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Nano Research 2016年第10期9卷 3162-3170页

作者： Feipeng Zhao Qiufang Gong Brian Traynor Duo Zhang Jiaojiao Li Hualin Ye Fengjiao Chen Na Han Yeyun Wang Xuhui Sun Yanguang Li Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University Suzhou 215123 China departments of Physics and chemistry Trinity College University of Dublin Dublin 2 Ireland

Nanostructured metal sulfides are potential electrode materials for sodium-ion batteries; however, they typically suffer from very poor cycling stability due to large volume changes and dissolution of discharge products. Herein we propose a rational material design strategy for sulfide-based materials to address these problems. Taking nickel sulfide （NiSx） as an example, we demonstrated that its electrochemical performance can be dramatically improved by confining the NiSx nanoparticles in a percolating conductive carbon nanotube network, and stabilizing them with an ultrathin carbon coating layer. The carbon layer serves as a physical barrier to alleviate the effects of both the volume change and dissolution of active materials. The hybrid material exhibited a large reversible specific capacity of 〉500 mAh/g and excellent cycling stability over 200 cycles. Given the traditionally problematic nature of NiSx as a battery anode material, we believe that the observed high performance reported here reflects the effectiveness of our material design strategy.

关键词： metal sulfides sodium-ion batteries composite carbon coating layer cycling stability

Binding of transition metals to S100 proteins

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Science China(Life Sciences) 2016年第8期59卷 792-801页

作者： Benjamin A.Gilston Eric P.Skaar Walter J.Chazin departments of Biochemistry and chemistry and Center for Structural BiologyVanderbilt UniversityNashville TN 37232-9717USA Department of Pathology Microbiology and ImmunologyVanderbilt University Medical CenterNashville TN 37232-2561USA

The S100 proteins are a unique class of EF-hand Ca^(2+) binding proteins distributed in a cell-specific, tissue-specific, and cell cycle-specific manner in humans and other vertebrates. These proteins are distinguished by their distinctive homodimeric structure, both intracellular and extracellular functions, and the ability to bind transition metals at the dimer interface. Here we summarize current knowledge of S100 protein binding of Zn^(2+), Cu^(2+) and Mn^(2+) ions, focusing on binding affinities, conformational changes that arise from metal binding, and the roles of transition metal binding in S100 protein function.

关键词： S100 Proteins Zinc Manganese Copper

Error Analysis of the Density-Matrix Renormalization Group Algorithm for a Chain of Harmonic Oscillators

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Chinese Physics Letters 2014年第6期31卷 20-23页

作者：麻永俊王加祥徐信业魏启 Sabre Kais State Key Laboratory of Precision Spectroscopy East China Normal University Shanghai 200062 departments of chemistry and Physics Purdue University Indiana 47907 USA Qatar Environment and Energy Research Institute Qatar Foundation Doha Qatar

We investigate the application of the density-matrix renormalization group （DMRG） algorithm to a one-dimensional harmonic oscillator chain and compare the results with exact solutions, aiming at improving the algorithm＇s ef- ficiency. It is demonstrated that the algorithm can show quite accurate results if the procedure is properly organized; for example, by using the optimized bases. The errors of calculated ground state energy and the energy gap between the ground state and the first excited state are analyzed, and they are found to be critically dependent upon the size of the system or the energy level structure of the studied system and the number of states targeted during the DMRG procedure.

关键词： Ground state

ORGANOMETALLIC PRECURSORS FOR DEPOSITION OF METAL NITRIDE THIN FILMS

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ORGANOMETALLIC PRECURSORS FOR DEPOSITION OF METAL NITRIDE TH...

