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Mid-term results of patterned laser trabeculoplasty for uncontrolled ocular hypertension and primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1199-1204页

作者： Gustavo Espinoza Yuly Andrea Castellanos-Castellanos Angelica Pedraza-Concha Ignacio Rodriguez-Una Maria Fernanda Acuna Juan Camilo Parra centro oftalmologico virgilio galvis BucaramangaSantander 681004Colombia Fundacion Oftalmologica de Santander BucaramangaSantander 681004Colombia Universidad Industrial de Santander BucaramangaSantander 680002Colombia Instituto oftalmologico Fernandez-Vega Universidad de OviedoOviedo 33012Spain

AIM:To describe the safety and efficacy of patterned laser trabeculoplasty(PLT)as an adjunctive treatment in primary open angle glaucoma(POAG)and ocular hypertension(OHT)after 18-month follow-up in Hispanic ***:A single-center,retrospective study was *** patients with OHT or POAG undergoing PLT from June 2016 to August 2016 were included in the *** parameters were intraocular pressure(IOP),the number of IOP-lowering medications,best corrected visual acuity(BCVA),laser parameters and postoperative adverse *** efficacy outcome measures were the proportion of eyes achieving an IOP reduction≥20%at 18 mo versus baseline medicated IOP or a reduction in the number of medications while maintaining IOP ***:From 40 PLT-treated eyes(mean baseline IOP 20.3±1.7 mm Hg),24 patients were analyzed(age 63.4±7.3 y).The mean IOP reductions from baseline across visits(months 1,3,6,9,12,and 18)ranged from 14.1%to 20.8%.Success rate after 18-month follow-up was 61.7%with a mean IOP of 16±3.2 mm Hg(P<0.001).The number of glaucoma IOP-lowering medications per eye(preoperative 2.1±1.1 and postoperative 2.3±1.1,P=0.86)and the mean BCVA(preoperative 0.10±0.22 and postoperative 0.11±0.22 logMAR,P=0.42)remained *** events comprised transitory IOP spikes in 4 eyes(10%)and peripheral anterior synechiae in 7 eyes(17.5%).CONCLUSION:Mid-term results of PLT show that this procedure may be an efficacious and safe technique to approach medically uncontrolled OHT or POAG patients.

关键词： glaucoma intraocular pressure ocular hypertension patterned laser trabeculoplasty

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Nonmetastatic castration-resistant prostate cancer: Novel agents to treat a lethal disease

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World Journal of Clinical Oncology 2021年第1期12卷 6-12页

作者： Ivan Henriquez Daniel Spratt Alfonso Gomez-Iturriaga Oscar Abuchaibe Felipe Counago Department of Radiation Oncology Hospital Universitario Sant JoanInstituto Investigación Pere i VirgiliReus 43204TarragonaSpain Department of Radiation Oncology Ann ArborUniversity of MichiganMichiganMI 48109United States Department of Radiation Oncology Hospital Universitario Cruces/Biocruces Health Research InstituteBarakaldo 48903BizcaiaSpain Department of Radiation Oncology Virgilio Galvis Ramirez Cancer CentreBucaramanga s/nSantanderColombia Department of Radiation Oncology Hospital Universitario Quironsalud MadridPozuelo de AlarconHospital La LuzClinical DepartmentFaculty of BiomedicineUniversidad EuropeaMadrid 28223Spain

Nonmetastatic castration-resistant prostate cancer(nmCRPC)-defined as prostate-specific antigen(PSA)>2 ng/mL,testosterone castration levels<1.7 nm/L,and the absence of metastatic lesions on conventional imaging(computed tomography or bone scan)-has been defined as a lethal disease by the Prostate Cancer Work ***-third of patients with prostate cancer who receive androgen deprivation therapy for biochemical recurrence after local treatment will develop CRPC,with death occurring an average of 2.5 years after diagnosis of castration *** patients diagnosed with nmCRPC are asymptomatic or minimally symptomatic at diagnosis due to local *** patients with short PSA doubling times(<10 mo)and high baseline PSA levels,there is a high risk of bone metastases followed by prostate cancer-related *** patients also present significant morbidity that negatively impacts quality of life(QoL).Recently,the results of three randomized trials(PROSPER,SPARTAN,and ARAMIS)were *** trials evaluated the efficacy of three different androgen receptor inhibitors-enzalutamide,apalutamide,and darolutamide-in patients with *** all three trials,the study drugs improved both metastasis-free survival and overall survival compared to placebo,plus on-going androgen deprivation therapy without a negative impact on *** patients with nmCRPC,the most important clinical objective is early detection and treatment to maintain a low tumor burden and to prolong the symptom-free *** patients with nmCRPC,these novel drugs offer new hope for better QoL and survival outcomes.

