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Throat Infection,Neck and Chest Pain and Cardiac Response:A Persistent Infection-Related Clinical Syndrome

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2009年第1期29卷 19-24页

作者：周昌清付向宁严江涛范巧李卓娅 Katherine Cianflone 汪道文 The Institute of Hypertension and Cardiovascular division Department of Internal Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Cardiology Hefei First People's Hospital Department of Immunology Tongji Medical College Huazhong University of Science and Technology Centre de Recherche Hopital Laval Universite Laval Y2186 2725 Chemin Ste Foy Ste Foy Quebec G1V 4G5 Canada

Dizziness, chest discomfort, chest depression and dyspnea are a group of symptoms that are common complaints in clinical practice. Patients with these symptoms are usually informed that while neurosis consequent to coronary heart disease is excluded nonetheless they remain unhealthy with no rational explanation or treatment. 165 cases of these symptoms and 85 control subjects were reviewed and underwent further medical history inquiry, routine EKG test and cardiac ultrasound examination. Thirty-five patients received coronary artery angiography to exclude coronary heart disease. Serum myocardial autoantibodies against beta1-adrenoceptor, alpha-myosin heavy chain, M2-muscarinic receptor and adenine-nucleotide translocator were tested, and inflammatory cytokines and high sensitivity C-reaction protein were measured and lymphocyte subclass was assayed by flow cytometry. All patients had a complex of four symptoms or tetralogy：（1） persistent throat or upper respiratory tract infection, （2） neck pain, （3） chest pain and （4） chest depression or dyspnea, some of them with anxiety. Anti-myocardial autoantibodies （AMCAs） were present in all patients vs. 8% in controls. TNF-α, IL-1 and IL-6 were significantly higher in patients than in controls （P〈0.01）. CD3^＋ and CD4-CD8^＋ lymphocytes were significantly higher and CD56＋ lymphocytes lower in patients than those in controls （P〈0.01）. The ratio of serum pathogen antibodies positive against Coxsackie virus-B, cytomegalovirus, Mycoplasma pneumoniae and Chlamydia pneumoniae were all markedly higher in patients. These data led to identification of a persistent respiratory infection-related clinical syndrome, including persistent throat infection, neck spinal lesion, rib cartilage inflammation, symptoms of cardiac depression and dyspnea with or without anxiety.

关键词： inflammation chest pain cardiac response diagnosis

Net effect of air pollution controls on health risk in the Beijing-Tianjin-Hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： changqing Lin Peter K.K.Louie Alexis K.H.Lau Jimmy C.H.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shakhaoat Hossain Chengcai Li Xiang Qian Lao division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public Health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the Beijing–Tianjin–Hebei(BTH)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTH(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide Health risk Carbon neutrality Mega-events

Role of the tomato fruit ripening regulator RIN in resistance to Botrytis cinerea infection

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Role of the tomato fruit ripening regulator RIN in resistanc...

Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia

中国植物病理学会2021年学术年会

作者： ZHENG Hui JIN Rong LIU Zimeng SUN Cui SHI Yanna Donald Grierson ZHU changqing LI Shan IAN Ferguson CHEN Kunsong College of Agriculture & Biotechnology Zhejiang UniversityZijinggang Campus Zhejiang Provincial Key Laboratory of Integrative Biology of Horticultural Plants Department of Horticulture and Agricultural Experiment StationZhejiang University Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang UniversityZijinggang Campus Plant and Crop Sciences division School of BiosciencesUniversity of NottinghamSutton Bonington Campus Zhejiang University(Visiting Scientist) Zijinggang Campus

Tomato MADS-RIN（RIN） transcription factor hasbeen shown to be a master activator regulating fruit *** studies have revealed it represses expression of XTH5,responsible for excess flesh softening and cell wall degradation,which might indicate it has a potential role in pathogen resistance of ripening *** this study,both wild type（WT） and RIN-knockout（RIN-KO） mutant tomato fruit were infected with Botrytis cinerea（***）,to investigate the function of RIN in ripening-related pathogen *** results showed that RIN-KO fruit were much more sensitive to *** with larger lesion *** ammonialyase（PAL） and chitinase（CHI） in RIN-KO fruit were affected by reduced transcripts of PALs,CHIs and decreased corresponding enzyme *** of genes including pathogenesis-related proteins（PRs） and APETALA2/Ethylene Response Factor（AP2/ERF） genes were reducedin RIN-KO fruit comparing to WT ***,RIN also repressed the expression of XTH5 that has been reported to be correlated with *** results supported the conclusion that RIN activates ripening-related resistance to grey mould infection through activating pathogen-resistance genes and defense enzyme activies as well as inhibiting over-softening.

