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The Iberian Roma Population Variant Server(IRPVS)

Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María nuñez-negrillo Alejandra Carvajal yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain centro investigación Biomédica en Red enfermedades neurodegenerativas(CIBERnED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain departamento de enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain departamento de neurología Hospital Virgen de las NievesGranadaSpain departamento de neurología Hospital Virgen de ValmeSevillaSpain centro de salud Utrera Sur SevillaSpain centro de salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain departamento de Antropología Social Universidad de GranadaSpain Unidad enfermedades neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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novel Pectin/Chia-Mucilage Membranes:Human Serum Albumin Adsorption,Biocompatibility,and Physical-Chemical Properties

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Journal of Renewable Materials 2023年第6期11卷 2647-2663页

作者： S.E.Burruel-Ibarra R.A.Esquer-Osuna R.G.Valdez-Melchor D.A.Cuevas-Acuña L.Quihui-Cota J.Juárez J.C.Campos-García E.Valbuena-Gregorio M.A.López-Mata departamento de investigación en Polímeros y Materiales Universidad de SonoraHermosilloSonoraMéxico departamento de ciencias de la salud Campus CajemeUniversidad de SonoraCd.ObregónSonoraMéxico departamento de nutrición Pública y salud Coordinación de NutriciónCentro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico departamento de Física Universidad de SonoraHermosilloSonoraMéxico

This study aimed to characterize the physical-chemical and biological properties of pectin(PC)/chia seed mucilage(CM)***/CM[100/0(control),80/20%,60/40%,and 40/60%w/w]membranes were prepared using the casting *** membranes(PC/CM)were thin,yellow,lightly opaque(≈10%)and capable of blocking light UVB(between 66 at 52%).SEM analysis showed the presence of aggregates in the shape of a sphere(≈13μm)and ovoid(≈25μm).The proportion of 80/20 showed an increase in tensile strength(29%)and elastic modulus(19%)when compared to the *** analysis exhibited intermolecular interactions between PCPC,PC-CM,and CM-CM in the *** thermal analysis(600°C)showed a slight improvement in the percentage of residual mass-loss of 3.31%(80/20)that *** 40/60 membrane showed the lowest percentage of hemolysis(2.94%)but limited human albumin adsorption *** results suggested that the blend PC/CM may be considered as a biomaterial for medical applications.

关键词： Pectin chia mucilage membrane hemolysis albumin biomaterial

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novel TInF2 gene mutation in dyskeratosis congenita with extremely short telomeres:A case report

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World Journal of Clinical Cases 2022年第33期10卷 12440-12446页

作者： Verónica Judith Picos-Cárdenas Saúl Armando Beltrán-Ontiveros JoséAlfonso Cruz-Ramos JoséAlfredo Contreras-Gutiérrez Eliakym Arámbula-Meraz Carla Angulo-Rojo Alma Marlene Guadrón-Llanos Emir Adolfo Leal-León Dora María Cedano-Prieto Juan Pablo Meza-Espinoza laboratorio de Genética Facultad de MedicinaUniversidad Autónoma de SinaloaCuliacán 80018SinaloaMexico centro de investigación y docencia en ciencias de la salud Hospital Civil de CuliacánUniversidad Autónoma de SinaloaCuliacán 80030SinaloaMexico departamento de Clínicas Médicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Facultad de Medicina Universidad Autónoma de SinaloaCuliacán 80018SinaloaMexico laboratorio de Genética y Biología Molecular Facultad de Ciencias Químico-BiológicasUniversidad Autónoma de SinaloaCuliacán 80010SinaloaMexico laboratorio de neurociencias Facultad de MedicinaUniversidad Autónoma de SinaloaCuliacán 80018SinaloaMexico laboratorio de Diabetes y Comorbilidades Facultad de MedicinaUniversidad Autónoma de SinaloaCuliacán 80018SinaloaMexico Facultad de Medicina Universidad Autónoma de TamaulipasMatamoros 87349TamaulipasMexico

