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Agricultural Biotechnology 2022年第1期11卷 82-85页

作者： Yi LI Luman HUO Mingyang LI Lixue DONG Lei WANG Liwu HAO Tangshan Food and Drug Comprehensive Inspection and Testing Center Tangshan 063000China Hebei Agricultural Product Quality and Safety Inspection Engineering technology Research Center Shijiazhuang 050091China Food Inspection Full Lab Automation Hebei Engineering Research CenterTangshan 063000China

[Objectives]This study was conducted to establish a qualitative method for rapid detection of pesticide residues in feed.[Methods]A rapid screening method for 82 pesticide residues in feed was established using ultra liquid chromatography coupled with quadrupole-time of flight mass spectrometry(UPLC-Q-TOF-MS)combined with optimized pretreatment methods.[Results]Feed samples were extracted with 0.2%formic acid-acetonitrile solution,shaken,centrifuged,and re-centrifuged,and the supernatant was filtered with a 0.22μm filter membrane for *** samples were separated on a Waters ACQUITY UPLC HSS T3 chromatographic column(2.1 mm×50 mm,1.8μm),and subjected to gradient elution with methanol-water solution as the mobile phase,and scanning was performed in ESI+mode.82 compounds could be accurately qualitatively detected in 13 min.[Conclusions]This method is simple to operate,time-saving,and can be applied to rapid screening of large-scale *** study provides a theoretical basis for the development of new methods in the future.

关键词： UPLC-Q-TOF-MS Feed Pesticide Rapid screening method

The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ

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Cellular & Molecular Immunology 2023年第12期20卷 1428-1444页

作者： Rongfei Wei Xiao Han Mengyuan Li Yuan Ji Lianfeng Zhang Maria-Ioanna Christodoulou Najwa Jameel Hameed Aga Caiyan Zhang Ran Gao Jiangning Liu Jinrong Fu Guoping Lu Xiaojun Xiao Xiaoyu Liu Ping-Chang Yang Iain B.McInnes Ying Sun Peisong Gao Chuan Qin Shau-Ku Huang Yufeng Zhou Damo Xu Institute of Laboratory Animal Science Chinese Academy of Medical Science(CAMS)and Comparative Medicine CenterPeking Union Medical College(PUMC)BeijingChina National Laboratory of Biomacromolecules CAS Center for Excellence in Biom––acromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China NHC Key Laboratory of Neonatal Diseases Children’s Hospital of Fudan Universityand the Shanghai Key Laboratory of Medical EpigeneticsInternational Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesFudan UniversityShanghai200032China Department of General Practice Medicine Third Affiliated Hospital of Shenzhen UniversityShenzhenChina Institute of Infection Immunity and InflammationUniversity of GlasgowGlasgowUK Tumor Immunology and Biomarkers Laboratory Basic and Translational Cancer Research CenterDepartment of Life SciencesSchool of SciencesEuropean University CyprusNicosia2404Cyprus Department of Critical Care Medicine Children’s Hospital of Fudan UniversityShanghaiChina Institute of Allergy and Immunology Health Science CenterShenzhen UniversityShenzhenChina Department of Immunology School of Basic Medical ScienceCapital Medical UniversityBeijingChina Department of Medicine Johns Hopkins University School of MedicineBaltimoreMDUSA National Institute of Environmental Health Sciences National Health Research InstitutesTaiwanChina State-level Regional Children’s Medical Center Children’s Hospital of Fudan University at Xiamen(Xiamen Children’s Hospital)Fujian Provincial Key Laboratory of Neonatal DiseasesXiamenChina

Cytokine storms are crucial in the development of various inflammatory diseases,including sepsis and autoimmune *** immunosuppressive cytokine INTERLEUKIN(IL)-37 consists of five isoforms(IL-37a-e).We identified IL-37a as a nuclear cytokine for the first *** to IL-37b,IL-37a demonstrated greater efficacy in protecting against Toll-like receptor-induced cytokine hypersecretion and lethal endotoxic *** full-length(FL)form of IL-37a and the N-terminal fragment,which is processed by elastase,could translocate into cell nuclei through a distinctive nuclear localization sequence(NLS)/importin nuclear transport *** forms exerted their regulatory effects independent of the IL-1R8 receptor by transcriptionally upregulating the nuclear receptor peroxisome proliferator-activated receptor(PPARγ).This process involved the recruitment of the H3K4 methyltransferase complex WDR5/MLL4/C/EBPβand H3K4me1/2 to the enhancer/promoter of *** receptor-independent regulatory pathway of the nuclear IL-37a–PPARγaxis and receptor-dependent signaling by secreted IL-37a maintain homeostasis and are potential therapeutic targets for various inflammatory diseases,including sepsis.

