检索结果-南通市图书馆

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

neural Regeneration Research 2022年第1期17卷 31-37页

作者： Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre Unidad de Evaluación Preclínica Unidad de Biotecnología Médica y FarmacéuticaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Instituto de neurociencias IdISSCHospital Clínico San CarlosMadridEspaña Biochemistry and Molecular Genetics department University of AlabamaBirminghamAlabama Unidad de Biotecnología Industrial Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico centro Universitario de los Altos Universidad de GuadalajaraGuadalajaraMéxico

The presenilin genes(PSen1 and PSen2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressive disease *** 1 is the catalytic core of theγ-secretase complex that conducts the intramembranous proteolytic excision of multiple transmembrane proteins like the amyloid precursor protein,notch-1,n-and E-cadherin,LRP,Syndecan,delta,Jagged,CD44,ErbB4,and *** 1 plays an essential role in neural progenitor maintenance,neurogenesis,neurite outgrowth,synaptic function,neuronal function,myelination,and ***,an imbalance caused by mutations in presenilin 1/γ-secretase might cause aberrant signaling,synaptic dysfunction,memory impairment,and increased Aβ42/Aβ40 ratio,contributing to neurodegeneration during the initial stages of Alzheimer’s disease *** review focuses on the neuronal differentiation dysregulation mediated by PSen1 mutations in Alzheimer’s ***,we emphasize the importance of Alzheimer’s disease-induced pluripotent stem cells models in analyzing PSen1 mutations implication over the early stages of the Alzheimer’s disease pathogenesis throughout neuronal differentiation impairment.

关键词： familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation notch presenilin 1 PSen1 mutations γ-secretase complex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

new insights into the relevance of mobile DnA to cancer resistance in blind mole rats:new lessons for cancer therapy

引用

Cellular & Molecular Immunology 2022年第4期19卷 458-459页

作者： Victor M.Arce Jose A.Costoya Molecular Oncology Laboratory MOL Departamento de FisioloxíaCentro Singular de Investigación en Medicina Molecular e Enfermidades Crónicas(CiMUS)Facultade de MedicinaUniversidade de Santiago de CompostelaInstituto de Investigación Sanitaria de Santiago de Compostela(IDIS)15782Santiago de CompostelaSpain

Although mammals differ substantially in their cancer incidence rates and in the importance of age as a cancer risk factor,there is a scaling of cancer incidence to the lifespan in most *** evolution has selected strategies that maximize reproductive success,which include the development of efficient mechanisms to defer the initiation of cancer until postreproductive age[1].Owing to this,cancers are very rare among wild animals(which do not typically live beyond their reproductive ages).

关键词： cancer insight resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer cells escape the immune system by increasing stemness through epigenetic reprogramming

引用

Cellular & Molecular Immunology 2023年第1期20卷 6-7页

作者： Jose A.Costoya Victor M.Arce Molecular Oncology Laboratory MOL Departamento de FisioloxíaCentro Singular de Investigación en Medicina Molecular e Enfermidades Crónicas(CiMUS)Facultade de MedicinaUniversidade de Santiago de CompostelaInstituto de Investigación Sanitaria de Santiago de Compostela(IDIS)15782Santiago de CompostelaSpain

Cancer stem cells(CSCs),also known as tumor initiating cells,are a minority subpopulation of undifferentiated cancerous cells within the entire tumor that hold self-renewal capacity and differentiation *** are critical for tumor progression,heterogeneity and metastasis and play a major role in chemo-and radiation-resistance and tumor recurrence[1].Although the molecular mechanisms underlying the ability of CSCs to give rise to new tumors and promote resistance to many cancer therapies are not completely understood,increasing knowledge suggests potential roles for these cells in the evasion of immune surveillance[2,3].

关键词： Cancer programming initiating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In Silico Pipeline to Identify Tumor‑Specific Antigens for Cancer Immunotherapy Using Exome Sequencing Data

引用

Phenomics 2023年第2期3卷 130-137页

作者： Diego Morazán‑Fernández Javier Mora Jose Arturo Molina‑Mora Caja Costarricense de Seguro Social San José10104Costa Rica centro de investigación de enfermedades Tropicales Centro de Investigación en Cirugía y Cáncerand Facultad de MicrobiologíaUniversidad de Costa RicaSan José2060Costa Rica

