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中国比较医学杂志 2008年第1期18卷 26-26页

作者： Charmaine Foltz Larry Carbone David DeLong Bernard E. Rollin Pascalle Van Loo Julia Whitaker Axel Wolff Division of Veterinary Resources National Institutes of Health Bethesda MD. University of California San Francisco San Francisco CA. Veterinary Medical Unit VA Medical Center Minneapolis MN. Colorado State University Fort Collins CO. Utrecht University The Netherlands. Department of Pathology and Laboratory Medicine Division of Laboratory Animal Medicine University of North Carolina Chapel Hill NC. Division of Compliance Oversight OLAW National Institutes of Health Bethesda MD. Correspondence should be addressed to Charmaine Foltz DVM

Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis

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四川生理科学杂志 2022年第12期44卷 2116-2116页

作者： Evan S Dellon From the Center for Esophageal Diseases and Swallowing University of North Carolina School of Medicine Chapel Hill (E.S.D.) Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine Cincinnati (M.E.R. M.H.C.) Northwestern University Feinberg School of Medicine Chicago (I.H.) Mount Sinai Center for Eosinophilic Disorders Icahn School of Medicine at Mount Sinai New York (M.C.) and Regeneron Pharmaceuticals Tarrytown (X.S. M.P.K. M.A.K. J.D.H. B.B. E.M. B.A. N.A. W.K.L. M.F.W. M.R. D.R.W. G.D.Y. B.S. J.M. A.G. A.S.) - both in New York Amsterdam University Medical Center Amsterdam (A.J.B.) Hospital General de Tomelloso Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas Madrid and Instituto de Investigación Sanitaria de Castilla-La Mancha Toledo - both in Spain (A.J.L.) Children's Hospital of Philadelphia Philadelphia (J.M.S.) University of California San Diego La Jolla and Rady Children's Hospital San Diego - both in California (S.A.) Sanofi Bridgewater NJ (K.P. E.L.) Sanofi Chilly-Mazarin France (L.P.M.) and Sanofi Cambridge MA (N.P.).

Background:Dupilumab,a fully human monoclonal antibody,blocks interleukin-4 and interleukin-13 signaling,which have key roles in eosinophilic ***:We conducted a three-part,phase 3 trial in which patients 12 years of age or older underwent randomization in a 1:1 ratio to receive subcutaneous dupilumab at a weekly dose of 300 mg or placebo(Part A)or in a 1:1:1 ratio to receive 300 mg of dupilumab either weekly or every 2 weeks or weekly placebo(Part B)up to week 24.

关键词： monoclonal placebo weekly

Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico

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四川生理科学杂志 2021年第10期43卷 1796-1796页

作者： Lisa M Dunkle From Novavax Gaithersburg (L.M.D. G.A. K.S. W.W. I.C. G.M.G. F.D.) the University of Maryland School of Medicine Baltimore (K.L.K. M.A.M. K.M.N.) the National Institute of Allergy and Infectious Diseases Bethesda (J.H.) and Walter Reed Army Institute of Research Silver Spring (J.A.A.) - all in Maryland FAICIC Clinical Research Veracruz (A.Q.B.H.) and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City (G.M.R.-P.) - both in Mexico Research Your Health Plano (J.M.A.) and the Texas Center for Drug Development Houston (V.G.-F.) - both in Texas M3-Wake Research Raleigh (W.L.H.) M3-Emerging Medical Research Durham (D.B.M.) and the University of North Carolina School of Medicine Chapel Hill (C.L.G.) - all in North Carolina SIMEDHealth Gainesville (D.M.D.) and Velocity Clinical Research Hallandale Beach (B.E.S.) - both in Florida the University of Nebraska Medical Center Omaha (D.F.F.) the University of Washington Medical Center (R.S.M. R.W.C. A.L.G.) and Fred Hutchinson Cancer Research Center (L.C.) Seattle and Lummi Indian Health Center Bellingham (D.C.L.) - all in Washington the Atlanta Center for Medical Research Atlanta (R.A.R.) and IACT Health Columbus (J.K.K.) - both in Georgia Velocity Clinical Research-Providence Warwick RI (D.L.F.) WR ClinSearch Chattanooga TN (M.M.) MedPharmics Metairie LA (R.J.J.) and Black hills Center for American Indian Health Rapid City SD (J.A.H.).

Background:NVX-CoV2373 is an adjuvanted,recombinant spike protein nanoparticle vaccine that was shown to have clinical efficacy for the prevention of coronavirus disease 2019(Covid-19)in phase 2b-3 trials in the United Kingdom and South Africa,but its efficacy had not yet been tested in North ***:We conducted a phase 3,randomized,observer-blinded,placebo-controlled trial in the United States and Mexico during the first half of 2021 to evaluate the efficacy and safety of NVX-CoV2373 in adults(≥18 years of age)who had not had severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** were randomly assigned in a 2:1 ratio to receive two doses of NVX-CoV2373 or placebo 21 days *** primary objective was to determine vaccine efficacy against reverse-transcriptase-polymerase-chain-reaction-confirmed Covid-19 occurring at least 7 days after the second *** efficacy against moderate-to-severe disease and against different variants was also assessed.

