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chinese PHYSICS B 2024年第9期33卷 374-382页

作者： Xu, Jingyang Guo, Li Qi, Xin Lu, Ronghua Zhang, Min Zhang, Jingtao Chen, Jing Shanghai Normal Univ Dept Phys Shanghai 200234 Peoples R China chinese acad sci Shanghai Inst Opt & Fine Mech Key Lab Quantum Opt Shanghai 201800 Peoples R China chinese acad sci Shanghai Inst Opt & Fine Mech Ctr Cold Atom Phys Shanghai 201800 Peoples R China Univ sci & Technol china Hefei Natl Res Ctr Phys Sci Microscale Hefei 230026 Peoples R China Univ sci & Technol china Sch Phys Sci Hefei 230026 Peoples R China Shenzhen Technol Univ Coll Engn Phys Shenzhen Key Lab Ultraintense Laser & Adv Mat Tech Shenzhen 518118 Peoples R China

A Wigner-distribution-like (WDL) function based on the strong-field approximation (SFA) theory is used to investigate the ionization time of the photoelectron emitted from the initial states with different magnetic quantum number m in elliptically polarized electric fields. The saddle-point method is adopted for comparisons. For different m states, a discrepancy exists in the WDL distributions of the photoelectrons emitted in a direction close to the major axis of the laser field ellipse. Based on the saddle-point analysis, this discrepancy can be ascribed to the interference between electrons ionized from two tunneling instants. Our results show that the relationships between the tunneling instants and kinetic energy of photoelectrons are the same for different m initial states when the Coulomb potential is not considered. Our work sheds some light on the ionization-time information of electrons from different magnetic quantum states.

关键词： strong-field ionization Wigner-distribution-like ionization instant 33.80.Rv 33.80.Wz 42.50.Hz IONIZATION

A citrullinated antigenic vaccine in treatment of autoimmune arthritis

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sciENCE BULLETIN 2024年第18期69卷 2920-2929页

作者： Jin, Xu Dong, Tianya Wang, Qian Xie, Yang Fang, Xiangyu Wei, Chaonan Liu, Shuyan Zheng, Xi Wang, Ping Zhu, Danxue Cao, Lulu Dong, Suwei Fang, Kechi Zhong, Chao Wang, Jing Hu, Fanlei Li, Zhanguo Peking Univ Peoples Hosp Dept Rheumatol & Immunol Beijing 100044 Peoples R China Beijing Key Lab Rheumatism Mech & Immune Diag Beijing 100044 Peoples R China Peking Univ Peking Tsinghua Ctr Life Sci Beijing 100871 Peoples R China Peking Univ Sch Pharmaceut Sci State Key Lab Nat & Biomimet Drugs Beijing 100191 Peoples R China Peking Univ Sch Basic Med Sci Dept Integrat Chinese & Western Med Beijing 100191 Peoples R China Peking Univ Sch Pharmaceut Sci Dept Chem Biol Beijing 100191 Peoples R China chinese acad sci Inst Psychol CAS Key Lab Mental Hlth Beijing 100101 Peoples R China Univ chinese acad sci Dept Psychol Beijing 100049 Peoples R China Peking Univ NHC Key Lab Med Immunol Beijing Key Lab Tumor Syst Biol Inst Syst BiomedDept ImmunolHlth Sci Ctr Beijing 100191 Peoples R China

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease triggered by antigenic peptides with environmental and genetic risk factors. It has been shown that antigen-specific targeting could be a promising therapeutical strategy for RA by restoring immune tolerance to self-antigens without compromising normal immunity. Citrullination of antigens enhances antigenic properties and induces autoimmune responses. Here, we showed that citrullinated antigenic (citAg) vaccine ameliorated collagen-induced arthritis with decreased T-helper 1 (Th1) and Th17 cells, downregulated proinflammatory cytokines including interlukin-6 and tumor necrosis factor-alpha, and inhibited antigen recall responses. B cell receptor sequencing further revealed that citAg vaccine could dampen the dysregulated V(D)J recombination, restoring the immune repertoire. Taken together, the results demonstrated that citAg vaccine might have a therapeutic effect on RA. (c) 2024 science china Press. Published by Elsevier B.V. and science china Press. This is an open access article under the CC BY license (http://***/licenses/by/4.0/).

