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novel strategies to tailor the photocatalytic activity of metal–organic frameworks for hydrogen generation: a mini-review

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Frontiers in energy 2022年第5期16卷 734-746页

作者： Luis A.ALFOnSO-HERRERA Leticia M.TORRES-MARTInEZ J.Manuel MORA-HERnAndeZ Universidad Autónoma de nuevo León UANLFacultad de Ingeniería CivilDepartamento de Ecomateriales y EnergíaAv.Universidad S/N Ciudad UniversitariaSan Nicolás de los GarzaNuevo León 66455México centro de investigación en materiales avanzados S.C.(CIMAV)Miguel de Cervantes No.120.Complejo Ind.ChihuahuaChihuahuaChih 31136México COnACYT-Universidad Autónoma de nuevo León UANLFacultad de Ingeniería CivilDepartamento de Ecomateriales y EnergíaAv.Universidad S/N Ciudad UniversitariaSan Nicolás de los GarzaNuevo León 66455México

This review provides a recompilation of the most important and recent strategies employed to increase the efficiency of metal-organic framework(MOF)-based systems toward the photocatalytic hydrogen evolution(PHE)reaction through specific strategies:tailoring the photocatalytic activity of bare MOFs and guest@MOF composites,formation of heterojunctions based on MOFs and various photocatalysts,and inorganic photocatalysts derived from *** to the data reported in this mini-review,the most effective strategy to improve the PHE of MOFs relies on modifying the linkers with new secondary building units(SBUs).Although several reviews have investigated the photocatalytic activity of MOFs from a general point of view,many of these studies relate this activity to the physicochemical and catalytic properties of ***,they did not consider the interactions between the components of the photocatalytic *** study highlights the effects of strength of the supramolecular interactions on the photocatalytic performance of bare and MOF-based materials during PHE.A thorough review and comparison of the results established that metal-nanoparticle@MOF composites have weak van der Waals forces between components,whereas heterostructures only interact with MOFs at the surface of bare *** material derivatives from MOFs,we found that pyrolysis destroyed some beneficial properties of MOFs for ***,we conclude that adding SBUs to organic linkers is the most efficient strategy to perform the PHE because the SBUs added to the MOFs promote synergy between the two materials through strong coordination bonds.

关键词： metal-organic frameworks(MOFs) photocatalytic hydrogen evolution MOF heterojunctions materials derived from MOFs bandgap recombination

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Effects of resveratrol and other polyphenols in hepatic steatosis

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World Journal of Gastroenterology 2014年第23期20卷 7366-7380页

作者： Leixuri Aguirre Maria Puy Portillo Elizabeth Hijona Luis Buja nutrition and Obesity Group Department of Nutrition and Food ScienceUniversity of Basque Country (UPV/EHU) and Centro de Investigación Lucio Lascaray01006 VitoriaSpain centro de investigación Biomédica en Fisiopatología de la Obesidad y nutrición (CIBERobn) Instituto de Salud Carlos Ⅲ01006 VitoriaSpain department of Gastroenterology University of the Basque Country (UPV/EHU)Donostia Hospital and Biodonostia Institute20014 San SebastiánSpain centro de investigación Biomédica en enfermedades Hepáticas (CIBERehd) Instituto de Salud Carlos Ⅲ20014 San SebastianSpain

non-alcoholic fatty liver disease covers a wide spectrum of liver pathologies which range from simple steatosis to non-alcoholic *** are members of a very large family of plant-derived compounds that can have beneficial effects on human health,and thus their study has become an increasingly important area of human nutrition *** aim of the present review is to compile published data concerning the effects of both isolated polyphenols as well as polyphenol extracts,on hepatocyte and liver fat accumulation under different steatosis-inducing *** results reported clearly show that this group of biomolecules is able to reduce fat accumulation,but further studies are needed to establish the optimal dose and treatment period *** regard to the potential mechanisms of action,there is a good *** anti-lipidogenic effect of polyphenols is mainly due to reduced fatty acid and triacylglycerol synthesis,increased in fatty acid oxidation,and reduced of oxidative stress and *** a general conclusion,it can be stated that polyphenols are biomolecules which produce hepatoprotective *** date,these beneficial effects have been demonstrated in cultured cells and animal ***,studies performed in humans are needed before these molecules can be considered as truly useful tools in the prevention of liver steatosis.

