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Dihydroartemisinin ameliorates innate inflammatory response induced by Streptococcus suis-derived muramidase-released protein via inactivation of TLR4-dependent NF-kB signaling

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1183-1194页

作者： Yun Ji Kaiji Sun Ying Yang Zhenlong Wu State Key Laboratory of Animal nutrition and Feeding China Agricultural UniversityBeijing100193China Beijing Advanced Innovation center for food nutrition and Human Health China Agricultural UniversityBeijing100193China

Muramidase-released protein(MRP)is now being recognized as a critical indicator of the virulence and pathogenicity of Streptococcus suis(***).However,the identification of viable therapeutics for *** infection was hindered by the absence of an explicit mechanism for MRP-actuated ***(DhA)is an artemisinin derivative with potential anti-inflammatory *** modulatory effect of DhA on the inflammatory response mediated by the virulence factor MRP remains *** research aimed to identify the signaling mechanism by which MRP triggers the innate immune response in mouse spleen and cultured *** the candidate mechanism in mind,we investigated DhA for its ability to dampen the pro-inflammatory response induced by *** innate immune response in mice was drastically triggered by MRP,manifesting as splenic and systemic inflammation with splenomegaly,immune cell infiltration,and an elevation in pro-inflammatory cytokines.A crucial role for Toll-like receptor 4(TLR4)in coordinating the MRP-mediated inflammatory response via nuclear factor-kappa B(NF-kB)activation was revealed by TLR4 *** addition,NFkB-dependent transducer and activator of transcription 3(STAT3)and mitogen-activated protein kinases(MAPKs)activation was required for the inflammatory signal transduction engendered by ***,we observed an alleviation effect of DhA on the MRP-induced immune response,which referred to the suppression of TLR4-mediated actuation of NF-kB-STAT3/MAPK *** inflammatory response elicited by MRP is relevant to TLR4-dependent NF-kB activation,followed by an increase in the activity of STAT3 or *** mitigates the inflammation process induced by MRP via blocking the TLR4 cascade,highlighting the therapeutic potential of DhA in targeting *** infection diseases.

关键词： Dihydroartemisinin Inflammation Muramidase-released protein Streptococcus suis Toll-like receptor 4

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Responses of Aerobic Rice (Oryza sativa L.) to Iron Deficiency

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Journal of Integrative Agriculture 2012年第6期11卷 938-945页

作者： SHI Rong-li HAO Hong-mei FAN Xiao-yun Md Rezaul Karim ZHANG Fu-SUO ZOU Chun-qin Key Laboratory of Plant-Soil Interaction Ministry of Education/Center for ResourcesEnvironment and Food SecurityDepartment of Plant NutritionChina Agricultural University

Aerobic rice has the advantage of saving water. Most published work has focused on improving its yield, while few reported on its micronutrient status. In fact, Fe deficiency is a common nutritional problem in the production of aerobic rice. Short- term hydroponic culture experiments were conducted to study the response of aerobic rice to Fe deficiency and the effect of root exudates from Fe-deficient wheat on its Fe uptake ability. The results indicate that the amount of phytosiderophores （PS） released from aerobic rice did not increase under Fe deficient conditions. The Fe（III） reducing capacity of Fe-deficient aerobic rice did not increase and the solution pH did not decrease significantly. What＇s more, no obvious swelling was observed in the root tips. Aerobic rice did not show special responses to improve their Fe nutrition under Fe deficiency as both strategy I and II plants though they were very sensitive to Fe deficiency. This may be a reason which causes Fe deficiency problem in aerobic rice. However, root exudates from Fe-deficient wheat （PSw） could improve its Fe nutrition in the presence of insoluble Fe（OH）3. This suggests that aerobic rice could utilize Fe activated by PSw.

