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Association between preterm birth risk and polymorphism and expression of the DNA repair genes OGG1 and APE1 in Saudi women

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BIOCELL 2018年第1期42卷 1-6页

作者： ARWA OSAMA NEMER MOHAMMAD SAUD AL ANAZI RAMESA SHAFI BHAT ARJUMAND S.WARSY ZENEB A BABAY MOHAMMAD HADDAR JILANI SHAIK SOOAD AL-DAIHAN Department of biochemistry College of Science Genome Research chair Department of BiochemistryCollege of Science Central Laboratory Female Center for Medical Studies and Scientific Section Department of Obs/Gyn College of MedicineKing Saud UniversityP.O.Box 22452Zip code 11495RiyadhSaudi Arabia

Genomic instability and mutations caused by increases in oxidative stress during pregnancy can damage the fetoplacental unit and can upshot preterm *** damage to DNA may possibly be involved in etiology of preterm birth(PTB)which can be repaired by DNA repair *** the present study,we assessed the association of base excision repair gene family by analyzing the association of single nucleotide polymorphisms and genes expression in 8-oxoguanine glycosylase-1(OGG1)and apurinic-apyrimidinic endonuclease 1(APE1)genes with risk of preterm birth in Saudi *** analyzed genotypes of four single nucleotide polymorphisms(SNPs)(rs1052133,rs293795,rs2072668 and rs2075747)in OGG1 gene and three SNPs(rs1130409,rs3136814,and rs3136817)in APE1 gene using TaqMan Genotyping assay kits in 50 pairs of preterm cases and individually matched ***,gene expression level was explored by RT-PCR in 10 pairs of preterm placental tissues and individually matched normal placental *** OGG1 SNP,rs1052133(OR=0.497;c2=1.11;p=0.292)and rs2072668(OR=0.408;c2=1.90;p=0.167)and one APE1 SNP rs3136817(OR=0.458;c2=0.40;p=0.527)showed nonsignificant protective effect against PTB *** expression of both genes under study was found lower in the PTB *** and allele frequencies of both gene SNPs did not show any association with the risk of preterm delivery in Saudi women(P˃0.05).However,synthesis and release of OGG1 and APE1 proteins decreased in preterm placental tissues compared to term delivery reflects the probability of being one of the mechanisms leading to preterm birth.

关键词： Preterm birth OGG1 and APE1 genes Oxidative stress SNPs

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Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter

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Journal of molecular Cell biology 2016年第1期8卷 2-16页

作者： Yanping Zhu Ta-Wei Liu Zarina Madden Scott A.Yuzwa Kelsey Murray Samy Cecioni Natasha Zachara David J.Vocadlo Department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6Canada Department of molecular biology and biochemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6Canada Department of Biological Chemistry Johns Hopkins University Medical SchoolBaltimoreMD 21205USA

O-glycosylation of the nuclear pore complex(NPC)by O-linked N-acetylglucosamine(O-GlcNAc)is conserved within *** nucleoporins(Nups)comprising the NPC are constitutively O-GlcNAcylated,but the functional role of this modification remains *** loss ofO-GlcNAc,induced by either inhibition ofO-GlcNAc transferase(OGT)or deletion of the gene encoding OGT,leads to decreased cellular levels of a number of natively O-GlcNAcylated *** of O-GlcNAc enables increased ubiquitination of these Nups and their increased proteasomal *** decreased half-life of these deglycosylated Nups manifests in their gradual loss from the NPC and a downstream malfunction of the nuclear pore selective permeability barrier in both dividing and post-mitotic *** findings define a critical role of O-GlcNAc modification of the NPC in maintaining its composition and the function of the selectivity *** results implicate NPC glycosylation as a regulator of NPC function and reveal the role of conserved glycosylation of the NPC among metazoans.