关键词： Nonmetastatic castration-resistant prostate cancer Prostate cancer Apalutamide Enzalutamide Darolutamide Toxicity

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A plant-pollinator system： How learning versus cost-benefit can induce periodic oscillations

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International Journal of Biomathematics 2018年第2期11卷 189-215页

作者： virgilio Vazquez Ignacio Barradas Instituto de Fisicay Matemdticas Universidad Tecnologica de la Mixteca Huajuapan de Leon Oaxaca 69000 Mexico centro de Investigacion en Matemdticas Apartado Postal 302 Guanajuato Guanajuato 36000 Mexico

In this paper, we propose a model describing the interaction between two species： a plant population that gets pollinated by an insect population. We assume the plant population is divided into two groups： the first group in mutualistic relationship with the insect and the second group attracting the insects while deceiving them and not delivering any reward. In addition, we assume that the insect population reduces the number of visits to the plants after several unsuccessful visits. We are interested in the conditions for the coexistence of both species, especially in the appearance of damped or sustained oscillations. We focus the analysis on the parameters that measure the balance among deceit, the benefit that the insect gets from the plant, and the learning by the pollinators. We are especially interested in analyzing the effect of learning by the insect population due to unsuccessfully visiting the deceiving plants.

关键词： Deceptive pollination mutualism learning oscillations Hopf bifurcation.

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Malaria epidemiology in the Democratic Republic of East Timor

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 283-287页

作者： Afonso de Almeida virgilio E do Rosario Ana Paula Arez Pedro Cravo Universidade Nacional de Timor Lorosae Avenida Cidade de LisboaDili-Timor Leste centro de Malaria e Outras Doencas Tropicais Instituto de Higiene e Medicina TropicalUniversidade Nova de LisboaRua da Junqueira 961349-008 Lisboa Portugal centro de Malaria e Outras Doencas Tropicais Instituto de Higiene e Medicina TropicalUniversidade Nova de LisboaRua da Junqueira 961349008 Lisboa Portugal Unidade de Biologia Molecular Instituto de Higiene e Medicina TropicalUniversidade Nova de LisboaRua da Junqueira 961349-008 Lisboa Portugal

Objective:To investigate malaria prevalence and socio-economic conditions in East Timor. Methods:Blood samples were collected from 650 individuals distributed among six districts in East Timor.434 and 216 individuals were sampled by passive and active case detection, respectively(PCD,ACD).Results:The results showed that the plasmodium infection prevalence was 18.9%with predominance of Plasmodium falciparum(***) infections(60.2%). The majority of cases were detected in children between 2-14 years old in both PCD and ACD. Participants residing in Same and Lospalos were at a higher risk of *** percentage of infections associated to the lack of bed net use was twice as high as users(25.2%vs 12.5%). The prevalence of malaria among participants who lived in brick/cement houses(8.3%) was two times less than those who lived in other types of houses(3.7%).There was a significantly lower prevalence of infection detected in individuals living in complete housing constructions with absence of domestic animals in or near the ***:The major risk factors for malaria in East Timor are age,lack of bed net use,incomplete housing constructions and exposure to mosquitoes.

关键词： East Timor Malaria epidemiology Children Risk factors Housing constructions

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Estimate of the Crystallization Kinetics in Stoichiometry Compositions Films of Ge:Sb:Te

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Journal of Surface Engineered Materials and Advanced Technology 2012年第1期2卷 44-46页

作者： Carlos virgilio Rivera Rodriguez Eduardo Morales Sanchez Jesus Gonzalez Hernandez Evgen Prokhorov Juan Munoz Saldana Gerardo Trapaga Martinez Ciencias Ambientales del Instituto Nacional de Investigaciones Nucleares La MarquesaMexico CICATA-IPN Unidad Queretaro QueretaroMexico centro de Investigacion en Materiales Avanzados ChihuahuaMexico CINVESTAV-Qro. QueretaroMexico

The aim of this work is to compare the isothermal crystallization kinetic in the films along GeTe-Sb2Te3 line with composition Ge2Sb2Te5, Ge1Sb2Te4 Ge1Sb4Te7 and Ge4Sb1Te5 using mainly Johnson–Mehl–Avrami-Kolmogorov (JMAK) model. Results obtained have shown different crystallization mechanism in the investigated films. In Ge2Sb2Te5 and Ge1Sb2Te4 films the analysis of the kinetic results (Avrani coefficient) showed that at the beginning of crystallization a metastable phase appeared with the Ge1Sb4Te7 composition, this is followed by the nucleation and growth of the stable fcc phase up to full crystallization. In contrast Ge4Sb1Te5 and Ge1Sb4Te7 films show diffusion control growing from small dimension grains with decreasing nucleation rate.

关键词： Crystallization Ge:Sb:Te JMAK Model

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