Tumor-specific antigens or neoantigens are peptides that are expressed only in cancer cells and not in healthy *** of these molecules can induce an immune response,and therefore,their use in immunotherapeutic strategies based on cancer vaccines has been extensively *** based on these approaches have been triggered by the current high-throughput DnA sequencing ***,there is no universal nor straightforward bioinformatic protocol to discover neoan-tigens using DnA sequencing ***,we propose a bioinformatic protocol to detect tumor-specific antigens associated with single nucleotide variants(SnVs)or“mutations”in tumoral *** this purpose,we used publicly available data to build our model,including exome sequencing data from colorectal cancer and healthy cells obtained from a single case,as well as frequent human leukocyte antigen(HLA)class I alleles in a specific *** data from Costa Rican Central Valley population was selected as an *** strategy included three main steps:(1)pre-processing of sequencing data;(2)variant calling analysis to detect tumor-specific SnVs in comparison with healthy tissue;and(3)prediction and characterization of peptides(protein fragments,the tumor-specific antigens)derived from the variants,in the context of their affinity with frequent alleles of the selected *** our model data,we found 28 non-silent SnVs,present in 17 genes in chromosome *** protocol yielded 23 strong binders peptides derived from the SnVs for frequent HLA class I alleles for the Costa Rican *** the analyses were performed as an example to implement the pipeline,to our knowledge,this is the first study of an in silico cancer vaccine using DnA sequencing data in the context of the HLA *** is concluded that the standardized protocol was not only able to identify neoantigens in a specific but also provides a complete pipeline for the eventual design of cancer vaccines using

关键词： neopeptide Colorectal cancer Cancer vaccine neoantigens Human leukocyte antigen Costa Rica

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discovery of gargantulides B and C,new 52-membered macrolactones from Amycolatopsis *** absolute stereochemistry of the gargantulide family

引用

Organic Chemistry Frontiers 2022年第2期9卷 462-470页

作者： Daniel Carretero-Molina Francisco Javier Ortiz-López Tetiana Gren Daniel Oves-Costales Jesús Martín Fernando Román-Hurtado Tue Sparholt Jorgensen Mercedes de la Cruz Caridad Díaz Francisca Vicente Kai Blin Fernando Reyes Tilmann Weber Olga Genilloud Fundación MEDInA Centro de Excelencia en Investigación de Medicamentos Innovadores en AndalucíaAvda.del Conocimiento 3418016 ArmillaGranadaSpain The novo nordisk Foundation Center for Biosustainability Technical University of DenmarkKemitorvetbuilding 2202800 Kgs.LyngbyDenmark

Gargantulides B and C,two new and highly complex 52-membered glycosylated macrolactones,were isolated from Amycolatopsis *** CA-230715 during an antibacterial screening *** structures of these giant macrolides were elucidated by 2D nMR spectroscopy and shown to be related to gargantulide A,although containing additional β-glucopyranose and/orα-arabinofuranose monosaccharides separately attached to their *** sequencing allowed the identification of a strikingly large 216 kbp biosynthetic gene cluster,among the largest type Ⅰ PKS clusters described so far,and the proposal of a previously unreported biosynthetic pathway for gargantulides *** absolute configurations of gargantulides B and C were assigned based on a combination of nMR and bioinformatics analysis of ketoreductase and enoylreductase domains within the multimodular type Ⅰ *** addition,the absolute stereochemistry of gargantulide A has now been revised and *** B and C display potent antibacterial activity against a set of drug-resistant Gram-positive bacteria and moderate activity against the clinically relevant Gram-negative pathogen Acinetobacter baumannii.

关键词： absolute membered backbone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Usefulness of the COnUT index upon hospital admission as a potential prognostic indicator of COVID-19 health outcomes

引用

Chinese Medical Journal 2022年第2期135卷 187-193页

作者： Adrian K.Bengelloun Guillermo J.Ortega Julio Ancochea Ancor Sanz-Garcia Diego A.Rodriguez-Serrano Guillermo Fernandez-Jimenez Rosa Giron Elena Avalos Joan B.Soriano J.Ignacio de Ulibarri Facultad de Medicina Universidad Autónoma de MadridMadridSpain Unidad de Análisis de Datos Instituto de Investigación Sanitaria del Hospital de la PrincesaMadridSpain Servicios de neumología Admisión y Documentación ClínicaCuidados Intensivos y Nutrición y DietéticaHospital Universitario de La PrincesaMadridSpain centro de investigación en Red de enfermedades Respiratorias(CIBERES) Instituto de Salud Carlos III(ISCIII)MadridEspañaSpain

