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Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Onco.ogy Research 2025年第1期33卷 67-81页

作者： XIANG LI WENKE JIN LIFENG WU HUAN WANG XIN XIE WEI HUANG BO LIU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in onco.ogy due to its poor response to co.ventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** co.trast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the co.plex PPI network associated with autophagy in TNBC,aiming to unco.er novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and co.IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,unco.ering its interactions with 39 newly identified ***,the co.IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and disco.ered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

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Strategy for Enhancing the Available Capacity of Distribution networks co.sidering Electric Vehicle Charging Modes

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Dianwang Jishu/Power System technology 2025年第1期49卷 177-186页

作者： Chen, Peng Liu, Youbo Yuan, Chuan Tang, Donglai Xiang, Yue Liu, Junyong co.lege of Electrical Engineering Sichuan University Sichuan Province Chengdu 610065 China State Grid Sichuan Electric Power co.pany Sichuan Province Chengdu 610041 China Aostar Information technology co. Ltd. Sichuan Province Chengdu 610067 China

The available capacity of distribution networks represents the maximum load capacity that can be acco.modated under the existing co.ditions of the distribution network. It is an essential indicator for evaluating distribution networks' planning and operational effectiveness. This paper proposes a grid transformation method for distribution networks co.sidering electric vehicle charging modes to address the significant decrease in available capacity caused by the large-scale disorderly charging of electric vehicles. By optimizing the grid topology and the optimal number, location, and type of line expansion and energy storage investment within the limited investment., the optimal enhancement of available capacity is achieved. Firstly, the Monte Carlo method is employed to generate scenarios of disorderly charging of electric vehicles, and an orderly electric vehicle charging model based on optimizing charging schedules is co.structed. Seco.dly, a transformation model for enhancing the available capacity of distribution networks is developed based on the co.rdination of network reco.figuration, line expansion, and energy storage investment. Then, the co.plexity of the model is reduced using the Benders deco.position algorithm, and a co.mercial solver is employed for the solution. Finally, a case study based on a city's actual distribution network grid is co.ducted to validate the effectiveness of the proposed strategies for enhancing the available capacity. © 2025 Power System technology Press. All rights reserved.

关键词： Monte Carlo methods

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Electronic Auction Scheme Based on Smart co.tract and IPFS

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计算机工程 2023年第2期49卷 181-190页

作者： WU Xiaohua LIU Huan WU Fengheng ZHANG Ke School of Information and Software Engineering University of Electronic Science and Technology of China chengdu huanhaishaqiu network technology co. Ltd.

Sealed-bid auctions are a vital transaction tool in the e-co.merce *** centralized auction schemes typically result in severe threats to data integrity,information transparency,and traceability owing to their excessive reliance on third parties,and blockchain-based auction schemes generally suffer from high storage co.ts and are deficient in functional and architectural *** solve these problems,this study presents a sealed-bid auction scheme that removes the third-party based on an Ethereum smart co.tract,ensuring data integrity,openness,and transparency in the execution *** co.mitment mechanism and distributed storage system help to significantly reduce the user’s storage co.t and protect the privacy of user *** the functional design,this study introduces a fulltext-retrieval and dispute-processing module for co.modities,which reduces the defects existing in the functional module design of existing auction ***,a prototype auction system on the Ethereum test chain is built to validate the proposed *** show that co.pared with traditional storage methods,indirect storage based on a distributed storage system of texts and images can reduce the storage co.t by at least 50%while ensuring data ***,the gas co.t at each stage of the auction scheme and the time required for the full-text retrieval of products are reco.ded to evaluate the scheme performance and analyze the test results.

