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food Science and Human Wellness 2023年第1期12卷 140-150页

作者： Lirong Xu Gangcheng Wu Jianhua Huang Hui Zhang Qingzhe Jin Xingguo Wang Institute of nutrition and Health Qingdao UniversityQingdao 266071China Collaborative Innovation center of food Safety and Quality Control in Jiangsu Province School of Food Science and TechnologyJiangnan UniversityWuxi 214122China

The flavor is a decisive sensory characteristic that determines the popularity of French fries(FFs).During high-oleic rapeseed oil(RO)frying,the flavor development of FFs showed three noticeable stages including break-in(3.5%-7.5%of total polar compounds(TPC)),optimum(7.5%-22.18%of TPC),and degrading stages(above 22.18%of TPC).Further,in order to distinguish the key aroma compounds in each stage,the FFs prepared in RO at TPC of 3.5%(FF4),14.5%(FF15),and 26.96%(FF27)and their relevant oils(RO4,RO15,RO27)were selected for sensory-directed *** results revealed that the FF4 had low contents of(E,E)-2,4-decadienal(deep-fried odor)which also caused lower sensory score in FF4 *** higher contents of(E,E)-2,4-decadienal in FF15 induced its higher deep-fried *** FF27 had higher hexanoic acid(sweaty odor),heptanoic acid,nonanoic acid,benzene acetaldehyde(stale odor),and trans-4,5-epoxy-(E)-2-decenal(metallic odor)compared with FF4 and FF15,thus leading to the undesirable flavor of ***,the decrease of 2,5-dimethylpyrazine and 2-ethyl-6-methyl-pyrazine in FF27 induced the lower roasty flavor,which may also lead to the decline of the sensory ***,the higher contents of(E)-2-undecenal,hexanoic acid,heptanoic acid,and nonanoic acid in RO27 lead to increase its rancid score and thus lower the sensory score.

关键词： French fries Frying stages Off-flavor Odor activity value Aroma recombination

Lactose-free milk powder can effectively relieve diarrhea symptoms in weaning SD rats and children

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food Science and Human Wellness 2024年第3期13卷 1494-1502页

作者： Manman Liu Shiwen Han Boya Li Cheng Chen Lu Yao Jung-il Kwon Juan Jin Huilian Che Beijing Advanced Innovation center for food nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Maeil Innovation center Maeil Dairies Co.Ltd.Seoul 03142South Korea

Diarrhea has become the leading cause of illness and death among infants and young children in developing ***,patients with diarrhea showed damaged intestinal epithelial villi,usually accompanied by lactase *** this study,we evaluated the therapeutic effects of lactose-free milk powder on rats and children with ***-associated diarrhea(AAD)model was established by gavage with antibiotic mixture in SD rats,followed by administration of milk powder containing lactose or *** results showed that lactose-free milk powder ameliorated A AD-related diarrhea symptoms,and accelerated the recovery from *** 16S sequencing results indicated lactose-free milk powder contributed to increase theα-andβ-diversity of intestinal flora,and restore the intestinal microbiota *** conclusion,our data demonstrate that lactose-free milk powder could alleviate diarrhea by restoring gut microbiota and intestinal barrier function.

关键词： Diarrhea Lactose-free Milk powder Intestinal barrier Gut microbiota

Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

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World Journal of Gastroenterology 2014年第42期20卷 15632-15649页

作者： Julio Plaza-Diaz Carolina Gomez-Llorente Luis Fontana Angel Gil Department of Biochemistry and Molecular Biology Ⅱ School of Pharmacy and Institute of Nutrition and Food Technology "Jose Mataix" Biomedical Research Center University of Granada

The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probiotics as live microorganisms that confer a health benefit to the host when administered in adequate amounts. However, dead bacteria and bacterial molecular components may also exhibit probiotic properties. The results of clinical studies have demonstrated the clinical potential of probiotics in many pathologies, such as allergic diseases, diarrhea, inflammatory bowel disease and viral infection. Several mechanisms have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Therefore, the modulation of gene expression mediated by probiotics is an important issue that warrants further investigation. In the present paper, we performed a systematic review of the probiotic-mediated modulation of gene expression that is associated with the immune system and inflammation. Between January 1990 to February 2014, PubMed was searched for articles that were published in English using the MeSH terms “probiotics' and 'gene expression' combined with “intestines', 'liver', 'enterocytes', 'antigen-presenting cells', 'dendritic cells', 'immune system', and 'inflammation'. Two hundred and five original articles matching these criteria were initially selected, although only those articles that included specific gene expression results (77) were later considered for this review and separated into three major topics: the regulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver. Particular strains of Bifidobacteria, Lactobacilli, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression of mucins, Toll-like receptors, caspases, nuclear factor-κ

