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Atherosclerosis-related biomarker PABPC1 predicts pan-cancer events

Stroke & Vascular Neurology 2024年第2期9卷 108-125,I0001-I0005页

作者： Miao Lin Liubing Hu Si Shen Jiyue Liu Yanyan Liu Yixian Xu Honglin Chen Kazuo Sugimoto Jianshuang Li Ikuo Kamitsukasa Takaki Hiwasa Hao Wang Anding Xu Stroke Center The First Affiliated HospitalJinan UniversityGuangzhouChina Department of Anesthesiology The First Affiliated HospitalJinan UniversityGuangzhouChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhouChina Department of Radiology Medical Imaging CenterThe First Affiliated HospitalJinan UniversityGuangzhouChina Department of Biochemistry and Genetics Graduate School of MedicineChiba UniversityChibaJapan Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina Department of Neurology Chiba Rosai HospitalChibaJapan Department of Neurology Chibaken Saiseikai Narashino HospitalChibaJapan Department of Neurological Surgery Graduate School of MedicineChiba UniversityChibaJapan

Background Atherosclerosis(AS)and tumours are the leading causes of death worldwide and share common risk factors,detection methods and molecular ***,searching for serum markers shared by AS and tumours is beneficial to the early diagnosis of *** The sera of 23 patients with AS-related transient ischaemic attack were screened by serological identification of antigens through recombinant cDNA expression cloning(SEREX),and cDNA clones were *** function enrichment analysis was performed on cDNA clones to identify their biological pathways and determine whether they were related to AS or ***,gene–gene and protein–protein interactions were performed and AS-associated markers would be *** expression of AS biomarkers in human normal organs and pan-cancer tumour tissues were ***,immune infiltration level and tumour mutation burden of various immune cells were *** curves analysis could show the expression of AS markers in *** AS-related sera were screened by SEREX,and 83 cDNA clones with high homology were *** functional enrichment analysis,it was found that their functions were closely related to AS and tumour *** multiple biological information interaction screening and the external cohort validating,poly(A)binding protein cytoplasmic 1(PABPC1)was found to be a potential AS *** assess whether PABPC1 was related to pan-cancer,its expression in different tumour pathological stages and ages was *** AS-associated proteins were closely related to cancer immune infiltration,we investigated and found that PABPC1 had the same role in ***,analysis of Kaplan-Meier survival curves revealed that high PABPC1 expression in pan-cancer was associated with high risk of *** Through the findings of SEREX and bioinformatics pan-cancer analysis,we concluded that PABPC1 might serve as a potential biomarker for the

关键词： diagnosis cancer organs

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Numerical analysis of a projecting wall type oscillating water column(PW-OWC)wave energy converter in regular waves

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Journal of Hydrodynamics 2024年第3期36卷 479-491页

作者： Lei Tan Ruiyuan Chang Tomoki Ikoma Department of Oceanic Architecture and Engineering College of Science and TechnologyNihon UniversityChibaJapan

Oscillating water column(OWC)based wave energy absorption devices are classic which have been widely used for harnessing ocean wave *** paper presents a numerical study on a projecting wall(PW)type OWC wave energy converter in regular *** computational fluid dynamics(CFD)modelling of a stationary floating PW-OWC model in a three-dimensional wave flume is achieved by the software *** analyses are carried out based on CFD simulations and the linear potential flow solutions with modifications to account for turbine-induced *** present numerical solutions are validated against our previous experimental *** is found that both the CFD and modified linear potential flow predictions are in reasonably good agreements with the experimental data in the first order results of OWC and air pressure *** the nonlinear responses are included in the result,the modified linear potential flow solution is found to slightly under-estimate the wave energy conversion performance at long *** the airflows above and below the chamber orifice,the CFD results suggest that they are almost unidirectional,oscillating in not only the base frequency but also subharmonic and ultraharmonic *** evolution of the OWC responses during an entire period and the phase analysis based on CFD simulations are *** phase results provide the crucial evidence to the reasonability of the physics-based modification of the potential flow model in modelling of *** present results and analysis are expected to be beneficial to the understanding on the physical mechanism of OWCs and the design of phase control strategies.

