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Signal Transduction and Targeted Therapy 2023年第5期8卷 2085-2087页

作者： Jesús Hernández Freddy dehesa-Canseco Alma B.Vázquez-López Mónica Reséndiz-Sandoval Graciela Caire-Juvera Mario Solís-Hernández Olivia Valenzuela Bruno Gómez-Gil Verónica Mata-Haro centro de investigación en Alimentación y desarrollo A.C.HermosilloSonora83304Mexico Comisión México-Estados Unidos para la Prevención de la Fiebre Aftosa y otras enfermedades Exóticas de los Animales(CPA) SENASICASADERCiudad de México05010Mexico departamento de Ciencias Químico Biológicas Universidad de SonoraHermosilloSonora83000Mexico

dear Editor,The emergence of Omicron subvariants has required additional boosters to induce a highly neutralizing antibody response.1 However,the new Omicron subvariants BQ.1 and XBB,evade the humoral response induced by multiple mRnA vaccinations and infections.2,3 CansinoBio(Ad5-nCoV)is a single-dose adenovirus vector-based vaccine with high protection against severe disease4 but lower efficacy and antibody response than mRnA ***,hybrid immunity induced by infection plus vaccine or heterologous vaccines has produced a robust neutralizing antibody response.

关键词： vaccination vaccine immunity

Relationships between soil pollution by heavy metals and melanin-dependent coloration of a fossorial amphisbaenian reptile

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Integrative Zoology 2022年第4期17卷 596-607页

作者： JoséMARTÍn Pablo RECIO Gonzalo RODRÍGUEZ-RUIZ Isabel BARJA Eduardo GUTIÉRREZ Luis VGARCÍA departamento de Ecología Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain departamento de Zoología Facultad de BiologíaUniversidad Autónoma de MadridMadridSpain centro de investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain departamento de Biogeoquímica Ecología Vegetal y MicrobianaInstituto de Recursos Naturales y Agrobiología de SevillaCSICSevillaSpain

Melanin is the basis of coloration in many animals,and although it is often used in communication,thermoregulation,or camouflage,melanin has many other physiological *** example,in polluted habitats,melanin can have a detoxifying *** coloration would help to sequester in the skin the heavy metal contaminants from inside the body,which will be expelled to the exterior when the skin is ***,animals should have evolved more melanic colorations in more polluted habitats(“industrial melanism”hypothesis).We examined whether the fossorial amphisbaenian reptile,Trogonophis wiegmanni,is able to eliminate heavy metals,derived from soil pollution by seagull depositions,through sloughing its *** results suggest a covariation between levels of soil pollution by heavy metals and the concentration of heavy metals in the sloughed skins of *** suggests that amphisbaenians may expel heavy metals from their bodies when they slough the *** also tested whether amphisbaenians inhabiting soils with higher levels of heavy metal pollution had darker(melanin-dependent)body ***,contrary to predictions from the“industrial melanization”hypothesis,we found a negative relationship between soil pollution and proportions of melanic *** contradictory result could,however,be explained because heavy metals have endocrine disruption effects that increase physiological stress,and higher stress levels could result in decreased *** suggest that although amphisbaenians might have some detoxifying mechanism linked to melanin in the skin,this process might be negatively affected by stress and result ineffective under conditions of high soil pollution.

关键词： amphisbaenians coloration fossorial reptiles heavy metals melanin soil pollution

HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium

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World Journal of Gastroenterology 2022年第29期28卷 3886-3902页

作者： nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García norma Velázquez-Guadarrama Laboratorio de investigación en enfermedades Infecciosas Hospital Infantil de México Federico GómezMexico City 06720Mexico Posgrado en Biomedicina y Biotecnología Molecular Laboratorio de Producción y Control de BiológicosEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Laboratorio de Adquisición de Hierro Universidad Autónoma de la Ciudad MéxicoPosgrado Ciencias GenómicaMexico City 03100Mexico Laboratorio Central de Microscopía Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico centro de estudios económicos y sociales en salud Hospital Infantil de México Federico GómezMexico City 06720Mexico Laboratorio de investigación en Biología del desarrollo y Teratogénesis Experimental Hospital Infantil de México Federico GómezMexico City 06720Mexico

BACKGROUnD The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence *** To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) *** Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional *** HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium *** technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS *** analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein

关键词： Hypothetical protein HP0953 Adherence Helicobacter pylori Glycocalyx Virulence factor Persistence

Aiming for the end of the COVID-19 pandemic:the what,how,who,where,and when

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Chinese Medical Journal 2023年第1期136卷 1-3页

作者： Joan B.Soriano Alberto Infante Servicio de neumología Hospital Universitario de la PrincesaMadridSpain Facultad de Medicina Universidad Autónoma de MadridMadridSpain centro de investigación en Red de enfermedades Respiratorias(CIBERES) Instituto de Salud Carlos III(ISCIII)MadridSpain national School of Public Health Institute of Health Carlos IIIMadridSpain

Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)is a new virus,still full of *** of September 2022,there have been over 605 million confirmed cases of coronavirus disease 2019(COVID-19),including 6.5 million deaths reported to the World Health Organization(WHO).[1]SARS-CoV-2 is a bad virus,which often produces new variants that scape natural immunity and sometimes vaccines[Figure 1].

