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Genetic Basis for Mucormycosis Progression in COVID-19 Patients:From Susceptibility to Severity

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Infectious Diseases & Immunity 2024年第2期4卷 86-92页

作者： Jethendra Kumar Muruganantham Ramakrishnan Veerabathiran Human Cytogenetics and Genomics Laboratory Faculty of Allied Health SciencesChettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkamTamilnadu 603103India.

The dynamics of COVID-19 and mucormycosis reveal a complex interplay of genetic factors that influence the susceptibility,severity,and immune ***-19,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),exhibits an increased incidence of mucormycosis,particularly in individuals with comorbidities or corticosteroid *** is a fungal infection that affects the sinuses,orbits,and lungs and demands timely intervention with antifungal medications and surgery because of its life-threatening *** on the genetic underpinnings of this intersection has unveiled key insights into the pathogenicity of *** in genetic tools have exposed virulence factors,such as the CotH protein family and high-affinity iron-uptake *** susceptibility is a pivotal element in identifying individuals at risk of developing COVID-19,facilitating early detection,and allowing for personalized treatment ***9,MIF,and TYK2 are among the genes implicated in COVID-19 severity,emphasizing the intricate relationship between genetic makeup and viral *** genetic landscape extends to viral entry mechanisms,thereby affecting infection *** polymorphisms in genes such as IFNAR2,OAS3,and TYK2 are associated with COVID-19 severity,indicating shared genetic bases between severe and hospitalized *** is genetically predisposed,particularly in immunocompromised *** challenge lies in understanding the genetic factors influencing susceptibility and offering insights into pathogenesis and potential therapeutic *** transplantation adds another layer,increasing susceptibility to infections such as COVID-19 and *** impact of immunosuppression on COVID-19 severity remains elusive,necessitating ongoing research on the immunological *** the challenges posed by emerging SARSCoV-2 variants,the intricate connection between genetic factors and the

关键词： COVID-19 Mucormycosis Pathogenesis Genetics basis

Seroprevalence of dengue virus among adults presenting with acute febrile illness at a tertiary care hospital in South India

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Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 95-97页

作者： Lavanya Mohanam Priyadarshini Shanmugam Department of Microbiology Chettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkamChennai 603103India

Dengue virus,a member of the Flavivirus genus in the Flaviviridae family,has four serotypes(DEN-1 to DEN-4),and is responsible for both mild and severe dengue fever(dengue hemorrhagic fever and dengue shock syndrome)[1].Dengue cases are under reported in India and the cases are treated clinically based on the clinical triage of symptoms[2].Nonstructural protein(NS1)antigen is a highly conserved glycoprotein found in Flavivirus group such as Dengue,Zika,and Japanese encephalitis *** detection of NS1 antigen,IgM and IgG antibody in a single cassette is used for testing primary and secondary dengue *** diagnosis of disease progression associated with severe dengue and accessibility to appropriate medical care reduces severe dengue fatality rates to less than 1%.This retrospective study,conducted from January 2021 to December 2021 in the tertiary care hospital,South India,was aimed to determine the seroprevalence of dengue adult patients with acute febrile illness.

关键词： febrile acute diagnosis

Genetics of endometriosis and its association with ovarian cancer

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Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 177-185页

作者： B.K.Iyshwarya Vajagathali Mohammed Ramakrishnan Veerabathiran Human Cytogenetics and Genomics Laboratory Faculty of Allied Health SciencesChettinad Hospital and Research Institute(CHRI)Chettinad Academy of Research and Education(CARE)KelambakkamTamilnadu603103India

Endometriosis is a chronic and destructive developmental gynecologic condition that affects approximately 10%percent of females worldwide,and is one of the most frequent causes of extreme pelvic *** endometriumlike tissue,glands,and stroma outside the uterine cavity are often affected by *** is estrogendependent and frequently affects the ovaries,fallopian tubes,and pelvic *** such as chronic pelvic pain,infertility,dyspareunia,as well as digestive and urinary symptoms often accompany *** overall condition shares characteristics with ovarian carcinoma such as enhanced vascular activation of the endothelial growth factor,local invasion,lymph angiogenesis,neoangiogenic,mechanism tolerance to apoptosis,and genome *** studies have shown that endometriotic lesions contain gene mutations related directly to malignancies,particularly the ARID1A,p53,KRAS,and PTEN ***,women with endometriosis have a lower risk of ovarian cancer than the general population,where endometriosis was seen in only 1.3%,and did not diagnose ovarian cancer progression among *** need to look into the connection between endometriosis and uterine carcinomas,as well as the common lesions and correlations in the uterine microenvironment,which may play a role in mutations and malignant *** endometriosis is a risk factor of ovarian cancer,malignant cells from the uterus can migrate to the ovary and cause endometriosis-related ovarian *** purpose of this article is to examine current data on genetic phenomena and molecular changes for endometriosis associated with ovarian cancer,focusing primarily on the proliferation of uterine and precise cell biomarkers.

