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Solid-Pseudopapillary Tumor: Case Report and Literature Review

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Open Journal of Pathology 2024年第1期14卷 11-15页

作者： Nomenjanahary Lalaina Rabarison Manoahasina Ranaliarinosy Razafimahefa Vahatra Joëlle Randrianjafisamindrakotroka Nantenaina Soa Laboratory of Anatomy and cytology Pathology CHU-JRA Antananarivo Madagascar Laboratory of Anatomy and cytology Pathology CHU-Andrainjato Fianarantsoa Madagascar

Solid-pseudopapillary tumor of the pancreas (SPT) or Frantz’s tumor is a rare epithelial neoplasm that represents 0.3% to 2.7% of exocrine pancreatic tumors. These tumors occur mainly in young women and have a good prognosis. We present a case of a 19-year-old female patient who presented to the emergency for abdominal pain. Physical examination reveals a left hypochondrium mass. Ultrasound imaging showed an encapsulated caudal pancreatic mass with cystic components. The patient underwent tumor excision and lymph node removal. Macroscopically, the tumor was encapsulated and measuring 12 × 8 × 7 cm. It has a solid-cystic and hemorrhagic appearance inside. Histologically, the tumor had two components: solid and papillary. Tumor tissue showed monomorphic tumor cells radiating around blood vessels. Perineural invasion and vascular emboli were not seen. Three lymph nodes without metastases were observed. The diagnosis of solid-pseudopapillary tumor of the pancreas (SPT) or Frantz’s tumor was retained. Solid-pseudo-papillary tumor of the pancreas is rare and not always suspected by the physician. The clinical and imaging patterns are not specific. Anatomopathological examination confirmed the diagnosis. The patient underwent curative surgery.

关键词： Pancreas Tumor Solid-Pseudopapillary Frantz Antananarivo

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

New Opportunities for Foreign Investment in China's Bond Market

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China Forex 2024年第2期 32-34页

作者： LIAN Ping GDD chief Industry Research Institute and President of the China chief Economist Forum

The 2023 China Balance of Payments Report reveals a notable shift in foreign investment trends,with a net inflow of US$14.1 billion into China's securities,marking a turnaround from the net outflow observed in *** surge is primarily attributed to heightened foreign capital allocation toward RMB-denominated bonds,fostering a gradual stabilization in foreign investment within China's securities *** evolving international and domestic macroeconomic policies.

关键词： investment Market securities

Message from the Best Paper Award Committee

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Computational Visual Media 2024年第3期10卷 397-397页

作者： Ming C.Lin Baoquan Chen Ying He Wenping Wang Kun Zhou Ralph Martin Associate Editor-in-chief University of Maryland at College Park USA 不详

Following the success of the past eight years,Tsinghua University Press has continued to sponsor an annual award for the best papers published in Computational Visual *** papers in 2023 from Computational Visual Media were recommended by Associate Editors as candidate papers for the Best Paper *** Editors-in-chief Ming *** and Ralph Martin led the Best Paper Award Committee to select the Best *** careful deliberation,the following paper was chosen with the unanimous consensus as the winner.

关键词： Visual Award Message

Unraveling the gut-brain axis:the impact of steroid hormones and nutrition on Parkinson's disease

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Neural Regeneration Research 2024年第10期19卷 2219-2228页

作者： Paula Maria Neufeld Ralf A.Nettersheim Veronika Matschke Matthias Vorgerd Sarah Stahlke Carsten Theiss Department of cytology Institute of AnatomyMedical FacultyRuhr-University BochumBochumGermany Department of Visceral Surgery University Hospital BergmannsheilRuhr-University BochumBochumGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr-University BochumBochumGermany

