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Multi-Strategy Assisted Multi-Objective Whale Optimization Algorithm for Feature Selection

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1563-1593页

作者： Deng Yang Chong Zhou Xuemeng Wei Zhikun Chen Zheng Zhang School of Information Engineering Hebei GEO UniversityShijiazhuang050031China Faculty of Science University of AlbertaEdmontonT2N1N4Canada college of Resources and Environment Beibu Gulf UniversityQinzhou535011China Clinical Laboratory The Frist Hospital of Hebei Medical UniversityShijiazhuang050000China

In classification problems,datasets often contain a large amount of features,but not all of them are relevant for accurate *** fact,irrelevant features may even hinder classification *** selection aims to alleviate this issue by minimizing the number of features in the subset while simultaneously minimizing the classification error ***-objective optimization approaches employ an evaluation function designed as an aggregate function with a parameter,but the results obtained depend on the value of the *** eliminate this parameter’s influence,the problem can be reformulated as a multi-objective optimization *** Whale Optimization Algorithm(WOA)is widely used in optimization problems because of its simplicity and easy *** this paper,we propose a multi-strategy assisted multi-objective WOA(MSMOWOA)to address feature *** enhance the algorithm’s search ability,we integrate multiple strategies such as Levy flight,Grey Wolf Optimizer,and adaptive mutation into ***,we utilize an external repository to store non-dominant solution sets and grid technology is used to maintain *** on fourteen University of California Irvine(UCI)datasets demonstrate that our proposed method effectively removes redundant features and improves classification *** source code can be accessed from the website:https://***/zc0315/MSMOWOA.

关键词： Multi-objective optimization whale optimization algorithm multi-strategy feature selection

Relative orbit determination algorithm of space targets with passive observation

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Journal of Systems Engineering and Electronics 2024年第3期35卷 793-804页

作者： DAI Chenchao QIANG Hongfu ZHANG Degang HU Shaolei GONG Baichun Zhijian Laboratory Rocket Force University of EngineeringXi’an 710025China college of Astronautics Nanjing University of Aeronautics and AstronauticsNanjing 210016China China flight Test Research Institute Xi’an 710089China Beijing Institute of Control and Electronic Technology Beijing 100038China

Angles-only relative orbit determination for space non-cooperative targets based on passive sensor is subject to weakly observable problem of the relative state between two spacecraft. Previously, the evidence for angles-only observability was found by using cylindrical dynamics, however, the solution of orbit determination is still not provided. This study develops a relative orbit determination algorithm with the cylindrical dynamics based on differential evolution. Firstly, the relative motion dynamics and line-of-sight measurement model for nearcircular orbit are established in cylindrical coordinate ***, the observability is qualitatively analyzed by using the dynamics and measurement model where the unobservable geometry is found. Then, the angles-only relative orbit determination problem is modeled into an optimal searching frame and an improved differential evolution algorithm is introduced to solve the problem. Finally, the proposed algorithm is verified and tested by a set of numerical simulations in the context of highEarth and low-Earth cases. The results show that initial relative orbit determination(IROD) solution with an appropriate accuracy in a relative short span is achieved, which can be used to initialize the navigation filter.

关键词： angles-only measurement relative orbit determination cylindrical coordinate differential evolution

Detailed characterization of kHz-rate laser-driven fusion at a thin liquid sheet with a neutron detection suite

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High Power Laser Science and Engineering 2024年第1期12卷 13-23页

作者： Benjamin M.Knight Connor M.Gautam Colton R.Stoner Bryan V.Egner Joseph R.Smith Chris M.Orban Juan J.Manfredi Kyle D.Frische Michael L.Dexter Enam A.Chowdhury Anil K.Patnaik Department of Engineering Physics Air Force Institute of TechnologyWPAFBOHUSA Physics Department Marietta CollegeMariettaOHUSA Department of Physics The Ohio State UniversityColumbusOHUSA Department of Materials Science and Engineering and Department of Electrical and Computer ScienceThe Ohio State UniversityColumbusOHUSA Intense Energy Solutions LLCPlain CityOHUSA

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs laser pulses on a thin(<1 μm) D_2O liquid sheet employing a measurement suite. At relativistic inte... 详细信息

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mJ, 40 fs laser pulses on a thin(flight analysis of the scintillator data shows the energy of the produced neutrons to be consistent with 2.45 MeV. Particle-in-cell simulations using the WarpX code support significant neutron production from D-D fusion events in the laser±target interaction region. This high-repetition-rate laser-driven neutron source could provide a low-cost, on-demand test bed for radiation hardening and imaging applications.