关键词： IL-37 isoforms IL-37a Nuclear cytokine receptor-independent

Quality Standard of Yi Herb Medicine Millettia dielsiana

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Medicinal Plant 2022年第5期13卷 26-30页

作者： Maliniu SHA Wenbing LI Dongmei SHA Meiyi TONG Jing WANG Xinjia YAN Yuan LIU College of Pharmacy Southwest Minzu UniversityChengdu 610041China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization technology Engineering Laboratory Chengdu 610225China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225China

[Objectives]The paper was to establish the quality standard of Yi herb medicine Millettia dielsiana.[Methods]Yi herb medicine *** was qualitatively identified by microscopic identification and thin layer *** content of total isoflavones was determined by UV-Vis spectrophotometry,and the contents of moisture,total ash,acid-insoluble ash and extract were checked according to the method introduced in Chinese Pharmacopoeia(2020 edition).[Results]The microscopic identification features,including stone cells,fiber bundles,calcium oxalate square crystals,starch granules,pigment blocks,ducts,etc.,were distinct.A TLC method for identification of *** was *** contents of water,total ash,acid-insoluble ash and extract should be no more than 13%,no more than 7%,no more than 0.5%and no less than 6%in 10 batches of samples,*** total isoflavones of *** based on genistein(C_(15)H_(10)O_(5)) should be no less than 0.25%.The linear relationship of genistein was good in the range of 0.002-0.007 mg/mL(R^(2)=0.9996);the average recovery was 97.01%and the RSD was 2.62%.[Conclusions]The method is simple,accurate and well-reproducible,and can be used for the quality control of Yi herb medicine ***.

关键词： Yi herb medicine Millettia dielsiana Genistein TLC UV-Vis spectrophotometry

Chemical Fertilizer Reduction and High Yield Cultivation Technique for Peanut

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Asian Agricultural Research 2019年第10期11卷 87-90页

作者： Yaping ZHENG Shifu WANG Zulin ZHENG Lili WANG Chunxiao WANG Zeqi LU Wei JIANG Hongwei ZANG Yongmei ZHENG Shandong Peanut Research Institute Qingdao 266100China Gansu Precious Metal Smelting Co. Ltd.Dingxi 730500 China Weifang Food and Drug Inspection and Testing Center Weifang 261100China Wendeng District Agricultural technology Extension Station of Weihai City Weihai 264400China Yantai Academy of Agricultural Sciences Yantai 265500China

For a long time,the amount of fertilizer applied to peanuts in China has been much higher than that of other main peanut producing *** the same time of increasing production,chemical fertilizers have also brought many adverse effects,which have brought potential threats to the sustainable development of peanut *** continuously increasing the yield,reducing the amount of chemical fertilizer has become an urgent problem to be solved in peanut production of *** on the research results of our team,this paper appropriately absorbed the latest research progress of chemical fertilizer reduction in related fields,and established the cultivation technique for peanut fertilizer reduction and high yield under different cultivation modes,to realize the synchronization of fertilizer reduction and yield increase for peanut *** technique includes two parts:common technology and different cultivation mode fertilization *** former includes crop rotation,proper deep tillage,application of organic fertilizer,selection of nutrient-efficient varieties,topdressing of foliar fertilizer,etc.,the latter includes film mulching spring peanut,continuous cropping field,acidified soil,peanuts interplanting with wheat,and summer direct sowing,*** technique provides a technical support for the chemical fertilizer reduction of peanut production in China.