This comprehensive review explores the intricate relationship between nutrition,the gut microbiome,steroid hormones,and Parkinson's disease within the context of the gut-brain *** gut-brain axis plays a pivotal role in neurodegenerative diseases like Parkinson's disease,encompassing diverse components such as the gut microbiota,immune system,metabolism,and neural *** gut microbiome,profoundly influenced by dietary factors,emerges as a key *** during the first 1000 days of life shapes the gut microbiota composition,influencing immune responses and impacting both child development and adult ***-fat,high-sugar diets can disrupt this delicate balance,contributing to inflammation and immune *** nutritional strategies,the Mediterranean diet's anti-inflammatory and antioxidant properties show promise in reducing Parkinson's disease ***-targeted dietary approaches and the ketogenic diet hold the potential in improving brain *** nutrition,emerging research uncovers potential interactions between steroid hormones,nutrition,and Parkinson's ***,with its anti-inflammatory properties and presence in the nervous system,offers a novel option for Parkinson's disease *** ability to enhance neuroprotection within the enteric nervous system presents exciting *** review addresses the hypothesis thatα-synuclein aggregates originate from the gut and may enter the brain via the vagus *** symptoms preceding motor symptoms support this *** gut-brain signaling during gut dysbiosis contributes to inflammation and neurotransmitter imbalances,emphasizing the potential of microbiota-based *** summary,this review uncovers the complex web of interactions between nutrition,the gut microbiome,steroid hormones,and Parkinson's disease within the gut-brain axis *** these connections not only offers novel therapeutic insi

关键词： diet gut-brain axis microbiome neurodegenerative diseases nutrition Parkinson's disease progesterone steroid hormones

Unraveling the regulatory network of flower coloration in soybean:Insights into roles of GmMYBA3 and GmMYBR1

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The Crop Journal 2024年第2期12卷 443-455页

作者： Ruifang Gao Yueqing Li Yanan Wang Xiaotong Shan Siqi Yang Ye Zhang Saiyu Ma Chunbao Zhang Jianchun Qin Li Wang Xiang Gao College of Plant Science Jilin UniversityChangchun 130062JilinChina Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics&cytology Northeast Normal UniversityChangchun 130024JilinChina Soybean Research Institute National Engineering Research Center for SoybeanJilin Academy of Agricultural SciencesChangchun 130033JilinChina

Anthocyanins play crucial roles in pollen protection and pollinator attraction in flowering ***,the mechanisms underlying flower color determination and whether floral anthocyanin regulators participate in other processes remain largely unresolved in soybeans(Glycine max).In this study,we investigated the genetic components and mechanisms governing anthocyanin biosynthesis in soybean *** and genetic studies have characterized two antagonistic regulators,the positive activator GmMYBA3 and the negative repressor GmMYBR1,that modulate the gene expression of anthocyanin biosynthesis in soybean *** findings revealed a regulatory interplay between GmMYBA3 and GmMYBR1 bridged by GmTT8a,highlighting the complexity of anthocyanin regulation in different soybean *** of additional soybean cultivars demonstrated the universality of GmMYBA3 and GmMYBR1 in regulating floral anthocyanin biosynthesis-related genes,with GmF3’5’H identified as a crucial determinant of white flower *** study provides a molecular mechanism underlying soybean flower color determination,paving the way for the molecular modification of soybean flowers to probably enhance their resistance to abiotic stresses and attractiveness to pollinators.

关键词： Anthocyanin Flower color determination MBW complex MYB repressor Pleiotropic regulator

Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention

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Chinese Chemical Letters 2024年第7期35卷 388-393页

作者： Zhi Li Wenpei Li Shaoping Jiang Chuan Hu Yuanyu Huang Maxim Shevtsov Huile Gao Shaobo Ruan Advanced Research Institute of Multidisciplinary Sciences School of Life ScienceBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Drug Targeting and Drug Delivery System West China School of PharmacySichuan UniversityChengdu 610041China Institute of cytology of Russian Academy of Sciences(RAS) St.Petersburg 194064Russia