BACKGROUnD Dyskeratosis congenita is a rare disease characterized by bone marrow failure and a clinical triad of oral leukoplakia,nail dystrophy,and abnormal skin *** genetics of dyskeratosis congenita include mutations in genes involved in telomere maintenance,including *** SUMMARy Here,we report a female patient who presented thrombocytopenia,anemia,reticulate hyperpigmentation,dystrophy in fingernails and toenails,and leukoplakia on the tongue.A histopathological study of the skin showed dyskeratocytes;however,a bone marrow biopsy revealed normal cell *** patient was diagnosed with dyskeratosis congenita,but her family history did not reveal significant ***-exome sequencing showed a novel heterozygous punctual mutation in exon 6 from the TInF2 gene,namely,nM_001099274.1:-c.854delp.(Val285-Alafs*32).An analysis of telomere length showed short telomeres relative to the patient’s *** The disease in this patient was caused by a germline novel mutation of TInF2 in one of her parents.

关键词： Dyskeratosis congenita TInF2 Germline mutation novel mutation Short telomeres Case report

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HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium

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World Journal of Gastroenterology 2022年第29期28卷 3886-3902页

作者： nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García norma Velázquez-Guadarrama laboratorio de investigación en enfermedades Infecciosas Hospital Infantil de México Federico GómezMexico City 06720Mexico Posgrado en Biomedicina y Biotecnología Molecular Laboratorio de Producción y Control de BiológicosEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico laboratorio de Adquisición de Hierro Universidad Autónoma de la Ciudad MéxicoPosgrado Ciencias GenómicaMexico City 03100Mexico laboratorio Central de Microscopía Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico centro de estudios económicos y sociales en salud Hospital Infantil de México Federico GómezMexico City 06720Mexico laboratorio de investigación en Biología del desarrollo y Teratogénesis Experimental Hospital Infantil de México Federico GómezMexico City 06720Mexico

BACKGROUnD The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence *** To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) *** Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLyCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional *** HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium *** technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS *** analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein

关键词： Hypothetical protein HP0953 Adherence Helicobacter pylori Glycocalyx Virulence factor Persistence

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Risk Factors and Gender Differences for depression in Chilean Older Adults:A Cross-Sectional Analysis from the national Health Survey 2016–2017

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International Journal of Mental Health Promotion 2022年第5期24卷 679-697页

作者： Gabriela nazar Carlos-María Alcover yeny Concha-Cisternas Igor Cigarroa Ximena Díaz-Martínez Mariela Gatica-Saavedra Fabián lanuza Ana María Leiva-Ordónez María Adela Martínez-Sanguinetti Miquel Martorell Fanny Petermann-Rocha Claudia Troncoso-Pantoja Carlos Celis-Morales departamento de Psicología Facultad de Ciencias SocialesUniversidad de ConcepciónConcepciónChile centro de Vida saludable Universidad de ConcepciónConcepciónChile departamento de Psicología Facultad de Ciencias de la SaludUniversidad Rey Juan CarlosMadridEspaña Pedagogía en Educación Física Facultad de EducaciónUniversidad AutónomaTalcaChile Escuela de Kinesiología Facultad de SaludUniversidad Santo TomásLosÁngelesChile Grupo de investigación Calidad de Vida Departamento de Ciencias de la EducaciónUniversidad del BiobíoChillánChile depto de Psiquiatría y salud Mental Facultad de MedicinaUniversidad de ConcepciónConcepciónChile centro de Epidemiología Cardiovascular y nutricional(EPICyn) Facultad de MedicinaUniversidad de La FronteraTemucoChile Biomarkers and nutrimetabolomics laboratory Department of NutritionFood Sciences and GastronomyFood Technology Reference Net(XIA)Nutrition and Food Safety Research Institute(INSA)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelona08028Spain Instituto de Anatomía Histología y PatologíaFacultad de MedicinaUniversidad Austral de ChileValdiviaChile Instituto de Farmacia Facultad de CienciasUniversidad Austral de ChileValdiviaChile departamento de nutrición y Dietética Facultad de Farmacia.Universidad de ConcepciónConcepciónChile Facultad de Medicina Universidad Diego PortalesSantiagoChile BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgowUK centro de investigación en Educación y desarrollo(CIEde-UCSC).departamento de salud Pública Facultad de MedicinaUniversidad Católica de la Santísima ConcepciónConcepciónChile laboratorio de Rendimiento Humano Grupo de Estudio en EducaciónActividad Física y Salud(GEEAFyS)Universidad Católica del MauleTalcaChile

