinese Medicine Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing100730China Institute of Basic Medicine sciences Chinese Academy of Medical SciencesBeijing100005China medical Research Center Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing100730China

Diabetic peripheral neuropathy (DPN) is a common and devastating complication of diabetes, for which effective therapies are currently lacking. Disturbed energy status plays a crucial role in DPN pathogenesis. However, the integrated profile of energy metabolism, especially the central carbohydrate metabolism, remains unclear in DPN. Here, we developed a metabolomics approach by targeting 56 metabolites using high-performance ion chromatography-tandem mass spectrometry (HPIC-MS/MS) to illustrate the integrative characteristics of central carbohydrate metabolism in patients with DPN and streptozotocin-induced DPN rats. Furthermore, JinMaiTong (JMT), a traditional chinese medicine (TCM) formula, was found to be effective for DPN, improving the peripheral neurological function and alleviating the neuropathology of DPN rats even after demyelination and axonal degeneration. JMT ameliorated DPN by regulating the aberrant energy balance and mitochondrial functions, including excessive glycolysis restoration, tricarboxylic acid cycle improvement, and increased adenosine triphosphate (ATP) generation. Bioenergetic profile was aberrant in cultured rat Schwann cells under high-glucose conditions, which was remarkably corrected by JMT treatment. In-vivo and in-vitro studies revealed that these effects of JMT were mainly attributed to the activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) and downstream peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). Our results expand the therapeutic framework for DPN and suggest the integrative modulation of energy metabolism using TCMs, such as JMT, as an effective strategy for its treatment.

关键词： Diabetic peripheral neuropathy JinMaiTong Energy metabolism Targeted metabolomics Adenosine monophosphate-activated protein kinase

Neuroinflammation attenuation effects by celastrol and PDIA3 in the amygdala, hippocampus and dorsal raphe nucleus of obese mice

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Journal of Pharmaceutical Analysis 2024年第2期14卷 287-290页

作者： Chunyan Zhu Xuemin Yao Dandan Liu Guoxin Zhang Yongping Zhu Hongyu Chi Shuangpan Zhang Jun Yang Ying Liu Jigang Wang Na Lin Institute of chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China

Nowadays,roughly 603.7 million people are bothered by obesity[1].More seriously,obesity brings inflammation to the peripheral and central nervous system,which compromises the comorbidity of obesity,major depression[2],and cognitive deficits[3].Drug competent in the comorbidity is still *** 2015,Liu et al.[4]reported celastrol(CEL)as a powerful anti-obesity *** our previous study.

关键词： inflammation obesity obese

Flame Synthesis of Zr/ZSM-5 Catalysts with Tunable Acidity for the Oxidative Dehydrogenation of Propane to Propene

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Journal of Thermal Science 2024年第1期33卷 268-283页

作者： DANIEL Samuel FONZEU MONGUEN Cedric Karel WU Lingnan TIAN Zhenyu Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China University of chinese academy of sciences Beijing 100049China

Tuning the surface acidity of ZSM-5 catalyst is essential to achieve desired propene selectivity and *** several ratios of Zr were utilized to modify ZSM-5 via flame spray pyrolysis technique coupled with a pulse spray evaporation *** interaction between Zr and ZSM-5 in the flame influenced the physicochemical and acidity properties of the Zr/*** increasing Zr ratio in ZSM-5 shows coated layers of irregular nano-sized Zr with an increase in crystallite sizes due to the synergetic effect between Zr and *** surface chemical analysis revealed increased lattice oxygen on the Zr modified ZSM-5(1:4) sample compared to other *** acidity analysis revealed the Lewis and Br?nsted acid distribution in the weak and medium acid sites on the catalyst ***,the increase in Zr loading decreased the concentration of Br?nsted acid sites and tuned the catalyst surface to more Lewis acidity,promoting propene selectivity and hindering the over-oxidation of *** modified ZSM-5 catalysts were examined in a fixed bed reactor within 300℃-700℃ at a gas hourly space velocity(GHSV) of 6000 mL·g(catalysts)^(-1)·h^(-1) for the oxidative dehydrogenation of propane(ODHP) to *** the catalysts,Zr/ZSM-5(1:4) exhibited the best propene yield, with 57.19% propane conversion and 75.54% selectivity to propene and the highest *** work provides a promising strategy for tuning the surface acidity of ZSM-5 with Zr for ODHP applications.

关键词： flame synthesis Zr modified ZSM-5 catalyst ODHP surface acidity lattice oxygen

A real-time calibration method based on time-to-digital converter for accelerator timing system

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Nuclear Science and Techniques 2024年第9期35卷 127-140页

作者： Qi-Hao Duan Liang Ge Yan-Hao Jia Jie-Yu Zhu Wei Zhang Institute of modern physics Chinese Academy of SciencesLanzhou 730000China University of chinese academy of sciences Beijing 100049China

The high-intensity heavy-ion accelerator facility(HIAF)is a scientific research facility complex composed of multiple cas-cade accelerators of different types,which pose a scheduling problem for devices distributed over a certain range of 2 km,involving over a hundred *** white rabbit,a technology-enhancing Gigabit Ethernet,has shown the capability of scheduling distributed timing devices but still faces the challenge of obtaining real-time synchronization calibration param-eters with high *** study presents a calibration system based on a time-to-digital converter implemented on an ARM-based System-on-Chip(SoC).The system consists of four multi-sample delay lines,a bubble-proof encoder,an edge controller for managing data from different channels,and a highly effective calibration module that benefits from the SoC *** performance was evaluated with an average RMS precision of 5.51 ps by measuring the time intervals from 0 to 24,000 ps with 120,000 data for every *** design presented in this study refines the calibration precision of the HIAF timing *** eliminates the errors caused by manual calibration without efficiency loss and provides data support for fault *** can also be easily tailored or ported to other devices for specific applications and provides more space for developing timing systems for particle accelerators,such as white rabbits on HIAF.

关键词： HIAF White rabbit Calibration system Time-to-digital converter(TDC)