Insufficient intratumoral retention of nanomedicines remains the major challenge for broad implementation in clinical ***,we proposed a legumain-triggered aggregable gold nanoparticle(GNP)delivery platform(GNPs-A&C).GNPs-A&C could form intratumoral or intracellular aggregates in response to the overexpressed *** aggregates with size increase not only could reduce back-flow from interstitial space to peripheral bloodstream but also could restrict the cellular exocytosis,leading to enhanced intratumoral *** vitro studies demonstrated that GNPs-A&C possessed an excellent legumain responsiveness and the increased size was closely relevant with legumain *** vivo studies demonstrated GNPs-A&C possessed slower clearance rate and much higher intratumoral retention within legumain-overexpressed tumor compared to non-aggregable NPs,regardless of intravenous or intratumoral *** importantly,this delivery platform significantly improved the chemotherapeutic effect of doxorubicin(DOX)towards subcutaneous xenograft C6 *** effectiveness of this stimulus-responsive aggregable delivery system provides a thinking for designing more intelligent size-tunable nanomedicine that can substantially improve intratumoral retention.

关键词： Legumain Size-tunable Enhanced retention Stimulus-responsive Nanomedicine

Calculation of Mass Concrete Temperature and Creep Stress under the Influence of Local Air Heat Transfer

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2977-3000页

作者： Heng Zhang Chao Su Xiaohu Chen Zhizhong Song Weijie Zhan Academy of Science and Technology Changjiang Institute of Survey Planning Design and ResearchWuhan430010China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210098China chief Engineer Office Wujiang Company of Goupitan Power Construction CooperationYuqing564408China

Temperature-induced cracking during the construction of mass concrete is a significant *** simulations of concrete temperature have primarily assumed that the concrete is placed in an open *** problem of heat transfer between the air and concrete has been simplified to the concrete’s heat dissipation ***,in the case of tubular concrete structures,where air inlet and outlet are relatively limited,the internal air temperature does not dissipate promptly to the external environment as it *** accurately simulate the temperature and creep stress in tubular concrete structures with enclosed air spaces during construction,we establish an air–concrete coupled heat transfer model according to the principles of conjugate heat transfer,and the accuracy of the model is verified through ***,we conduct a case study to analyze the impact of airflow within the ship lock corridor on concrete temperature and creep *** results demonstrate that enhancing airflow within the corridor can significantly reduce the maximum concrete *** with cases in which airflow within the corridor is neglected,the maximum concrete temperature and maximum tensile stress can be reduced by 12.5°C and 0.7 MPa,respectively,under a wind speed of 4 m/*** results of the traditional calculation method are relatively close to those obtained at a wind speed of 1 m/***,the temperature reduction process in the traditional method is faster,and the method yields greater tensile stress values for the corridor location.

关键词： Conjugate heat transfer temperature field mass concrete creep stress

Approach to cardiac masses: Thinking inside and outside the box

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World Journal of Clinical Cases 2024年第28期12卷 6132-6136页

作者： Elia De Maria chief of Arrhythmology Lab Cardiology UnitRamazzini HospitalCarpi 41012ModenaItaly

In this editorial we comment on the article by Huffaker et al,published in the current issue of the World Journal of Clinical *** masses encompass a broad range of lesions,potentially involving any cardiac structure,and they can be either neoplastic or *** cardiac tumors are rare,while metastases and pseudotumors are relatively *** masses frequently pose significant diagnostic and therapeutic *** imaging is fundamental for differential diagnosis,treatment,and surgical *** particular cardiac magnetic resonance(CMR)is currently the gold standard for noninvasive tissue *** allows evaluation of the relationship between the tumor and adjacent structures,detection of the degree of infiltration or expansion of the mass,and prediction of the possible malignancy of a mass with a high *** flow charts of diagnostic work-up have been proposed,based on clinical,laboratory and imaging findings,with the aim of helping physicians approach the problem in a pragmatic way(“thinking inside the box”).However,the clinical complexity of cancer patients,in particular those with rare syndromes,requires a multidisciplinary approach and an open mind to go beyond flow charts and diagnostic algorithms,in other words the ability to“think outside the box”.

关键词： Cardiac masses Cardiac tumors Cardio-oncology Cardiac magnetic resonance Primitive cardiac tumors