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Hepatobiliary Surgery and nutrition 2023年第5期12卷 746-751页

作者： Jose María Pinazo-Bandera Miren García-Cortés Raúl J.Andrade Service of Gastroenterology and Hepatology University Hospital Virgen de la VictoriaInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BionandUniversidad de MálagaMálagaSpain centro de investigación Biomédico en Red enfermedades Hepáticas y Digestivas(CIBERehd) MadridSpain

Drug-induced liver injury(DILI)is a term used to describe an unexpected liver reaction to drugs,but also to herbal products and dietary supplements(HDS).In the current therapeutic armamentarium,only a small number of available drugs are still capable of causing liver damage in overdose.These include,in addition to paracetamol-the prototypical example of this group-niacin(now rarely used to treat hypercholesterolaemia),intravenous methotrexate and probably ketamine(an intravenous hypnotic used in critically ill patients for rapid sequence induction)(1).

关键词： Drug-induced liver injury(DILI) hepatotoxicity causality assessment Revised Electronic Causality Assessment Method(RECAM)

Clinical Profiles at the Time of Diagnosis of SARS-CoV-2 Infection in Costa Rica During the Pre-vaccination Period Using a Machine Learning Approach

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Phenomics 2022年第5期2卷 312-322页

作者： Jose Arturo Molina-Mora Alejandra González Sergio Jiménez-Morgan Estela Cordero-Laurent Hebleen Brenes Claudio Soto-Garita Jorge Sequeira-Soto Francisco Duarte-Martínez centro de investigación en enfermedades Tropicales(CIET)and Facultad de Microbiología Universidad de Costa RicaSan José2060Costa Rica Instituto Costarricense de investigación y enseñanza en nutrición y Salud(InCIenSA) Tres Ríos 30301Costa Rica Escuela de Medicina Universidad de Costa RicaSan José2060Costa Rica

The clinical manifestations of COVID-19,caused by the SARS-CoV-2,define a large spectrum of symptoms that are mainly dependent on the human host conditions.In Costa Rica,more than 169,000 cases and 2185 deaths were reported during the year 2020,the pre-vaccination period.To describe the clinical presentations at the time of diagnosis of SARS-CoV-2 infection in Costa Rica during the pre-vaccination period,we implemented a symptom-based clustering using machine learning to identify clusters or clinical profiles at the population level among 18,974 records of positive cases.Profiles were compared based on symptoms,risk factors,viral load,and genomic features of the SARS-CoV-2 sequence.A total of 18 symptoms at time of diagnosis of SARS-CoV-2 infection were reported with a frequency>1%,and those were used to identify seven clinical profiles with a specific composition of clinical manifestations.In the comparison between clusters,a lower viral load was found for the asymptomatic group,while the risk factors and the SARS-CoV-2 genomic features were distributed among all the clusters.no other distribution patterns were found for age,sex,vital status,and hospitalization.In conclusion,during the pre-vaccination time in Costa Rica,the symptoms at the time of diagnosis of SARS-CoV-2 infection were described in clinical profiles.The host co-morbidities and the SARS-CoV-2 genotypes are not specific of a particular profile,rather they are present in all the groups,including asymptomatic cases.In addition,this information can be used for decision-making by the local healthcare institutions(first point of contact with health professionals,case definition,or infrastructure).In further analyses,these results will be compared against the profiles of cases during the vaccination period.

关键词： COVID-19 Costa Rica Machine learning Diagnosis SARS-CoV-2 Clinical profiles

Carbon dioxide fixation into cyclic carbonates at room temperature catalyzed by heteroscorpionate aluminum complexes

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Green Chemical engineering 2022年第3期3卷 280-287页

作者： Felipe de la Cruz-Martinez Jose A.Castro-Osma Agustin Lara-Sanchez Universidad de Castilla-La Mancha Departamento de Quimica InorganicaOrganica y Bioquimica-Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Facultad de Ciencias y Tecnologias QuimicasCiudad Real13071Spain Instituto de investigaciones Quimicas(IIQ) Departamento de Quimica Inorganica and Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Consejo Superior de Investigaciones Cientificas(CSIC)and University of SevillaSevilla41092Spain Universidad de Castilla-La Mancha Departamento de Quimica InorganicaOrganica y Bioquimica-Centro de Innovacion en Quimica Avanzada(ORFEO-CINQA)Facultad de FarmaciaAlbacete02071Spain

novel mono-and bimetallic scorpionate aluminum compounds have been designed and characterized by spec-troscopic methods.These organometallics complexes,in combination with tetrabutylammonium bromide as cocatalyst,displayed good catalytic activity for the cycloaddition of styrene oxide and CO_(2) under ambient con-ditions.Among the compounds tested,monometallic complex 3 featuring diethylamino groups showed the highest catalytic activity.This catalytic system catalyzed the formation of cyclic carbonate products from their corresponding epoxides at room temperature and 1 bar of CO_(2) pressure in the absence of a solvent in good yields and excellent selectivities.