关键词： Polyphenols Resveratrol Quercetin liver Steatosis non-alcoholic fatty liver disease

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Long-term outcome of chronic hepatitis C patients with sustained virological response to peginterferon plus ribavirin

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World Journal of Gastroenterology 2011年第4期17卷 493-498页

作者： María Trapero-Marugán Jorge Mendoza María Chaparro Leticia González-Moreno José Andrés Moreno-Monteagudo María Jesús Borque Ricardo Moreno-Otero Gastroenterology-Hepatology department University Hospital La Princesa and Princesa Research Institute Autonomous University of Madrid and CIBERehd (Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas)

AIM: To assess the clinical, biochemical and virological long-term outcome in chronic hepatitis C (CHC) patients with a sustained virological response (SVR) after peginterferon (PEG-IFn) plus ribavirin combination therapy. METHODS: One hundred and fifty three patients with a SVR after treatment with PEG-IFn plus ribavirin were included in a 5-year follow-up study in a single Spanish center, based on standard clinical practice. Clinical anamnesis, biochemical analysis, hepatitis C virus RnA and alpha-fetoprotein measurement, ultrasonography and transient elastography were performed annually. RESULTS: The mean follow-up period of the 153 patients was 76 ± 13 mo after they obtained a SVR. Five patients (3.26%) presented with cirrhosis before treatment and 116 (75.8%) had genotype 1. no patient showed evidence of hepatic decompensation. One patient (0.65%) developed a hepatocellular carcinoma at month 30 after achieving SVR. There were no virological relapses during this follow-up period. Persistently elevated alanine aminotransferase was found in only one patient (0.65%). At the end of the 5-year follow-up, the mean value of transient elastography was 7 ± 4.3 kPa (F1). There were no deaths and no other tumors. COnCLUSIOn: The long-term outcome of 153 CHC patients with SVR to PEG-IFn plus ribavirin was good. no evidence of a virological relapse was seen. One patient (0.65%) developed a hepatocellular carcinoma.

关键词： Chronic hepatitis C Peginterferon Ribavirin Sustained virological response Long-term effects

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Influence of ZnO nanoparticles on the microstructure of a CoCrFeMoni matrix via powder metallurgy

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International Journal of Minerals,Metallurgy and Materials 2019年第11期26卷 1467-1476页

作者： C.D.Gómez-Esparza A.Duarte-Moller C.López-Díaz de León R.Martínez-Sánchez J.F.Hernández-Paz C.A.Rodríguez-González centro de investigación en materiales avanzados(cimav) laboratorio nacional de nanotecnologíamiguel de cervantes no.120chihuahua 31136chi8.mexico facultad de ingeniería civil mecánica e industrialuniversidad de la salle bajíoav.universidad 602león 37150gto.mexico instituto de ingeniería y tecnología universidad autónoma de ciudad juárez(uacj)av.del charro 450 nortec4.juárez 32310chi8.mexico

In the last decade,extensive research has been carried out on the microstructural behavior of high-entropy alloys(HEA),for which the in-situ formation of nanoparticles has been ***,studies of the incorporation of nanoparticles in HEA have been rarely *** this work,the addition of zinc oxide nanoparticles(ZnO nP)as reinforcement in a CoCrFeMoni high-entropy alloy matrix,as well as the morphological,structural,and microstructural evolution of composites synthesized via powder metallurgy,were *** electron microscopy and X-ray diffraction analysis were performed in order to study the microstructural and phase characterization of the *** sintering,it was found that the ZnO nP addition(0.5 wt%,1 wt%and 2 wt%)had a significant influence on the microstructure and hardness of the CoCrFeMoni high-entropy *** bonding among metal particles was promoted with the additions of Zn O nP.A reduction in porosity as a function of ZnO nP content was also *** microhardness results showed that the composite reached its highest reinforcement in bulk samples with 1 wt%ZnO nP(HV 870),which represented a 20%improvement over the unreinforced HEA matrix.