关键词： aerobic rice Fe(III)-reduction iron nutrition phytosiderophore release root tip swelling

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Effects of forsythin extract in Forsythia leaves on intestinal microbiota and short-chain fatty acids in rats fed a high-fat diet

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food Science and Human Wellness 2024年第2期13卷 659-667页

作者： Lanlan Gui Shaokang Wang Jing Wang Wang Liao Zitong Chen Da Pan Hui Xia Guiju Sun Su Tian Department of nutrition and food Hygiene School of Public HealthSoutheast UniversityNanjing 210009China Nanjing Municipal center for Disease Control and Prevention Nanjing 210003China Department of nutrition and food Hygiene School of Public HealthHebei Medical UniversityShijiazhuang 050017China

Forsythia suspensa,belonging to the deciduous shrubs of the Luteaceae family,a traditional Chinese medicine,has effects of alleviating swelling,clearing heat,detoxification and promoting blood *** leaves of *** contain multiple chemical components and have a long history of use in folk medicines and health *** purpose of this study was to explore the effects of forsythin extract from *** leaves on intestinal microbiota and short-chain fatty acid(SCFA)content in rats with obesity induced by a high-fat *** extract in *** leaves increased the abundance of the intestinal microbiota,ameliorated intestinal microbiota disorders and inhibited the increase in total SCFA content in the intestinal tract in rats with obesity induced by a high-fat *** results suggested that forsythin extract in *** leaves may slow the development of obesity induced by a high-fat diet;thus,its active components and efficacy are worthy of further study.

关键词： Forsythin High-fat diet Intestinal microbiota Short-chain fatty acid(SCFA)

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Correlation of Serum Leptin Level with Bone Mineral Density and Bone Turnover Markers in Chinese Adolescent Dancers

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Biomedical and Environmental Sciences 2009年第5期22卷 369-373页

作者： LI-CHEN YANG YAN LAN JING HU YAN-HUA YANG QIAN ZHANG JIAN-HUA PIAO Institute for nutrition and food Safe Chinese Center for DiseaseControl and Prevention Beijing 100050 China Beijing Dance Academy Beijing 100081 China

Objective To investigate plasma leptin concentrations in adolescent female dancers and to determine whether leptin has some effects on their bone mineral density （BMD） and bone turnover markers. Methods Sixty dancers aged 15-17 years and 77 healthy controls were enrolled in the study. Bone mineral density （BMD） and body composition were detected by dual energy X-ray absorptiometry. Serum leptin concentrations were measured by radioimmunoassay （RIA）. Two bone turnover markers, bone-specific alkaline phosphatase （BAP） and tartrate-resistant acid phosphatase（TRACP）, were determined by ELISA. Results The dancers had a lower fat mass and a lower leptin level than the controls, while they had a relatively higher BMD of the total body and legs after adjustment for BMI and age. The levels of bone resorption and formation of markers were higher in the dancers than in the controls. Leptin was positively correlated with BMI, body weight, fat mass, and percentage of body fat. In dancers, Leptin was positively correlated with the BMD of the total body and the left leg. However, after adjustment for BMI, no correlation of serum leptin concentrations with BMD values was found in either dancers or controls. Nor correlation was found between leptin and bone turnover markers after adjustment for BMI. Conelusion The leptin profile is different between the controls and the dancers with a lower BMI and a lower fat mass. Circulating plasma leptin level depends on BMI and is not a direct determinant of BMD in Chinese adolescent dancers.

关键词： Leptin Bone mineral density Bone turnover marker Adolescent dancer China

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Peptide WCPFSRSF ameliorates excitotoxicity and elevates synaptic plasticity in glutamate-damaged SH-SY5Y cells by modulating the PI3K/mTOR/EIF4E and BDNF/CREB/TrkB pathways

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food Bioscience 2022年第3期47卷 819-828页

作者： Qi Zhang Lin Zheng Guowan Su Donghui Luo Mingtao Huang Yunzi Feng Mouming Zhao School of food Science and Engineering South China University of TechnologyGuangzhou510640China Chaozhou Branch of chemistry and Chemical Engineering Guangdong Laboratory Chaozhou521000China Guangdong food Green Processing and nutrition Regulation Technologies Research center Guangzhou510650China