关键词： vaccine doses prevention

Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents

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四川生理科学杂志 2021年第11期43卷 1723-1723页

作者： Samantha M Olson From the Covid-19 Response Team Centers for Disease Control and Prevention (S.M.O. A.M.P. L.D.Z. A.P.C. M.M.P.) and the Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and the Department of Pediatrics Emory University School of Medicine (S.K.) - both in Atlanta the Department of Anesthesiology Critical Care and Pain Medicine Boston Children's Hospital (M.M.N. A.G.R.) and the Departments of Anaesthesia and Pediatrics Harvard Medical School (A.G.R.) - both in Boston the Division of Pediatric Infectious Diseases Department of Pediatrics Vanderbilt University Medical Center Nashville (N.B.H.) the Department of Pediatrics Baylor College of Medicine Immunization Project Texas Children's Hospital Houston (J.A.B. L.C.S.) and the Department of Pediatrics Division of Critical Care Medicine University of Texas Southwestern Children's Medical Center Dallas Dallas (M.M.) the Division of Infectious Diseases Children's Hospital Los Angeles and Departments of Pediatrics and Molecular Microbiology and Immunology University of Southern California Los Angeles (P.S.P.) the Division of Pediatric Hospital Medicine UC San Diego-Rady Children's Hospital San Diego (M.A.C.) the Division of Critical Care Medicine UCSF Benioff Children's Hospital Oakland (N.Z.C.) and the Department of Pediatrics Divisions of Critical Care Medicine and Allergy Immunology and Bone Marrow Transplant University of California San Francisco San Francisco (M.S.Z.) - all in California Section of Pediatric Critical Care Department of Pediatrics Arkansas Children's Hospital Little Rock (K.I.) the Department of Pediatrics University of North Carolina at Chapel Hill Children's Hospital Chapel Hill (T.C.W. S.P.S.) the Department of Pediatrics Section of Critical Care Medicine University of Colorado School of Medicine and Children's Hospital Colorado Aurora (A.B.M.) the Division of Pediatric Critical Care Medicine Medical University of South Carolina Charleston (E.H.M.) the Department of

Background:The increasing incidence of pediatric hospitalizations associated with coronavirus disease 2019(Covid-19)caused by the B.1.617.2(delta)variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in the United States has offered an opportunity to assess the real-world effectiveness of the BNT162b2 messenger RNA vaccine in adolescents between 12 and 18 years of ***:We used a case-control,test-negative design to assess vaccine effectiveness against Covid-19 resulting in hospitalization,admission to an intensive care unit(ICU),the use of life-supporting interventions(mechanical ventilation,vasopressors,and extracorporeal membrane oxygenation),or *** July 1 and October 25,2021,we screened admission logs for eligible case patients with laboratory-confirmed Covid-19 at 31 hospitals in 23 *** estimated vaccine effectiveness by comparing the odds of antecedent full vaccination(two doses of BNT162b2)in case patients as compared with two hospitalbased control groups:patients who had Covid-19-like symptoms but negative results on testing for SARS-CoV-2(test-negative)and patients who did not have Covid-19-like symptoms(syndrome-negative).

关键词： vaccine doses acute

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Treatment for Mild Chronic Hypertension during Pregnancy

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四川生理科学杂志 2022年第2期44卷 328-328页

作者： Alan T Tita From the Department of Obstetrics and Gynecology (A.T.T. W.W.A.) the Center for Women's Reproductive Health (A.T.T. J.M.S. N.A. S.O. G.R.C. W.W.A.) the Department of Biostatistics (J.M.S. G.R.C.) the Division of Neonatology Department of Pediatrics (N.A.) and the Division of Cardiovascular Disease Department of Medicine (S.O.) University of Alabama Birmingham the Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill (K.B.) and the Department of Obstetrics and Gynecology Duke University Durham (B.L.H.) - both in North Carolina the Department of Obstetrics and Gynecology University of Pennsylvania (L.D.) and the Department of Obstetrics and Gynecology Drexel University College of Medicine (L.P.) Philadelphia St. Luke's University Health Network Fountain Hill (J.B.) and the Department of Obstetrics and Gynecology Magee Women's Hospital University of Pittsburgh Pittsburgh (H.N.S.) - all in Pennsylvania the Department of Obstetrics and Gynecology University of Texas (B.S.) and the Department of Obstetrics and Gynecology Baylor College of Medicine and Texas Children's Hospital Houston (K.A.) the Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center Dallas (B.C.) the Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston (G.R.S.) and the Department of Women's Health University of Texas Austin (L.H.) the Department of Obstetrics and Gynecology Columbia University (K.L.) Weill Cornell University (P.A.) and the Department of Obstetrics and Gynecology New York Presbyterian Queens Hospital (D.S.) New York and the Department of Obstetrics and Gynecology Winthrop University Hospital Mineola (W.K.) - all in New York the Department of Obstetrics and Gynecology University of Oklahoma Health Sciences Oklahoma City (R.K.E.) MetroHealth System Cleveland (K.G.) the Department of Obstetrics and Gynecology Indiana University Indianapolis (D.M.H.) the Department of Obstetrics and Gynecology

