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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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Touristic urbanization and greening of coastal dune fields:A long-term assessment of a temperate sandy barrier of Argentina

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Journal of Geographical Sciences 2025年第1期35卷 206-230页

作者： GARZO Pedro Andrés DADON José Roberto ISLA Federico Ignacio Instituto de Investigaciones Marinas y Costeras (IIMyC-conicet/UNMDP) Instituto de Geología de Costas y del Cuaternario Dr.Enrique J.Schnack (IGCC-CIC/UNMDP) Universidad de Buenos Aires Facultad de Arquitectura Dise?o y Urbanismo Centro de Investigaciones Gestión de Espacios Costeros (GEC-FADU/UBA) Consejo nacional de Investigaciones Científicas y Técnicas (conicet)

Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world. However, a century ago, they were considered hazardous environments due to their great dynamic nature. As a result, stabilization practices were considered necessary. The systematic introduction of fast-growing exotic trees helped stabilize the sand, making it easier for tourism urbanization to take place, but also leading to erosion processes. This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina. This complex region includes urban resorts, afforestation zones, and protected areas. A GIS-based geospatial analysis was conducted using a large satellite database(> 350 images), and the future evolution of the vegetation was modeled. The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover, accompanied by a concurrent reduction in sandy areas. In 1986, the dune area comprised 75% more surface than vegetation, whereas in 2021, it represented 60% less than vegetation. Furthermore, the 2050 scenario suggests a potential 40% reduction of dunes in certain areas. It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance. Long-term management strategies must focus on restoring native plant communities and controlling invasive species, and avoiding new dune fixation initiatives based on the introduction of exotic species.

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Reproductive strategies in males of the world’s southernmost lizards

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Integrative Zoology 2017年第2期12卷 132-147页

作者： Jimena B.FERNÁNDEZ Marlin MEDINA Erika L.KUBISCH JoséA.SCOLARO Nora R.IBARGÜENGOYTÍA INIBIOMA-conicet Zoology DepartmentCentro Regional Universitario Bariloche InstituteUniversidad Nacional del ComahueSan Carlos de BarilocheArgentina CIEMEP-conicet Biology DepartmentUniversidad Nacional de la Patagonia San Juan BoscoEsquelArgentina CENPAT-conicet Universidad Nacional de la Patagonia San Juan BoscoTrelewArgentina

Reproductive and life history patterns in reptiles are tightly related to the environmental conditions,so male reproductive cycles have been historically characterized as continuous,for tropical lizards,or seasonal,for temperate ***,males of Liolaemus and Phymaturus lizards(Liolaemidae),from cold temperate climates of high altitudes or latitudes in Argentina and Chile,have developed a variety of reproductive cycles to coordinate with the short female reproductive season and to deal with the low frequency of reproductive females in the *** gonadal histology and morphological analysis,we describe the male reproductive biology,fat storage and sexual dimorphism of the viviparous lizards Liolaemus sarmientoi and Liolaemus magellanicus that inhabit an austral grass steppe at 51°S,in the southern limit of the American *** of *** and *** are reproductively available during the entire activity season of approximately 5 *** addition,males of both species exhibit greater body sizes than females in morphological variables relevant in sexual ***,females of both species exhibit larger inter-limb length than conspecific males,which suggests fecundity selection to increase space for a larger litter *** continuous sperm production throughout the activity season allows these liolaemids to mate at any time when females ovulate,representing a selective advantage to deal with the short activity season and the adversities of the cold environment they inhabit.

关键词： adaptations Liolaemidae reproductive activity sexual dimorphism temperate-cold environments

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A simple and fast method to calculate the coil currents and the external poloidal flux and magnetic field for fixed boundary equilibria

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Plasma Science and Technology 2024年第11期26卷 65-70页

作者： Ricardo FARENGO Pablo L GARCÍA-MARTÍNEZ Hugo E FERRARI centro Atómico Bariloche Comisión Nacional de Energía AtómicaBariloche 8400Argentina Instituto Balseiro Universidad Nacional de CuyoBariloche 8400Argentina conicet CCT-Patagonia Norte Bariloche 8400Argentina

A simple and fast method to calculate the coil currents and the external poloidal flux and magnetic field consistent with a given internal magnetohydrodynamic(MHD) equilibrium and coil geometry is presented. The constrained optimization technique employed allows to fix the exact position of the X-points. The external poloidal flux and field are calculated using Green's functions expressed in terms of elliptic integrals that are calculated using a fast and accurate *** calculation can be limited to the region between the plasma and the device wall. An example for a double null configuration is presented.