关键词： Gene expression Immunity Immunotolerance Inflammation Microbiota Probiotics Gut Liver

Effect of co-inoculation of different halophilic bacteria and yeast on the flavor of fermented soy sauce

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food Bioscience 2023年第1期51卷 669-675页

作者： Weiyu Wu Tao Chen Mouming Zhao Yunzi Feng School of food Science and Engineering South China University of TechnologyGuangzhou510640China Guangdong food Green Processing and nutrition Regulation Technologies Research center Guangzhou510650China

The flavor of soy sauce is closely related to the succession and interaction of the microbial community during *** this study,the selected potential flavor-producing microorganisms(7 species of bacteria and 4 species of yeast)were applied in the co-culture rapid fermentation model and their growth,physicochemical changes,volatile flavor compounds(VFCs),and sensory characteristics were *** showed that yeast promoted the growth of bacteria,while bacteria inhibited the growth of yeast in the co-culture *** on the results of VFCs and sensory evaluation,the combined fermentation of Zygosaccharomyces rouxii and Lactobacillus fermentum was the best strategy out of the 40 *** effect of this combination was also validated in a 20 L fermentation application of soy sauce,which indeed enhanced the intensity of sauce-like,fruity,smoky,and caramel-like notes,as well as umami and kokumi *** results provide a theoretical basis for the exploration and industrial application of flavor-producing microorganisms in soy sauce fermentation.

关键词： Soy sauce Flavor Co-inoculation Interaction Zygosaccharomyces rouxii Lactobacillus fermentum

Serum Levels of Antioxidant Vitamins in Relation to Coronary Artery Disease: A Case Control Study of Koreans

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Biomedical and Environmental Sciences 1996年第2期9卷 229-235页

作者： KIM S. Y. LEE-KIM Y. C. KIM M. K. SUH J. Y. CHUNG E. J. CHO. S. Y. CHO. B. K. AND SUHI(Department of food and nutrition Cardiovascular center Department of Preventive Medicine Yonsei University, Seoul, Korea) Department of food and nutrition Yonsei University Seoul Korea

With the changes in trends of disease pattern from infectious to chronic degenerative disease, cardiovascular disease has been considered as the major cause of death in *** studies have been done on the antioxidant effects of some vitamins in the prevention of chronic illness, but not many in relation to the cardiovascular ***, the relation between antioxidant vitamins, mainly α-tocopherol (α-T) and B-carotene (B-C), and coronary artery disease (CAD) such as angina pectoris and myocardial infarction has been investigated in this *** blood samples were obtained from the CAD patients who were angiographically diagnosed within a month (100 case group). Patients who had an experience of PTCA or CABG were excluded from the study. Control subjects were healthy adults who had normal EKG values, no chest pain and no past history of cardiac disease (100 control group). All subjects were free of serum lipid lowering drugs. Serum α-T and B-C were analysed using HPLC. In addition to antioxidant vitamins, serum lipids (total cholesterol, HDL, TG) were also measured. Each case and control was matched in terms of age and sex. And all the CAD risk factors such as blood pressure, smoking, alcohol, serum lipid profile and BMI were adjusted to determine pure effect(s) of α-T and B-C on the *** concentrations of both α-T and B-C were significantly lower in the CAD group than those in control group (P<0.05); in CAD group, mean values of α-T and B-C were 11.9±7.2 (μg/ml), 35.8±3.1 (μg/dl) respectively. As for the levels of B-C, it shows inverse relation with age, but not for the α-T Ievels. Serum levels of both vitamins did not show any significant differences in terms of sex, but men have a tendency o higher levels of B-C,but lower levels of α-T

关键词： Case Serum Levels of Antioxidant Vitamins in Relation to Coronary Artery Disease A Case Control Study of Koreans GSH

A comprehensive method to explore inhibitory kinetics and mechanisms of an anticoagulant peptide derived from Crassostrea gigas

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food Science and Human Wellness 2022年第6期11卷 1491-1499页

作者： Shuzhen Cheng Di Wu Hanxiong Liu Xianbing Xu Beiwei Zhu Ming Du Department of food Science and Engineering National Engineering Research Center of SeafoodDalian Polytechnic UniversityDalian 116034China Beijing Advanced Innovation center for food nutrition and Human Health College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