关键词： high-entropy alloy mechanical alloying nanoparticles composites

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network-centric medicine for peripheral nerve injury:treating the whole to boost endogenous mechanisms of neuroprotection and regeneration

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neural Regeneration Research 2019年第7期14卷 1122-1128页

作者： David Romeo-Guitart Caty Casas Institut de neurociències(Inc) and department of Cell Biology Physiology and ImmunologyUniversitat Autònoma de Barcelona (UAB) & Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED)

Peripheral nerve injuries caused by accidents may lead to paralysis,sensory disturbances,anaesthesia,and lack of autonomic *** recovery after disconnection of the motoneuronal soma from target tissue with proximal rupture of axons is determined by several factors:motoneuronal soma viability,proper axonal sprouting across inhibitory zones and elongation toward specific muscle,effective synapse contact rebuilding,and prevention of muscle ***,such as adjuvant drugs with pleiotropic effects,that promote functional recovery after peripheral nerve injury are *** this aim,we designed a drug discovery workflow based on a network-centric molecular vision using unbiased proteomic data and neural artificial computational *** focus is on boosting intrinsic capabilities of neurons for neuroprotection;this is in contrast to the common approach based on suppression of a pathobiological pathway known to be associated with disease *** our workflow,we discovered neuroheal,a combination of two repurposed drugs that promotes motoneuronal soma neuroprotection,is anti-inflammatory,enhances axonal regeneration after axotomy,and reduces muscle *** drug discovery workflow has thus yielded a therapy that is close to its clinical application.

关键词： motoneuron neurodegeneration axonal regeneration muscle atrophy systems biology neuroheal PI3K/AKT sirtuin 1 motor function recovery

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KCl:Eu^(2+) as a solar UV-C radiation dosimeter. Optically stimulated luminescence and thermoluminescence analyses

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Journal of Rare Earths 2009年第4期27卷 579-583页

作者： I.Aguirre de Cárcer H.L.D'Antoni M.Barboza-Flores V.Correcher F.Jaque departamento Física de materiales Universidad Autónoma Madrid Spain nASA Ames Research Center Moffett Field California USA centro de Investig ción en Física Universidad de Sonora México centro investigaciones energía y Medioambientales (CIEMAT) Madrid Spain

The KCI：Eu2＋ system response to UV-C was investigated by analyzing the optically stimulated luminescence （OSL） and ther- mo-luminescence （TL） signal produced by ultraviolet light exposure at room temperature. It was found that after UV-C ***, OSL was produced on a wide band of visible wavelengths with decay time that varied by several orders of magnitude depending on the Eu2＋ aggregation state. In spite of the low intensity of solar UV-C reaching the Earth＇s surface in Madrid （40° n, 700 m a.s.1.）, it was possible to measure the UV-C radiation dose at 6：48 solar time by using the TL response of the KCI：Eu2＋ system and differentiate it from the ambient beta radiation dose.

关键词： thermo-luminescence rare-earth-doped alkali halides solar ultraviolet dosimeter environmental radiation

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Patterns of local recurrence in rectal cancer after a multidisciplinary approach

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World Journal of Gastroenterology 2011年第13期17卷 1674-1684页

作者： Jose M enríquez-navascués nerea Borda Aintzane Liz-erazu Carlos Placer Jose L Elosegui Juan P Ciria Adelaida Lacasta Luis Bujanda Colorectal Cancer Multidisciplinary Unit Donostia Hospital University of the Basque CountryCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas 20010 San Sebastian Spain