关键词： Computational fluid dynamics(CFD)simulation hydrodynamic analysis oscillating water column(OWC)damping orifice airflow phase difference

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Natural history of asymptomatic gallbladder stones in clinic without beds:A long-term prognosis over 10 years

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World Journal of Clinical Cases 2024年第1期12卷 42-50页

作者： Yuji Sakai Toshio Tsuyuguchi Hiroshi Ohyama Junichiro Kumagai Takashi Kaiho Masayuki Ohtsuka Naoya Kato Tadao Sakai Department of Gastroenterology Sakai ClinicKimistu 299-1162Japan Department of Gastroenterology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Chiba Prefectural Sawara HospitalChiba Prefectural Sawara HospitalSawara 287-0003Japan Department of Gastroenterology Kimitsu Central HospitalKisarazu 292-8535Japan Department of Surgery Kimitsu Central HospitalKisarazu 292-8535Japan Department of General Surgery Graduate School of MedicineChiba UniversityChiba 260-8677Japan

BACKGROUND Several studies have explored the long-term prognosis of patients with asymp-tomatic gallbladder *** reports were primarily conducted in facilities equipped with beds for addressing symptomatic *** To report the long-term prognosis of patients with asymptomatic gallbladder stones in clinics without bed *** We investigated the prognoses of 237 patients diagnosed with asymptomatic gallbladder stones in clinics without beds between March 2010 and October *** symptoms developed,patients were transferred to hospitals where appropriate treatment was *** investigated the asymptomatic and survival periods during the *** Among the 237 patients,214(90.3%)remained asymptomatic,with a mean asymptomatic period of 3898.9279±46.871 d(50-4111 d,10.7 years on average).Biliary complications developed in 23 patients(9.7%),with a mean survival period of 4010.0285±31.2788 d(53-4112 d,10.9 years on average).No patient died of biliary *** The long-term prognosis of asymptomatic gallbladder stones in clinics without beds was *** the condition became symptomatic,the patients were transferred to hospitals with beds that could address it;thus,no deaths related to biliary complications were *** finding suggests that follow-up care in clinics without beds is possible.

关键词： Gallbladder stone Acute cholangitis Acute cholecystitis Asymptomatic gallbladder stone Symptomatic gallbladder stone

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Need for education of psychiatric evaluation of offenders with mental disorders:A questionnaire survey for Japanese designated psychiatrists

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World Journal of Psychiatry 2024年第5期14卷 726-734页

作者： Akihiro Shiina Tomihisa Niitsu Masaomi Iyo Chiyo Fujii Division of Medical Treatment and Rehabilitation Chiba University Center for Forensic Mental HealthChiba-shi 2608670Japan Department of Psychiatry Chiba University Graduate School of MedicineChiba-shi 2608670Japan Department of Community Mental Health&Law National Center of Neurology and PsychiatryKodaira-shi 1878553Japan

BACKGROUND The management of offenders with mental disorders has been a significant concern in forensic *** Japan,the introduction of the Medical Treatment and Supervision Act in 2005 addressed the ***,numerous psychiatric patients at risk of violence still find themselves subject to the administrative involuntary hospitalization(AIH)scheme,which lacks clarity and updated *** To explore current as well as optimized learning strategies for risk assessment in AIH decision *** We conducted a questionnaire survey among designated psychiatrists to explore their experiences and expectations regarding training methods for psychiatric assessments of offenders with mental *** The findings of this study’s survey suggest a prevalent reliance on traditional learning approaches such as oral education and on-the-job *** This underscores the pressing need for structured training protocols in AIH ***,feedback derived from inpatient treatment experiences is identified as a crucial element for enhancing risk assessment skills.

关键词： Forensic psychiatry Administrative involuntary hospitalization Psychiatric assessment Risk assessment Mental disorders Training protocols Clinical practice Structured learning Feedback mechanisms Program development

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An Inverse Laplace Transform on Lattice Spacing

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Chinese Physics Letters 2013年第3期30卷 32-35页

作者： Hirofumi Yamada Division of Mathematics and Science Chiba Institute of TechnologyShibazono 2-1-1NarashinoChiba 275-0023Japan

An inverse Laplace transform on lattice spacing is introduced as a computational framework of the extrapolation of the strong coupling expansion to the scaling *** apply the transform to the two-dimensional nonlinear O(N)model at N≥3 and show that the approximation of the continuum limit of the susceptibility agrees with the existing theoretical and Monte Carlo data.