关键词： Endometriosis Ovarian carcinoma Genetic polymorphism Malignant transformation Biomarkers

Submicron Size Patterned Nickel Soft Lithographic Masters Using Aluminium Template

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Soft Nanoscience Letters 2011年第2期1卷 41-45页

作者： T. Prakash chettinad hospital and Research Institute

Nickel masters are widely used to produce surface relief grating like patterned antireflection coatings of polysiloxane material by simple embossing process. In the present work, patterned nickel master was prepared by using aluminium template, which is a foil peeled off from the commercial compact disk. Nickel was deposited using Watts nickel bath by pulsed electrodeposition for different relaxation times on patterned aluminium template. The deposition led to the transfer of patterns of aluminium replica to the nickel deposit. After deposition, the aluminium template was etched out chemically. Observation under an optical microscope showed that the obtained pattern was highly homogenous only for Ton = 0.1 ms, Toff = 0.9 ms duty cycles as compared with other ‘on’ and ‘off’ times of pulse cycles. This simple single step cost effective nickel master can serve as stamps for the subsequent embossing process. The preparation conditions and its salient features are discussed in this paper in detail.

关键词： Soft Lithography Pulsed Electrodeposition Nickel Master

Investigation of FOXP3 (rs3761548) polymorphism with the risk of preeclampsia and recurrent spontaneous abortion: A systemic review and meta-analysis

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Asian pacific Journal of Reproduction 2022年第3期11卷 117-124页

作者： Govinda Sri Varshini Sivakumar Harshini Muhammed Ali Siham Govindaraj Krishnamurthy Tejaswini Yasam Santhosh Kumar Langeswaran Kulanthaivel Gowtham Kumar Subbaraj Faculty of Allied Health Sciences Chettinad Hospital and Research InstituteChettinad Academy of Research and Education(Deemed to be University)KelambakkamTamil Nadu 603103India Department of Bioinformatics Alagappa UniversityKaraikudi-630003Tamil NaduIndia

Objective:To investigate the association between forkhead box P3(FOXP3)(rs3761548)polymorphism and the risk of preeclampsia and recurrent spontaneous ***:Literature on the association of FOXP3 gene polymorphisms and susceptibility to preeclampsia and unexplained recurrent spontaneous abortion was retrieved by searching databases such as PubMed,Science Direct,Google Scholar and Embase from 2000 to *** association measure was analyzed using an odds ratio(OR)and 95%confidence interval(CI).All the statistical analyses were executed using RevMan 5.4 ***:In the present meta-analysis,11 articles were *** pooled results showed no association between FOXP3 gene polymorphism(rs3761548)and preeclampsia risk in allelic,recessive,dominant and over dominant contrast ***3 gene polymorphism(rs3761548)showed an association with recurrent abortion in allelic,recessive and dominant models(OR 1.85,CI 1.59-2.14;OR 2.02,95%CI 1.56-2.62;OR 2.69,95%CI 1.50-4.83,respectively),while no association in the over dominant contrast model(OR 1.35,CI 0.87-2.10).Conclusions:In the present study,FOXP3 gene(rs3761548)polymorphism is associated with risk of recurrent spontaneous abortion but not ***,larger sample size and multiracial studies are needed in the future to confirm the findings.

关键词： Preeclampsia FOXP3 gene Single nucleotide polymorphism rs3761548 Unexplained recurrent spontaneous abortion

Ejaculatory Dysfunction—A Mini Review

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Advances in Sexual Medicine 2015年第2期5卷 39-42页

作者： Shah Dupesh Khan N. Pandiyan Department of Reproductive Medicine Chettinad Academy of Research and Education Chettinad Super Specialty Hospital Chennai India

For decades the field of male sexual dysfunction has remained controversial in terms of both diagnosis and management. There is a clear lack of rational, scientific and evidence-based practice in the field. Treatment remains arbitrary. This brief review tries to summarize concisely the etiology, diagnosis and management of the four categories of Ejaculatory dysfunction (EjD). This review also challenges the role of pharmacotherapy in the management of Ejaculatory dysfunction (EjD).

关键词： Premature Ejaculation Retrograde Ejaculation Anejaculation

Pathogenesis of trigeminal neuralgia

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Neural Regeneration Research 2014年第8期9卷 877-877页

作者： Vengalathur Ganesan Ramesh chettinad hospital & Research Institute ChennaiIndia

To the editor,I read with interest the article, ＂Dif- ferences in individual susceptibility affect the development of trigeminal neuralgia＂ by Duransoy et al. （2013）. The authors have analyzed the possible pathogenesis of trigeminal neuralgia, with illustrative case examples. They have drawn very important conclu- sions, which may have implications in management of trigeminal neuralgia.

