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Physiological significance of oxidative stress and its role in adaptation of the human body to deleterious factors

Frontiers in biology 2018年第1期13卷 19-27页

作者： Vadim V. Davydov Alexander V. Shestopalov Evgenya R. Grabovetskaya chair of biochemistry and molecular biology Pirogov Russian National Research Medical University Moscow 117997 Russia chair of biochemistry V.N. Karazin Kharkov National University Ukraine Kharkov 61077 Ukraine

BACKGROUND： Oxidative stress is an extremely widespread condition manifested in an increased rate of free-radical processes and accumulation of reactive oxygen species （ROS） in the tissues. It appears in different physiologic states and pathological processes accompanied by stimulation of the sympathetic adrenal system or tissue hypoxia or under stress. However, until now, there is still no clarity on the issue of the significance of oxidative stress in the development of adaptation processes in the organism. OBJECTIVE： In the present work we will review the most recent finding about physiologic role of oxidative stress and its participation in adaptation of an organism to effect of different adverse factors. METHODS： A systematic literature search was performed using the Pubmed search engine. Studies published over past 18 years, i.e. between 1998 and 2015 were considered for review. Followed keywords were used：＂oxidative stress,＂＂free radical oxidation,＂＂ROS,＂＂endogenous aldehydes,＂＂adaptation.＂ RESULTS： The article cites arguments supporting the notion that oxidative stress serves as a nonspecific link in the adaptation of the human body to the effects of injurious factors. Oxidative stress exerts regulatory effects by changing the redox state of the cell. Oxidative stress affects on various intracellular proteins containing cysteine residues, e.g., enzymes, chaperones, and transcription factors, etc. For this reason, the use of antioxidants for the treatment and prophylaxis of a wide range of diseases is not recommended. CONCLUSION： Further investigation is needed in this field. The most attention should be paid to careful experimental verification aimed at quantitative assessment of the ROS level in tissues under oxidative stress, as well as at the study of possibility of enhancing the catabolism of free radical oxidation carbonyl products in order to prevent tissue damage under oxidative stress.

关键词： oxidative stress free radical oxidation ROS adaptation endogenous aldehydes

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SOX transcription factors and glioma stem cells:Choosing between stemness and differentiation

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World Journal of Stem Cells 2021年第10期13卷 1417-1445页

作者： Milena Stevanovic Natasa Kovacevic-Grujicic Marija Mojsin Milena Milivojevic Danijela Drakulic Laboratory for Human molecular Genetics Institute of Molecular Genetics and Genetic EngineeringUniversity of BelgradeBelgrade 11042Serbia chair biochemistry and molecular biology Faculty of BiologyUniversity of BelgradeBelgrade 11158Serbia Department of Chemical and Biological Sciences Serbian Academy of Sciences and ArtsBelgrade 11000Serbia

Glioblastoma(GBM)is the most common,most aggressive and deadliest brain ***,remarkable progress has been made towards understanding the cellular and molecular biology of *** tumor initiation,progression and relapse as well as resistance to treatments are associated with glioma stem cells(GSCs).GSCs exhibit a high proliferation rate and self-renewal capacity and the ability to differentiate into diverse cell types,generating a range of distinct cell types within the tumor,leading to cellular *** tumors may contain different subsets of GSCs,and some of them may adopt a quiescent state that protects them against chemotherapy and *** enriched in recurrent gliomas acquire more aggressive and therapy-resistant properties,making them more malignant,able to rapidly *** impact of SOX transcription factors(TFs)on brain tumors has been extensively studied in the last *** all SOX genes are expressed in GBM,and their expression levels are associated with patient prognosis and *** SOX TFs are involved in the maintenance of the stemness of GSCs or play a role in the initiation of GSC *** fine-tuning of SOX gene expression levels controls the balance between cell stemness and ***,innovative therapies targeting SOX TFs are emerging as promising tools for combatting *** GBM has been a demanding and challenging goal for *** current therapeutic strategies have not yet provided a cure for GBM and have only resulted in a slight improvement in patient *** approaches will require the fine adjustment of multimodal therapeutic strategies that simultaneously target numerous hallmarks of cancer cells to win the battle against GBM.

关键词： Glioblastoma SOX transcription factors Glioma stem cells Stemness Differentiation

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Exosomes and their role in the micro-/macro-environment： acomprehensive review

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The Journal of Biomedical Research 2017年第5期31卷 386-394页

作者： Naureen Javeed Debabrata Mukhopadhyay Department of biochemistry and molecular biology Mayo Clinic Rochester MN 55905 USA Department of biochemistry and molecular biology Mayo Clinic Jacksonville FL 32224 USA.