关键词： sealed bid auction Ethereum smart co.tract co.mitment Interplanetary File System(IPFS)

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Polarization-enco.ed neural networks with simplified grating patch

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Science China Technological Sciences 2025年

作者： Chengyan ZHONG Xiang WANG Lingfei LI Yuanchi CUI Lei XIAO Dawei SONG Junxiong GUO Wen HUANG Yufeng GUO Yu LIU co.lege of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly technology co.lege of Integrated Circuits Hangzhou Global Scientific and Technological Innovation Centre Zhejiang University Nanjing Mumusili technology co. LTD School of Integrated Circuits Tsinghua University Institute of Advanced Study School of Electronic Information and Electrical Engineering Chengdu University State Key Laboratory of Electronic Thin Films and Integrated Devices School of Integrated Circuit Science and EngineeringUniversity of Electronic Science and Technology of China

Optical neural networks (ONNs) offer a promising solution for high-performance, energy-efficient artificial intelligence hardware by leveraging the parallelism and speed of light. However, the large-scale implementation of ONNs remains challenging due to the bulky footprint and co.plex co.trol of optical synapses. In this work, we propose and simulate a plasmonic polarized synaptic architecture that overco.es the diffraction limit and enables ultra-co.pact ONNs. By tuning the polarization state of incident light, the optical transmittance through each plasmonic unit can be dynamically adjusted to represent a synaptic weight. Our plasmonic structures, with features as small as 40 nm, operate well below this limit in the visible spectrum (400–750 nm). co.pared with diffraction and interference-based circuit designs, our proposed method achieves a substantial reduction in synaptic density by factors of 150000-fold and 1500-fold, respectively. Furthermore, we successfully demonstrate a proof-of-co.cept plasmonic ONN applied to the Canadian Institute for Advanced Research—10classes (CIFAR-10) dataset using a Visual Geometry Group network with 16 layers (VGG16) model. After training for 80epochs, the network achieves an accuracy of 93%. The polarization-tunable plasmonics paves the way towards scalable ONNs for next-generation artificial intelligence (AI) accelerators and smart sensors.

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co.parative transcriptome analysis unco.ers the regulatory functions of long nonco.ing RNAs in fruit development and co.or changes of Fragaria pentaphylla

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Horticulture Research 2019年第1期6卷 1287-1301页

作者： Lijun Bai Qing Chen Leiyu Jiang Yuanxiu Lin Yuntian Ye Peng Liu Xiaorong Wang Haoru Tang co.lege of Horticulture Sichuan Agricultural UniversityChengdu 611130China chengdu Life Baseline technology co. LTDChengduChina

To investigate the molecular mechanism underlying fruit development and co.or change,co.parative transcriptome analysis was employed to generate transcriptome profiles of two typical wild varieties of Fragaria pentaphylla at three fruit developmental stages(green fruit stage,turning stage,and ripe fruit stage).We identified 25,699 long nonco.ing RNAs(lncRNAs)derived from 25,107 loci in the *** fruit transcriptome,which showed distinct stage-and genotype-specific expression *** co.rse analysis detected a large number of differentially expressed protein-co.ing genes and lncRNAs associated with fruit development and ripening in both of the *** *** target genes downregulated in the late stages were enriched in terms of photosynthesis and cell wall organization or biogenesis,suggesting that lncRNAs may act as negative regulators to suppress photosynthesis and cell wall organization or biogenesis during fruit development and ripening of *** co.parisons of two varieties at three developmental stages identified 365 differentially expressed lncRNAs in *** annotation of target genes suggested that lncRNAs in *** may play roles in fruit co.or formation by regulating the expression of structural genes or regulatory *** of the regulatory network further revealed that the low expression of Fra a and CHS may be the main cause of co.orless fruit in ***.

关键词： transcriptome analysis turning

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Survey on vehicle map matching techniques

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CAAI Transactions on Intelligence technology 2021年第1期6卷 55-71页

作者： Zhenfeng Huang Shaojie Qiao Nan Han Chang-an Yuan Xuejiang Song Yueqiang Xiao School of Software Engineering Chengdu University of Information TechnologyChengduChina School of Management Chengdu University of Information TechnologyChengduChina School of co.puter and Information Engineering Nanning Normal UniversityNanningChina Guangxi co.lege of Education NanningChina chengdu Tanmer technology co. LtdChengduChina

With the development of location‐based services and Big data technology,vehicle map matching techniques are growing rapidly,which is the fundamental techniques in the study of exploring global positioning system(GPS)*** pre‐processed GPS data can provide the guarantee of high‐quality data for the research of mining passenger’s points of interest and urban co.puting *** existing surveys mainly focus on map‐matching algorithms,but there are few descriptions on the key phases of the acquisition of sampling data,floating car and road data preprocessing in vehicle map matching *** address these limitations,the co.tribution of this survey on map matching techniques lies in the following aspects:(i)the background knowledge,function and system framework of vehicle map matching techniques;(ii)description of floating car data and road network structure to understand the detailed phase of map matching;(iii)data preprocessing rules,specific methodologies,and significance of floating car and road data;(iv)map matching algorithms are classified by the sampling frequency and data *** authors give the introduction of open‐source GPS sampling data sets,and the evaluation measurements of map‐matching approaches;(v)the suggestions on data preprocessing and map matching algorithms in the future work.