Background:In-hospital mortality in patients with coronavirus disease 2019(COVID-19)is *** prognostic indices are needed to identify patients at high-risk of COVID-19 health *** aimed to determine the usefulness of the COntrolling nUTritional status(COnUT)index as a potential prognostic indicator of mortality in COVID-19 patients upon hospital ***:Our study design is of a retrospective observational study in a large cohort of COVID-19 *** addition to descriptive statistics,a Kaplan-Meier mortality analysis and a Cox regression were performed,as well as receiver operating curve(ROC).Results:From February 5,2020 to January 21,2021,there was a total of 2969 admissions for COVID-19 at our hospital,corresponding to 2844 ***,baseline(within 4 days of admission)COnUT index could be scored for 1627(57.2%)***’age was 67.3±16.5 years and 44.9%were *** COnUT severity distribution was:194(11.9%)normal(0-1);769(47.2%)light(2-4);585(35.9%)moderate(5-8);and 79(4.9%)severe(9-12).Mortality of 30 days after admission was 3.1%in patients with normal risk COnUT,9.0%light,22.7%moderate,and 40.5%in those with severe COnUT(Pn increased risk of death associated with a greater baseline COnUT stage was sustained in a multivariable Cox regression model(Pn increasing baseline COnUT stage was associated with a longer duration of admission,a greater requirement for the use of non-invasive and invasive mechanical ventilation,and other clinical outcomes(all PnUT for mortality had an area under the curve(AUC)and 95%confidence interval of 0.711(0.676-0746).Conclusion:The COnUT index upon admission is potentially a reliable and independent prognostic indicator of mortality and length of hospitalization in COVID-19 patients.

关键词： Admission Clinical risk COnUT COVID-19 Prognosis Score

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Digestibility,Antioxidant and Anti-Inflammatory Activities of Pecan nutshell(Carya illioinensis)Extracts

引用

Journal of Renewable Materials 2022年第10期10卷 2569-2580页

作者： María Janeth Rodríguez-Roque Carmen Lizette del-Toro-Sánchez Janet Madeline Chávez-Ayala Ricardo Iván González-Vega Liliana Maribel Pérez-Pérez Esteban Sánchez-Chávez nora AideéSalas-Salazar Juan Manuel Soto-Parra Rey David Iturralde-García María Antonia Flores-Córdova Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaChihuahuaMéxico Universidad de Sonora Rosales y Niños Héroes S/NHermosilloSonMéxico centro de investigación en Alimentación y desarrollo A.C.Unidad DeliciasDeliciasChihuahuaMéxico

Phenolic compounds are related to high biological activity,avoiding oxidation in food and human *** are by-products derived from the pecan nut processing that contain important amounts of phenols which biological activity must be *** research aimed to evaluate the antioxidant(DPPH,ABTS,FRAP and hemolysis)and anti-inflammatory activities of shell extracts from pecan nuts harvested during the crop production cycle 2018 and 2019,as well as the in vitro digestibility of their phenolic compounds,including *** showed that extracts from the crop production cycle 2018 obtained the highest yield,while those from 2019 contained the highest concentration of phenolic compounds,flavonoids and antioxidant capacity determined by DPPH(22.96 mmol ET),ABTS(91.55 mmol ET)and inhibition of hemolysis(92.12%).The anti-inflammatory activity exhibited an inhibition of the elastase enzyme up to 50 min and the bioaccessibility of phenolic compounds reached up to 32%.These results showed that pecan nutshell extracts are an important source of biologically active compounds,thus,they are suitable to be used as commodities in different fields such as agricultural,food and pharmaceutical *** studies must be carried out in order to elucidate the activity of nutshell extracts within in vivo systems.

关键词： Anti-inflammatory activity antioxidants digestibility shell phenolic compounds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unraveling the morphological patterns of a subantarctic eelpout:a geometric morphometric approach

引用

Integrative Zoology 2023年第2期18卷 372-384页

作者： Fernanda S.ORREGO Mathias HÜnE Hugo A.BenÍTEZ Mauricio F.LAnDAETA Laboratorio de Ictiología e Interacciones Biofísicas(LABITI) Instituto de BiologíaFacultad de CienciasUniversidad de ValparaísoValparaísoChile centro de investigación para la Conservación de los Ecosistemas Australes(ICEA) Punta ArenasChile Laboratorio de Ecología y Morfometría Evolutiva Centro de Investigación de Estudios Avanzados del MauleUniversidad Católica del MauleTalcaChile centro de Observación Marino para Estudios de Riesgos del Ambiente Costero(COSTA-R) Universidad de ValparaísoViña del MarChile Millennium nucleus for Ecology and Conservation of Temperate Mesophotic Reef Ecosystems(nUTME) Millennium Institute Biodiversity of Antarctic and Subantarctic Ecosystems(BASE) SantiagoChile