The importance of extracellular vesicles(EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Compelling evidence supports the role of EVs in the horizontal transfer of cellular material which has the potential to influence normal cellular physiology and promote various disease states. Of the different types of EVs, exosomes have garnered much attention in the past decade due to their abundance in various biological fluids and ability to affect multiple organ systems. The main focus of this review will be on cancer and how cancer-derived exosomes are important mediators of metastasis, angiogenesis, immune modulation, and the tumor macro-/microenvironment. We will also discuss exosomes as potential biomarkers for cancers due to their abundance in biological fluids, ease of uptake, and cellular content. Exosome use in diagnosis, prognosis, and in establishing treatment regimens has enormous potential to revolutionize patient care.

关键词： tumor macro-environment microenvironment exosomes cancer biomarker therapeutics metastasis

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Operando electrochemical SERS monitors nanoparticle reactions by capping agent fingerprints

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Nano Research 2022年第5期15卷 4517-4524页

作者： Kevin Wonner Steffen Murke Serena RAlfarano Pouya Hosseini Martina Havenith Kristina Tschulik chair of Analytical Chemistry Ⅱ Faculty of Chemistry and BiochemistryRuhr University BochumBochum 44801Germany chair of Physical Chemistry Ⅱ Faculty of Chemistry and BiochemistryRuhr University BochumBochum 44801Germany

Nanomaterials are frequently employed in daily life goods,including health,textile,and food industry.A comprehensive picture is lacking on the role of the capping agents,added ligand molecules,in case of nanoparticle reactions and degradation in aqueous solutions,like surface waters or ***,we aim to elucidate the capping agent influence on nanoparticle reactivity probing two commonly employed capping agents citrate and polyvinylpyrrolidone(PVP).Their influence on silver nanoparticle(AgNP)transformation is studied,which is particularly important due to its application as an antimicrobial *** induce oxidation and reduction processes of AgNPs in halide solutions and we monitor the associated transformations of particles and capping agents by spectro-electrochemical surface-enhanced Raman spectroscopy(SERS).Raman bands of the capping agents are used here to track chemical changes of the nanoparticles under operando *** sparingly soluble and non-plasmon active silver salts(AgBr and AgCl)are formed under potential *** addition,we spectroscopically observe plasmon-mediated structural changes of citrate to cis-or trans-aconitate,while PVP is *** different behavior of the capping agents implies a change in the physical properties on the surface of AgNPs,in particular with respect to the surface ***,we showcase that reactions of the capping agents induced by different external stimuli,such as applied bias or laser irradiation,can be *** results demonstrate how SERS of capping agents can be exploited to operando track nanoparticle conversions in liquid *** approach is envisaged to provide a more comprehensive understanding of nanoparticle fates in complex liquid environments and varied redox conditions.

关键词： capping agent electrochemical surface-enhanced Raman spectroscopy silver nanoparticle nanoparticle reaction

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Ribosomal proteins:functions beyond the ribosome

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Journal of molecular Cell biology 2015年第2期7卷 92-104页

作者： Xiang Zhou Wen-Juan Liao Jun-Ming Liao Peng Liao Hua Lu Department of biochemistry&molecular biology and Tulane Cancer Center Tulane University School of MedicineNew OrleansLA 70112USA

Although ribosomal proteins are known for playing an essential role in ribosome assembly and protein translation,their ribosomeindependent functions have also been greatly *** the past decade,more than a dozen of ribosomal proteins have been found to activate the tumor suppressor p53 pathway in response to ribosomal *** addition,these ribosomal proteins are involved in various physiological and pathological *** review is composed to overview the current understanding of how ribosomal stress provokes the accumulation of ribosome-free ribosomal proteins,as well as the ribosome-independent functions of ribosomal proteins in tumorigenesis,immune signaling,and *** propose the potential of applying these pieces of knowledge to the development of ribosomal stress-based cancer therapeutics.

关键词： ribosomal protein ribosomal stress p53 MDM2 cancer immunity ribosomopathy

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In Memoriam: Professor Ray WU

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Science China(Life Sciences) 2010年第4期53卷 531-532页

作者： HUANG Bing-Ren National Laboratory of Medical molecular biology, Department of biochemistry and molecular biology, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100005, China 1. National Laboratory of Medical molecular biology Department of Biochemistry and Molecular Biology Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100005 China

During the Chinese New Year holidays in 2008, Professor Zhang Nai-Heng, former chair of the Department of biochemistry, Beijing Medical College, informed me of the sad news that Professor Ray Wu had passed away in Ith... 详细信息

关键词： In Memoriam very Professor Ray WU DNA

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Memories of Ray Wu by a Colleague

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Science China(Life Sciences) 2009年第2期52卷 133-134页

作者：杨碧瓘 molecular biology & Genetics at Cornell University

I first met Ray Wu in the spring of 1977 during my inter-view at Cornell where he was the chair of the Section of biochemistry, molecular and Cell biology. The meeting was brief and unremarkable but it achieved what it was meant to achieve. After I joined the Section of BMCB at Cornell as assistant professor that fall, I soon appreciated that