depressive disorders are recognized as one of the most common mental health conditions across different age ***,the risk factors associated with depression among older people from low-and middle-income countries remains *** study aims to identify socio-demographic,health and psychosocial-related factors associated with depression in Chilean older adults.A cross-sectional study was carried out in a representative sample of 1,765 adults aged≥60 years participants from the Chilean national Health Survey 2016–***-sion was assessed with the Composite International Diagnostic Interview(CIDI-SF).Associations between the exposure variables and depression were investigated using Poisson regression *** mainﬁndings indi-cated that women showed higher likelihood of depression than men(Prevalence Ratio(PR)=2.6[95%CI:1.40;4.89]).An increased likelihood of depression was found in older adults with chronic pain,multimorbidity(≥2 diseases),previous diagnose of depression,high perception of stress,ﬁnancial stress,and difﬁculties for social *** women,higher likelihood of depression was found for those with the frailty phenotype(PR:8.53[95%CI:1.68;43.32]),rheumatoid arthritis(PR:2.41[95%CI:1.34;4.34]),insomnia(PR:2.99[95%CI:1.74;5.12])and low self-rated well-being(PR:4.94[95%CI:2.26;10.79]).Men who were divorced(PR:7.10[95%CI:1.44;34.90])or widowed(PR:10.83[95%CI:3.71;31.58]),obese(PR:5.08[95%CI:1.48;17.42])and who had asthma(PR:7.60[95%CI:2.31;24.99])were associated with higher odds of *** currentﬁndings may have clinical implications for the early identiﬁcation of older adults more susceptible to depression and also suggest the need to implement cultural and age-sensitive strategies to promote mental health in late life.

关键词： depression older adults aging late-life depression risk factors

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Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation

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neural Regeneration Research 2019年第10期14卷 1787-1795页

作者： Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto Alma y. Gálvez-Contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda laboratorio de Microscopía de Alta Resolución Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico laboratorio de neurociencias Facultad de PsicologíaUniversidad de ColimaColimaMéxico División de Inmunología Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico División de neurociencias Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico Instituto de investigación en ciencias Biomédicas (IICB) Departamento de Biología Molecular y GenómicaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Unidad de Atención en neurociencias Departamento de Neurociencias. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico

Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult ***,this effect has not been observed in long-term sleep *** precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this *** this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword *** results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate *** observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep *** addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated *** findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived *** procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval ***-16610)on January 2,2016.

关键词： sleep-deprivation melatonin microRnA neurogenesis Sirtuin 1 SIRT1 methyl-CpG-binding protein 2 MECP2 epigenetic text-mining mir-9 let-7b

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Insights into myelin dysfunction in schizophrenia and bipolar disorder

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World Journal of Psychiatry 2022年第2期12卷 264-285页

作者： Marcela Valdés-Tovar Alejandra Monserrat Rodríguez-Ramírez Leslye Rodríguez-Cárdenas Carlo E Sotelo-Ramírez Beatriz Camarena Marco Antonio Sanabrais-Jiménez Héctor Solís-Chagoyán Jesús Argueta Germán Octavio López-Riquelme departamento de Farmacogenética Subdirección de Investigaciones ClínicasInstituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico departamento de Farmacogenética Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico Doctorado en Biología Experimental Universidad Autónoma Metropolitana-IztapalapaMexico City 09340Mexico laboratorio de neurofarmacología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico laboratorio de Socioneurobiología Centro de Investigación en Ciencias CognitivasUniversidad del Estado de MorelosCuernavaca 62209MorelosMexico

Schizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide prevalence of approximately 1%.Both disorders present chronic and deteriorating prognoses that impose a large burden,not only on patients but also on society and health *** mental illnesses share several clinical and neurobiological traits;of these traits,oligodendroglial dysfunction and alterations to white matter(WM)tracts could underlie the disconnection between brain regions related to their symptomatic *** is mainly composed of heavily myelinated axons and glial *** internodes are discrete axon-wrapping membrane sheaths formed by oligodendrocyte *** ensheathment allows fast and efficient conduction of nerve impulses through the nodes of Ranvier,improving the overall function of neuronal *** and precisely synchronized nerve impulse conduction through fibers that connect distant brain structures is crucial for higher-level functions,such as cognition,memory,mood,and *** cellular and subcellular anomalies related to myelin and oligodendrocytes have been found in postmortem samples from patients with schizophrenia or bipolar disorder,and neuroimaging techniques have revealed consistent alterations at the macroscale connectomic level in both *** this work,evidence regarding these multilevel alterations in oligodendrocytes and myelinated tracts is discussed,and the involvement of proteins in key functions of the oligodendroglial lineage,such as oligodendrogenesis and myelination,is *** molecular components of the axo-myelin unit could be important targets for novel therapeutic approaches to schizophrenia and bipolar disorder.

关键词： Myelin sheath Oligodendroglia Schizophrenia Bipolar disorder White matter

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neuroprotective effect of immunomodulatory peptides in rats with traumatic spinal cord injury

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neural Regeneration Research 2021年第7期16卷 1273-1280页

作者： Dulce Parra-Villamar Liliana Blancas-Espinoza Elisa Garcia-Vences Juan Herrera-García Adrian Flores-Romero Alberto Toscano-Zapien Jonathan Vilchis Villa Rodríguez Barrera-Roxana Soria Zavala Karla Antonio Ibarra Raúl Silva-García Unidad de investigación Médica en Inmunología Hospital de PediatríaCentro Médico Nacional Siglo XXI/Instituto Mexicano del Seguro Social/Ciudad de MéxicoMéxico centro de investigación en ciencias de la salud(CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac MéxicoCampus NorteHuixquilucanEdo de MéxicoMéxico centro de investigación del Proyecto Camina A.C Ciudad de MéxicoMéxico

Several therapies have shown obvious effects on structural conservation contributing to motor functional recovery after spinal cord injury(SCI).nevertheless, neither strategy has achieved a convincing *** purposed a combined therapy of immunomodulatory peptides that individually have shown significant effects on motor functional recovery in rats with *** objective of this study was to investigate the effects of the combined therapy of monocyte locomotion inhibitor factor(MLIF), A91 peptide, and glutathione monoethyl ester(GSH-MEE) on chronic-stage spinal cord *** Sprague-Dawley rats underwent a laminectomy of the T9 vertebra and a moderate *** groups were included: sham, PBS, MLIF + A91, MLIF + GSH-MEE, A91 + GSH-MEE, and MLIF + A91 + *** months after injury, motor functional recovery was evaluated using the open field *** and white matter preservation was evaluated using hematoxylin & eosin staining and Luxol Fast Blue staining, *** number of motoneurons in the ventral horn and the number of axonal fibers were determined using hematoxylin & eosin staining and immunohistochemistry, *** deposition was evaluated using Masson's trichrome *** combined therapy of MLIF, A91, and GSH-MEE greatly contributed to motor functional recovery and preservation of the medullary parenchyma, white matter, motoneurons, and axonal fibres, and reduced the deposition of collagen in the lesioned *** combined therapy of MLIF, A91, and GSH-MEE preserved spinal cord tissue integrity and promoted motor functional recovery of rats after *** study was approved by the national Commission for Scientific Research on Bioethics and Biosafety of the Instituto Mexicano del Seguro Social under registration number R-2015-785-116(approval date november 30, 2015) and R-2017-3603-33(approval date June 5, 2017).