关键词： Peanut Chemical fertilizer reduction High yield cultivation

Research on the Construction of Industrial Catalysis Course Under the Background of Specialty-Innovation Integration

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Journal of Contemporary Educational Research 2023年第9期7卷 8-13页

作者： Yuxue Wei Sixue Chen Fengye Zhou Jie Liu Lisheng Guo Fang Chen Mengdie Cai Jingshuai Chen Jiaqi Bai Qin Cheng Song Sun School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601Anhui ProvinceChina Sinosteel New Materials Co. Ltd.Maanshan 243000Anhui ProvinceChina Anhui Chuzhou Ecological Environment Monitoring Center Chuzhou 239082Anhui ProvinceChina HeBei Zhisheng Green technology Co. Ltd.Handan 056001Hebei ProvinceChina

“Specialty-innovation integration”is a positive response of higher education to economic and social development needs,and it is also an inherent requirement for the reform and development of higher *** paper discusses the construction of an“industrial catalysis”curriculum system under the background of specialty-innovation ***,it raises students’comprehensive quality from three aspects,including teaching content,teaching method,and the concept of specialty-innovation integration,aiming to cultivate students as the innovative talents required by the development of the era for national and regional development.

关键词： Specialty-innovation integration Industrial catalysis Innovation Entrepreneurship Professional education

Dissection of cellular and molecular mechanisms of aristolochic acid-induced hepatotoxicity via single-cell transcriptomics

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Precision Clinical Medicine 2022年第4期5卷 199-214页

作者： Piao Luo Jiayun Chen Qian Zhang Fei Xia Chen Wang Yunmeng Bai Huan Tang Dandan Liu Liwei Gu Qingfeng Du Wei Xiao Chuanbin Yang Jigang Wang Department of Geriatric Medicine Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan University/The First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China Artemisinin Research Center and Institute of Chinese Materia MedicaChinese Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Glucolipid Metabolic Disorder Ministry of EducationGuangdong Pharmaceutical UniversityGuangzhou 510006China Department of Nephrology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Center for Reproductive Medicine Dongguan Maternal and Child Health Care HospitalSouthern Medical UniversityDongguan 523125China

Background:Aristolochic acids(AAs),a class of carcinogenic and mutagenic natural products from Aristolochia and Asarum plants,are well-known to be responsible for inducing nephrotoxicity and urothelial ***,accumulating evidence suggests that exposure to AAs could also induce hepatotoxicity and even hepatocellular carcinoma,though the mechanisms are poorly ***:Here,we aimed to dissect the underlying cellular and molecular mechanisms of aristolochic acid I(AAI)-induced hepatotoxicity by using advanced single-cell RNA sequencing(scRNA-seq)and proteomics *** established the first single-cell atlas of mouse livers in response to ***:In hepatocytes,our results indicated that AAI activated NF-κB and STAT3 signaling pathways,which may contribute to the inflammatory response and *** liver sinusoidal endothelial cells(LSECs),AAI activated multiple oxidative stress and inflammatory associated signaling pathways and induced ***,AAI induced infiltration of cytotoxic T cells and activation of proinflammatory macrophage and neutrophil cells in the liver to produce inflammatory cytokines to aggravate ***:Collectively,our study provides novel knowledge of AAs-induced molecular characteristics of hepatotoxicity at a singlecell level and suggests future treatment options for AAs associated hepatotoxicity.

关键词： aristolochic acid scRNA-seq hepatotoxicity proteomics

纳米技术——一种针对促肿瘤中性粒细胞的肺癌治疗新策略（英文）

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Engineering 2023年第8期 106-126页

作者： Jian Zhang Shasha Jiang Shilin Li Jipeng Jiang Jie Mei Yandong Chen Yongfu Ma Yang Liu Ying Liu Department of Thoracic Surgery The First Medical Center of the Chinese PLA General Hospital School of Medicine Nankai University Postgraduate School Medical School of the Chinese PLA CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China University of Chinese Academy of Science The Great Bay Area National Institute for Nanotechnology Innovation

Primary and metastatic lung cancers are malignant lung tumors each with of which has a different pathogenesis, although both threaten patient lives. Tumor development and progression involve communication between tumor cells and the host microenvironment. Neutrophils are the most abundant immune cells in the tumor microenvironment(TME); they participate in the generation of an inflammatory milieu and influence patient survival through their anti-and pro-tumor abilities. Neutrophils can be classified into various categories according to different criteria; frequent categories include N1 antitumor neutrophils and N2 immunosuppressive neutrophils. The antitumor effects of neutrophils are reported to be mediated through a combination of reactive oxygen species, tumor necrosis factor-related apoptosis-inducing ligand, and receptor for advanced glycation end-products–cathepsin G association,as well as the regulation of the activities of other immune cells. There have also been reports that neutrophils can function as tumor promoters that contribute to lung cancer progression and metastasis by influencing processes including carcinogenesis, angiogenesis, cancer cell proliferation, and invasion ability, as well as having similar roles in the lung metastasis of other cancers. The rapid development of nanotechnology has provided new strategies for cancer treatment targeting neutrophils.