A comprehensive method was applied to evaluate the anticoagulant activity of a novel anticoagulant peptide(NAESLRK)derived from oyster(Crassostrea gigas).The anticoagulant peptide drastically reduced the extrinsic clotting activity and also impaired the intrinsic clotting activity *** with clotting data,the thrombin peak height was reduced to 84.7 nmol/L from 123.4 nmol/L,and thrombin generation time was delayed to 4.67 min from 4.42 min when the extrinsic trigger was *** inhibitory kinetics of FⅪa,FⅨa,FⅩa,FⅡa,and APC in a purified component system rationally explained the reduction of extrinsic clotting activity and impairment of thrombin *** the inhibition of FⅩa and FⅡa activity,the activation processes of FⅩand FⅡby intrinsic/extrinsic tenase complex and prothrombinase were also *** anticoagulant activity in the plasma system was the result of comprehensive inhibition of various *** research provided a novel method for anticoagulant evaluation and inhibitory mechanism of bioactive peptides from food products.

关键词： Oyster Anticoagulant peptide Inhibitory kinetics Coagulation factor Non-specific inhibitor

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Lipid Accumulation and IL-6 Production in L02 Hepatocytes Induced by Sodium Oleate:Dose and Time Dependence

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Biomedical and Environmental Sciences 2021年第12期34卷 998-1004页

作者： CHEN Chen HUO Jun Sheng ZHUO Qin LI Yan MA Yan WANG Jing Bo JIA Xu Dong Key Laboratory of Trace Element nutrition of National Health Commission(NHC) National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Key Laboratory of food Safety Risk Assessment of Ministry of Health China National Center for Food Safety Risk AssessmentBeijing 100021China

To explore interleukin-6(IL-6)production and characterize lipid accumulation in L02 hepatocytes induced by sodium oleate.L02 hepatocytes were incubated with 0,37.5,75,150,300,600,or 1,200μmol/L sodium oleate for 24 h,and the supernatant was collected to detect the concentration of IL-6.L02 hepatocytes were incubated with 300,150,75,or 0μmol/L sodium oleate for 0–24 *** supernatant was collected for detection of IL-6 and free fatty acids.L02 hepatocytes treated with 300μmol/L sodium oleate for 0–24 h were stained with Oil Red *** extended sodium oleate incubation time,IL-6 levels increased,and free fatty acids *** 24 h incubation,IL-6 levels increased as sodium oleate increased from 37.5 to 300μmol/L(P<0.05 for 37.5μmol/L,P<0.01 for 75μmol/L and P<0.001 for concentrations 150μmol/L or higher).Lipid accumulation increased as the sodium oleate concentration and incubation time *** Red O staining intensified with incubation time extending beyond 2 ***-6 production and lipid accumulation in L02 hepatocytes are influenced by sodium oleate in a dose-and time-dependent manner.

关键词： L02 intensified Lipid

Zearalenone induces apoptosis and autophagy by regulating endoplasmic reticulum stress signalling in porcine trophectoderm cells

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Animal nutrition 2023年第1期12卷 186-199页

作者： Jun Bai Jun Li Ning Liu Hai Jia Xuemeng Si Yusong Zhou Zhian Zhai Ying Yang Fazheng Ren Zhenlong Wu State Key Laboratory of Animal nutrition Department of Companion Animal ScienceChina Agricultural UniversityBeijing100193China Beijing Advanced Innovation center for food nutrition and Human Health China Agricultural UniversityBeijing100193China

Zearalenone(ZEA),a mycotoxin produced mainly by fungi belonging to Fusarium species in foods and feeds,causes a serious hazard to humans and *** studies have revealed that ingesting ZEA can disrupt the reproductive function and impair the reproductive process in *** experiment was to investigate the toxicological effect and the mechanism of ZEA exposure on reproduction in pigs during early stages of *** the present study,we treated with 0 to 80μmol/L ZEA for 12 or 24 h in trophoblast ectoderm(pTr)*** results showed that ZEA had significantly decreased cell proliferation(P<0.05),which was accompanied by DNA damage-related cell cycle arrest at G2/M phase,activation of the apoptosis and endoplasmic reticulum(ER)stress,as well as impairment of barrier function(P<0.05).Western blot analysis and transmission electron microscopy(TEM)showed that exposure to ZEA can activation of autophagy in pTr ***,pretreatment with chloroquine(CQ)or 3-methyladenine(3-MA)led to increased apoptosis in pTr ***,pTr cells pretreated with 4-phenylbutyric acid(4-PBA),an inhibitor of ER stress,resulted in reduced cell death in pTr cells,indicating a critical role for ER stress in the activation of *** conclusion,these results reveal that ZEA-triggered ER stress is critical for the cell fate decision of pTr cells during early porcine embryonic *** of small molecules with ability of blocking ER stress might be therapeutic option to reduce the deleterious effect of ZEA in pregnant animals.