关键词： high-repetition-rate laser-driven fusion laser-plasma interaction liquid target neutron detectors

High-strength antiswelling adhesive achieves both hemostasis and wound healing

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Journal of Pharmaceutical Analysis 2024年第6期14卷 781-784页

作者： Xin Zhao Jinlong Luo Ying Huang Lei Mu Jueying Chen Zhen Liang Zhanhai Yin Dake Chu Yong Han Baolin Guo State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi'an Jiaotong UniversityXi'an710049China Department of Plastic Surgery Xijing HospitalAir Force Medical UniversityXi'an710032China Department of Orthopaedics The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi'an Jiaotong UniversityXi'an710049China

Skin is one of the most vulnerable tissues,but there is a lack of injectable bioactive hydrogel dressings,which possess high strength,antiswelling capacity,and wet tissue adhesiveness,but also a rapid gelling process to enable rapid hemostasis,sutureless wound closure,and scarless healing of infected skin wounds[1e5].A new injectable,antibacterial,and multifunctional hydrogel dressings based on poly(citric acid-co-polyethylene glycol)-g-dopamine(PCPD)and amino-terminated Pluronic F127(APF)mi-celles loaded with astragaloside IV(AS)was developed for this pur-pose,as shown in Fig.1A[6].

关键词： healing wound stasis

Chinese Society of Cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis

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Science China(Life Sciences) 2024年第5期67卷 913-939页

作者： Chinese Society of Cardiology,Chinese Medical Association,Writing Group Jiangang Jiang Hongyang Shu Dao Wen Wang Rutai Hui Chenze Li Xiao Ran Hong Wang Jing Zhang Shaoping Nie Guanglin Cui Dingcheng Xiang Qun Shao Shengyong Xu Discussion experts:Ning Zhou Yuming Li Wei Gao Yuguo Chen Yuan Bian Guoping Wang Liming Xia Yan Wang Chunxia Zhao Zhiren Zhang Yuhua Zhao Jianan Wang Shaoliang Chen Hong Jiang Jing Chen Xianjin Du Mao Chen Yinxian Sun Sheng Li Hu Ding Xueping Ma Hesong Zeng Li Lin Shenghua Zhou Likun Ma Ling Tao Juan Chen Yiwu Zhou Xiaomei Guo 不详 Tongji hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Fuwai hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Zhongnan hospital of Wuhan University Wuhan 430062China Fuwai Huazhong Cardiovascular hospital Zhengzhou 450003China Beijing Anzhen hospital Capital Medical UniversityBeijing 100029China Guangzhou General hospital of Guangzhou Military Command Guangzhou 510010China Harbin Medical University Cancer hospital Harbin 150081China Union hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Taida hospital Tianjin 300457China Peking University Third hospital Beijing 100191China Qilu hospital of Shandong University Jinan 250012China Kanghua hospital DongguanGuangzhou 523080China Second Affiliated hospital Zhejiang University School of Medicine Hangzhou 310003China Nanjing First hospital Nanjing Medical UniversityNanjing 210006China Renmin hospital of Wuhan University Wuhan 430060Wuhan West China hospital Sichuan UniversityChengdu 610044China First hospital of China Medical University Shenyang 110002China General hospital of Ningxia Medical University Yinchuan 750003China The Second Xiangya hospital Central South UniversityChangsha 410012China The First Affiliated hospital of USTC University of Science and Technology of ChinaHefei 230002China The First Affiliated hospital of air force Medical University Xi’an 710032China Central hospital of Wuhan City Wuhan 430014China Tongji Medical college Huazhong University of Science and TechnologyWuhan 430030China

Fulminant myocarditis is an acute diffuse inflammatory disease of *** is characterized by acute onset,rapid progress and high risk of *** pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory *** to China’s practical experience,the adoption of the“life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core)can significantly improve the survival rate and long-term *** emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.