关键词： CO_(2) Epoxides Cyclic carbonates Aluminum complexes

Synthesis and characterization of nano-hydroxyapatite added with magnesium obtained by wet chemical precipitation

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Progress in natural Science:Materials International 2021年第4期31卷 575-582页

作者： Brandon A.Correa-Pi?a Omar M.Gomez-Vazquez Sandra M.Londo?o-Restrepo Luis F.Zubieta-Otero Beatriz M.Millan-Malo Mario E.Rodriguez-García Posgrado en ciencia e Ingeniería de Materiales Centro de Física Aplicada y Tecnología Avanzada Universidad Nacional Autónoma de México Campus Juriquilla departamento de nanotecnología Centro de Física Aplicada y Tecnología Avanzada Universidad Nacional Autónoma de México Campus Juriquilla

Biogenic hydroxyapatites from mammalian bones naturally contain traces of ions, like Mg, which play a vital role in the bone remodeling process. In this way, synthetic hydroxyapatites should include this kind of mineral. In this work, hydroxyapatite added with Mg was synthesized by wet precipitation using（nH;）H;PO;, Ca（nO;）;.4 H;O,and Mg（nO;）;.6 H;O（0, 0.032, 0.061, and 0.123 M）. Inductively coupled plasma and X-ray diffraction evidenced the Mg inclusion in the hydroxyapatite lattice in the same levels reported for natural hydroxyapatites. The calcination at 600℃ was performed to remove the reaction by-products, but it also gave rise to physicochemical changes as the coalescence and crystals recrystallization. It produced, in turn, an improvement in the crystalline quality, according to Raman analysis. despite those physicochemical changes, all the samples remained nanometric according to scanning electron microscopy imaging.

关键词： Magnesium Physicochemical properties Calcination nanometric crystal size Coalescence Recrystallization

Differential distribution of gene polymorphisms associated with hypercholesterolemia,hypertriglyceridemia,and hypoalphalipoproteinemia among native American and Mestizo Mexicans

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World Journal of Hepatology 2022年第7期14卷 1408-1420页

作者： Rafael Torres-Valadez Sonia Roman Claudia Ojeda-Granados Karina Gonzalez-Aldaco Arturo Panduro department of Genomic Medicine in Hepatology Civil Hospital of Guadalajara Fray Antonio Alcalde/Health Sciences CenterUniversity of GuadalajaraGuadalajaraJalisco 44280Mexico Unidad Especializada en investigación Desarrollo e Innovación en Medicina Genómica Centro Nayarita de Innovación y Transferencia de TecnologíaUniversidad Autónoma de NayaritUnidad Académica de Salud IntegralTepicNayarit 63173Mexico

BACKGROUnD Dyslipidemias are metabolic abnormalities associated with chronic diseases caused by genetic and environmental factors.The Mexican population displays regional differences according to ethnicity with an impact on the type of dyslipidemia.AIM To define the main dyslipidemias,the frequency of lipid-related risk alleles,and their association with hyperlipidemic states among different ethnic groups in West Mexico.METHODS In a retrospective study,1324 adults were selected to compare dyslipidemias and lipid-related gene polymorphisms.demographic,clinical,and laboratory data were collected.A subgroup of 196 normal weight subjects without impaired glucose was selected for the association analyses.Genotyping was determined by allelic discrimination assay.RESULTS Hypercholesterolemia was the most prevalent dyslipidemia(42.3%).The frequency of the risk alleles associated with hypoalphalipoproteinemia(ABCA1)and hypercholesterolemia(APOE,LDLR)was higher in the native Americans(P=0.047).In contrast,the Mestizos with European ancestry showed a higher frequency of the risk alleles for hypertriglyceridemia(APOE2,MTTP)(P=0.045).In normal weight Mestizo subjects,the APOB TT and LDLR GG genotypes were associated risk factors for hypercholesterolemia(OR=5.33,95%CI:1.537-18.502,P=0.008 and OR=3.90,95%CI:1.042-14.583,P=0.043,respectively),and displayed an increase in low-density lipoprotein cholesterol levels(APOB:β=40.39,95%CI:14.415-66.366,P=0.004;LDLR:β=20.77,95%CI:5.763-35.784,P=0.007).COnCLUSIOn Gene polymorphisms and dyslipidemias showed a differential distribution.Regional primary health care strategies are required to mitigate their prevalence considering the genetic and environmental features which could have important implications for personalized medicine within the new era of precision medicine.

