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Analysis of the incidence and influencing factors of hyponatremia before ^(131)I treatment of differentiated thyroid carcinoma

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World Journal of Clinical Cases 2021年第36期9卷 11173-11182页

作者： Jing-Jia Cao Can-Hua Yun Juan Xiao Yong Liu Wei Wei Wei Zhang Department of Nuclear medicine The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033Shandong ProvinceChina

BACKGROUND Hyponatremia is a common clinical electrolyte ***,the association between hyponatremia and acute hypothyroidism is *** hypothyroidism is usually seen in patients who undergo preparation for radioactive iodine *** To analyze the incidence and influencing factors of hyponatremia in a condition of iatrogenic acute hypothyroidism in patients with differentiated thyroid cancer(DTC)before ^(131)I *** The study group consisted of 903 DTC patients who received ^(131)I *** clinical data before and after surgery,as well as on the day of ^(131)I treatment were *** to the blood sodium level before ^(131)I treatment,patients were divided into the non-hyponatremia group and hyponatremia *** between serum sodium levels before ^(131)I treatment and baseline data were *** analysis and binary logistic regression were performed to identify the influencing factors of *** A total of 903 patients with DTC,including 283(31.3%)males and 620(68.7%)females,with an average age of 43.8±12.7 years,were included in this *** serum sodium levels before surgery and ^(131)I treatment were 141.3±2.3 and 140.5±2.1 mmol/L,respectively(P=0.001).However,the serum sodium levels in males and females before ^(131)I treatment were lower than those before *** aged more than 60 years and less than 60 years also showed decreased serum sodium levels before ^(131)I *** addition,the estimated glomerular filtration rate(eGFR)in males and females decreased before ^(131)I treatment compared with those before surgery(P=0.001).Moreover,eGFR in patients over 60 years and under 60 years decreased before ^(131)I treatment,when compared with that before *** were no significant differences in serum potassium,calcium,albumin,hemoglobin,and blood glucose in patients before surgery and ^(131)I treatment(P>0.05).Among the 903 patients,23(2.5%)were diagnosed with h

关键词： Differentiated thyroid cancer Hyponatremia Incidence Low iodine diet Logistic regression analysis

Prior transfusion of umbilical cord mesenchymal stem cells can effectively alleviate symptoms of motion sickness in mice through interleukin 10 secretion

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World Journal of Stem Cells 2021年第2期13卷 177-192页

作者： Hua-Su Zhu Dong Li Cong Li Jin-Xian Huang Shan-Shan Chen Lan-Bo Li Qing Shi Xiu-Li Ju Department of Pediatrics Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Stem Cell and Regenerative medicine Research Center Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Animal Laboratory Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Pediatrics Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Motion sickness(MS)is a disease that occurs during unbalanced movement,characterized by gastrointestinal symptoms and autonomic nervous system *** clinical treatments for MS are *** evidence indicates that the levels of pro-inflammatory cytokines increase during MS and are associated with an inner ear immune *** the present study,mesenchymal stem cells(MSCs)have been shown to exert strong immunosuppressive *** To explore whether umbilical cord-derived mesenchymal stem cells(UC-MSCs)can prevent the occurrence of MS,and the underlying mechanism regulated by MSCs in a mouse model of *** A total of 144(equal numbers of males and females)5wkold BALB/c mice were randomly divided into five groups:Normal group(n=16),MS group(n=32),MSCs group(n=32),MS+MSCs group(n=32),and MS+AS101/MSCs group(n=32).The MSCs group(n=32),MS+MSCs group(n=32),and MS+AS101/MSCs group(n=32)were preventively transplanted with UC-MSCs or AS101-treated UC-MSCs(1×106 cells/mouse).Mice in the MS(n=32),MS+MSCs,and MS+AS101/MSCs groups were subjected to rotation on a centrifuge for 10 min at 8×g/min for MS model establishment on days 3,5,8,and 10 after UC-MSCs *** Morris water maze(MWM)test was used to observe the symptom of ***-linked immunosorbent assay(ELISA)and reverse transcription-quantitative polymerase chain reaction(RT-qPCR)were used to detect the levels of inflammatory cytokines in mice peripheral blood and the petrous part of the temporal bone *** blot analysis was performed to analyze the JAK2/STAT3 signaling pathway in the cochlear *** examination was performed by hematoxylin and eosin(HE)staining for conventional morphological evaluation in the petrous part of temporal bone *** The MWM test demonstrated that UC-MSCs improved the symptoms of *** MS+MSCs group was faster than the MS group on days 3 and 5(P=0.036 and P=0.002,respectively).ELISA and RT-qPCR showed that