关键词： CitAg Citrullination Collagen type II Therapeutic vaccine Immune tolerance Rheumatoid arthritis RHEUMATOID-ARTHRITIS LUNGS SUPPRESSION TOLERANCE PROTEINS

Spatiotemporal Evaluation and Future Projection of Diurnal Temperature Range over the Tibetan Plateau in CMIP6 Models

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ADVANCES IN ATMOSPHERIC sciENCES 2024年第11期41卷 2245-2258页

作者： Zhang, Suguo Hu, Qin Meng, Xianhong Lue, Yaqiong Yang, Xianyu Chengdu Univ Informat Technol Sch Atmospher Sci Plateau Atmosphere & Environm Key Lab Sichuan Prov Chengdu 610225 Peoples R China Sun Yat Sen Univ Sch Atmospher Sci Zhuhai 519082 Peoples R China Tech Univ Munich Sch Engn & Design Earth Syst Modelling Munich Germany chinese acad sci Northwest Inst Ecoenvironm & Resources Lanzhou 730000 Peoples R China chinese acad sci Inst Mt Hazards & Environm Chengdu 610041 Peoples R China

The diurnal temperature range (DTR) serves as a vital indicator reflecting both natural climate variability and anthropogenic climate change. This study investigates the historical and projected multitemporal DTR variations over the Tibetan Plateau. It assesses 23 climate models from phase 6 of the Coupled Model Intercomparison Project (CMIP6) using CN05.1 observational data as validation, evaluating their ability to simulate DTR over the Tibetan Plateau. Then, the evolution of DTR over the Tibetan Plateau under different shared socioeconomic pathway (SSP) scenarios for the near, middle, and long term of future projection are analyzed using 11 selected robustly performing models. Key findings reveal: (1) Among the models examined, BCC-CSM2-MR, EC-Earth3, EC-Earth3-CC, EC-Earth3-Veg, EC-Earth3-Veg-LR, FGOALS-g3, FIO-ESM-2-0, GFDL-ESM4, MPI-ESM1-2-HR, MPI- ESM1-2-LR, and INM-CM5-0 exhibit superior integrated simulation capability for capturing the spatiotemporal variability of DTR over the Tibetan Plateau. (2) Projection indicates a slightly increasing trend in DTR on the Tibetan Plateau in the SSP1-2.6 scenario, and decreasing trends in the SSP2-4.5, SSP3-7.0, and SPP5-8.5 scenarios. In certain areas, such as the southeastern edge of the Tibetan Plateau, western hinterland of the Tibetan Plateau, southern Kunlun, and the Qaidam basins, the changes in DTR are relatively large. (3) Notably, the warming rate of maximum temperature under SSP2-4.5, SSP3-7.0, and SPP5-8.5 is slower compared to that of minimum temperature, and it emerges as the primary contributor to the projected decrease in DTR over the Tibetan Plateau in the future.

关键词： Tibetan Plateau CMIP6 models diurnal temperature range model assessment historical period future projection SOLAR-RADIATION CLIMATE TRENDS 20TH-CENTURY VARIABILITY REGION china

Quantum confinement of carriers in the type-I quantum wells structure

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chinese PHYSICS B 2024年第9期33卷 553-558页

作者： Li, Xinxin Deng, Zhen Jiang, Yang Du, Chunhua Jia, Haiqiang Wang, Wenxin Chen, Hong chinese acad sci Inst Phys Beijing Natl Lab Condensed Matter Phys Key Lab Renewable EnergyBeijing Key Lab New Energ Beijing 100190 Peoples R China Univ chinese acad sci Ctr Mat & Optoelect Engn Beijing 100049 Peoples R China Yangtze River Delta Phys Res Ctr Liyang 213300 Peoples R China Songshan Lake Mat Lab Dongguan Peoples R China

Quantum confinement is recognized to be an inherent property in low-dimensional structures. Traditionally, it is believed that the carriers trapped within the well cannot escape due to the discrete energy levels. However, our previous research has revealed efficient carrier escape in low-dimensional structures, contradicting this conventional understanding. In this study, we review the energy band structure of quantum wells along the growth direction considering it as a superposition of the bulk material dispersion and quantization energy dispersion resulting from the quantum confinement across the whole Brillouin zone. By accounting for all wave vectors, we obtain a certain distribution of carrier energy at each quantized energy level, giving rise to the energy subbands. These results enable carriers to escape from the well under the influence of an electric field. Additionally, we have compiled a comprehensive summary of various energy band scenarios in quantum well structures relevant to carrier transport. Such a new interpretation holds significant value in deepening our comprehension of low-dimensional energy bands, discovering new physical phenomena, and designing novel devices with superior performance.