关键词： fulminant myocarditis guidelines life support-based comprehensive treatment regimen diagnosis treatment cytokine storm overactivation of immunity

A unified intelligent control strategy synthesizing multi-constrained guidance and avoidance penetration

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Science China(Information Sciences) 2024年第7期67卷 329-330页

作者： Sibo ZHAO Jianwen ZHU Weimin BAO Xiaoping LI School of Aerospace Science and Technology Xidian University college of Missile Engineering Rocket Force University of Engineering China Aerospace Science and Technology Corporation

Satisfying various terminal constraints and achieving evasive flight in no-flying-zones (NFZs) are two important flight missions undertaken by high velocity vehicles. We studied an intelligent maneuvering guidance strategy using deep reinforcement learning (DRL) methods to achieve the coordination and unification of evasive flight and multi-constrained guidance with minimal energy loss.

关键词： Energy dissipation

Study on the mechanism of SND in the treatment of anxiety disorders based on network pharmacology, molecular docking and experiment validation

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Pharmacology Discovery 2024年第2期4卷 10-23页

作者： Fei-Yan Wang Ping Yuan Mei-Ling Zheng Xiao-Di Guo Long Li Jin Wang Shan Miao Ya-Jun Shi Shan-Bo Ma Xiao-Peng Shi college of pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Department of Pharmacy Xijing HospitalAir Force Medical UniversityXi’an 710032China Outpatient Department of University hospital Northwestern Polytechnical University HospitalXi’an 710072China The college of Life Sciences Northwest UniversityXi’an 710127China

Background:Sini decoction(SND)is a classic traditional Chinese medicine(TCM)formulation that can be used to treat anxiety-related disorders,but the active substance and underlying molecular mechanism of its anxiolytic effects are *** this study,network pharmacology,molecular docking research and experimental verification methods were used to preliminarily explore the bioactive compounds and potential target mechanisms of SND ***:The active components and corresponding targets of SND were collected by ***,OMIM,PharmGkb,TTD and Drugbank were used to search for the targets of anxiety *** core target of SND in the treatment of anxiety was screened by PPI.R language was used to analyze the intersection targets of SND in the treatment of anxiety disorders by GO and KEGG enrichment *** Vina was used for molecular docking,and Discovery Studio was used for visual conformation analysis after *** anti-anxiety effect and molecular mechanism of SND were studied by in vivo ***:Based on network pharmacological analysis,we obtained 112 active ingredients and 350 effective targets related to anxiety from *** PPI analysis,26 targets such as STAT3,MAPK3,MAPK1,MAPK14,SRC,HSP90AA1,TP53 and PIK3CA were identified as core *** and KEGG analysis showed that the anxiolytic mechanism of SND may be related to the neuroactive ligand-receptor interaction pathway and inflammatory *** docking showed that quercetin,naringenin,licochalcone A had high affinity with JAK2,MAPK14 and *** experiments have shown that SND reverses the upregulation of GluN2B(NMDAR)and GluA1(AMPAR)proteins,and SND improves anxiety disorders by regulating glutamate transmitter levels,which may be related to neuroactive ligand-receptor interaction pathways,particularly glutamate ***:This study shows that SND can improve FS-induced behavioral changes in mice and can modulate hippocampal synapse-asso

关键词： SND anxiety disorders network pharmacology molecular docking pharmacological mechanisms

Identifying the effective combination of acupuncture and traditional Chinese medicinal herbs for postmenopausal osteoporosis therapy through studies of their molecular regulation of bone homeostasis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 212-219页