关键词： post-translational modiﬁcation O-GlcNAcylation nuclear pore complex protein stability ubiquitination nucleoporin glycosylation

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Influence of conformational change of chain unit on the intrinsic negative thermal expansion of polymers

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Chinese Chemical Letters 2021年第4期32卷 1515-1518页

作者： Qiangsheng Sun Ke Jin Yuhui Huang Jia Guo Thanyada Rungrotmongkol Phornphimon Maitarad Changchun Wang State Key Laboratory of molecular Engineering of Polymers and Department of Macromolecular Science Fudan UniversityShanghai 200433.China Biocatalyst and Environmental Biotechnology Research Unit Department of BiochemistryFaculty of Science and Program in Bioinformatics and Computational BiologyGraduate SchoolChulalongkom UniversityBangkok 10330Thailand Research Center of Nano Science and Technology Shanghai UniversityShanghai 200444China

Negative thermal expansion(NTE) behavior has roused wide interest for the control of thermomechanical properties of functional *** NTE behaviors have been found in kinds of compounds,it remains challenging for polymers to achieve intrinsic NTE *** this work,we systematically studied the conformational change of dibenzocyclooctadiene(DBCOD) derivatives between chair(C) and twist-boat(TB) forms based on density-functional theo ry(DFT) calculations,and found clear evidence of the relationship between the structure of DBCOD units and the thermal contraction behavior of the related *** order to obtain the polymer with NTE property,two conditions should be met for the thermal contracting DBCOD related units as follows:(i) the TB conformation can turn into C conformation as the temperature increases,and(ii) the volume of C conformation is smaller than that of TB *** rule should offer a guidance to exploration of the new intrinsic NTE polymers in the future.

关键词： Negative thermal expansion Conformational change Polyarylamides Density-functional theory Dibenzocyclooctadiene

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Model systems to study the life cycle of human papillomaviruses and HPV-associated cancers

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Virologica Sinica 2015年第2期30卷 92-100页

作者： Louise T.Chow Department of biochemistry and molecular Genetics University of Alabama at Birmingham Birmingham 35294-0005 USA

The prevalent human papillomaviruses(HPVs) infect either cutaneous or mucosal epithelium. Active Infections lead to epithelial hyperprolifeation and are usually cleared in healthy individuals within a year. Persistent infections in the anogenital tracts by certain high-risk genotypes such as HPV-16, HPV-18 and closely related types, can progress to high grade dysplasias and carcinomas in women and men, including cervical, vulva, penile and anal cancers. A significant fraction of the head and neck cancers are also caused by HPV-16. The viral oncogenes responsible for neoplastic conversion are E6 and E7 that disrupt the pathways controlled by the two major tumor suppressor genes, p53 and members of p RB family. Because HPV cannot be propagated in conventional submerged monolayer cell cultures, organotypic epithelial raft cultures that generate a stratified and differentiated epithelium have been used to study the viral life cycle. This article describes several systems to examine aspects of the viral productive phase, along with the advantages and limitations. Animal model systems of HPV carcinogenesis are also briefly described.

关键词： human papillomaviruses(HPVs) productive program HPV-associated cancers model systems

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Screening for variants in the <i>MUTYH</i>gene in Saudis

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Open Journal of Genetics 2011年第3期1卷 70-77页

作者： Jameela Shinwari Abdulla Alamri Mohammad Alanazi Nada Al Tassan Department of biochemistry Genome Research Chair College of Science King Saud University

MUTYH is a base excision repair glycosylase responsible for correcting the G:A mismatches that arise from replication of a damaged DNA, such impairment results from attacks by reactive oxygen species that are produced from different sources including cigarette smoking. The produced reactive oxygen species trigger the oxidation of guanine in to 8-oxo-G and the latter mispairs with adenine. Alterations in the MUTYH gene can affect its glycosylase function and hence the DNA repair capacity that is tightly linked to cancer development. Defects in the MUTYH were found to be associated with predisposition to colorectal cancer;the third most common cancer in the world. Although some studies suggested the existence of an ethnic differentiation among MUTYH mutations, there are no documented reports regarding this gene in Saudi cases or controls so far. 153 healthy Saudi individuals including smokers were screened for the IVS1 + 5 G/C, V22M, Y165C, R231C, H324Q and G382D MUTYH variants using either ARMS or RFLP or direct sequencing. Allelic frequencies were calculated and were found to be as follows: IVS1 + 5 G/C = 1/0, V22M = 0.99/0.01, Y165C = 1/0, R231C = 1/0, H324Q = 0.29/0.71 and G382D = 0.997/0.003. Comparison of the allele frequencies between Saudis and other populations revealed a significant difference between the Saudis and Europeans for the V22M (p-value: 0.0003, OR: 5.899, 95% CI: 1.999 - 17.408);and between the Saudis and Asians for the H324Q (p-value: MUTYH variants in Saudi populations and support the existence of an ethnic difference between MUTYH variants which is beneficial as some MUTYH common polymorphisms in certain populations may correlate with disease predisposition in other rare populations.