关键词： Mesenchymal stem cell Motion sickness Inflammation Immune microenvironment Interleukin-10 JAK2/STAT3

Immunotherapy combined with antiangiogenic agents in patients with advanced malignant pleural mesothelioma: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8284-8290页

作者： Tian-Tian Xuan Guang-Yi Li Si-Bo Meng Zhan-Mei Wang Lin-Li Qu Department of Medical Oncology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266035Shandong ProvinceChina Department of Respiratory Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266035Shandong ProvinceChina

BACKGROUND Malignant pleural mesothelioma has limited therapeutic options and a poor outcome. Antiangiogenic agents might increase the efficacy of immunotherapy as second-line treatment of advanced-stage *** SUMMARY A patient with stage ⅢB pleural mesothelioma received second-line treatment with a combination of pembrolizumab, bevacizumab and chemotherapy following standard chemotherapy under the guidance of second-generation sequencing. He achieved a partial response after four cycles of treatment with progression-free survival of 5 mo. Pembrolizumab was suspended due to grade 2 immunerelated pneumonia, which was resolved by oral ***, disease progression was observed after immunotherapy rechallenge and anlotinib therapy. The patient had disease progression, multiorgan dysfuntion and died suddenly in October *** The combination of immune checkpoint inhibitor, anti-angiogenic agents and chemotherapy showed effective response for advanced pleural mesothelioma, but with adverse reactions.

关键词： Pleural mesothelioma Immune checkpoint inhibitor Next-generation Sequencing Immunerelated pneumonia Immunotherapy rechallenge Case report

Single-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-γ-producing γδ T cells

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Cellular & Molecular Immunology 2021年第4期18卷 954-968页

作者： Yuan Hu Keke Fang Yanan Wang Nan Lu Haoyu Sun Cai Zhang Institute of Immunopharmaceutical Sciences School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinanShandongChina Institute of Diagnostics School of MedicineCheeloo College of MedicineShandong UniversityJinanShandongChina Institute of Immunology School of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhuiChina

γδ T cells are heterogeneous lymphocytes located in various ***,a systematic and comprehensive understanding of the origins of γδ T cell heterogeneity and the extrathymic developmental pathway associated with liver γδ T cells remain largely *** this study,we performed single-cell RNA sequencing(scRNA-seq)to comprehensively catalog the heterogeneity of γδ T cells derived from murine liver and thymus *** revealed the developmental trajectory of γδ T cells and found that the liver contains γδ T cell precursors(pre-γδ T cells).The developmental potential of hepatic γδ T precursor cells was confirmed through in vitro coculture experiments and in vivo adoptive transfer *** adoptive transfer of hematopoietic progenitor Lin^(-)Sca-1^(+)Mac-1^(+)(LSM)cells from fetal or adult liver samples to sublethally irradiated recipients resulted in the differentiation of liver LSM cells into pre-γδ T cells and interferon-gamma^(+)(IFN-γ^(+))but not interleukin-17a^(+)(IL-17a^(+))γδ T cells in the ***,thymectomized mouse models showed that IFN-γ-producing γδ T cells could originate from liver LSM cells in a thymus-independent *** results suggested that liver hematopoietic progenitor LSM cells were able to differentiate into pre-γδ T cells and functionally mature γδ T cells,which implied that these cells are involved in a distinct developmental pathway independent of thymus-derived γδ T cells.