关键词： energy band quantum confinement type-I quantum wells low-dimensional structures 73.21.Fg 73.20.At 73.63.-b

Epigenetics and environmental health

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FRONTIERS OF medICINE 2024年第4期18卷 571-596页

作者： Zhang, Min Hu, Ting Ma, Tianyu Huang, Wei Wang, Yan chinese acad med sci & Peking Union med Coll Natl Canc Ctr Key Lab Canc & Microbiome State Key Lab Mol OncolNatl Clin Res Ctr CancCan Beijing 100021 Peoples R China Capital med Univ Sch Basic Med Sci Dept Biochem & Mol Biol Beijing Key Lab Canc Invas & Metastasis Res Beijing 100069 Peoples R China

Epigenetic modifications including DNA methylation, histone modifications, chromatin remodeling, and RNA modifications complicate gene regulation and heredity and profoundly impact various physiological and pathological processes. In recent years, accumulating evidence indicates that epigenetics is vulnerable to environmental changes and regulates the growth, development, and diseases of individuals by affecting chromatin activity and regulating gene expression. Environmental exposure or induced epigenetic changes can regulate the state of development and lead to developmental disorders, aging, cardiovascular disease, Alzheimer's disease, cancers, and so on. However, epigenetic modifications are reversible. The use of specific epigenetic inhibitors targeting epigenetic changes in response to environmental exposure is useful in disease therapy. Here, we provide an overview of the role of epigenetics in various diseases. Furthermore, we summarize the mechanism of epigenetic alterations induced by different environmental exposures, the influence of different environmental exposures, and the crosstalk between environmental variation epigenetics, and genes that are implicated in the body's health. However, the interaction of multiple factors and epigenetics in regulating the initiation and progression of various diseases complicates clinical treatments. We discuss some commonly used epigenetic drugs targeting epigenetic modifications and methods to prevent or relieve various diseases regulated by environmental exposure and epigenetics through diet.

关键词： epigenetics environmental exposure health prevention and therapy DNA-METHYLATION HISTONE MODIFICATION OXIDATIVE STRESS NONCODING RNAS BLOOD-PRESSURE EXPOSURE CANCER CELLS GENE MICROBIOTA

Advanced strategies for 3D-printed neural scaffolds: materials, structure, and nerve remodeling

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BIO-DESIGN AND MANUFACTURING 2024年第5期7卷 747-770页

作者： He, Jian Qiao, Liang Li, Jiuhong Lu, Junlin Fu, Zhouping Chen, Jiafang Zhang, Xiangchun Hu, Xulin Henan Univ sci & Technol Coll Basic Med & Forens Med Luoyang 471023 Peoples R China Henan Univ sci & Technol Affiliated Hosp 1 Coll Clin Med Luoyang 471003 Peoples R China chinese acad Agr sci Tea Res Inst Hangzhou 310008 Peoples R China Chengdu Univ Affiliated Hosp Clin Med Coll Chengdu 610081 Peoples R China Sichuan Univ West China Hosp Dept Cardiovasc Surg Dept BiotherapyCanc Ctr Chengdu 610041 Peoples R China Sichuan Univ West China Hosp State Key Lab Biotherapy Chengdu 610041 Peoples R China Sichuan Univ West China Hosp Dept Neurosurg Chengdu 610041 Peoples R China

