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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Neural Regeneration research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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晶格畸变增强卤化锑晶体团簇的自陷激子发射（英文）

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Science china materials 2025年第1期 132-140页

作者：刘达何敬敬孙玉婷刘心翊彭玉李庆杨化桂牛强杨双侯宇 Key Laboratory for Ultrafine materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical Nanomaterials School of Materials Science and Engineering East China University of Science and Technology china National Enterprise Technology center Inner Mongolia Erdos Electric Power and Metallurgy Group Company Limited

零维钙钛矿材料以自陷激子引起的宽带发射为特征,是一种很有前途的刺激响应和光加密材料.然而,现有的研究主要集中在结构相变对光物理性质的影响上,对自陷激子的发射机制缺乏深入了解.本文证明了零维卤化锑单晶中的脱水反应,在不诱导结...

零维钙钛矿材料以自陷激子引起的宽带发射为特征,是一种很有前途的刺激响应和光加密材料.然而,现有的研究主要集中在结构相变对光物理性质的影响上,对自陷激子的发射机制缺乏深入了解.本文证明了零维卤化锑单晶中的脱水反应,在不诱导结构相变的基础上显著增强了自陷激子的发射,导致光致发光量子产率从3.5%大幅提高到91.4%.利用原位X射线衍射和光致发光技术揭示了晶体结构和光致发光强度之间的定性关系,证明了在脱水过程中引入了丰富的晶格畸变.温度依赖的荧光光谱和瞬态吸收光谱表明,晶格畸变导致中等的电子-声子耦合强度和更高的激子结合能,加速了自陷激子从非辐射复合单重态弛豫到辐射复合三重态,进而表现出增强的光致发光.作为概念验证,在防伪、可重写发光纸和湿度传感等多重场景中实现了应用.这一发现阐明了自陷激子的发射机制,并为设计可切换发光材料提供了一条新途径.

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Growth behavior and electronic regulation of Pt on various Mo-based supports for hydrogen evolution electrocatalysis

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Science china Chemistry 2025年

作者： Lulu Chen Yichao Huang Jiajun Wang Meihong Liao Zhiyuan Liu Meiqi Liu Hanqing Cai Lin Wang Lidong Gao Dawei Hu Lianming Zhao Ning Pu Zhuangjun Fan State Key Laboratory of Chemical Safety School of Materials Science and Engineering China University of Petroleum (East China) School of Mechanical and Electronic Engineering Qingdao Binhai University Qingdao Chuangqi New Energy Catalysis Technology Co.Ltd. Sinopec research Institute of Petroleum Processing Co.Ltd. Institute of Energy Hefei Comprehensive National Science Center

Insight into the growth behavior and electronic regulation of platinum （Pt） on various transition metal supports is paramount in developing high-performing electrocatalysts for hydrogen evolution reactions （HER）.Herein,we studied the influence of molybdenum-based supports （MoX,X=C,N,P,and S） on the growth behavior and electronic regulation of *** found that the formation energy variations between Pt single atom and clusters on MoX supports play a pivotal role in the growth behavior of ***,the electronic regulation of Pt induced by metal-support interaction may reflect the valence changes of Pt in Pt-MoX/*** Pt-MoC/C catalyst with a moderate valence state of Pt exhibits the best HER activity with an overpotential of 12.0 mV at 10 mA cm-2and a mass activity of 27.1 A mgPt-1,12.3 times as high as that of commercial 20 wt% Pt/*** work provides constructive guidance for the design of high-performance HER catalysts.

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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Development of target fabrication for laser-driveninertial confinement fusion at research center oflaser fusion

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High Power Laser Science and Engineering 2017年第1期5卷 25-33页

作者： Tao Wang Kai Du Zhibing He Xiaoshan He research center of Laser Fusion China Academy of Engineering PhysicsMianyang 621900China

As the basic conditions for laser inertial confinement fusion(ICF) research, the targets are required to be well specified and elaborately fabricated. Because of the characteristics of the targets, the research and fabrication process is a systematically tough task, which needs fundamental and deep insights into film deposition, mechanical machining,precise measurement and assembly, etc. As a result, knowledge of material science, physics, mechanical as well as electronics is a necessity for target researchers. In this paper, we give introductions to the state of art on target fabrication for ICF research at research center of Laser Fusion(RCLF) in china.