关键词： apply spacing susceptibility

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High-spin structure in ^(187)Pt

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Science China(Physics,Mechanics & Astronomy) 2008年第8期51卷 1053-1071页

作者： OSHIMA M TOH Y KOIZUMI M OSA A HATSUKAWA Y SUGAWARA M Japan Atomic Energy Agency TokaiIbaraki 319-1195Japan chiba Institute of Technology NarashinoChiba 275-0023Japan

High-spin states in 187Pt were studied via the 173Yb(18O,4n) reaction. Rotational bands based on the νi13/2,ν7/2-[503],νi213/2νj,ν3/2-[512] and ν1/2-[521] configurations were observed,and interpreted within the framework of the cranked shell model. The TRS calculations show that the νi13/2 band has an appreciable negative γ deformation,and the negative-parity bands tend to have a near prolate shape with small positive γ values. Experimental values of B(M1) /B(E2) ratios have been extracted and compared with theoretical values from the semi-classical D-nau and Frauendof approach,strongly suggesting a low frequency πh9/2 alignment in the ν7/2-[503] band.

关键词： rotational band configuration shape coexistence

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Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Psychiatry 2024年第4期14卷 334-346页

作者： Tomoko Uchida Daisuke Matsuzawa Tadashi Shiohama Katsunori Fujii Akihiro Shiina Masamitsu Naka Katsuo Sugita Eiji Shimizu Naoki Shimojo Hiromichi Hamada Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan Research Center for Child Mental Development Chiba University Chiba Japan Division of Medical Care and Treatment Center for Forensic Mental Health Chiba University Chiba Japan Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan

Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments.

关键词： Working Memory Attention-Deficit/Hyperactivity Disorder Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation

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Investigation of Inside-Out Tracking Methods for Six Degrees of Freedom Pose Estimation of a Smartphone in Augmented Reality

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Computers, Materials & Continua 2024年第5期79卷 3047-3065页

作者： Chanho Park Takefumi Ogawa Graduate School of Engineering The University of TokyoTokyo113-0033Japan Information Technology Center The University of TokyoChiba277-0882Japan

Six degrees of freedom(6DoF)input interfaces are essential formanipulating virtual objects through translation or rotation in three-dimensional(3D)space.A traditional outside-in tracking controller requires the installation of expensive hardware in *** inside-out tracking controllers have been proposed,they often suffer from limitations such as interaction limited to the tracking range of the sensor(e.g.,a sensor on the head-mounted display(HMD))or the need for pose value modification to function as an input interface(e.g.,a sensor on the controller).This study investigates 6DoF pose estimation methods without restricting the tracking range,using a smartphone as a controller in augmented reality(AR)*** approach involves proposing methods for estimating the initial pose of the controller and correcting the pose using an inside-out tracking *** addition,seven pose estimation algorithms were presented as candidates depending on the tracking range of the device sensor,the tracking method(e.g.,marker recognition,visual-inertial odometry(VIO)),and whether modification of the initial pose is *** two experiments(discrete and continuous data),the performance of the algorithms was *** results demonstrate enhanced final pose accuracy achieved by correcting the initial ***,the importance of selecting the tracking algorithm based on the tracking range of the devices and the actual input value of the 3D interaction was emphasized.

关键词： Smartphone inside-out tracking 6DoF pose 3D interaction augmented reality

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Neural plasticity in Parkinson's disease:a neuroimaging perspective

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Neural Regeneration Research 2024年第6期19卷 1203-1205页

作者： Christina Andica Koji Kamagata Department of Radiology Juntendo University Graduate School of MedicineTokyoJapan Faculty of Health Data Science Juntendo UniversityChibaJapan

Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least *** disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.

关键词： rigidity tremor primarily

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Systematic Properties of the 1／2[660]^i13／2 Bands in Odd-A Au Nuclei

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Chinese Physics Letters 2004年第7期21卷 1243-1246页

作者： SONGLi-Tao ZHOUXiao-Hong ZHANGYu-Hu GUOYing-Xiang SUNZhi-Yu M.Oshima T.Toh A.Osa M.Koizumi J.Katakura Y.Hatsukawa M.Matsuda M.Sugawara 1nstituteofModernPhysics ChineseAcademyofSciencesLanzhou730000 JapanAtomicEnergyResearchInstitute TokaiIbaraki319-1195Japan chibaInstituteofTechnology NarashinoChiba275-0023Japan

A standard in-beam γ-spectroscopy experiment for 179Au has been performed via the 149Sm (35Cl, 5n) reaction at beam energies of 164–180MeV. Based on the analysis of the experimental results, a rotational band built on the 1/2[660](πi13/2) proton intruder orbital is established for 179Au for the first time. Systematic properties of the 1/2[660](i13/2) band in odd-A Au nuclei are discussed, and the evolution of bandhead energy and deformation with changing neutron number are revealed.

关键词： Ultraviolet spectroscopy

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