关键词： Zearalenone Porcine trophectoderm Apoptosis Endoplasmic reticulum stress Autophagy

Identification and molecular mechanism of angiotensin-converting enzyme inhibitory peptides from Larimichthys crocea titin

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food Science and Human Wellness 2020年第3期9卷 257-263页

作者： Yue Fan Zhipeng Yu Wenzhu Zhao Long Ding Fuping Zheng Jianrong Li Jingbo Liu College of food Science and Engineering Bohai UniversityJinzhou121013China Beijing Advanced Innovation center for food nutrition and Human Health Beijing Technology and Business University(BTBU)Beijing102488China College of food Science and Engineering Northwest A&F UniversityYangling712100China Lab of nutrition and Functional food Jilin UniversityChangchun130062China

This study aimed to identify novel ACEI peptides from Larimichthys crocea titin using in silico approaches and to clarify the molecular interaction *** hydrolyzed peptides of titin were compared with known ACEI peptides in the AHTPDB and BIOPEP-UWM ***,peptides were evaluated for their solubility,ADMET properties,ΔG(kcal/mol)values,and in vitro ACEI *** mechanism of ACE-peptide was performed by molecular interactions and binding orientation *** results revealed that IC50 values of Trp-Ala-Arg(WAR)and Trp-Gln-Arg(WQR)were(31.2±0.8)and(231.33±0.02)mol/L,*** docking interactions result suggested that ACE-WAR and ACEWQR complexes have same binding site,including the residues LYS511,TYR520,TYR523,HIS353,and *** docking of two tripeptides WAR and WQR with ACE studies predicted their binding site and clarified the interaction between ACE and its *** molecular docking data are consistent with the ACE inhibitory activity of the studied *** results showed that Larimichthys crocea titin may be a valuable source for developing nutraceutical food.

关键词： ACE peptide Identification In silico approaches ADMET Molecular docking

Leucine Supplementation in a Chronically Protein-Restricted Diet Enhances Muscle Weight and Postprandial Protein Synthesis of Skeletal Muscle by Promoting the mTOR Pathway in Adult Rats

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Engineering 2017年第5期3卷 760-765页

作者： Bo Zhang Licui Chu Hong Liu Chunyuan Xie Shiyan Qiao Xiangfang Zeng Beijing Advanced Innovation center for food nutrition and Human Health College of Animal Science and Technology China Agricultural UniversityBeijing 100193 China State Key Laboratory of Animal nutrition China Agricultural University Beijing 100193 China

Low protein intake causes a decrease in protein deposition in most animal tissues. The purpose of this study was to investigate whether leucine supplementation would increase the synthesis rate of protein and muscle weight in adult rats, which chronically consume only 58.8% of their protein requirements. Thirty-six male Sprague-Dawley rats were assigned to one of three dietary treatments including a 20% casein diet （CON）, a 10% casein ＋ 0.44% alanine diet （R）, and a 10% casein ＋ 0.87% leucine diet （RL）. After a 10 d dietary treatment, plasma amino acid levels were measured after feeding, the gastrocnemius muscles and soleus muscles were harvested and weighed, and the fractional synthesis rate （FSR） and mammalian target of rapamycin （mTOR） signaling proteins in skeletal muscle were measured. Regarding the plasma amino acid level, the RL group had the highest concentration of leucine （P 〈 0.05） and the lowest concentration of isoleucine （P 〈 0.05） among the three groups, and the CON group had a lower concentration of valine （P 〈 0.05） than the R and RL groups. Compared with the R and RE groups, the CON group diet significantly increased （P 〈 0.05） feed intake, protein synthesis rate, and the phosphorylation of eukaryutic initiation factor 4E binding protein 1 （4E-BP1）, and decreased the weight of abdominal adipose. Compared with the R group, the RL group significantly increased in gastrocnemius muscle weight, protein synthesis rate, and phosphorylation of both ribosomal protein $6 kinase 1 （56K1） and 4E-BP1. In conclusion, when protein is chronically restricted in adult rat diets, leucine supplementation moderately improves body weight gain and increases muscle protein synthesis through mTOR activation,

关键词： Low-protein diet Leucine Growth performance Muscle weight Protein synthesis Adult rats