The purpose of this study was to illustrate the beneficial effects and underlying mechanisms of peptide Trp-Cys-Pro-Phe-Ser-Arg-Ser-Phe (WCPFSRSF) against excitotoxicity by transcriptome analysis combined with western blot in glutamate-treated neuronal *** results demonstrated that WCPFSRSF restored the cell membrane damage induced by glutamate and promoted cell survival in SH-SY5Y *** RNA-sequencing analysis illustrated 376 genes (98 upregulated and 278 downregulated) were differentially expressed between the glutamate- and WCPFSRSF-treated ***,RNA-sequencing screening and further western blot results showed that WCPFSRSF regulated cAMP-related signaling and synapse-related function,which further promoted the translation and protein synthesis,followed by cell survival,neurotrophic pathway and long-term *** potential mechanisms of WCPFSRSF were related to the Akt/mTOR/EIF4E signaling pathway and CREB/TrkB/BDNF *** together,our study demonstrated that WCPFSRSF could be used as a regulator for synaptic plasticity and neurotrophic-related pathway,which provided evidence that WCPFSRSF is a promising therapeutic strategy for neuroprotection and memory enhancement.

关键词： Peptide EIF4E RNA-Sequencing analysis Neurotrophin Synaptic plasticity

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Discovery,characterization and stability evaluation of self-assembled submicroparticles in chrysanthemum tea infusions

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food Bioscience 2022年第3期47卷 484-492页

作者： An Peng Lianzhu Lin Mouming Zhao School of food Science and Engineering South China University of TechnologyGuangzhou510641China Guangdong food Green Processing and nutrition Regulation Technologies Research center Guangzhou510641China Chaozhou Branch of chemistry and Chemical Engineering Guangdong Laboratory Chaozhou521000China

Chrysanthemum tea infusions are famous and nutritious beverages *** results showed that numerous negatively charged spherical particles of 60–1000 nm in diameter generally existed in all chrysanthemum tea infusions prepared from 9 kinds of chrysanthemums for tea *** Chrysanthemum morifolium ‘Hangbaiju ’ tea infusion as an example,crushing,heating and increasing flower-to-water ratio were three strategies to prepare optimal submicroparticles with the smallest mean hydrodynamic diameter as 288.40 nm and polydispersity index as *** submicroparticles were stable when temperature change,dialysis,centrifugation,storage,pH change (2–9) and ionic strength change were applied but unstable when freeze-thaw,lyophilization,ultrafiltration,concentration and pH change (10) were *** and phenolics were dominant components of submicroparticles which were maintained by hydrogen bonds and hydrophobic interactions among polysaccharides and *** study provided a novel perspective to decipher and control supramolecular aggregation in chrysanthemum tea infusions for rational manufacturing.

关键词： Chrysanthemum tea Submicroparticles Polysaccharides Phenolics Stability Supramolecular aggregation

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Effect of high temperature cooking on the quality of rice porridge

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International Journal of Agricultural and Biological Engineering 2021年第5期14卷 247-254页

作者： Cunshe Chen Siyuan Jiang Mengfei Li You Li He Li Fen Zhao Zhihua Pang Xinqi Liu Beijing Engineering and Technology Research center of food Additives Beijing 100048China Beijing Advanced Innovation center for food nutrition and Human Health Beijing 100048China School of food and Health Beijing Technology and Business UniversityBeijing 100048China

In order to explore the effect of high-temperature cooking instant porridge on the taste and quality of porridge,this study explored the changes in the taste quality of rice porridge under different heating times(15 min,20 min,25 min and 30 min)at a higher initial temperature(100°C),and compared with that cooked at room temperature(25°C),and explained the reasons for the *** the perspective of migration rate in moisture content,the rice porridge with special treatment has a more rapid moisture change,which makes texture,whiteness,smell and other factors change in a shorter time and increases the taste *** was concluded that under special treatment condition of starting with 100°C water and heating for 15 min,the kinds of rice flavor increased 2.2 times,the white of rice decreased by 10.04%,hardness decreased by 3.54 times,and the elasticity decreased by 35.48%*** general,cooking with higher initial temperature(100°C)is more valuable than cooking from 25°C,in terms of the texture,flavor,saving time,and stable quality during the household and industrial production of instant porridge.