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通过鉴定关键靶标蛋白探究青蒿素抗疟机制（英文）

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Engineering 2023年第12期 86-97页

作者： Peng Gao Jianyou Wang Jiayun Chen Liwei Gu Chen Wang Liting Xu Yin Kwan Wong Huimin Zhang Chengchao Xu Lingyun Dai Jigang Wang State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Center and Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Pharmaceutical College Henan University Shandong Academy of Chinese Medicine Department of Infectious Disease Shenzhen Clinical Research Centre for Geriatrics Shenzhen People’s Hospital & the First Affiliated Hospital of Southern University of Science and Technology

The widespread use of artemisinin(ART) and its derivatives has significantly reduced the global burden of malaria; however, malaria still poses a serious threat to global health. Although significant progress has been achieved in elucidating the antimalarial mechanisms of ART, the most crucial target proteins and pathways of ART remain unknown. Knowledge on the exact antimalarial mechanisms of ART is urgently needed, as signs of emerging ART resistance have been observed in some regions of the world. Here, we used a combined strategy involving mass spectrometry-coupled cellular thermal shift assay(MS-CETSA)and transcriptomics profiling to identify a group of putative antimalarial targets of ART. We then conducted a series of validation experiments on five prospective protein targets, demonstrating that ART may function against malaria parasites by interfering with redox homeostasis, lipid metabolism, and protein synthesis processes. Taken together, this study provides fresh perspectives on the antimalarial mechanisms of ART and identifies several crucial proteins involved in parasite survival that can be targeted to combat malaria.

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Families of Dothideomycetes

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Fungal Diversity 2013年第6期63卷 1-313页

作者： Kevin D.Hyde E.B.Gareth Jones Jian-Kui Liu Hiran Ariyawansa Eric Boehm Saranyaphat Boonmee Uwe Braun Putarak Chomnunti Pedro W.Crous Dong-Qin Dai Paul Diederich Asha Dissanayake Mingkhuan Doilom Francesco Doveri Singang Hongsanan Ruvishika Jayawardena James D.Lawrey Yan-Mei Li Yong-Xiang Liu Robert Lücking Jutamart Monkai Lucia Muggia Matthew P.Nelsen Ka-Lai Pang Rungtiwa Phookamsak Indunil C.Senanayake Carol A.Shearer Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Nalin N.Wijayawardene Saowanee Wikee Hai-Xia Wu Ying Zhang Begoña Aguirre-Hudson S.Aisyah Alias AndréAptroot Ali H.Bahkali Jose L.Bezerra D.Jayarama Bhat Erio Camporesi Ekachai Chukeatirote Cécile Gueidan David L.Hawksworth Kazuyuki Hirayama Sybren De Hoog Ji-Chuan Kang Kerry Knudsen Wen-Jing Li Xing-Hong Li Zou-Yi Liu Ausana Mapook Eric H.C.McKenzie Andrew N.Miller Peter E.Mortimer Alan J.L.Phillips Huzefa A.Raja Christian Scheuer Felix Schumm Joanne E.Taylor Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yong Wang Jian-Chu Xu Supalak Yacharoen Ji-Ye Yan Min Zhang Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201Yunnan China World Agroforestry Centre East Asia NodeHeilongtanKunming 650201China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute Ocean Earth Sciences Kuala Lumpur 50603SelangorMalaysia Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia 42 Longacre Drive LivingstonNJ 07039USA Institut für Biologie Bereich Geobotanik und Botanischer GartenHerbariumMartin-Luther-UniversitätNeuwerk 2106099 Halle(Saale)Germany CBS-KNAW Fungal Biodiversity Centre Uppsalalaan 83584CT UtrechtThe Netherlands Musée National d’histoire Naturelle 25 rue Munster2160 LuxembourgLuxembourg Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Via dei Funaioli 22 57126 LivornoItaly Department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA International Fungal Research and development Centre Key Laboratory of Resource Insect Cultivation&Utilization State Forestry AdministrationKunming 650224People’s Republic of China The Research Institute of Resource Insects Chinese Academy of ForestryKunming 650224People’s Republic of China Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006People’s Republic of China Science and Education Integrative Research(Botany)The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA Institute of Plant Sciences University of GrazHolteigasse 68010 GrazAustria Department of Life Science University of TriesteVia L.Giorgieri 10TriesteItaly Committee on Evolutionary Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA Institute ofMarine Biology and Center of Excellence for the Oceans Taiwan