关键词： immunity acute respiratory

Common misconceptions about 5-aminosalicylates and thiopurines in inflammatory bowel disease

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World Journal of Gastroenterology 2011年第30期17卷 3467-3478页

作者： Javier P Gisbert María Chaparro Fernando Gomollón Gastroenterology Unit Hospital Universitario de La PrincesaInstituto de Investigación SanitariaPrincesa(IP)and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas28006 MadridSpain Gastroenterology Unit Hospital Clínico Universitario and Centro de Investigación Biomédica en Redde Enfermedades Hepáticasy DigestivasIACS50009 ZaragozaSpain

Misconceptions are common in the care of patients with inflammatory bowel disease(IBD).In this paper,we state the most commonly found misconceptions in clinical practice and deal with the use of 5-aminosalicylates and thiopurines,to review the related scientificevidence,and make appropriate *** of errors needs knowledge to avoid making such errors through ***,the amount of knowledge is increasing so quickly that one new danger is an overabundance of *** is a model of a very complex disease and our goal with this review is to summarize the key evidence for the most common daily clinical *** regard to the use of 5-aminosalicylates,the best practice may to be consider abandoning the use of these drugs in patients withsmall bowel Crohn's *** combined approach with oral plus topical 5-aminosalicylates should be the first-line therapy in patients with active ulcerative colitis;once-daily treatment should be offered as a first choice regimen due to its better compliance and higher *** regard to thiopurines,they seem to be as effective in ulcerative colitis as in Crohn's *** of thiopurines is a form of *** should probably be continued indefinitely because their withdrawal is associated with a high risk of *** is a safe alternative in patients with digestive intolerance or hepatotoxicity due to ***,thiopurine methyltransferase(TPMT)screening cannot substitute for regular monitoring because the majority of cases of myelotoxicity are not TPMT-related.

关键词：氨基水杨酸小肠炎症鸡传染性法氏囊病溃疡性结肠炎硫唑嘌呤临床实践科学证据

Variability in mentum deformities of Tanytarsus larvae(Diptera,Chironomidae)in a metal rich basin in northern Mexico

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Water Biology and Security 2022年第2期1卷 1-9页

作者： Orestes Carlos Bello-Gonzalez Perla Alonso-EguíaLis Cesar Arturo Ilizaliturri Hernandez norman Mercado-Silva centro de investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosCuernavacaMorelosMexico Instituto Mexicano de Tecnología del Agua JiutepecMorelosMexico Facultad de Medicina-centro de investigacion Aplicada en Ambiente y Salud Universidad Autonoma de San Luis PotosíCoordinacion para la Aplicacion de la Ciencia y la Tecnología-(CIACyT-CIAAS)San Luis PotosíMexico

Mentum deformities in chironomids have been commonly used as indicators of metal contamination in freshwater *** of these deformities suggests sublethal effects and can provide early signals of environmental *** anthropogenic metal pollution is known to lead to an increase in deformities in chironomids,natural background deformity incidence information is key to their effective use as biomonitoring *** we explore the incidence of deformities from 5000 Tanytarsus(Diptera,Chironomidae)menta in relation to water physicochemical,and sediment metal(Al,As,Cu,Fe,Mn,Pb,Zn)concentration data from numerous sites in the naturally metal-rich Sonora River(nW Mexico)obtained over a two-year *** metal concentrations were found in the upper *** salinity,total suspended solids and conductivity were found in the lower *** As and Cu were occasionally found above published threshold effect levels(TEL).The proportion of deformities(%D)was low(2.1%)and a generalized linear model only explained 25.36%of%D variability among samples;this model included several physicochemical *** only metal significantly related to deformities was *** significant spatial and temporal variability in all metal concentrations and other physicochemical parameters in the basin,we were unable to explain a strong relationship between metal concentration and deformity *** results,based on consistent%D quantification from 5000 samples from a single taxon,suggest that natural variation in metal concentrations,even when statistically significant,is not associated with notable variations in the incidence of deformities.