关键词： γδT cells liver extrathymic development subpopulation differentiation

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BIOCELL 2023年第1期47卷 109-123页

作者： LIPING GONG MING JIA Department of Academic Research The Secondary HospitalCheeloo College of MedicineShandong UniversityJinan250033China Department of Cancer Center The Secondary HospitalCheeloo College of MedicineShandong UniversityJinan250033China

ATP binding cassette subfamily C member 8(ABCC8)encodes a protein regulating the ATP-sensitive potassium *** the level of ABCC8 mRNA in lower grade glioma(LGG)correlates with immune cell infiltration and patient outcomes has not been evaluated until *** of ABCC8 expression between different tumors and normal tissues were evaluated by exploring publicly available *** association between ABCC8 and tumor immune cell infiltration,diverse gene mutation characteristics,tumor mutation burden(TMB),and survival in LGG was also investigated in several independent *** enrichment analysis was conducted to search for ABCC8-associated signaling *** an online database,we found that ABCC8 expression in LGG was lower than in normal ***,the association of ABCC8 expression and immune cell infiltration in LGG was *** we expected,the ABCC8 mRNA levels were negatively associated with non-T immune cell infiltration levels in all ***,TCGA_LGG RNA-seq data revealed that ABCC8 downregulated several non-T immune cell-associated signaling pathways in gene set enrichment *** ABCC8 expression groups showed diverse gene mutation characteristics and *** high expression of ABCC8 was linked to improved survival of LGG patients.A pathway enrichment analysis of ABCC8-associated genes indicated that the GABAergic synapse signaling pathway might be involved in regulating immunity in *** findings show that ABCC8 reflects LGG tumor immunity and is an ideal prognostic biomarker for LGG.

关键词： ABCC8 Lower grade glioma Tumor immunity Tumor mutation burden Prognostic biomarker

Use of the alkaline phosphatase to prealbumin ratio as an independent predictive factor for the prognosis of gastric cancer

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World Journal of Gastroenterology 2020年第44期26卷 6963-6978页

作者： Yang Li Jin-Shen Wang Yun Guo Tao Zhang Le-Ping Li Departments of Gastrointestinal Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina Center for Reproductive medicine Cheeloo College of MedicineJinan 250012Shandong ProvinceChina Department of Biostatistics School of Public HealthShandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Gastric cancer(GC)is characterized by a low 5-year survival *** prognosis is still not satisfactory although it has significantly improved due to developments in ***,the identification of more efficient indices for the evaluation of GC prognosis is *** propose,for the first time,that the alkaline phosphatase(ALP)to prealbumin(PA)ratio(APR)can be used as an independent prognostic factor in *** To evaluate the prognostic value the APR in *** According to the exclusion strategy,we collected the preoperative serologic examination results and clinical information of 409 GC patients treated in shandong Provincial Hospital from January to December,*** calculating the APR,the neutrophil and lymphocyte ratio(NLR),C-reactive protein(CRP)and albumin(ALB)ratio,platelet and lymphocyte ratio,lymphocyte and monocyte ratio,and the relationship with clinical information,we verified the role of preoperative APR ratio in the prognosis of *** addition,we used a Cox model combined with the APR and tumor stage to demonstrate its efficacy in assessing the prognosis of GC *** Preoperative APR was an independent prognostic factor for *** median age of patients in the APR-high group was greater compared with that in the APR-low *** with a higher APR had a more advanced clinical stage,higher neutrophil to lymphocyte,CRP to ALB,and platelet to lymphocyte ratios,but a lower lymphocyte to monocyte ratio(P<0.05).The APR-high group also had higher glycoprotein antigen 199 and carbohydrate antigen 125 levels than the APR-low group(P<0.05).Median overall survival and disease-free survival were significantly longer in the APR-low group than in the APR-high *** addition,a Cox model based on the APR and tumor stage was more effective in evaluating the prognosis of patients than models based on stage alone or stage plus the *** A higher APR is an independent and negative prognostic factor for *** prognosis of