Dothideomycetes comprise a highly diverse range of fungi characterized mainly by asci with two wall layers(bitunicate asci)and often with fissitunicate *** species are saprobes,with many asexual states comprising important plant *** are also endophytes,epiphytes,fungicolous,lichenized,or lichenicolous *** occur in terrestrial,freshwater and marine habitats in almost every part of the *** accept 105 families in Dothideomycetes with the new families Anteagloniaceae,Bambusicolaceae,Biatriosporaceae,Lichenoconiaceae,Muyocopronaceae,Paranectriellaceae,Roussoellaceae,Salsugineaceae,Seynesiopeltidaceae and Thyridariaceae introduced in this *** family is provided with a description and notes,including asexual and asexual states,and if more than one genus is included,the type genus is also *** family is provided with at least one figure-plate,usually illustrating the type genus,a list of accepted genera,including asexual genera,and a key to these genera.A phylogenetic tree based on four gene combined analysis add support for 64 of the families and 22 orders,including the novel orders,Dyfrolomycetales,Lichenoconiales,Lichenotheliales,Monoblastiales,Natipusillales,Phaeotrichales and *** paper is expected to provide a working document on Dothideomycetes which can be modified as new data comes to *** is hoped that by illustrating types we provide stimulation and interest so that more work is carried out in this remarkable group of fungi.

关键词： Acrospermales Asterinales Botryosphaeriales Capnodiales Dothideales Dyfrolomycetales Hysteriales Jahnulales Lichenoconiales Lichenotheliales Microthyriales Monoblastiales Myriangiales Mytilinidiales Natipusillales Patellariales Phaeotrichales Phylogeny Pleosporales Strigulales Taxonomy Trypetheliales Tubeufiales Type species Venturiales

黄土高原典型流域淤地坝系泥沙拦截动态模拟（英文）

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Engineering 2023年第8期 209-221页

作者： Pengcheng Sun Yiping Wu Key Laboratory of Degraded and Unused Land Consolidation Engineering the Ministry of Natural Resources Shaanxi Provincial Land Engineering Construction Group Co.Ltd. Key Laboratory of Soil and Water Conservation on the Loess Plateau of Ministry of Water Resources Yellow River Institute of Hydraulic Research technology Innovation Center for Land Engineering and Human Settlement Shaanxi Provincial Land Engineering Construction Group Co.Ltd.& Xi'an Jiaotong University

Check-dam construction is an effective and widely used method for sediment trapping in the Yellow River Basin and other places over the world that are prone to severe soil erosion. Quantitative estimations of the dynamic sediment trapped by check dams are necessary for evaluating the effects of check dams and planning the construction of new ones. In this study, we propose a new framework, named soil and water assessment tool(SWAT)–dynamic check dam(DCDam), for modeling the sediment trapped by check dams dynamically, by integrating the widely utilized SWAT model and a newly developed module called DCDam. We then applied this framework to a typical loess watershed, the Yan River Basin, to assess the time-varying effects of check-dam networks over the past 60 years(1957–2016). The DCDam module generated a specific check-dam network to conceptualize the complex connections at each time step(monthly). In addition, the streamflow and sediment load simulated by using the SWAT model were employed to force the sediment routing in the check-dam network. The evaluation results revealed that the SWAT-DCDam framework performed satisfactorily, with an overestimation of 11.50%,in simulating sediment trapped by check dams, when compared with a field survey of the accumulated sediment deposition. For the Yan River Basin, our results indicated that the designed structural parameters of check dams have evolved over the past 60 years, with higher dams(37.14% and 9.22% increase for large dams and medium dams, respectively) but smaller controlled areas(46.03% and 10.56% decrease for large dams and medium dams, respectively) in recent years. Sediment retained by check dams contributed to approximately 15.00% of the total sediment load reduction in the Yan River during 1970–2016. Thus, our developed framework can be a promising tool for evaluating check-dam effects,and this study can provide valuable information and support to decision-making for soil and water conservation and check-dam

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