Kinetic Studies on Aniline-catalyzed Carbohydrate Oxime Formation via Real-time NMR

40th IUPAC Congress

作者： Lisa McElwee-White Benjamin C. Brooks Laurel L. Reitfort Corey B. Wilder David H. Powell Omar J. Bchir Hiral M. Ajmera Timothy J. Anderson departments of chemistry and Chemical Engineering University of FloridaUSA departments of chemistry and Chemical Engineering University of FloridaUSA departments of chemistry and Chemical Engineering University of FloridaUSA departments of chemistry and Chemical Engineering University of FloridaUSA departments of chemistry and Chemical Engineering University of FloridaUSA departments of chemistry and Chemical Engineering University of FloridaUSA departments of chemistry and Chemical Engineering University of FloridaUSA departments of chemistry and Chemical Engineering University of FloridaUSA

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Chemical Research in Chinese Universities 2011年第5期27卷 886-890页

作者： WANG Wen-jun CAO Chen-ming JIN Chen WANG Xin WANG George-peng College of Pharmacy Nankai University Tianjin 300071 P. R. China State Key Laboratory of Element-Organic chemistry Nankai University Tianjin 300071 P. R. China departments of chemistry and Biochemistry The Ohio State University Columbus OH 43210 USA

The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide with hydroxylamine can be obtained in high efficiency at pH=5.4.

关键词： Glycoconjugate Aniline Catalysis Kinetics Real-time NMR

Highly Fluorescent Dye-Doped Silica Nanoparticles Increase Flow Cytometry Sensitivity for Cancer Cell Monitoring

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Nano Research 2009年第6期2卷 448-461页

作者： M.-Carmen Estévez Meghan B.OʼDonoghue Xiaolan Chen Weihong Tan Center for Research at the Bio/Nano Interface Departments of Chemistry and Department of Physiology and Functional GenomicsShands Cancer Center and UF Genetics InstituteMcKnight Brain InstituteUniversity of FloridaGainesvilleFlorida 32611-7200USA

Early and accurate diagnosis and treatment of cancer depend on rapid,sensitive,and selective detection of tumor *** diagnosis of cancers,especially leukemia,relies on histology and fl ow cytometry using single dye-labeled ***,this combination may not lead to high signal output,which can hinder detection,especially when the probes have relatively weak affi nities or when the receptor is expressed in a low concentration on the target cell *** solve these problems,we have developed a novel method for sensitive and rapid detection of cancer cells using dye-doped silica nanoparticles(NPs)which increases detection sensitivity in fl ow cytometry analyses between 10-and 100-fold compared to standard *** NPs are~60 nm in size and can encapsulate thousands of individual dye molecules within their *** have extensively investigated surface modifi cation strategies in order to make the NPs suitable for selective detection of cancer cells using fl ow *** NPs are functionalized with polyethylene glycol(PEG)to prevent nonspecifi c interactions and with neutravidin to allow universal binding with biotinylated *** virtue of their reliable and selective detection of target cancer cells,these NPs have demonstrated their promising usefulness in conventional fl ow ***,they have shown low background signal,high signal enhancement,and effi cient functionalization,either with antibody-or aptamer-targeting moieties.

关键词： Silica nanoparticle flow cytometry aptamer cell detection polyethylene glycol fl uorophore

Intracellular siRNA delivery with novel spermine based surfactants

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Chinese Science Bulletin 2012年第31期57卷 3979-3984页

作者： XU RongZuo WANG XuLi LU Zheng-Rong departments of Pharmaceutics and Pharmaceutical chemistry University of Utah Salt Lake City UT84108 USA Department of Biomedical Engineering Case Western Reserve University Cleveland OH 44106 USA

The design and development of safe and effective multifunctional siRNA delivery systems are critical for clinical application of RNAi therapeutics. Here we evaluated eight new spermine-based surfactant multifunctional carriers for siRNA delivery. These carriers complexed with siRNA forming stable compact nanoparticles with sizes around 100 nm. The multifunctional carriers mediated higher intracellular siRNA transfection than Lipofectamine-2000. The siRNA nanoparticles of the multifunctional carriers exhibited low cytotoxicity as shown by MTT assay. Three of the eight multifunctional carriers showed higher silencing efficiency than Lipofectamine-2000 in both U87-Luc cells and CHO-GFP cells. SKAHCO showed the highest siRNA delivery efficiency among the carriers. It resulted in 84.6±5.5% silencing of luciferase activity in U87-Luc cells, much higher than that (62.8± 3.4%) from Lipofectamine-2000. In conclusion, the spermine based multifunctional carriers are promising for highly efficient intracellular siRNA delivery.