关键词： glutathione monoethyl ester monocyte locomotion inhibitor factor motor functional recovery neuroprotection neurorestoration peptides protective autoimmunity spinal cord injury

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Assessment of effectiveness of oral supplementation of isolated fiber of carrot on metabolic parameters in mature rats

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Food Science and Human Wellness 2023年第6期12卷 2022-2028页

作者： Maria Rosana Ramirez debora Manuale Juan Carlos yori Instituto Universitario de ciencias de la salud Fundación BarcelóCONICETCenteno 710CP 3340Santo TomeCorrientesArgentina Consejo nacional de investigaciones Científi cas Técnicas(COnICET) Buenos Aires C1033AAJArgentina Instituto de investigaciones en Catálisis y Petroquímica(InCAPE)FIQ-UnL-COnICET Parque Tecnológico Litoral Centro 3000Santa FeArgentina Facultad de Ingeniería Química Universidad nacional del Litoral 3000Santa FeArgentina

This present study was conducted to evaluate the metabolic effects of isolated fi ber of carrot supplementation in *** properties of fi ber were *** groups were as follows:animals fed a standard diet,control group;high fi ber supplementation(70 mg);low fi ber supplementation(35 mg);for 12 *** samples were collected at the time of sacrifi *** weights of heart,liver,kidneys and spleen of the experimental rats with respect to body weight were *** kits were used to determine serum glucose concentration,lipid profi le(cholesterol,HDL-cholesterol,triglycerides),and the two main aminotransferases glutamic-oxalacetic transaminase(GOT)/glutamate-pyruvate transaminase(GPT).A histopathological assay was performed on the heart,liver,and spleen tissues of *** with fi ber favors weight loss in female((242.03±23.73)-(197.81±10.45)g);and male rats((262.50±32.21)-(213.96±12.56)g and induces a decrease in glucose levels in the supplemented *** the exception of total high-density lipoprotein cholesterol,the other lipid fractions decrease signifi cantly in rats *** supplementation did not induce changes in the dissected organs of the supplemented *** conclusion supplementation of fiber,improves glucose control,lower plasma lipid concentrations and reduced body weight in normal rats.

关键词： Carrot fiber Oral supplementation Animal studies

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Does wetland watershed land use influence amphibian larval development? A relevant effect of agriculture on biota

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Journal of Oceanology and Limnology 2019年第1期37卷 160-168页

作者： GARCíA-MU?OZ enrique GUERRERO Francisco ARECHAGA Garbi?e PARRA Gema departamento de Biología Animal Biología Vegetal y Ecología Campus de las Lagunillas centro de Estudios Avanzados en ciencias de la Tierra Campus de las Lagunillas departamento de ciencias de la salud Campus de las Lagunillas

Agriculture practices have been widely proposed as the major cause of amphibian population decline. However, the majority of these results have been based on laboratory experiments. The present study was conducted to test the repercussion of wetland sediment provenance on amphibian larval *** bufo larvae were used in two dif ferent treatments in an outdoor experiment, the ?rst one using sediment from one wetland surrounded by intensive agricultural practices, and the second using sediment with no record of agrochemical uses. A negative ef fect was observed in the agricultural treatment, from subcellular to individual level. The results showed that the sediment from agricultural practices watershed generates a reduction in survival. Furthermore, individuals that developed under this treatment showed a lower total length and a delay in the time necessary to complete metamorphosis; these features are connected with recruitment success. In the same way, biochemical analysis showed high values of lipid peroxidation in metamorphs developing in sediments from an agricultural area. Finally, the results obtained highlight the importance of considering the sediments, not only the water, as origin treatment, allowing us to understand the consequences on amphibian populations that inhabit areas af fected by intensive agriculture.

关键词： amphibian decline Bufo bufo survival ecotoxicology agricultural practices

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