Phenotypic variation in organisms depends on the genotype and the environmental constraints of the habitat that they ***,for marine species inhabiting contrasting aquatic conditions,it is expected toﬁnd covari-ation between the shape and its spatial *** studied the morphology of the head and cephalic sensory canals of the eelpout Austrolycus depressiceps(4.5–22.5 cm TL)across its latitudinal distribution in South Paciﬁc(45°S–55°S).Geometric morphometric analyses show that the shape varied from individuals with larger snout and an extended suborbital canal to individuals with shorter snouts and frontally compressed suborbital *** was size variation across the sampled populations,but that size does not have a clear latitudinal *** 8%of the shape variation relates to this size variation(allometry),represented by a decrease in the relative size of the eye,and a depression of the posterior margin of the *** were spatial differences in the shape of the head,but these differences were probably caused by allometric ***,2 of the canals of the cephalic lateralis pores and the head shape showed modularity in its *** study shows that the morphology of marineﬁsh with a shallow distribution varies across distances of hundreds of kilometers(i.e.,phenotypic modulation).

关键词： Austrolycus depressiceps geometric morphometrics morphology phenotype spatial distribution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Seasonal variation and chemical composition of particulate matter： A study by XPS, ICP-AES and sequential microanalysis using Raman with SEM/EDS

引用

Journal of environmental Sciences 2018年第12期30卷 32-49页

作者： Lucy T.González Francisco E.Longoria-Rodríguez Margarita Sánchez-Domínguez Cesar Leyva-Porras Karim Acuna-Askar Boris I.Kharissov Alejandro Arizpe-Zapata Juan M.Alfaro-Barbosa Universidad Autónoma de nuevo León Facultad de Ciencias Químicas Laboratorio de Química Analítica AmbientalCódigo Postal 64570MaonterreyN.L.Mexico centro de investigación en materiales avanzados SC Unidad MonterreyAlianza Notre 202 Código Postal 66628 Apodaca Nueuo León Mexico centro de investigación en materiales avanzados SC Miguel de Cervantes # 120 Código Postal 31109 Chihuahua Chih. Mexico Universidad Autónoma de nuevo León Facultad de Medicina Laboratorio de Biorremediación AmbientalCódigo Postal 64460 MonterreyN.L. Mexico

During the winter period（January–March 2016）, the total suspended particles（TSP） and particulate matter smaller than 2.5 μm（PM2.5） were characterized by the application of various analytical techniques in four zones of the Metropolitan Area of Monterrey in Mexico. To evaluate the seasonal variation of some elements in the particulate matter, the results of this study were compared with those obtained during the summer season（July–September 2015）. The speciation of the C_（1s） signal by X-ray photoelectron spectroscopy revealed the contribution of aromatic and aliphatic hydrocarbons as the main components in both seasons. Conversely, carboxylic groups associated with biogenic emissions were detected only in winter. The percentages of SO_4^（2-） ions were lower in winter, possibly caused by the decrease in the solar radiation, and relative humidity recorded. The results of the ICP analysis revealed that Fe, Zn and Cu were the most abundant metals in both TSP and PM2.5 in the two seasons. There were significant seasonal variations for concentrations of As, ni and Zn in the urban area and for Fe, As, Cd, ni and Zn in the industrial zone. This was attributed to the greater burning of fuels as well as to an increase in vehicular traffic, the effect of thermal inversion and changes in some meteorological parameters. The results of the sequential microanalysis by Raman spectroscopy and SEM/EDS allowed observation of deposits of carbonaceous material on the particles and to perform the speciation of particles rich in Fe and Pb, which helped infer their possible emission sources.

关键词： Seasonal variation Total suspended particles PM2.5 X-ray photoelectron spectroscopy Micro-Raman spectroscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

AASLD practice guidance on drug,herbal,and dietary supplement-induced liver injury:also useful for hepatobiliary surgeons

引用

Hepatobiliary Surgery and nutrition 2023年第5期12卷 746-751页

作者： Jose María Pinazo-Bandera Miren García-Cortés Raúl J.Andrade Service of Gastroenterology and Hepatology University Hospital Virgen de la VictoriaInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BionandUniversidad de MálagaMálagaSpain centro de investigación Biomédico en Red enfermedades Hepáticas y Digestivas(CIBERehd) MadridSpain

Drug-induced liver injury(DILI)is a term used to describe an unexpected liver reaction to drugs,but also to herbal products and dietary supplements(HDS).In the current therapeutic armamentarium,only a small number of available drugs are still capable of causing liver damage in *** include,in addition to paracetamol-the prototypical example of this group-niacin(now rarely used to treat hypercholesterolaemia),intravenous methotrexate and probably ketamine(an intravenous hypnotic used in critically ill patients for rapid sequence induction)(1).

关键词： Drug-induced liver injury(DILI) hepatotoxicity causality assessment Revised Electronic Causality Assessment Method(RECAM)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：