关键词： Gastric cancer Prognosis Alkaline phosphatase Prealbumin Evaluating efficiency

Neurotoxicity due to dimethylamine borane poisoning via skin absorption:a case report

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World Journal of Emergency medicine 2022年第6期13卷 500-503页

作者： Guang-cai Yu Ya-qian Li Tian-zi Jian Bao-tian Kan Si-qi Cui Ping Han Xiang-dong Jian Department of Poisoning and Occupational Diseases Emergency MedicineQilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250012China shandong university of Traditional Chinese medicine Jinan 250012China Department of Geriatric medicine Qilu Hospital of Shandong UniversitySchool of NursingCheeloo College of MedicineShandong UniversityJinan 250012China School of Public Health Cheeloo College of MedicineShandong UniversityJinan 250012China

Dear editor,Dimethylamine borane(DMAB,CAS no.74-94-2),also called boron-dimethylamine complex,is a white crystalline *** has an amine odour under mild conditions.[1]As an excellent reducing agent,DMAB is widely used in the semiconductor industry,pharmaceutical manufacturing,[2]oligomer and polymer production,and hydrogen storage.[3]Acute DMAB exposure may cause eye or respiratory irritation,throat discomfort,vomiting,diarrhoea,and pulmonary oedema.[1,4]Isolated reports indicated that DMAB exposure causes acute cerebellar oedema and peripheral neuropathy.[1,5,6]Herein,we report a case of DMAB poisoning via dermal absorption in which the central and peripheral nervous systems were the primary sites of toxic *** highlight the use of brain magnetic resonance imaging(MRI)and electromyography(EMG)for evaluation after exposure.

关键词： conditions. absorption boron

Beware of the serious harm of veterinary drug poisoning:a case report

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World Journal of Emergency medicine 2024年第2期15卷 153-155页

作者： Ping Dai Jin Sun Tongyue Zhang Zhiqiang Zhou Zixi Wen Tianzi Jian Aerbusili Genjiafu Baotian Kan Xiangdong Jian Department of Poisoning and Occupational Diseases Emergency MedicineQilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012China Emergency Department Affiliated the Jianhu Clinical Medical College of Yangzhou UniversityYancheng 224700China Department of Occupational and Environmental Health School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China School of Nursing and Rehabilitation Cheeloo College of MedicineShandong UniversityNursing Theory&Practice Innovation Research Center of Shandong UniversityJinan 250012China Department of Geriatric medicine Qilu HospitalNursing Theory Innovation and Research Center of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250012China

Veterinary drugs are substances(including pharmaceutical feed additives)used to prevent,treat,and diagnose diseases or regulate the physiological functions of *** drug poisoning in humans is relatively rare both in China and the rest of the ***,we report a case of death from veterinary drug poisoning from ***-closantel is a broad-spectrum antiparasitic drug,which has high efficacy against a variety of trematodes and nematodes.

关键词： drug drugs diseases

Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting

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Signal Transduction and Targeted Therapy 2020年第1期5卷 279-293页

作者： Xianglei Fu Yanbin Shi Tongtong Qi Shengnan Qiu Yi Huang Xiaogang Zhao Qifeng Sun Guimei Lin Department of Pharmaceutics Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012 ShandongChina School of Mechanical and Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353 ShandongChina The Second Hospital Cheeloo College of MedicineShandong UniversityJinan 250033 ShandongChina

Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final *** optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level,which play a key role in ***,to improve the therapeutic efficiency of drugs,researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular *** this review,we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations,aiming at providing guidance in the overall design of precise ***,future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine.

关键词： therapeutic drugs precise