关键词： Dyslipidemia Ethnicity Genes Obesity Lipids Liver disease Diet

Onto the sense of smell in macaws, amazons and toucans: can they use volatile cues of fruits to make foraging decisions?

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Integrative Zoology 2023年第4期18卷 762-771页

作者： M.Carmen HERnÁndeZ Ana María VILLADA Isabel BARJA Unidad Zoología Departamento de BiologíaUniversidad Autónoma de MadridCampus Universitario de CantoblancoMadridSpain Toucan Rescue Ranch HerediaCosta Rica centro de investigación en Biodiversidad y Cambio Global(CIBC-UAM)Universidad Autónoma de Madrid MadridSpain

Over the past decades,empirical evidence has been accumulated indicating that olfactory information plays a fundamental role in bird life history.nonetheless,many aspects of avian olfaction remain poorly understood.Our purpose was to broaden the knowledge about the importance of the sense of smell in some neglected bird groups:psittaciformes and ramphastids,and to compare how the response varied between the species.Because of the lack of information about the use of chemical cues for locating food in fruit-eating species,we also aimed to delve into this question.We conducted a 3-choice(water/vinegar/papaya and banana juice)scent test in 5 Costa Rican native species:scarlet macaw(Ara macao),red-lored amazon(Amazona autumnalis),yellow-naped amazon(Amazona auropalliata),keel-billed toucan(Ramphastos sulfuratus),and yellow-throated toucan(Ramphastos ambiguus).Results revealed that macaws and toucans allocated signiﬁcantly more time to interacting with the fruit scent container,indicating that these species can perceive the volatile chemicals emitted by ripe fruits and that they can use this information to make foraging decisions.However,amazons did not dedicate more time to interact with the fruit treatment.Our research provides theﬁrst evidence of the ability to exploit chemical volatile cues in macaws and toucans.

关键词： avian olfaction bird senses frugivorous birds psittaciformes ramphastids scent test

novel Pectin/Chia-Mucilage Membranes:Human Serum Albumin Adsorption,Biocompatibility,and Physical-Chemical Properties

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Journal of Renewable Materials 2023年第6期11卷 2647-2663页

作者： S.E.Burruel-Ibarra R.A.Esquer-Osuna R.G.Valdez-Melchor D.A.Cuevas-Acuña L.Quihui-Cota J.Juárez J.C.Campos-García E.Valbuena-Gregorio M.A.López-Mata departamento de investigación en Polímeros y Materiales Universidad de SonoraHermosilloSonoraMéxico departamento de ciencias de la Salud Campus CajemeUniversidad de SonoraCd.ObregónSonoraMéxico departamento de nutrición Pública y Salud Coordinación de NutriciónCentro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico departamento de Física Universidad de SonoraHermosilloSonoraMéxico

This study aimed to characterize the physical-chemical and biological properties of pectin(PC)/chia seed mucilage(CM)membranes.PC/CM[100/0(control),80/20%,60/40%,and 40/60%w/w]membranes were prepared using the casting method.The membranes(PC/CM)were thin,yellow,lightly opaque(≈10%)and capable of blocking light UVB(between 66 at 52%).SEM analysis showed the presence of aggregates in the shape of a sphere(≈13μm)and ovoid(≈25μm).The proportion of 80/20 showed an increase in tensile strength(29%)and elastic modulus(19%)when compared to the control.FTIR analysis exhibited intermolecular interactions between PCPC,PC-CM,and CM-CM in the membranes.The thermal analysis(600°C)showed a slight improvement in the percentage of residual mass-loss of 3.31%(80/20)that control.The 40/60 membrane showed the lowest percentage of hemolysis(2.94%)but limited human albumin adsorption capacity.These results suggested that the blend PC/CM may be considered as a biomaterial for medical applications.

