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单叶细辛中一个新的马兜铃酸类化合物

药学学报 2011年第2期46卷 188-192页

作者：谢百波尚明英王璇蔡少青 Kuo-hsiung LEE 北京大学药学院天然药物与仿生药物国家重点实验室北京100191 Natural Products Research Laboratories Eshelman School of PharmacyUniversity of North CarolinaChapel HillNorth Carolina 27599-7568USA

为了研究单叶细辛(Asarum himalaicum)的化学成分,利用溶剂提取、硅胶柱色谱、凝胶(SephadexLH-20)柱色谱和半制备型高效液相色谱(semi-preparative high performance liquid chromatography,HPLC)等手段进行分离、纯化,从单叶细辛全草中共分离鉴定了15个化合物。其结构经1H NMR、13C NMR、HR-ESI-MS等谱学方法分别鉴定为4-去甲氧基马兜铃酸BII(4-demethoxyaristolochic acid BII,1)、马兜铃酸I(aristolochicacid I,2)、马兜铃酸Ia(aristolochic acid Ia,3)、7-羟基马兜铃酸I(7-hydroxyaristolochic acid I,4)、马兜铃酸IV(aristolochic acid IV,5)、马兜铃次酸II(aristolic acid II,6)、青木香酸(debilic acid,7)、马兜铃内酰胺I(aristololactam I,8)、9-羟基马兜铃内酰胺I(9-hydroxyaristololactam I,9)、7-甲氧基马兜铃内酰胺IV(7-methoxyaristololactam IV,10)、(2S)-柚皮素-5,7-二-O-β-D-吡喃葡萄糖苷((2S)-naringenin 5,7-di-O-β-D-pyranosylglucoside,11)、4-羟基苯甲酸(4-hydroxybenzoic acid,12)、3,4-二羟基苯甲酸(3,4-dihydroxybenzoic acid,13)、4-羟基肉桂酸(4-hydroxycinnamic acid,14)和β-谷甾醇(β-sitosterol,15)。其中,化合物1为新化合物,化合物3～6、9、12～14为首次从细辛属植物中分离得到,所有化合物均为首次从单叶细辛中分离得到。据文献报道,马兜铃酸和马兜铃内酰胺类成分具肾毒性,本研究提示单叶细辛药用的安全问题值得关注。

关键词：单叶细辛 4-去甲氧基马兜铃酸BII 马兜铃酸马兜铃内酰胺

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职业生涯时间、震荡史、踢球位置对前职业足球运动员白质微结构及功能神经的影响

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国际医学放射学杂志 2018年第3期 346-346页

作者： M.D.Clark E.M.L.Varangis A.A.Champagne K.S.Giovanello F.Shi Z.Y.Kerr 吕晓虹 Department of Exercise and Sport Science University of North Carolina at Chapel Hill

摘要目的了解美国前足球运动员颅脑所受震荡和冲击伤,白质完整性与功能任务相关的神经活动之间的关系。材料与方法本横断研究共纳入2011—2013年期间61名认

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Health care reform in the USA: Recommendations from USA and non-USA radiologists

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World Journal of Radiology 2012年第2期4卷 44-47页

作者： Lauren MB Burke Diego R Martin Till Bader Richard C Semelka Department of Radiology University of North Carolina Chapel Hill NC 27599-7510 United States Department of Radiology Emory University School of Medicine Atlanta GA 30322 United States Department of Radiology Medical University of Vienna Waehringer Guertel 18-20 1090 Vienna Austria

AIM: To compare the opinions and recommendations of imaging specialists from United States (USA) and non-USA developed nations for USA health care reform. METHODS: A survey was emailed out to 18 imaging specialists from 17 non-USA developed nation countries and 14 radiologists within the USA regarding health care reform. The questionnaire contained the following ques tions: what are the strengths of your health care system, what problems are present in your nation's health care system, and what recommendations do you have for health care reform in the USA. USA and non-USA radiologists received the same questionnaire. RESULTS: Strengths of the USA health care system include high quality care, autonomy, and access to timely care. Twelve of 14 (86%) USA radiologists identified medicolegal action as a major problem in their health care system and felt that medicolegal reform was a critical aspect of health care reform. None of the non-USA radiologists identified medicolegal aspects as a problem in their own country nor identified it as a subject for USA health care reform. Eleven of 14 (79%) USA radiologists and 16/18 (89%) non-USA radiologists identified universal health care coverage as an important recommendation for reform. CONCLUSION: Without full universal coverage, meaningful health care reform will likely require medicolegal reform as an early and important aspect of improved and efficient health care.