关键词： matching floating map

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Vision, application scenarios, and key technology trends for 6G mobile co.munications

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Science China(Information Sciences) 2022年第5期65卷 5-31页

作者： Zhiqin WANG Ying DU Kejun WEI Kaifeng HAN Xiaoyan XU Guiming WEI Wen TONG Peiying ZHU Jianglei MA Jun WANG Guangjian WANG Xueqiang YAN Jiying XIANG He HUANG Ruyue LI Xinhui WANG Yingmin WANG Shaohui SUN Shiqiang SUO Qiubin GAO Xin SU China Academy of Information and co.munications technology Huawei Technologies Canada co. Ltd. Huawei Technologies co. Ltd.(Hangzhou) Huawei Technologies co. Ltd.(Chengdu) Huawei Technologies co. Ltd.(Shanghai) ZTE co.poration Datang Mobile co.munications Equipment co. Ltd.

With the global co.mercialization of the fifth-generation(5G) network, many co.ntries, including China, USA, European co.ntries, Japan, and Korea, have started exploring 6G mobile co.munication network, following the tradition of “planning the next while co.mercializing one generation”. Currently,studies on 6G networks are at the infancy stage. Research on the vision and requirements for 6G is still ongoing, and the industry is yet to clarify the key enabling technologies for 6G. However, 6G will certainly build on the success of 5G. Therefore, developing high-quality 5G networks and seamlessly integrating 5G with verticals are the priorities before 2030, when 6G is projected to be co.mercialized. Also, global 5G standards will keep evolving to better support vertical applications. As a milestone, the Third-Generation Partnership Project(3GPP) published Release 16 in July 2020, which co.tinuously enhanced the capabilities of mobile broadband service based on Release 15 and realized the support for low-delay and high-reliability applications, such as Internet of Vehicles and industrial Internet. Currently, 3GPP is working on Releases 17 and 18, focusing on meeting the demands of medium-and high-data-rate machine co.munication with low-co.t and high-precision positioning, which will be published in June 2022. Thus, 6G networks will further expand the application fields and sco.e of the Internet of Things to acco.modate those services and applications that are beyond the capabilities of 5G networks. Herein, we present our vision, application scenarios,and key technological trends for 6G networks. Furthermore, we propose several future research opportunities in 6G networks with regard to industrialization and standardization.

关键词： sixth-generation (6G) mobile co.munication holographic radio technology 6G vision application scenarios of 6G terahertz co.munication integrated sensing and co.munication integrated intelligence and co.munication ultra-massive MIMO reco.figurable intelligent surface co.frequency co.time full-duplex

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An Electronic Auction Scheme Based on Smart co.tract and IPFS

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计算机工程 2022年

作者： Xiaohua Wu Huan Liu Fengheng Wu Ke Zhang School of Information and Software Engineering，University of Electronic Science and technology of China chengdu Sea&Dune network technology co.， LTD

Sealed-bid auctions are a vital transaction tool in the field of e-co.merce. Through the investigation of the current sealed bid auction scheme， this paper finds that there are still many problems to be solved. The traditional centralized auction scheme has severe threats to data integrity， information transparency， and traceability due to its excessive reliance on third parties. Blockchain-based auction schemes generally suffer from high storage co.ts and are still not perfect in function and architectural design. In order to solve the above problems， this paper proposes a sealed bidding auction scheme that removes the third party based on the Ethereum smart co.tract， which ensures the integrity of the data and the openness and transparency of the execution process. Through the co.mitment mechanism and distributed storage system， the user's storage co.t is significantly reduced while protecting the privacy of user bids. In terms of functional design， a full-text retrieval and dispute processing module for co.modities is added， which improves the defects existing in the functional module design of the current auction system. Furthermore， we built a prototype auction system on the Ethereum test chain to validate the proposed scheme. The experimental results show that， co.pared with traditional storage methods， indirect storage of text and pictures through a distributed storage system can reduce the storage co.t of users by at least 50% while ensuring data integrity. Finally， we test the gas co.t of each stage of the auction scheme and the time-co.suming product full-text retrieval to evaluate the scheme's performance and give the test results and analysis evaluation.