关键词： Macroinvertebrate Pollution Sonora river desert river Copper Arsenic

Forage offering and seasonal intake comparisons to evaluate European rabbit threat in nothofagus forests of southern Patagonia

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Ecological Processes 2022年第1期11卷 604-617页

作者： Alejandro Huertas Herrera Mónica Toro‑Manríquez Laura Borrelli María Vanessa Lencinas Guillermo Martínez Pastur centro de investigación en Ecosistemas de la Patagonia(CIEP) Camino Baguales s/n Km 4CoyhaiqueChile Ulterarius Consultores Ambientales y Científicos Ltda. Ignacio Serrano 420CoyhaiqueChile Instituto nacional de Tecnología Agropecuaria(InTA) EEA BarilocheModesta Victoria 44508400 San Carlos de BarilocheRío NegroArgentina Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas(CADIC)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Houssay 2009410 UshuaiaTierra del FuegoArgentina.

Background:The European rabbit(Oryctolagus cuniculus L.1758)was introduced into different regions of the world,generating significant trade‑offs that critically impacted native ***,we evaluate the rabbit’s forage intakes in three vegetation types(forests,shrublands,and grasslands)along the four seasons in a temperate forest landscape in Southern Patagonia and discuss the potential threats over native *** formulated the following questions:(i)what is the forage offer at each vegetation type?(ii)what is the rabbit’s forage intake and how it varied across the seasons along the year?and(iii)which vegetation types and plant life forms were more used according to the rabbit’s forage intakes?Methods:We censused understory vegetation to characterize the forage offer at each vegetation type and determined seasonal dietary intakes using microhistological analysis of *** plant species identified in the field were grouped according to life form classes(tree regeneration,shrubs,forbs,graminoids,orchids,ferns,bryophytes,and hemiparasites).Data were analysed through uni‑and multi‑variate analyses,determining relationships between forage offer and the rabbit’s forage ***:Forage intakes revealed changes in plant life form consumption across vegetation types,where intake pressure was considerably different for tree regeneration(p=0.001),graminoids(p=0.001),and hemiparasites(p=0.001).Besides,significant changes in consumption among seasons were detected for shrubs(p=0.001),ferns(p=0.030),and hemiparasites(p=0.002).Although many species play an important role in the rabbit’s forage intake networks(e.g.,Chiliotrichum diffusum,Holcus lanatus),the strongest intake linkages were found in exotic grasses(e.g.,Poa pratensis and Festuca sp.),native hemiparasites(e.g.,Misodendrum sp.),native shrubs(e.g.,Empetrum rubrum),and native trees(e.g.,nothofagus sp.).The summer and autumn seasons presented higher intake compared to the winter and spring seasons.F

关键词： Forest ecology Oryctolagus cuniculus Plant-animal interaction Vegetation type Herbivory Habitat use

Analytical and technological aspects of amylose inclusion complexes for potential applications in functional foods

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Food Bioscience 2022年第3期47卷 17-31页

作者： Andrea E.Di Marco Vanesa Y.Ixtaina Mabel C.Tomás centro de investigación y desarrollo en Criotecnología de Alimentos CIDCA CCT La Plata CONICETFacultad de Ciencias Exactas FCE-UNLPCICPBAcalle 47 y 1161900La PlataArgentina Facultad de Ciencias Agrarias y Forestales FCAyF-UnLP calle 60 y 1191900La PlataArgentina

The linear component of starch,amylose,has the ability to interact with hydrophobic molecules forming inclusion complexes(ICs).These structures have gained a particular interest for potential food applications,either as dietary fiber or as delivery systems of bioactive *** the second case,the complexation of sensitive molecules is directed to protect them from processing,storage and stomach conditions and to guarantee a sustained release in the gastrointestinal *** present review covers the analytical and technological aspects of inclusion complexes,with focus on their potential application in the development of functional *** was addressed by first explaining the methodologies used for the analytical assessment of their structural,thermal,and functional properties,followed by the study of the functionality of ICs as carrier agents of different bioactive compounds and food ingredients,including alpha-lipoic acid,α-linolenic and linoleic fatty acids,conjugated linoleic acid,ascorbyl palmitate,phenolic compounds,and *** also covers the application of ICs in food products and the analysis of the potential industrial scalability of the formation *** analytical methodologies allowed a complete characterization of the *** structures have shown suitable functional properties as delivery systems of the bioactive compounds and flavors covered in this *** incorporation of ICs in food has led to the development of products with improved nutritional and/or functional *** successful formation of complexes using methods suitable for an industrial scale represents promising preliminary results to achieve the scalability of the ICs production in the near future.