Nerve regeneration holds significant potential in the treatment of various skeletal and neurological disorders to restore lost sensory and motor functions. The potential of nerve regeneration in ameliorating neurological diseases and injuries is critical to human health. Three-dimensional (3D) printing offers versatility and precision in the fabrication of neural scaffolds. Complex neural structures such as neural tubes and scaffolds can be fabricated via 3D printing. This review comprehensively analyzes the current state of 3D-printed neural scaffolds and explores strategies to enhance their design. It highlights therapeutic strategies and structural design involving neural materials and stem cells. First, nerve regeneration materials and their fabrication techniques are outlined. The applications of conductive materials in neural scaffolds are reviewed, and their potential to facilitate neural signal transmission and regeneration is highlighted. Second, the progress in 3D-printed neural scaffolds applied to the peripheral and central nerves is comprehensively evaluated, and their potential to restore neural function and promote the recovery of different nervous systems is emphasized. In addition, various applications of 3D-printed neural scaffolds in peripheral and neurological diseases, as well as the design strategies of multifunctional biomimetic scaffolds, are discussed.

关键词： Nerve regeneration 3D printing based neural scaffolds Biomaterials Nervous system Design strategies SPINAL-CORD-INJURY PERIPHERAL-NERVE STEM-CELLS 3D FABRICATION DIFFERENTIATION INKS

Non-perturbative dynamics of flat-band systems with correlated disorder

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chinese PHYSICS B 2024年第9期33卷 547-551页

作者： Li, Qi Liu, Junfeng Liu, Ke Hu, Zi-Xiang Li, Zhou chinese acad sci Aerosp Informat Res Inst GBA Branch Guangzhou 510535 Peoples R China Guangdong Prov Key Lab Terahertz Quantum Electrom Guangzhou 510700 Peoples R China Univ chinese acad sci Beijing 100039 Peoples R China Guangzhou Univ Sch Phys & Mat Sci Guangzhou 510006 Peoples R China Chongqing Univ Dept Phys Chongqing 401331 Peoples R China Chongqing Univ Chongqing Key Lab Strongly Coupled Phys Chongqing 401331 Peoples R China

We develop a numerical method for the time evolution of Gaussian wave packets on flat-band lattices in the presence of correlated disorder. To achieve this, we introduce a method to generate random on-site energies with prescribed correlations. We verify this method with a one-dimensional (1D) cross-stitch model, and find good agreement with analytical results obtained from the disorder-dressed evolution equations. This allows us to reproduce previous findings, that disorder can mobilize 1D flat-band states which would otherwise remain localized. As explained by the corresponding disorder-dressed evolution equations, such mobilization requires an asymmetric disorder-induced coupling to dispersive bands, a condition that is generically not fulfilled when the flat-band is resonant with the dispersive bands at a Dirac point-like crossing. We exemplify this with the 1D Lieb lattice. While analytical expressions are not available for the two-dimensional (2D) system due to its complexity, we extend the numerical method to the 2D alpha-T3 model, and find that the initial flat-band wave packet preserves its localization when alpha = 0, regardless of disorder and intersections. However, when alpha not equal 0, the wave packet shifts in real space. We interpret this as a Berry phase controlled, disorder-induced wave-packet mobilization. In addition, we present density functional theory calculations of candidate materials, specifically Hg1-xCdxTe. The flat-band emerges near the Gamma point (k = 0) in the Brillouin zone.

关键词： flat-band system dynamics correlated disorder 72.80.Ng 78.20.Bh 67.80.de 05.50.+q HUBBARD-MODEL FERROMAGNETISM LOCALIZATION INSULATOR

BSAlign: A Library for Nucleotide Sequence Alignment

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GENOMICS PROTEOMICS & BIOINFORMATICS 2024年第2期22卷 qzae025页

作者： Shao, Haojing Ruan, Jue chinese acad Agr sci Agr Genom Inst Shenzhen Shenzhen Branch Guangdong Lab Lingnan Modern AgrGenome Anal LabM Shenzhen 518120 Peoples R China

