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Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China

Chinese Medical Journal 2012年第3期125卷 455-460页

作者： Wang Lu-xi Li Xiu-jun Fang Li-qun Wang Duo-chun Cao Wu-chun Kan Biao Beijing Inst Microbiol & Epidemiol State Key Lab Pathogen & Biosecur Beijing 100071 Peoples R China Chinese ctr dis control & prevent Natl Inst Communicable Dis Control & Prevent State Key Lab Infect Dis Prevent & Control Beijing 102206 Peoples R China Shandong Univ Sch Publ Hlth Jinan 250012 Shandong Peoples R China changping dist ctr dis control & prevent Beijing 102200 Peoples R China

Background Typhoid/paratyphoid fever （TPF） is endemic in *** conducted wavelet analysis and Spearman＇s rank correlation analysis to explore the impact of meteorological variations on TPF infection in Guizhou,in an attempt to assess the risk factors associated with TPF *** We examined the association between TPF incidence in Guizhou and temperature,precipitation and relative humidity using 24 years of data from 1984 to *** of TPF incidence and the impact of climate factors on the TPF were detected by Spearman＇s rank correlation and wavelet analysis,Results Temperature and precipitation with a 1-month lag were positively correlated with the monthly incidence of *** multiyear incidence pattern of TPF in Guizhou was explicitly ***,the association and driving effect of precipitation on TPF were observed,and the results showed that the incidence of TPF in Guizhou had a closer correlation with precipitation than with *** Safe water supply is the key issue for TPF control in ***,climate variation might impact the enteric infections,which may inform policy assessment for TPF control in Guizhou.

关键词： typhoid/paratyphoid fever meteorological variables

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HBV genotype C is independently associated with cirrhosis in community-based population

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World Journal of Gastroenterology 2010年第3期16卷 379-383页

作者： Yin, Jian-Hua Zhao, Jun Zhang, Hong-Wei Xie, Jia-Xin Li, Wei-Ping Xu, Guo-Zhang Shen, Jie Dong, Hong-Jun Zhang, Jun Wang, Lin Han, Jian-Kang Wang, Hong-Yang Cao, Guang-Wen Second Mil Med Univ Dept Epidemiol Shanghai 200433 Peoples R China Second Mil Med Univ Affiliated Hosp 3 Dept Hepatobiliary Surg Shanghai 200438 Peoples R China Second Mil Med Univ Dept Ultrasonog Affiliated Hosp 1 Shanghai 200433 Peoples R China Municipal ctr dis control & prevent Ningbo Ningbo 315010 Zhejiang Peoples R China Municipal ctr dis control & prevent Soochow Suzhou 215007 Jiangsu Peoples R China dist ctr dis control & prevent Yangpu Shanghai 200090 Peoples R China Municipal ctr dis control & prevent Huzhou Huzhou 313000 Zhejiang Peoples R China Second Mil Med Univ Lab Signal Transduct Affiliated Hosp 3 Shanghai 200438 Peoples R China

AIM:To determine the association of hepatitis B virus (HBV) genotypes with probable cirrhosis and fatty liver in community-based ***: A multi-stage cluster probability sampling method was applied to recruit 10 167 subjects aged between 6 and 72 years from our epidemiological bases in Eastern China. After excluding the subjects co-infected with hepatitis C or hepatitis D viruses, the hepatitis B surface antigen (HBsAg)-positive subjects were examined for HBV genotype, serum viral load, alanine aminotransferase (ALT), hepatitis B e antigen (HBeAg) status, and ultrasonographic changes. Logistic regression models were used to determine the factors associated with probable cirrhosis and fatty ***: Of 634 HBsAg-positive subjects with HBV genotype determined, 82 had probable cirrhosis (ultrasonographic score ≥5), 42 had ultrasonographic fatty liver. Probable cirrhosis was only found in the HBeAg-negative subjects, and more frequently found in the subjects with genotype C than in those with genotype B (14.8% vs 8.0%, P=0.018). In HBeAg-negative subjects, high viral load was frequently asso-ciated with abnormal ALT level, while ALT abnormality was more frequent in those with probable cirrhosis than those without (19.5% vs 7.8%, P=0.001). Univariate analysis showed that age, sex, HBV genotypes, and viral load were not significantly associated with ultrasonographic fatty liver, whereas ALT abnormality was significantly related to ultrasonographic fatty liver (OR=4.54,95% CI:2.11-9.75, P<0.001). Multivariate analysis demonstrated that HBV genotype C, age (≥45 years), male sex, and ALT abnormality were independently associated with probable cirrhosis (AOR=2.30,95% CI:1.26-4.19; AOR =1.81,95% CI:1.10-2.99;AOR=1.74,95% CI:1.03-2.95; AOR=2.98,95% CI:1.48-5.99, respectively).CONCLUSION: A crude prevalence of probable cirrhosis is 12.9% in the community-based HBV-infected subjects. HBV genotype C is independently associated with probable cirrhosis in the HBe

关键词： Hepatitis B virus Genotype Viral load Alanine aminotransferase Probable cirrhosis Ultrasonography

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Differences in the population of genetics of Mycobacterium tuberculosis between urban migrants and local residents in Beijing, China

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Chinese Medical Journal 2013年第21期126卷 4066-4071页

作者： Dai Guang-ming Zhang Zhi-guo Ding Peng-ju Zhang Qian Wang Li Wang Li-xia van Soolingen, Dick Huang Hai-rong Li Wei-min Li Chuan-you Beijing TB & Thorac Tumor Res Inst Natl TB Clin Lab China Beijing 101149 Peoples R China changping TB prevent & control Inst Beijing Beijing 102206 Peoples R China Henan Univ Technol Coll Bioengn Zhengzhou 450001 Henan Peoples R China Chinese Acad Sci Inst Genet & Dev Biol Beijing 100101 Peoples R China Hangzhou Normal Univ Sch Med Hangzhou 3110036 Zhejiang Peoples R China Chinese ctr dis control & prevent Natl Ctr TB Control & Prevent Beijing 102206 Peoples R China Natl Inst Publ Hlth & Environm RIVM Natl Mycobacteria Reference Lab NL-3720 BA Bilthoven Netherlands Capital Med Univ Beijing Chest Hosp Beijing Key Lab Drug Rresistant TB Res Beijing 101149 Peoples R China TB & Thorac Tumor Res Inst Dept Bacteriol & Immunol Beijing 101149 Peoples R China

Background Currently, migration has become one of the risk factors of high burden of tuberculosis in China. This study was to explore the influence of mass migration on the dynamics of Mycobacterium （M.） tuberculosi... 详细信息

关键词： Beijing lineage Mycobacterium tuberculosis urban migrants phylogeny population of genetics

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