关键词： Botrytis cinerea chitinase ERF over-softening phenylalanine ammonialyase pathogen resistance RIN tomato fruit

来源： cnki会议评论

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 177-191页

作者： Yaqiang Hong Dake Zhang Xiangtian Zhou Aili Chen Amir Abliz Jian Bai Liang Wang Qingtao Hu Kenan Gong Xiaonan Guan Mengfei Liu Xinchang Zheng Shujuan Lai Hongzhu Qu Fuxin Zhao Shuang Hao Zhen Wu Hong Cai Shaoyan Hu Yue Ma Junting Zhang Yang Ke Qian-Fei Wang Wei Chen changqing Zeng CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Beijing Advanced Innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Tsinghua-Peking Center for Life Sciences School of Life SciencesTsinghua UniversityBeijing 100084China School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical UniversityWenzhou 325035China The State Key Laboratory of Optometry Ophthalmology and Vision ScienceWenzhou 325035China Key Laboratory of Carcinogenesis and Translational Research(MOE) Laboratory of GeneticsPeking University Cancer Hospital&InstituteBeijing 100142China Skull Base and Brainstem Tumor division Department of NeurosurgeryBeijing Tian Tan HospitalCapital Medical UniversityBeijing 100050China China National Clinical Research Center for Neurological Diseases Beijing 100050China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Department of Hematology and Oncology Children’s Hospital of Soochow UniversitySuzhou 215025China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Collaborative Innovation Center for Genetics and Development Shanghai 200438China University of Chinese Academy of Sciences Beijing 100049China

Postzygotic mutations are acquired in normal tissues throughout an individual’s lifetime and hold clues for identifying mutagenic ***,we investigated postzygotic mutation spectra of healthy individuals using optimized ultra-deep exome sequencing of the time-series samples from the same volunteer as well as the samples from different *** blood,sperm,and muscle cells,we resolved three common types of mutational *** A and B represent clocklike mutational processes,and the polymorphisms of epigenetic regulation genes influence the proportion of signature B in mutation ***,signature C,characterized by C>T transitions at GpCpN sites,tends to be a feature of diverse normal *** of this type are likely to occur early during embryonic development,supported by their relatively high allelic frequencies,presence in multiple tissues,and decrease in occurrence with *** none of the public datasets for tumors feature this signature,except for 19.6%of samples of clear cell renal cell carcinoma with increased activation of the hypoxia-inducible factor 1(HIF-1)signaling ***,the accumulation of signature C in the mutation profile was accelerated in a human embryonic stem cell line with drug-induced activation of HIF-1α.Thus,embryonic hypoxia may explain this novel signature across multiple normal *** study suggests that hypoxic condition in an early stage of embryonic development is a crucial factor inducing C>T transitions at GpCpN sites;and individuals’genetic background may also influence their postzygotic mutation profiles.

关键词： Postzygotic mutation Mutational signature Healthy individual Embryonic development Hypoxia

Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm

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Journal of Pancreatology 2023年第3期6卷 87-95页

作者： Wu Wenming Cai Shouwang Chen Rufu Fu Deliang Ge Chunlin Hao Chunyi Hao Jihui Huang Heguang Jian Zhixiang Jin Gang Li Fei Li Haimin Li Shengping Li Weiqin LiYixiong Liang Tingbo Liu Xubao Lou Wenhui Miao Yi Mou Yiping Peng Chenghong Qin Renyi Shao Chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang Wei Wang Weilin Wei Junmin Wu Heshui Wu Zheng Yan changqing Yang Yinmo Yin Xiaoyu Yu Xianjun Yuan Chunhui Zhao Yupei Department of General Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Hepatobiliary Surgery PLA General HospitalBeijing 100853China Department of General Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Pancreatic Surgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Department of Hepatobiliary and Pancreatic Surgery Hunnan Division of The First Hospital of China Medical UniversityShenyang 110167China Department of Hepato-Pancreato-Biliary Surgery Peking University Cancer Hospital&InstituteBeijing 100142China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of General Surgery Fujian Medical University Union HospitalFuzhou 350001China Department of General Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Affiliated to Navy Medical University(Second Military Medical University)Shanghai 200433China Department of General Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Hepatobiliary Surgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Hepatobiliary and Pancreatic Surgery Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Critical Care Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002China Department of General Surgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department

In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small *** to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat *** response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert *** consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects.

关键词： 2 cm Clinical diagnosis Non-functional pancreatic neuroendocrine neoplasms Treatment