Increasing the accuracy of the nucleotide sequence alignment is an essential issue in genomics research. Although classic dynamic programming (DP) algorithms (e.g., Smith-Waterman and Needleman-Wunsch) guarantee to produce the optimal result, their time complexity hinders the application of large-scale sequence alignment. Many optimization efforts that aim to accelerate the alignment process generally come from three perspectives: redesigning data structures [e.g., diagonal or striped Single Instruction Multiple Data (SIMD) implementations], increasing the number of parallelisms in SIMD operations (e.g., difference recurrence relation), or reducing search space (e.g., banded DP). However, no methods combine all these three aspects to build an ultra-fast algorithm. In this study, we developed a Banded Striped Aligner (BSAlign) library that delivers accurate alignment results at an ultra-fast speed by knitting a series of novel methods together to take advantage of all of the aforementioned three perspectives with highlights such as active F-loop in striped vectorization and striped move in banded DP. We applied our new acceleration design on both regular and edit distance pairwise alignment. BSAlign achieved 2-fold speed-up than other SIMD-based implementations for regular pairwise alignment, and 1.5-fold to 4-fold speed-up in edit distance-based implementations for long reads. BSAlign is implemented in C programing language and is available at https://***/ruanjue/bsalign.

关键词： Pairwise alignment Edit distance Striped vectorization Banded dynamic programming F evaluation READ ALIGNMENT SPEED-UP

Overflow of Siling Co on the central Tibetan Plateau and its environmental impacts

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sciENCE BULLETIN 2024年第18期69卷 2829-2832页

作者： Lei, Yanbin Zhou, Jing Yao, Tandong Bird, Broxton W. Yu, Yifan Wang, Shujin Yang, Kun Zhang, Yinsheng Zhai, Jianqing Dai, Yufeng chinese acad sci Inst Tibetan Plateau Res State Key Lab Tibetan Plateau Earth Syst Environm Beijing 100101 Peoples R China Univ chinese acad sci Coll Resources & Environm Beijing 100049 Peoples R China Indiana Univ Purdue Univ Indianapolis IUPUI Dept Earth Sci Indianapolis IN 46202 USA Tsinghua Univ Dept Earth Syst Sci Key Lab Earth Syst Modeling Minist Educ Beijing 100084 Peoples R China china Meteorol Adm Natl Climate Ctr Beijing 100081 Peoples R China

The Tibetan Plateau(TP)and its surroundings are also referred to as“Asian Water Tower”,which is the headwater of ten major rivers in Asia and provides ecosystem service for nearly two billion people[1].The interior TP boasts the greatest concentration of high-latitude inland lakes in the world,providing essential water resources,regulating regional climate and maintaining ecological *** the past 50 years,the TP has experienced rapid climate warming and overall wetting,which has led to glacier mass loss,thawing of permafrost,reduction in snow cover,and shortening of lake ice duration[1].Changes in lake water storage provide a means of assessing the regional hydrological response to recent climate change in this sparsely populated region.

关键词： Tibetan glacier inland

World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Cupping

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WORLD JOURNAL OF ACUPUNCTURE-MOXIBUSTION 2024年第3期34卷 222-226页

作者： Li, Dan Li, Yu-Jia Guo, Yi Zhao, Xue Wu, Xiao-Dong Yuan, Xiao-Ning Yasuo, Ono Zhang, Jia-Yin Zhou, Yu-Fan Yang, Yi Zhao, Tian-Yi Chen, Bo Wang, Zi-Qi Wen, Hao-Yang Fu, Tian-Cong Chen, Ze-Lin Jin, Jun Tianjin Univ Tradit chinese med Tianjin 301617 Peoples R China Int Clin Res Ctr chinese med Acupuncture & Moxibus Tianjin 300381 Peoples R China Tianjin Inst Tradit chinese med standardizat Tianjin 301617 Peoples R China china acad chinese med sci Inst Acupuncture & Moxibust Beijing 100700 Peoples R China Coll Tradit chinese med & Pharmacol Canada Toronto ON M1T 3J3 Canada Kounandia CARE Niigata 9518106 Japan Tung Shin Hosp Kuala Lumpur 55100 Malaysia Harmony TCM Studio Brisbane Qld 4113 Australia

World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Cupping , developed under the leadership of Tianjin University of Traditional chinese medicine, was approved by WFAS. This technical benchmark was issued on October 9, 2023, and implemented on December 31, 2023. The main contents include the scope, normative references, terms and definitions, procedures and rules, and safety. This article focuses on the above contents, an outlook on the application, popularization, and update plan of this technical benchmark is proposed. (c) 2024 World Journal of Acupuncture - Moxibustion House. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://***/licenses/by-nc-nd/4.0/ )

关键词： Cupping Technical benchmark World Federation of Acupuncture-Moxibustion Societies (WFAS) Standard