关键词： root Pathogenesis of trigeminal neuralgia

Calcium phosphate conversion technique:A versatile route to develop corrosion resistant hydroxyapatite coating over Mg/Mg alloys based implants

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Journal of Magnesium and Alloys 2022年第7期10卷 1821-1845页

作者： G.S.Hikku C.Arthi R.B.Jeen Robert K.Jeyasubramanian R.Murugesan Medical Bionanotechnology Faculty of Allied Health SciencesChettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkamTamilnadu 603103India Nanobiotechnology Amirta Centre for Nanoscience and Molecular MedicineAmirtha Vishwa VidhyapeethamErnakulamKerala 682041India Department of Mechanical Engineering AAA College of Engineering and TechnologySivakasiTamilnadu 626005India Department of Chemistry Mepco Schlenk Engineering CollegeSivakasiTamilnadu 626005India Karpaga Vinayaga Institute of Medical Sciences and Research Centre PalayanoorTamilnadu 603308India

Globally,vast research interest is emerging towards the development of biodegradable orthopedic implants as it overcomes the toxicity exerted by non-degradable implants when fixed in the human body for a longer *** this context,magnesium(Mg)plays a major role in the production of biodegradable implants owing to their characteristic degradation nature under the influence of body ***,Mg is one of the essential nutrients required to perform various metabolic activities by the human cells,and therefore,the degraded Mg products will be readily absorbed by the nearby ***,the higher corrosion rate in the biological environment is the primary downside of using Mg implants that liberate H2gas resulting in the formation of ***,in certain cases,Mg undergoes complete degradation before the healing of damaged bone tissue and cannot serve the purpose of providing mechanical ***,many studies have been focused on the development of different strategies to improve the corrosion-resistant behavior of Mg according to the *** this regard,the present review focused on the limitations of using pure Mg and Mg alloys for the fabrication of medical implants and how the calcium phosphate conversion coating alters the corrosive tendency through the formation of hydroxyapatite protective films for enhanced performance in medical implant applications.

关键词： Biodegradable implants Magnesium Controlled corrosion Alloying Hydroxyapatite Calcium phosphate conversion coating

Tailoring S-scheme-based carbon nanotubes(CNTs)mediated Ag-CuBi_(2)O_(4)/Bi_(2)S_(3)nanomaterials for photocatalytic dyes degradation in the aqueous system

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Journal of Materials Science & Technology 2023年第31期162卷 11-24页

作者： Vishal Dutta Anita Sudhaik Sonu Pankaj Raizada Archana Singh Tansir Ahamad Sourbh Thakur Quyet Van Le Van-Huy Nguyen Pardeep Singh School of Advanced Chemical Sciences Shoolini UniversitySolanHimachal Pradesh173212India Department of Chemistry University Centre for Research and DevelopmentChandigarh UniversityGharuanMohaliPunjabIndia Advanced Materials and Processes Research Institute Hoshangabad RoadBhopal462026MPIndia Department of Chemistry College of ScienceKing Saud UniversityRiyadhSaudi Arabia Department of Organic Chemistry Bioorganic Chemistry and BiotechnologySilesian University of TechnologyB.Krzywoustego 444-100 GliwicePoland Department of Materials Science and Engineering Institute of Green Manufacturing TechnologyKorea University145Anam-ro Seongbuk-guSeoul02841Republic of Korea Faculty of Allied Health Sciences Chettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkam603103Tamil NaduIndia

In this study,S-scheme-based hydrothermal synthesis of Ag-CuBi_(2)O_(4)/CNTs/Bi_(2)S_(3)layered composites has been successfully *** photo-degradation of toxic dyes,*** orange(MO),and methylene blue(MB),has been used to examine nanocomposites with varying weight percent of Bi_(2)S_(3)for photocat-alytic activity in the visible *** candidates,Ag-CuBi_(2)O_(4)/CNTs/Bi_(2)S_(3)with a 10%loading of Bi_(2)S_(3)outperformed both pure and hybrid composites in photocatalytic *** MO degradation,the hybrid composite with 10%Bi_(2)S_(3)loading degrades 7.04 times higher than pristine CuBi_(2)O_(4)and Bi_(2)S_(3)samples,and for MB degradation,it degrades 4.96 times higher than pristine *** surface area,less re-combination rate of photogenerated charge carriers,photogenerated carriers faster separation,and high redox ability of Ag-CuBi_(2)O_(4)/CNTs/Bi_(2)S_(3)(10%)are all attributed to the improving photocatalytic *** after ten cycles,the hybrid composite is chemically stable and *** nanotubes(CNTs)are a transfer bridge in layered structure for electrons because of their coordinated Fermi level between Ag-CuBi_(2)O_(4)and Bi_(2)S_(3).In addition,the scavenger and electron spin resonance(ESR)experiments verified that·O_(2)^(−),·OH,and h+were the important reactive species that successfully facilitated the pho-tocatalytic degradation process to degrade *** study presents a straightforward and economical approach for obtaining a stable semiconductor-based photocatalytic system and a potential technique for future applications.

关键词： Ag-CuBi_(2)O_(4) Bi_(2)S_(3) Carbon nanotubes(CNTs) S-scheme charge transfer Dye degradation