关键词： Pectin chia mucilage membrane hemolysis albumin biomaterial

Impact of ZnSO_(4)^(-)and ZnO nanoparticles on Seed Germination and Seedling Growth of Lettuce

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Phyton-International Journal of Experimental Botany 2023年第6期92卷 1831-1840页

作者： Adalberto Benavides-Mendoza Rebeca Betancourt-Galindo nazario Francisco-Francisco departamento de Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México departamento de Materiales Avanzados Centro de Investigación en Química AplicadaSaltillo25294México departamento de Agricultura Sustentable y Protegida Universidad Tecnológica de TehuacánTehuacán75859México

Micronutrient nanoparticles(nPs)are currently an option for chemical fertilization and biostimulation in crops.However,there is little information on the phytotoxic or biostimulatory effects of nPs at low concentrations of some elements,such as Zn.In this study,the effect of low concentrations of Zn oxide(ZnO)nPs on germination,growth variables,and nutritional attributes of lettuce(Lactuca sativa L.)was evaluated in comparison to Zn sulfate.Romaine lettuce seeds were treated with ZnSO_(4)^(-)×7H_(2)O and ZnO nPs at Zn molar concentrations of 1×10^(−3),5×10^(−3),1×10^(−4),5×10^(−4),1×10^(−5),5×10^(−5),1×10^(−6),and 5×10^(−6).The seeds treated with ZnSO4−at 5×10^(−6)registered the highest radicle length,73%more than the control treatment.The seeds treated with ZnSO4−at 5×10^(−3)registered the lowest values,with 50%less than the control treatment.ZnO nPs at 5×10^(−6)significantly increased content of chlorophyll A and B and total phenolics.These results indicate the possible existence of a mechanism related to the intrinsic nanoparticle properties,especially at low concentrations.

关键词： Micronutrients biostimulation nanotechnology nanofertilizers germination chlorophyll total phenols

Digestibility,Antioxidant and Anti-Inflammatory Activities of Pecan nutshell(Carya illioinensis)Extracts

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Journal of Renewable Materials 2022年第10期10卷 2569-2580页

作者： María Janeth Rodríguez-Roque Carmen Lizette del-Toro-Sánchez Janet Madeline Chávez-Ayala Ricardo Iván González-Vega Liliana Maribel Pérez-Pérez Esteban Sánchez-Chávez nora AideéSalas-Salazar Juan Manuel Soto-Parra Rey David Iturralde-García María Antonia Flores-Córdova Facultad de ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaChihuahuaMéxico Universidad de Sonora Rosales y Niños Héroes S/NHermosilloSonMéxico centro de investigación en Alimentación y desarrollo A.C.Unidad DeliciasDeliciasChihuahuaMéxico

Phenolic compounds are related to high biological activity,avoiding oxidation in food and human systems.nutshells are by-products derived from the pecan nut processing that contain important amounts of phenols which biological activity must be studied.This research aimed to evaluate the antioxidant(DPPH,ABTS,FRAP and hemolysis)and anti-inflammatory activities of shell extracts from pecan nuts harvested during the crop production cycle 2018 and 2019,as well as the in vitro digestibility of their phenolic compounds,including flavonoids.Results showed that extracts from the crop production cycle 2018 obtained the highest yield,while those from 2019 contained the highest concentration of phenolic compounds,flavonoids and antioxidant capacity determined by DPPH(22.96 mmol ET),ABTS(91.55 mmol ET)and inhibition of hemolysis(92.12%).The anti-inflammatory activity exhibited an inhibition of the elastase enzyme up to 50 min and the bioaccessibility of phenolic compounds reached up to 32%.These results showed that pecan nutshell extracts are an important source of biologically active compounds,thus,they are suitable to be used as commodities in different fields such as agricultural,food and pharmaceutical industries.Future studies must be carried out in order to elucidate the activity of nutshell extracts within in vivo systems.

关键词： Anti-inflammatory activity antioxidants digestibility shell phenolic compounds

Hydrodeoxygenation of vegetable oil in batch reactor:Experimental considerations

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Chinese Journal of Chemical engineering 2020年第6期28卷 1670-1683页

作者： Alexis K.noriega Alexis Tirado Cecilia Méndez Gustavo Marroquín Jorge Ancheyta Instituto Politécnico nacional Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada Unidad LegariaLegaria 694Col.Irrigación 11500Mexico Instituto Mexicano del Petróleo Eje Central Lázaro Cárdenas Norte 152San Bartolo Atepehuacan 07730Mexico

The generation of reliable experimental data in any experimental scale requires proper procedures not only for the reaction step but also for the feed preparation,separation,and characterization of products as well as calculations of conversion and product yields.Batch reactor is the most used experimental setup for carrying out exploratory studies for catalyst screening and development.This work is focused on describing and discussing a step-by-step methodology for conducting experiments for catalytic hydrotreating of vegetable oils in batch reactor.The proposed methodology considers literature and own experiences on advantages and disadvantages of different feed types,catalysts,experimental setup and procedures,effect of reaction parameters,separation and characterization of products,and calculations.

关键词： Vegetable oils Hydrotreating Batch reactor