Improvements in surgery and the application of combined approaches to fight rectal cancer have succeeded in reducing the local recurrence (LR) rate and when there is LR it tends to appear later and less often in isolation. Moreover, a subtle change in the distribution of LRs with respect to the pelvis has been observed. In general terms, prior to total mesorectal excision the most common LRs were central types (perianastomotic and anterior) while lateral and posterior forms (presa-cral) have become more common since the growth in the use of combined treatments. no differences have been reported in the current pattern of LRs as a function of the type of approach used, that is, neo-adjuvant therapies (short-term or long-course radiotherapy, orchemoradiotherapy versus extended lymphadenectomy, though there is a trend towards posterior or presacral LR in patients in the Western world and lateral LR in Asia. nevertheless, both may arise from the same mechanism. Moreover, as well as the mode of treatment, the type of LR is related to the height of the initial tumor. nowadays most LRs are related to the advanced nature of the disease. Involvement of the circumferential radial margin and spillage of residual tumor cells from lymphatic leakage in the pelvic side wall are two plausible mechanisms for the genesis of LR. The patterns of pelvic recurrence itself (pelvic subsites) also have important implications for prognosis and are related to the potential success of salvage curative approach. The re-operability for cure and prognosis are generally better for anastomotic and anterior types than for presacral and lateral recurrences. Overall survival after LR diagnosis is lower with radio or chemoradiotherapy plus optimal surgery approaches, compared to optimal surgery alone.

关键词： Rectal cancer Local neoplasm recurrence pelvis Pattern of recurrence multidisciplinary approach

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endoscopic shielding technique, a new method in therapeutic endoscopy

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World Journal of Gastroenterology 2017年第21期23卷 3761-3764页

作者： Ignacio Bon Ramon Bartolí Vicente Lorenzo-Zúniga Institut investigació en Ciències de la Salut Germans Trias i Pujol centro de investigación Biomédica en Red de enfermedades Hepáticas y Digestivas endoscopy Unit Department of GastroenterologyHospital Universitari Germans Trias i Pujol

Prevention of late complications after large endoscopic resection is inefficient with current *** shielding,as a simple and safe technique,has been proposed to improve the incidence of these *** methods,sheets or hydrogels,have showed proven efficacy in the prevention of late bleeding and perforation,as well as the improvement of tissue repair,in experimental models and in clinical practice.

关键词： endoscopic shielding technique Late complication Therapeutic endoscopy

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A novel and Functional Artificial Bruch’s Membrane Made of Poly (ε-Caprolactone)/Gelatin for Retinal Pigment Epithelium Restoration

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Advances in Bioscience and Biotechnology 2024年第8期15卷 443-461页

作者： López Edith Silva-Bermudez Phaedra Gonzalez-Salinas Roberto Velasquillo Cristina Torres-Romero Abigail López-Colomé Ana María Pérez Armando Gina Prado-Prone Edgar Ramos-Martínez Iván Ramos-Martínez Quiroz-Mercado Hugo Hernández-Zimbrón Luis Fernando Instituto de Fisiologa Celular Universidad Nacional Autnoma de Mxico Ciudad de Mxico City Mxico Unidad de Ingeniería de Tejidos Terapia Celular y Medicina Regenerativa Instituto Nacional de Rehabilitación Luis Guiller-mo Ibarra Ibarra Ciudad de México México departamento de investigacin Asociacin Para Evitar la Ceguera Ciudad de Mxico Mxico Subdireccin de investigacin Tecnolgica Instituto Nacional de Rehabilitacin Luis Guillermo Ibarra Ibarra Ciudad de Mxico Mxico departamento de Biologa Celular y Tisular Facultad de Medicina Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico Escuela de Ciencias Universidad Autnoma Benito Jurez de Oaxaca Oaxaca Mxico departamento de Medicina y Zootecnia de Cerdos Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional utnoma de Mxico Mxico Laboratorio de investigacion Interdisciplinaria rea de Optometria Escuela Nacional de Estudios Superiores Unidad Len Universidad Nacional Autnoma de Mxico Len Guanajuato Mxico Laboratorio nacional de ptica de la Visin-centro de investigaciones en ptica Len Guanajuato Mxico