关键词： Health care reform Health care policy

非小细胞肺癌:FDG-PET显像纵隔浓集灶对N0-N1期病灶预后的重要意义

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国际医学放射学杂志 2011年第6期 592-593页

作者： M.Saynak N.K.Veeramachaneni D.V.Fried M.R.Jagtap W.K.Chiu 饶良俊 Department of Radiation Oncology University of North Carolina School of Medicine101 Manning DrBox 7512Chapel HillNC 27514

目的评价非小细胞肺癌(NSCLC)行根治性切除,纵隔淋巴结(LN)组织学检查阴性,但PET显示FDG异常浓集(阳性)时对病人预后的意义。我们假设即便LN组织学检查阴性,PET上的阳性灶仍对预后有价值。材料与方法本研究通过专业审查委员会批准,遵从H... 详细信息

目的评价非小细胞肺癌(NSCLC)行根治性切除,纵隔淋巴结(LN)组织学检查阴性,但PET显示FDG异常浓集(阳性)时对病人预后的意义。我们假设即便LN组织学检查阴性,PET上的阳性灶仍对预后有价值。材料与方法本研究通过专业审查委员会批准,遵从HIPAA。收集2000

关键词：纵隔阳性术前胸膜间间隙胸小细胞肺癌 PET FDG-PET N0-N1 浓集病灶预后

无卷边单分子层WS2纳米片原子结构的高分辨电子显微术研究

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电子显微学报 2017年第2期36卷 96-102页

作者：李云朋陈友虎田天王元斐秦禄昌安徽理工大学安徽淮南232001 中国科学院宁波材料技术与工程研究所浙江宁波315201 University of North Carolinaat chapel hill Chapel HillNC27599-3255USA

本文利用高分辨电子显微术(HRTEM)确定了无卷边的单分子层WS_2纳米片的原子结构像。通过对样品不同区域HRTEM像进行傅里叶变换(FFT)分析,得到了各个区域的WS_2纳米片的晶体取向,确定了WS_2纳米片分子层数分布。根据电子显微像强度与样... 详细信息

本文利用高分辨电子显微术(HRTEM)确定了无卷边的单分子层WS_2纳米片的原子结构像。通过对样品不同区域HRTEM像进行傅里叶变换(FFT)分析,得到了各个区域的WS_2纳米片的晶体取向,确定了WS_2纳米片分子层数分布。根据电子显微像强度与样品层数的线性关系以及WS_2纳米片的单分子层数分布模型,确定不同区域WS_2纳米片的分子层数。为了进一步定量分析结果的正确性,通过模拟电子显微像在不同碳膜厚度及不同成像条件下WS_2纳米片的HRTEM像,也确定了在像衬度上与实验像很好的匹配。

关键词：单层WS2纳米片高分辨电子显微术衬度模拟

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美罗华在成人难治性特发性血小板减少性紫癜中的临床应用

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临床血液学杂志 2010年第6期23卷 701-704页

作者：罗曼张克俭 Eshelman School of Pharmacy University of North Carolina at Chapel Hill(USA) 武汉大学中南医院血液科

特发性血小板减少性紫癜（idiopathic thrombocytopenic purpura,ITP）是一种器官特异性自身免疫性疾病,在临床上为最常见的出血性疾病。成年ITP年发病率在北美为5.6～20/105〔1〕,欧洲为3.3/105〔2〕,多表现为慢性病程,糖皮质激素治疗... 详细信息

特发性血小板减少性紫癜（idiopathic thrombocytopenic purpura,ITP）是一种器官特异性自身免疫性疾病,在临床上为最常见的出血性疾病。成年ITP年发病率在北美为5.6～20/105〔1〕,欧洲为3.3/105〔2〕,多表现为慢性病程,糖皮质激素治疗对大多数患者有效,但作用短暂。

关键词：血小板减少性紫癜,特发性,难治性美罗华

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Stereochenlical effects on functional selectivity at the dopamine D2L receptor

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Stereochenlical effects on functional selectivity at the dop...