关键词：邓小平杨振宁李政道钱三强四化科举

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Carotenoids: New Applications of “Old” Pigments

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Phyton-International Journal of Experimental Botany 2021年第4期90卷 1041-1062页

作者： Stefan M.Kolašinac Zora P.DajićStevanović Sofija N.Kilibarda AleksandarŽ.Kostić Faculty of Agriculture University of BelgradeChair of AgrobotanyBelgrade11080Serbia Faculty of Agriculture University of BelgradeChair of Chemistry and BiochemistryBelgrade11080Serbia

Carotenoids represent a large group of mainly red,orange,and yellow natural metabolites mainly involved in regulation of many metabolic *** are beneficial for human *** study describes the importance,chemical composition and functioning of *** is well known that carotenoids support pigments acting in light absorbance mechanisms during photosynthesis,and are known to protect the chlorophyll molecules from oxidative stress and reactive oxygen species(ROS)*** are involved in signaling processes in plants,responses to environmental stresses,pollination,germination and reproduction,and development *** nutrients of strong antioxidant activity that is primarily linked to their polyene molecular structure,the carotenoids are reported as immune-enhancement and anticancer agents,which are also involved in prevention of eye-,gastric and neurocognitive disorders,and in regulation of obesity and *** the wide prospective applications of carotenoids as pharmaceuticals and nutraceuticals,there are some critical aspects associated with carotenoids’bioavailability and challenges in their *** mostly refers to the needs for identification and cloning of genes responsible for carotenoid biosynthesis and transformation and related development of transgenic carotenoid-rich *** the recent years,technologies of micro-and nanoencapsulation have addressed the needs of carotenoid entrapping to enhance their bioavailability,solubility and chemical stability,and to ensure the target delivery and manifestation of their strong antioxidant and other biological *** standard and some advanced analytic tools for carotenoid determination(e.g.,High performance liquid chromatography-HPLC,Liquid chromatography–mass spectrometry-LC-MS,Ultra high performance liquid chromatography-UHPLC,High-performance thin-layer chromatography-HPTLC and others),the vibrational spectroscopy techniques,primaril

关键词： Antioxidant and biological activity biosynthesis of carotenoids encapsulation raman spectroscopy role in plants

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Extracellular and intracellular functions of coiled-coil domain containing 3

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Journal of molecular Cell biology 2023年第6期15卷 1-10页

作者： Sara Omari Hyemin Lee Jieqiong Wang Shelya X.Zeng Hua Lu Department of biochemistry&molecular biology Tulane University School of MedicineNew OrleansLA 70112USA Tulane Cancer Center Tulane University School of MedicineNew OrleansLA 70112USA

Coiled-coil domain containing 3(CCDC3,also called Favine)is a highly conserved protein initially identified as a protein secreted from adipocytes and endothelial cells in the vascular system with endocrine-like ***,CCDC3 was also found to function as a nuclear tumor suppressor in breast *** it is still understudied,CCDC3,since its discovery,has been shown to play multiple roles in lipid metabolism,fatty liver,abdominal obesity,anti-inflammation,atherosclerosis,and *** essay is thus composed to offer an overview of these extracellular endocrine-like and intracellular(nuclear)functions of *** also discuss the possible underlying cellular and molecular mechanisms of CCDC3,the implications for clinical translation,and the remaining puzzles about this special molecule.

关键词： CCDC3 p53 MDM2 lipid metabolism p63 fatty liver(steatosis) tumor suppressor

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Age-dependent peculiarities modulation of activity of aldehyde scavenger enzymes in mitochondria of rat thigh muscle during stress

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Frontiers in biology 2016年第1期11卷 28-31页

作者： Vadim V. Davydov Evgenya R. Grabovetskaya Amjad Hamdallah chair of biochemistry State Academican LP.Pavlov Medical University Ryazan 390026 Russia chair of Medical Chemistry Kharkov National Medical University Kharkov 61022 Ukraine chair of biochemistry EN. Karazin Kharkov National University Kharkov 61077 Ukraine

The purpose of this study was a comparative investigation of activity of aldehyde scavenger enzymes in mitochondrial fraction of a thigh muscle in intact and immobilized rats of different ages. It has been shown that 12- month-old （adult） rats have high basal levels of aldehyde dehydrogenase, aldehyde reductase and glutathione transferase activity in mitochondrial fraction of thigh muscle. Aldehyde dehydrogenase activity increases during immobilization stress in adult rats. This change promote to enhance the effectiveness of utilization of carbonyl products of free radical oxidation in mitochondria of skeletal muscle of 12-month-old rats during stress. Immobilization of old and pubertal rats is accompanied by metabolic preconditions leading to accumulation of endogenous aldehydes in mitochondria, and, as a result, to the injury of muscular fibers and intensification of sarcopenia manifestations.

关键词： aldehydes mitochondria muscle immobilization stress aging

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