Purpose: The primary aim of this paper is to design, create, and improve functional and artificial Bruch’s membranes (BM) using bioengineering techniques, which can be applied in the treatment of maculopathies by supporting the growth and maintenance of retinal pigment epithelium (RPE) cells, thereby potentially enabling subretinal implantation in patients. Methods: We fabricated by electrospinning ultrathin 3D nanofibrous membranes from Polycaprolactone (PCL), and different concentrations of gelatin (5%, 15% and 30%). ARPE-19 cells were seeded onto these artificial membranes. MTT assays were performed in order to evaluate ARPE-19 cell viability and cytotoxicity. IF assays were realized to observe the ARPE-19 cells onto each membrane. Ultrastructure of the modified Bruch’s membrane and ARPE-19 morphology after 25 days of culture were studied with transmission and scanning electron microscopy. To evaluate expression changes in markers of ARPE-19 (RPE65 and ZO-1) qRT-PCR assays were realized. Data from three independent experiments were pooled and expressed as the mean SD. A confidence level of P 0.05 was considered to be statistically significant. Results ARPE-19 cells grew on PCL/Gelatin membranes mainly in PCL/30% gelatin combination, which had not cytotoxic effect. RPE65/cytokeratin-18/ and actin-positive ARPE-19 cells formed a correctly orientated monolayer of polygonal cells with morphological polarity. The apical cell surfaces exhibited abundant protruding microfolds. Moreover, zones of polygonal border look as if ARPE-19 cells fused among, suggesting the presence of tight junctions. The expression of RPE65 and ZO-1 was unchanged. Conclusions: PCL/30% Gelatine membranes may imitate the natural BM to such extent that they support RPE-cells and exhibited RPE-like morphology. The engineering of a human RPE monolayer with these artificial BM, emulating the in vivo retina, arouse their potential subretinal implantation in patients with wet age-related macular degene

关键词： Artificial Bruch’s Membrane Electrospinning ARPE-19 Cells Age-Related Macular degeneration

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Mouse models of pancreatic cancer

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World Journal of Gastroenterology 2012年第12期18卷 1286-1294页

作者： Marta Herreros-Villanueva Elizabeth Hijona Angel Cosme Luis Bujanda Schulze Center for novel Therapeutics Division of Oncology ResearchDepartment of MedicineMayo ClinicRochesterMN 55905United States department of Gastroenterology Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd)University of the Basque CountryDonostia HospitalSan Sebastian 20014Spain department of Gastroenterology Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd)University of the Basque CountryDonostia Hospital

Pancreatic cancer is one of the most lethal of human malignancies ranking 4th among cancer-related death in the western world and in the United States,and potent therapeutic options are *** during the last few years there have been important advances in the understanding of the molecular events responsible for the development of pancreatic cancer,currently specific mechanisms of treatment resistance remain poorly understood and new effective systemic drugs need to be developed and *** vivo models to study pancreatic cancer and approach this issue remain limited and present different molecular features that must be considered in the studies depending on the purpose to fit special research *** the last few years,several genetically engineered mouse models of pancreatic exocrine neoplasia have been *** models mimic the disease as they reproduce genetic alterations implicated in the progression of pancreatic *** alterations such as activating mutations in KRas,or TGFb and/or inactivation of tumoral suppressors such as p53,InK4A/ARF BRCA2 and Smad4 are the most common drivers to pancreatic carcinogenesis and have been used to create transgenic *** mouse models have a spectrum of pathologic changes,from pancreatic intraepithelial neoplasia to lesions that progress histologically culminating in fully invasive and metastatic disease and represent the most useful preclinical model *** models can characterize the cellular and molecular pathology of pancreatic neoplasia and cancer and constitute the best tool to investigate new therapeutic approaches,chemopreventive and/or anticancer ***,we review and update the current mouse models that reproduce different stages of human pancreatic ductal adenocarcinoma and will have clinical relevance in future pancreatic cancer developments.

关键词： K-Ras Mouse models Transgenic Pancre-atic cancer Xenografts

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