Background:The benefits and safety of the treatment of mild chronic hypertension(blood pressure,<160/100 mm Hg)during pregnancy are *** are needed on whether a strategy of targeting a blood pressure of less than 140/9... 详细信息

关键词： pregnancy fetal hypertension

Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of Cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie Hawksworth’s seventieth birthday

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Fungal Diversity 2017年第3期84卷 139-207页

作者： Robert Lücking Manuela Dal Forno Bibiana Moncada Luis Fernando Coca Leidy Yasmín Vargas-Mendoza André Aptroot Laura Juliana Arias Betty Besal Frank Bungartz Diego Mauricio Cabrera-Amaya Marcela E.S.Cáceres José Luis Chaves Sionara Eliasaro Martha Cecilia Gutiérrez Jesús E.Hernández Marin María de los Ángeles Herrera-Campos María E.Holgado-Rojas Harald Jonitz Martin Kukwa Fabiane Lucheta Santiago Madriñán Marcelo Pinto Marcelli Suzana Maria de Azevedo Martins Joel A.Mercado-Díaz Jorge Alberto Molina Eduardo A.Morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata Javier Robayo Camilo Rodríguez Diego Fernando Simijaca Edier Soto-Medina Adriano Afonso Spielmann Alejandra Suárez-Corredor Jean-Marc Torres Carlos Alberto Vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk Marcela Celis Pacheco Mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick M.Gillevet Masoumeh Sikaroodi James D.Lawrey Botanical Garden and Botanical Museum Berlin KöniginLuise-Straße 6-814195 BerlinGermany Science Education The Field Museum1400 South Lake ShoreChicagoIL 60605USA Department of Botany Smithsonian InstitutionNational Museum of Natural History10th St Constitution Ave NWWashingtonDC 20560USA Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030-4444USA Licenciatura en Biologı´a Universidad Distrital Francisco Jose´de CaldasCra.4 No.26D-54Torre de LaboratoriosHerbarioBogota´D.C.Colombia Herbario Universidad de Caldas(FAUC) Edificio BicentenarioCalle 65No.26-10ManizalesA.A.275CaldasColombia ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Biologı´a Universidad del Quindı´oCarrera 15 Calle 12 NorteArmeniaQuindı´oColombia 120 Chavis Avenue LexingtonVA 24450USA Charles Darwin Foundation Puerto AyoraSanta Cruz IslandGala´pagosEcuador Schedestraße 8 53113 BonnGermany Jardı´n Bota´nico de Bogota´Jose´Celestino Mutis Avenida Calle 63 No.68-95Bogota´D.C.Colombia Departamento de Biocieˆncias Universidade Federal de SergipeAvenida Vereador Olı´mpio Grandes/n.ItabaianaCEP:49.500-000 SergipeBrazil Laboratorio de Hongos Instituto Nacional de Biodiversidad(INBio)Apdo.22-3100Santo Domingo de HerediaCosta Rica Departamento de Botaˆnica Universidade Federal do Parana´Campus Polite´cnicoSetor de Cieˆncias Biolo´gicasAv.Cel.Francisco H.dos Santoss/nJardim das Ame´ricas81531-980 CuritibaPRBrazil Ingenierı´a Ambiental Universidad Distrital Francisco Jose´de CaldasCarrera 5 Este No.15-82Av.CircumvalarBogota´D.C.Colombia Instituto Experimental Jardı´n Bota´nico Dr.Tobı´as Lasser Centro de Investigacio´n y DesarrolloUniversidad Central de VenezuelaAve.Salvador AllendeJardı´n Bota´nico de CaracasApartado#2156Caracas 1010-AVenezuela Departamento de Bota´nica Instituto de Biologı´aUniversidad Nacional Auto´noma de Me´xicoApartado Postal 70-36704510 Ciudad De Me´xicoMexico Facultad de Ciencias Escuela Profesional de Biologı´aUniv

Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 *** on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been *** of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is *** new species are:Cora accipiter Moncada,Madrin˜a´n&Lücking ***.,*** Moncada,Soto-Medina&Lücking ***.,*** Moncada,Dal Forno&Lücking ***.,*** Dal Forno,Chaves&Lücking ***.,*** Moncada,***ı´guez&Lücking ***.,*** Lücking,Moncada&*** ***.,*** Moncada,Ya´nez-Ayabaca&Lücking ***.,*** Moncada,Patin˜o&Lücking ***.,*** Lücking,***&Dal Forno ***.,*** Holgado,Rivas Plata&Perlmutter ***.,*** Dal Forno,Eliasaro&Spielmann ***.,*** Nugra,Dal Forno&Lücking ***.,*** Lücking,Martins&Lucheta ***.,*** Moncada,R.-***´rez&Lücking ***.,*** Moncada,***.&Lücking ***.,*** Moncada,CabreraAmaya&Lücking ***.,*** Moncada,R.-***´rez&***.,*** Lücking,***&Dal Forno ***.,*** Moncada,***´rez-Corredor&Lücking ***.,*** Moncada,***&Lücking ***.,***

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