关键词： siRNA 表面活性剂传递系统精胺细胞转染功能载体多功能脂质体

Characterization of a new monoclonal anti-glypican-3 antibody specific to the hepatocellular carcinoma cell line, HepG2

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World Journal of Hepatology 2017年第7期9卷 368-384页

作者： Preeyanat Vongchan Robert J Linhardt Department of Medical Technology Faculty of Associated Medical SciencesChiang Mai University Rensselaer Polytechnic Institute Departments of ChemistryBiologyChemical and Biomedical Engineering

AIM To characterize the antigen on HepG2 cell that is specifically recognized by a new monoclonal antibody raised against human liver heparan sulfate proteoglycan(HSPG), clone *** The antigen recognized by m Ab 1E4-1D9 was immunoprecipitated and its amino acid sequence was analyzed LC/MS. The transmembrane domain, number of cysteine residues, and glycosylation sites were predicted from these entire sequences. Data from amino acid analysis was aligned with glypican-3(https://***/Tools/msa/clustalo/). The competitive reaction of mA b 1E4-1D9 and anti-glypican-3 on HepG2 cells was demonstrated by indirect immunofluorescence and analyzed by flow cytometry. Moreover, co-immunoprecipitation of mA b 1E4-1D9 and anti-glypican-3 was performed in HepG2 cells by Western immunoblotting. The recognition by mA b 1E4-1D9 of a specific epitope on solid tumor and hematopoietic cell lines was studied using indirect immunofluorescence and analyzed by flow *** Monoclonal antibody 1E4-1D9 reacted with an HSPG isolated from human liver and a band of 67 kD was detected under both reducing and non-reducing conditions. The specific antigen pulled down by m Ab 1E4-1D9, having a MW of 135 kD, was analyzed. The results showed two sequences of interest, gi30722350(1478 amino acid) and gi60219551(1378 amino acid). In both sequences no transmembrane regions were observed. Sequence number gi30722350 was 99.7% showed a match to FYCO1, a molecule involved in induction of autophagy. Sequence number gi60219551 contained 15 cysteines and 11 putative glycosylation sites with 6 predicted N-glycosylation sites. It was also matched with all PDZ domain proteins. Moreover, it showed an 85.7% match to glypican-3. Glypican-3 on HepG2 cells competitively reacted with both phycoerythrin-conjugated anti-glypican-3 and mA b 1E4-1C2 and resulted in an increase of double-stained cell population when higher concentration of m Ab 1E4-1D9 was used. Moreover, antigens precipitated fro

关键词： Monoclonal anti-glypican-3 Hepatocellular carcinoma HepG2 Heparan sulfate proteoglycan Coimmunoprecipitation

Ultrahigh Li ion diffusivity in anodic SEI suppresses dendrite growth in lithium metal batteries

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Science China Materials 2023年第10期66卷 4131-4132页

作者： Wenchao Bi Guozhong Cao departments of Physics College of ScienceUniversity of Shanghai for Science and TechnologyShanghai 200093China departments of Materials Science and Engineering and Chemical Engineering University of WashingtonSeattleWA 98195-2120USA

New chemistry and new materials for high-energy-density batteries are in great demands as advanced portable electronics and long-range electric vehicles require ever increasing energy and power;current lithium(Li)-ion batteries based on graphite anode(a theoretical specific capacity of 372 mA h g^(-1))reach the limited theoretical energy density of 350 W h kg^(-1)[1].

关键词： lithium anodic batteries

X-ray scattering from liquid interfaces

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Nuclear Science and Techniques 2006年第6期17卷 322-333页

作者： LI Ming Mark L. SCHLOSSMAN Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China departments of Physics and chemistry University of Illinois at Chicago 845 W. Taylor St Chicago IL 60607 USA

Synchrotron radiation X-ray scattering is a useful tool for structural characterization of liquid interfaces. Specular reflectivity provides precise measurement of the interfacial widths and of the ordering of surfactants adsorbed to these interfaces. Diffuse scattering gives information on phase transitions and domain formation in surfactant monolayers and on interfacial fluctuations confined by and coupled across fluidic films.

关键词： X-射线散射液体界面同步加速器反射率