关键词： development ICF target fabrication

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Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and materials 2025年第2期32卷 233-255页

作者： Youpeng Xu Sheng Pang Liangwei Cong Guoyu Qian Dong Wang Laishi Li Yusheng Wu Zhi Wang College of materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

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Chelating ligand-bridged IO-Gd nanoparticles with enhanced contrast performance for dual-mode MRI

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Journal of materials Science & Technology 2024年第17期184卷 54-63页

作者： Lili Hao Haoyang Ding Xiangchuan Xu Hongli Mao Zhongwei Gu research Institute for Biomaterials Tech Institute for Advanced MaterialsBio-inspired Biomedical Materials&Devices CenterCollege of Materials Science and EngineeringJiangsu Collaborative Innovation Center for Advanced Inorganic Function CompositesSuqian Advanced Materials Industry Technology Innovation CenterNanjing Tech UniversityNanjing 211816China NJTech-BARTY Joint research center for Innovative Medical Technology Nanjing 210000China

Magnetic resonance imaging(MRI)is a non-invasive medical imaging technique that has been widely applied in the clinical diagnosis of diseases across various ***,there is a dearth of high-performance dual-mode contrast agents that provide precise diagnostic information for complex *** this study,iron oxide-gadolinium nanoparticles(IO-Gd NPs)bridged by hydrophilic ligand ethylenedi-amine tetramethylenephosphonic acid(EDTMP)are designed inspired by Solomon-Bloembergen-Morgan(SBM)theory,where T_(1)and T_(2)relaxivity increase with a reduction in Gd *** particular,the NPs with minimum Gd content exhibit excellent dual-mode contrast performance(r_(1)=94.42 mM^(−1)s^(−1),r_(2)=343.62 mM^(−1)s^(−1)).The underlying mechanism is that the bridged EDTMP coordinate limits Gd tum-bling and forces Gd^(3+)to expose itself to the surface of the *** provides more opportunities for water molecules to coordinate with Gd^(3+)and significantly enhances proton ***,the hy-drophilicity of the ligand enhances the water dispersion stability of the NPs and increases the exchange rate of water protons near the NPs,further enhancing the dual-mode contrast ***,the biocom-patibility and in vitro/vivo imaging performances of the IO@EDTMP-Gd NPs are systematically evaluated,and the results demonstrate their potential as dual-mode contrast *** study provides a new strategy for developing dual-mode MRI contrast agents that can further improve the accuracy of MRI in the diagnosis of complex diseases.

关键词： Magnetic resonance imaging Dual-mode contrast agent Chelating ligand Iron oxide Gadolinium

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A-D-A′-D-A型非稠环电子受体及其在有机太阳电池与光探测器中的应用（英文）

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Science china materials 2025年第1期 1-20页

作者：魏文魁周霞杨明群吴宝奇段春晖 Institute of Polymer Optoelectronic materials and Devices Guangdong Basic Research Center of Excellence for Energy & Information Polymer MaterialsState Key Laboratory of Luminescent Materials and Devices South China University of Technology School of New Energy Ningbo University of Technology

A–D–A′–D–A型非稠环电子受体(NFREA)是由给电子单元(D)桥连不同的吸电子单元(A和A′)组成.由于给/吸电子单元之间通过碳-碳单键连接, A–D–A′–D–A型非稠环电子受体通常具有合成简单、光电性能易于调控等优点.近年来,其在有机...

A–D–A′–D–A型非稠环电子受体(NFREA)是由给电子单元(D)桥连不同的吸电子单元(A和A′)组成.由于给/吸电子单元之间通过碳-碳单键连接, A–D–A′–D–A型非稠环电子受体通常具有合成简单、光电性能易于调控等优点.近年来,其在有机太阳电池(OSC)和有机光探测器(OPD)领域,逐渐成为一类非常有潜力的电子受体.本文系统回顾了A–D–A′–D–A型非稠环电子受体的进展,包括分子设计、器件性能、结构-性质关系,以及其在OSC和OPD中的应用.最后,本文讨论了该类电子受体当前所面临的挑战,并展望了其未来的发展前景.

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Cyano migration-mediated radical-polar crossover cyclopropanation

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Science china Chemistry 2025年第01期 241-248页

作者： Ziqiang Wang Yasu Chen Jie Li Chen Zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

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Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei Panpan Zhao Yongchun Wang Mingxi Li Li Sun Department of Neurology and Neuroscience center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs

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