Erratum to:Hierarchical aging pathways and signatures of thermodynamic transition in molecular glasses (vol 62,issue 6,pg 864,2019)

第十五届国际药理学大会

作者： Fowler J. Corey Filizola Marta Weinstein Harel Javitch Jonathan Mailman Richard Department of Medicinal Chemistry. University of North Carolina Chapel Hill NC. Department of Physiology and Biophysics. Weill Medical College of Cornell University. New York. NY. Department of Physiology and Biophysics. Weill Medical College of Cornell University. New York. NY. Departments of Pharmacology and Psychiatry. Columbia University. New York. NY. Department of Medicinal Chemistry. University of North Carolina Chapel Hill NC.

＜正＞ The novel mechanism of functional selectivity （differential activation of pathways linked to a single receptor） has been shown for dopamine hD2L receptor regulated endpoints such as GIRK. MAPK. ACase. etc. The current work explored the hypothesis that functionally selective ligands induce unusual receptor conforma-tional states that lead to differential activation. We docked the propylnorapo-morphine enantiomers [ RNPA ＆ SNPA] to the D2R receptor to identify potential residues of importance, and then made and expressed selected mutant receptors. WT D2R binding confirmed that RNPA forms p - OH H bonds with both S5.46 and T3.37 whereas the m OH interacts with S5.42, while SNPA H- bonds to S5.42 （p ＆ m OH）. When mutated, differential effects were seen on functional endpoints （e.g.. S5.42A caused loss of D2R mediated effects on ACase. but not MAPK or AA release）. These data demonstrate that single point receptor mutations can make a "normal" ligand become functionally selective, or change the character of a functionally selective compound. We hypothesize that ligandspecific residue interactions contribute to the conformational changes needed to result in activation of specific heterotrimeric complexes.

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Science China Materials 2021年第1期64卷 266-266页

作者： Shiyu Liu Yao Yu Lin Liu Yue Wu School of Materials Science and Engineering and State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China Wuhan National High Magnetic Field Center Huazhong University of Science and TechnologyWuhan430074China Department of Physics and Astronomy University of North Carolina at Chapel HillChapel HillNC27599-3255USA

In the version of the article originally published in the volume 62, issue 6, 2019 of Sci China Mater (2019, 62(6): 864–872, https://***/10.1007/s40843-018-9382-5 ), the ... 详细信息

In the version of the article originally published in the volume 62, issue 6, 2019 of Sci China Mater (2019, 62(6): 864–872, https://***/10.1007/s40843-018-9382-5 ), the affiliation of the third author (Lin Liu) was incorrectly labeled. The corrected version of the authors’ affiliations is as below: Shiyu Liu1,2, Yao Yu1,2*, Lin Liu1 and Yue Wu3*

关键词： glass transition hierarchical aging pathways thermodynamic transition metastability

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

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Nano Research 2019年第6期12卷 1313-1320页

作者： Junjie Yan Xudong Zhang Yang Liu Yanqi Ye Jicheng Yu Qian Chen Jinqiang Wang Yuqi Zhang Quanyin Hu Yang Kang Min Yang Zhen Gu Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State UniversityRaleighNC 27695USA Molecular Imaging Center Key Laboratory of Nuclear MedicineMinistry of HealthJiangsu Key Laboratory of Molecular Nuclear MedicineJiangsu Institute of Nuclear MedicineWuxi 214063China Department of Bioengineering University of CaliforniaLos AngelesCA 90095USA California NanoSystems Institute University of CaliforniaLos AngelesCA 90095USA Department of Materials Science & Engineering North Carolina State UniversityRaleighNC 27695USA Jonsson Comprehensive Cancer Center University of CaliforniaLos AngelesCA 90095USA Center for Minimally Invasive Therapeutics University of CaliforniaLos AngelesCA 90095USA

The capping agents for liquid metal (LM) nanodroplets in aqueous solutions are restricted to thiol-containing and positively-charged molecules or ***,both thiolate-metal complex and electrostatic interaction are liable to detachment upon strong mechanical forces such as sonication,leading to limited stability and *** address this,we utilized ultrasmall water soluble melanin nanoparticles (MNPs) as the capping agent,which exhibited strong metal binding capability with the oxide layer of gallium based LMs and resulted in enhanced ***,shape-controlled synthesis of LM nanodroplets can be achieved by the incorporation of *** EGaln nanostructures including nanorice,nanosphere and nanorod were obtained by simply tuning the feed ratio,sonication time,and suspension *** these shapes,EGaln nanorice has the best photothermal conversion efficiency,which could be leveraged for photothermal therapy.

关键词： liquid metal melanin nanoparticles nanomedicine shape-controlled synthesis photothermal therapy