关键词： rice porridge low frequency NMR sensory evaluation GC-MS confocal laser scanning microscope

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Contamination and Transmission of SARS-CoV-2 Variants in Cold-Chain food and food Packaging

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China CDC weekly 2023年第22期5卷 485-491页

作者： Gang Li Yeru Wang Zhenhua Wang Yibaina Wang Yan Qi Li Bai Zhaoping Liu Ning Li Beijing Advanced Innovation center for food nutrition and Human Health School of Food and HealthBeijing Technology and Business UniversityBeijingChina China National center for food Safety Risk Assessment BeijingChina NHC Key Lab of food Safety Risk Assessment BeijingChina

INTRODUCTION The emergence of coronavirus disease 2019(COVID-19)has posed a significant threat to global health and *** serves as a vital strategy in preventing and mitigating the severity of clinical ***,due to natural selection,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has evolved,resulting in various mutations(1).Currently,the World Health Organization(WHO)has identified five variants of concern,including Alpha,Beta,Gamma,Delta,and Omicron(2).Of these,only Omicron remains in circulation and has already produced nearly one thousand sub-lineages or *** mutating variants demonstrate increased infectivity and vaccine breakthrough rates,as well as more pronounced antibody escape rates(3).

关键词： acute vaccine respiratory

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Characteristics of flax oil and milk mixture

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International Journal of Agricultural and Biological Engineering 2022年第4期15卷 264-270页

作者： Cunshe Chen Ping Liu Mengfei Li Xin Zhang Beijing Advanced Innovation center for food nutrition and Human Health Beijing Technology&Business UniversityBeijing 100048China

In order to develop milk products both with better taste and more health benefits,a blended system of dairy products and flax oil was studied based on the Budwig *** amounts of flax oil added to the pure milk or yogurt were varied and the system was fully mixed without adversely affecting the *** effects of flax oil addition on the frictional and rheological properties of different dairy products were investigated,and the optimal addition ratio was determined combined with the sensory *** experimental results showed that the addition ratio of flax oil significantly affected the friction characteristics and rheological properties of dairy products,in which the friction coefficient of the mixture tended to decrease as the addition of flax oil increased,and with the added increase the viscosities of both ordinary yogurt mixture and pure milk mixture tended to ***,based on physical characteristics and sensory properties the optimal addition ratios of flax oil to pure milk,ordinary yogurt,and non-fat yogurt are obtained,which are 2.5wt%,2.5wt%,and 5wt%,*** study provides a quantified analysis way for the additions to the dairy products and the obtained data can be used for reference in production.

关键词： rheology tribology flax oil milk yogurt mixture characteristics

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Structural characteristics of the hydrophobic patch of azurin and its interaction with p53: a site-directed spin labeling study

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Science China(Life Sciences) 2010年第10期53卷 1181-1188页

作者： XU Chao YIN JunJie ZHAO BaoLu State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate University of the Chinese Academy of Sciences Beijing 100049China center for food Safety and applied nutrition Food and Drug AdministrationCollege ParkMD 20740USA

Site-directed spin labeling (SDSL) is a powerful tool for monitoring protein structure, dynamics and conformational changes. In this study, the domain-specific properties of azurin and its interaction with p53 were studied using this technique. Mutations of six residues, that are located in the hydrophobic patch of azurin, were prepared and spin labeled. Spectra of the six azurin mutants in solution showed that spin labeled residues 45 and 63 are in a very restricted environment, residues 59 and 65 are in a spacious environment and have free movement, and residues 49 and 51 are located in a relatively closed pocket. Polarity experiments confirmed these results. The changes observed in the spectra of spin labeled azurin upon interaction with p53 indicate that the hydrophobic patch is involved in this interaction. Our results provide valuable insight into the topographic structure of the hydrophobic domain of azurin, as well as direct evidence of its interaction with p53 in solution via the hydrophobic patch. Cytotoxicity studies of azurin mutants showed that residues along the hydrophobic patch are important for its cytotoxicity.

关键词： azurin p53 spin label protein-protein interaction anticancer ESR

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