作者： REN Ping WANG Quanwu BAI Wei SUN Miao LIU Zheling GAO Ming WANG Liang PENG Bo XU Liguang Department of Health Management the Third Affiliated Clinical Hospital of Changchun University of Chinese MedicineChangchun 130117China Department of Dirty Tuina the affiliated Hospital to Changchun University of Chinese MedicineChangchun 130117China Department of Acupuncture the affiliated Hospital to Changchun University of Chinese MedicineChangchun 130117China Department of Rehabilitation Medicine the 924th Hospital of the PLA Joint Logistic Support ForceFoshan 528226China Department of college of Acupuncture and Massage Changchun University of Chinese MedicineChangchun 130117China

Worldwide,as the population age,osteoporosis is becoming increasingly common,and osteoporotic fractures have a significant economic *** women are the most susceptible to developing osteoporosis and the most critical time to prevent it is during the perimenopausal and early menopausal *** this regard,we hypothesize rational combination of acupuncture and Traditional Chinese Medicine(TCM)in the form of herbal extract could prevent osteoporosis in *** deficiency during menopause causes low-level inflammation that stimulates the formation of osteoclasts,the boneresorbing cells,and simultaneously inhibits the viability and function of osteoblasts,the bone-forming *** most potent inflammatory cytokine in skeletal homeostasis is the receptor activator of nuclear factor kappa B ligand(RANKL)that stimulates osteoclast ***,the canonical Wnt pathway is essential for osteoblastogenesis and bone formation,and estrogen deficiency leads to diminished functioning of this *** and acupuncture could target the RANKL and the Wnt pathway in favorable ways to prevent the accelerated bone loss experienced during the early menopausal stage and promote the gain in bone mass in postmenopausal *** this review,we propose a rational combination of specific TCM and acupuncture targeting those signaling molecules/pathways by the drugs that are in clinical use for the treatment of postmenopausal *** rational approach revealed that Danshen(Radix Salviae Miltiorrhizae)could exert a synergistic effect with *** then propose a translational path for developing the putative combination in women with postmenopausal osteoporosis to curtail the risk of osteoporotic fractures.

关键词： medicine traditional osteogenic anti-resorptive review

Cardiac regeneration: Pre-existing cardiomyocyte as the hub of novel signaling pathway

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Genes & Diseases 2024年第2期11卷 747-759页

作者： Tao Wang Xinzhe Chen Kai Wang Jie Ju Xue Yu Wanpeng Yu Cuiyun Liu Yin Wang Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityCollege of MedicineQingdao UniversityQingdaoShandong 266023China college of Medicine Qingdao UniversityQingdaoShandong 266023China

In the mammalian heart,cardiomyocytes are forced to withdraw from the cell cycle shortly after birth,limiting the ability of the heart to regenerate and *** development of multimodal regulation of cardiac proliferation has verified that pre-existing cardiomyocyte proliferation is an essential driver of cardiac *** the continuous development of genetic lineage tracking technology,it has been revealed that cell cycle activity produces polyploid cardiomyocytes during the embryonic,juvenile,and adult stages of cardiogenesis,but newly formed mononucleated diploid cardiomyocytes also elevated sporadically during myocardial *** implied that adult cardiomyocytes have a weak regenerative capacity under the condition of ischemia injury,which offers hope for the clinical treatment of myocardial ***,the regeneration frequency and source of cardiomyocytes are still low,and the mechanism of regulating cardiomyocyte proliferation remains further *** is noteworthy to explore what force triggers endogenous cardiomyocyte proliferation and heart ***,we focused on summarizing the recent research progress of emerging endogenous key modulators and crosstalk with other signaling pathways and furnished valuable insights into the internal mechanism of heart *** addition,myocardial transcription factors,non-coding RNAs,cyclins,and cell cycle-dependent kinases are involved in the multimodal regulation of pre-existing cardiomyocyte ***,awakening the myocardial proliferation endogenous modulator and regeneration pathways may be the final battlefield for the regenerative therapy of cardiovascular diseases.

关键词： Cardiac regeneration Cell cycle re-enter Myocardial infarction Pre-existing cardiomyocyte proliferation Regenerative therapy of cardiovascular diseases