关键词： Amylose inclusion complex delivery system Bioactive compound V-type structure

Caerulin-induced pancreatitis in rats: Histological and genetic expression changes from acute phase to recuperation

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World Journal of Gastroenterology 2006年第25期12卷 3999-4003页

作者： Javier Magaa-Gómez Guillermo López-Cervantes Ana María Calderón de la Barca departamento de nutrición centro de investigación en Alimentación y desarrollo A.C. HermosilloSonoraMéxicoDepartamento de Patología Hospital Infantil del Estado de SonoraHermosilloSonoraMéxicoDepartamento de Nutrición Centro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico

瞄准：为了学习组织学、联系胰腺炎的蛋白质 mRnA 累积，在老鼠从导致 caerulin 的胰腺炎的尖锐阶段胰改变到恢复。方法：尖锐胰腺炎被 caerulein 在男 Wistar 老鼠导致并且列在后面在上面为 90 d 由组织学并且胰的 mRnA 分析。胰在 0 ... 详细信息

瞄准：为了学习组织学、联系胰腺炎的蛋白质 mRnA 累积，在老鼠从导致 caerulin 的胰腺炎的尖锐阶段胰改变到恢复。方法：尖锐胰腺炎被 caerulein 在男 Wistar 老鼠导致并且列在后面在上面为 90 d 由组织学并且胰的 mRnA 分析。胰在 0 点被把， 9， 24 h 并且 3， 5， 15， 30， 60， 90 d 正式就职以后。浮肿(E) ， polymorphonuclear neutrophil (PMn ) 渗入，细胞质的空泡形成(V) ，酶原小粒弄空(ZD ) 和腺泡组织的破坏(广告) 是评估的用显微镜。联系胰腺炎的蛋白质(奶头) 和 L13A mRnAs 的累积被即时 PCR 确定。结果：主要组织学的变化出现在为 PMn 渗入和细胞质的 V 正式就职以后的 9 h 在为 E 和 ZD 的 24 h 和 3 d 分别地。所有参数在 5 d 以后被恢复，除了推迟了超过 30 d 的 ZD。主要广告在 15 d 以后被观察，值在 30 d 以后回到了正常。同样到组织学的变化， PAP mRnA 的累积在 24 h 与最高的累积在 9 h 被增加，差别消失在 5 d 以后。结论：从尖锐阶段发生到胰的胰腺炎，新生和重新区别的恢复并且奶头表示是只胰腺炎的尖锐回答。

关键词：雨蛙肽胰腺炎组织遗传疾病

Precision medicine in pantothenate kinase-associated neurodegeneration

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neural Regeneration Research 2019年第7期14卷 1177-1185页

作者： Mónica álvarez-Córdoba Marina Villanueva-Paz Irene Villalón-García Suleva Povea-Cabello Juan M.Suárez-Rivero Marta Talaverón-Rey Javier Abril-Jaramillo Ana Belén Vintimilla-Tosi José A.Sánchez-Alcázar centro Andaluz de Biología del desarrollo(CABD-CSIC-Universidad Pablo de Olavide) and Centro de Investigación Biomédica en Red:Enfermedades RarasInstituto de Salud Carlos Ⅲ centro de neurología Avanzada centro Civet

neurodegeneration with brain iron accumulation is a broad term that describes a heterogeneous group of progressive and invalidating neurologic disorders in which iron deposits in certain brain areas,mainly the basal *** predominant clinical symptoms include spasticity,progressive dystonia,Parkinson's disease-like symptoms,neuropsychiatric alterations,and retinal *** the neurodegeneration with brain iron accumulation disorders,the most frequent subtype is pantothenate kinase-associated neurodegeneration(PKAn) caused by defects in the gene encoding the enzyme pantothenate kinase 2(PAnK2)which catalyzed the first reaction of the coenzyme A biosynthesis *** there is no effective treatment to prevent the inexorable course of these *** aim of this review is to open up a discussion on the utility of using cellular models derived from patients as a valuable tool for the development of precision medicine in ***,we have described that dermal fibroblasts obtained from PKAn patients can manifest the main pathological changes of the disease such as intracellular iron accumulation accompanied by large amounts of lipofuscin granules,mitochondrial dysfunction and a pronounced increase of markers of oxidative *** addition,PKAn fibroblasts showed a morphological senescence-like ***,pantothenate supplementation,the substrate of the PAnK2 enzyme,corrected all pathophysiological alterations in responder PKAn fibroblasts with low/residual PAnK2 enzyme ***,pantothenate treatment had no favourable effect on PKAn fibroblasts harbouring mutations associated with the expression of a truncated/incomplete *** correction of pathological alterations by pantothenate in individual mutations was also verified in induced neurons obtained by direct reprograming of PKAn *** observations indicate that pantothenate supplementation can increase/stabilize the expression levels of PAnK2 in s

关键词： neurodegeneration with brain iron accumulation pantothenate kinase-associated neurodegeneration pantothenate kinase 2 pantothenate induced neurons precision medicine induced neuron fibroblast