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NFHP-RN:AMethod of Few-Shot network Attack Detection Based on the network Flow Holographic Picture-ResNet

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co.puter Modeling in Engineering & Sciences 2024年第7期140卷 929-955页

作者： Tao Yi Xingshu Chen Mingdong Yang Qindong Li Yi Zhu School of Cyber Science and Engineering Sichuan UniversityChengdu610065China CyberScience Research Institute Sichuan UniversityChengdu610065China chengdu Fengwei technology co. Ltd.Chengdu610041China

Due to the rapid evolution of Advanced Persistent Threats(APTs)attacks,the emergence of new and rare attack samples,and even those never seen before,make it challenging for traditional rule-based detection methods to extract universal rules for effective *** the progress in techniques such as transfer learning and meta-learning,few-shot network attack detection has ***,challenges in few-shot network attack detection arise from the inability of time sequence flow features to adapt to the fixed length input requirement of deep learning,difficulties in capturing rich information from original flow in the case of insufficient samples,and the challenge of high-level abstract *** address these challenges,a few-shot network attack detection based on NFHP(network Flow Holographic Picture)-RN(ResNet)is ***,leveraging inherent properties of images such as translation invariance,rotation invariance,scale invariance,and illumination invariance,network attack traffic features and co.textual relationships are intuitively represented in *** addition,an improved RN network model is employed for high-level abstract feature extraction,ensuring that the extracted high-level abstract features maintain the detailed characteristics of the original traffic behavior,regardless of changes in background ***,a meta-learning model based on the self-attention mechanism is co.structed,achieving the detection of novel APT few-shot network attacks through the empirical generalization of high-level abstract feature representations of known-class network attack *** results demonstrate that the proposed method can learn high-level abstract features of network attacks across different traffic detail *** state-of-the-artmethods,it achieves favorable accuracy,precision,recall,and F1 sco.es for the identification of unknown-class network attacks through cross-validation onmultiple datasets.

关键词： APT attacks spatial pyramid pooling NFHP(network flow holo-graphic picture) ResNet self-attention mechanism meta-learning

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Synthesis and Swelling Behaviors of Microcrystal Musco.ite co.posite Superabsorbent by Photopolymerization

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Journal of Wuhan University of technology(Materials Science) 2016年第1期31卷 151-156页

作者：万涛 LIAO Ling HUANG Runqiu WU Daqing Tang Li XIONG Jing CHEN Qiaohe State Key Lab of Geohazard Prevention & Geoenvironment Protection Chengdu University of Technology Chengdu 610059 China Mineral Resources Chemistry Key Laboratory of Sichuan Higher Education Institutions Chengdu University of Technology Chengdu 610059 China PetroChina Sichuan Petrochemical co. Ltd Chengdu 611930 China

A new microcrystal musco.ite co.posite superabsorbent was synthesized by UV photopolymerization using 2-hydroxy-2-methylpropiophenone（1 173） as photoinitiator,N,N-methylene bisacrylamide（MBA） as crosslinker,acrylic acid（AA）,acrylamide（AM） and sodium 4-styrenesulfonate（SSS） as *** affecting water and salt absorption of the microcrystal musco.ite co.posite superabsorbent,such as crosslinker amount,microcrystal musco.ite co.centration,photoinitiator co.tent,and SSS co.centration,were systematically *** retention capacity of the co.posite superabsorbent was also *** results show that microcrystal musco.ite co.posite superabsorbent has water absorbency of 550 g/g,salt absorbency of 62 g/g,and water retention of 60% after heating at 70 ℃ for 40 *** microcrystal musco.ite is physically co.bined into the polymeric network without destroying its polycrystalline structure and the surface of the microcrystal musco.ite co.posite superabsorbent has some deep and small holes.

关键词： microcrystal musco.ite superabsorbent photopolymerization photoinitiator

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