关键词： MUTYH Allele Frequencies Single Nucleotide Polymorphism Mutations Colorectal Cancer

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Mutations of TP53 Gene and Oxidative Stress in Alzheimer’s Disease Patients

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Advances in Alzheimer's Disease 2014年第1期3卷 24-32页

作者： Jolanta Dorszewska Agata Rozycka Anna Oczkowska Jolanta Florczak-Wyspianska Michal Prendecki Mateusz Dezor Izabela Postrach Pawel P.Jagodzinski Wojciech Kozubski Laboratory of Neurobiology Department of NeurologyPoznan University of Medical SciencesPoznanPoland Department of biochemistry and molecular biology Poznan University of Medical SciencesPoznanPoland chair and Department of Neurology Poznan University of Medical Sciences10Fredry Str.61-701 PoznanPoland

Alzheimer’s disease (AD) leads to the generation of β-amyloid (Aβ), which may damage DNA and thus lead to apoptosis induction by the p53 pathway. Dysfunction of the p53 protein may then be connected with the development of AD. Studies were conducted on 28 AD patients and 30 non-AD controls. Analysis of TP53 mutations in exon 7 was performed on DNA isolated from whole blood and biochemical parameters in the peripheral lymphocytes of these individuals. Our study showed a silent mutation TP53 C708T (21%) [p TP53 C748A (4%) only in the AD patients. Moreover, in AD patients with the TP53 C748A mutation, the level of 8-oxo-2’- deoxyguanosine (8-oxo2dG) was more than 5 times higher than the average level in this study group. In AD patients with the wild-type TP53 gene, the level of 8-oxo2dG was correlated with the level of protein p53 (R = +0.7388, p TP53 (p TP53 (C748A, C708T) may be associated with pathogenesis of AD.

关键词： TP53 8-oxo2dG p53 OGG1 AD

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Negative auto-regulators trap p53 in their web

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Journal of molecular Cell biology 2017年第1期9卷 62-68页

作者： Xiang Zhou Bo Cao Hua Lu Fudan University Shanghai Cancer Center and the Institutes of Biomedical Sciences Fudan University Shanghai 200032 China Department of biochemistry & molecular biology and Tulane Cancer Center Tulane University School of Medicine New Orleans LA 70112 USA

The transcriptional factor p53 activates the expression of a myriad of target genes involving a complicated signalling network, resulting in various cellular outcomes, such as growth arrest, senescence, apoptosis, and metabolic changes, and leading to con- sequent suppression of tumour growth and progression. Because of the profoundly adverse effect of p53 on growth and prolifer- ation of cancer cells, several feedback mechanisms have been employed by the cells to constrain p53 activity. Two major antagonists MDM2 and MDMX （the long forms） are transcriptionally induced by p53, but in return block p53 activity, forming a negative feedback circuit and rendering chemoresistance of several cancer cells. However, they are not alone, as cancer cells also employ other proteins encoded by p53 target genes to inhibit p53 activity at transcriptional, translational, and posttransla- tional levels. This essay is thus composed to review a recent progress in understanding the mechanisms for how cancer cells hijack the p53 autoregulation by these proteins for their growth advantage and to discuss the clinical implications of these auto- regulatory loops.

关键词： p53 MDM2 NGFR transcription feedback loop chemoresistance

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Coping with extremes:convergences of habitat use,territoriality,and diet in summer but divergences in winter between two sympatric snow finches on the Qinghai-Tibet Plateau

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Integrative Zoology 2020年第6期15卷 533-543页

作者： Dongming LI Jason E.DAVIS Yanfeng SUN Gang WANG Ghulam NABI John C.WINGFIELD Fumin LEI Key Laboratory of Animal Physiology Biochemistry and Molecular Biology of Hebei ProvinceCollege of Life SciencesHebei Normal UniversityShijiazhuangHebei ProvinceChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijingChina Department of Neurobiology Physiology and BehaviorUniversity of CaliforniaDavisCaliforniaUSA Department of biology Radford UniversityRadfordVirginiaUSA Ocean College Hebei Agricultural UniversityQinhuangdaoHebei ProvinceChina University of Chinese Academy of Sciences BeijingChina Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingChina

On the Qinghai-Tibet Plateau,extreme environmental conditions have imposed intense selective pressure on the evolution of phenotypic traits of wild *** date,limited information is available on behavioral and ecological traits concerning niche differentiation among sympatric animals on the Qinghai-Tibet Plateau,especially during winter when the environments are most ***,we studied the seasonal variations in habitat occurrence,territorial behavior,and diet in two sympatric snow finches(the white-rumped snow finch,Onychostruthus taczanowskii,WRSF;and the rufous-necked snow finch,Pyrgilauda ruficollis,RNSF)to determine convergence and divergence of ecological traits in such severe climatic *** results showed that:(i)WRSF occupied rural areas as a dominant species throughout the annual cycle while RNSF occupied the rural areas in summer and then shifted to human-occupied areas in winter and spring;(ii)WRSFs exhibited robust aggressive behavior and territoriality during winter relative to RNSFs;(iii)the diets of both species varied with the season but did not vary between species except that WRSF ate significantly more seeds but RNSF consumed more starchy material derived from human food waste during ***,the separations in the spatial niche and territoriality between WRSF and RNSF,especially in winter,may contribute to alleviating the pressure of interspecific competition,and promoting the coexistence of the two sympatric snow finches in the extreme environments on the Qinghai-Tibet Plateau.

关键词： diet habitat use Qinghai-Tibet Plateau snow finch territorial behavior

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Insect Hydrocarbons. biology, biochemistry, and Chemical Ecology

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Insect Science 2012年第6期19卷 703-704页

作者： Sofija Pavković‐Lučić Dragana Miličić Luka Lučić (chair of Genetics and Evolution) (chair of Animal Morphology Systematics and Phylogeny) (chair of Animal Development) Institute of Zoology Faculty of Biology University of Belgrade Studentski trg 16 11000 Belgrade Serbia Email: sofija@bio.bg.ac.rs draganam@bio.bg.ac.rs luka@bio.bg.ac.rs

Gary J. Blomquist and Anne-Genevirve Bagnbres （eds.）, Cambridge University Press, 2010 ISBN 978-0- 521-89814-0, Hardback, pp. 492, 70.00 Who of us does not know how magic is love dancing in dragonflies, or waggle honebees＇ dance, flushing in the firefly, or traveling of ＂orange cloud＂ during migration of monarch butterflies？ And, if those behaviors are magical for us, how magical are they for themselves？ How special is insect ＂vocabulary＂ during their communication？

关键词： Insect Hydrocarbons biology biochemistry

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Disruptor of telomeric silencing 1-like(DOT1L) is involved in breast cancer metastasis via transcriptional regulation of MALAT1 and ZEB2

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Journal of Genetics and Genomics 2019年第12期46卷 591-594页

作者： Yang Duan Xingyan Zhang Lihong Yang Xu Dong Zhanye Zheng Yiming Cheng Hao Chen Bei Lan Dengwen Li Jun Zhou Chenghao Xuan Tianjin Key Laboratory of Medical Epigenetics Key Laboratory of Breast Cancer Prevention and Therapy(Ministry of Education)Tianjin Key Laboratory of Spine and Spinal CordDepartment of Biochemistry and Molecular BiologyTianjin Medical UniversityTianjin300070China Department of Gynecology Tianjin Medical University NanKai HospitalTianjin 300100China Department of Genetics and Cell biology College of Life SciencesNankai UniversityTianjin 300071China Department of Pharmacology Tianjin Medical UniversityTianjin300070China Institute of Biomedical Sciences College of Life SciencesShandong Normal UniversityShandong 250014China

Epigenetics refers to how chromatin-associated factors and reversible chromatin modifications maintain DNA-based programs by regulating the chromatin structure(Strahl and Allis,2000).In recent years,genome sequencing studies of cancer have shown that genes encoding epigenetic factors are commonly mutated in cancer(Garraway and Lander,2013).Dys regulated,or mutant.

关键词： MALAT1 ZEB2 1-like(DOT1L)

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