关键词： MHD equilibrium Green's functions tokamak

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Soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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Ecological Processes 2024年第1期13卷 3-24页

作者： Pablo L.Peri Juan Gaitán Matías Mastrangelo Marcelo Nosetto Pablo E.Villagra Ezequiel Balducci Martín Pinazo Roxana P.Eclesia Alejandra Von Wallis Sebastián Villarino Francisco Alaggia Marina González Polo Silvina Manrique Pablo A.Meglioli Julián Rodríguez-Souilla Martín Mónaco Jimena E.Chaves Ariel Medina Ignacio Gasparri Eugenio Alvarez Arnesi María Paula Barral Axel von Müller Norberto M.Pahr Josefina Uribe Echevarria Pedro Fernández Marina Morsucci Dardo López Juan Manuel Cellini Leandro Alvarez Ignacio Barberis Hernán Colomb Ludmila La Manna Sebastián Barbaro Cecilia Blundo Ximena Sirimarco Laura Cavallero Gualberto Zalazar Guillermo Martínez Pastur Instituto nacional de Tecnología Agropecuaria (INTA) Universidad nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad nacional de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigaciones en Energía No Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ecología Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad nacional de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de La Plata (UNLP) Administración de Parques nacionales (APN) Parque Nacional Los Alerces centro de Estudios Ambientales Integrados (CEAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determined contribution（NDC） presented by Argentina within the framework of the Paris Agreement is aligned with the decisions made in the context of the United Nations Framework Conven-tion on Climate Change（UNFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（REDD+）. In addition, climate change constitutes one of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（SOC） stocks of native forests have not been incorporated into the Forest Reference Emission Levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model SOC stocks to 30 cm of native forests at a national scale using climatic, topographic and vegetation as predictor variables, and（ii） to relate SOC stocks with spatial–temporal remotely sensed indices to determine biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to generate spatially explicit estimates of SOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of SOC. All covariate maps were uploaded to the Google Earth Engine cloud-based computing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on Enhanced Vegetation Index（EVI） and land surface temperature（LST） images from Landsat *** SOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean SOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic carbon Biodiversity Native forest Climate change mitigation Modelling Resilience

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Quality evaluation of Nothofagus pumilio seeds linked to forest management and climatic events

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Ecological Processes 2024年第1期13卷 98-107页

作者： Julian Rodríguez-Souilla Jimena E.Chaves María Vanessa Lencinas Juan Manuel Cellini Fidel A.Roig Pablo L.Peri Guillermo Martinez Pastur Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de la Plata (UNLP) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IAN-IGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background Forest ecosystems undergo significant transformations due to harvesting and climate fluctuations, emphasizing the critical role of seeding in natural regeneration and long-term structural preservation. Climate change further amplifies these dynamics, affecting phenology across species and regions. In Tierra del Fuego(Argentina), Nothofagus pumilio(lenga) forests represent the most important timber resource, and it is managed through different silvicultural strategies. This species demonstrates notable post-disturbance regeneration, yet seed fall exhibits signifi-cant variability, leading to variations in seed quality(e.g., viability). This study aims to assess fluctuations in N. pumilio seed quality, determine how it varies concerning forest management strategies, annual productivity, and the co-occurrence of climatic phenomena including El Ni?o-Southern Oscillation(ENSO) and the Southern Annular Mode(SAM).Results Viable seeds represented 18.4% of the total, notably higher in unharvested than in managed areas. Con-versely, empty seeds were more prevalent in harvested areas(> 75%). Seed quality exhibited significant differences across silvicultural treatments, except for insect-predated seeds, which had similar proportions across all areas, though dispersed retention showed higher predation. When considering years with varying production levels, high-production years favoured full and viable seeds, particularly in unharvested forests and aggregated retention, while low-production years saw reduced viability across all treatments. Quadratic models revealed that viability increased with seed production, where unharvested forests achieved the highest values. Climate variability influenced seed proportions, where ENSO+/SAM+ promoting more full and viable seeds, while ENSO–/SAM+ favoured non-predated seeds, especially in unharvested *** Seed quality varies among treatments and years with different levels of seeding. Variations in seed qual-ity, l

关键词： Forest management Seeding Climate change Extreme event Patagonia

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A cloud-based platform to predict wind pressure coefficients on buildings

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Building Simulation 2022年第8期15卷 1507-1525页

作者： Facundo Bre Juan M.Gimenez centro de Investigacion de Metodos Computacionales(CIMEC) UNLCONICETPredio"Dr.Alberto Cassano"Colectora Ruta Nacional 168 s/n3000Santa FeArgentina

Natural ventilation(NV)is a key passive strategy to design energy-efficient buildings and improve indoor air ***,accurate modeling of the NV effects is a basic requirement to include this technique during the building design ***,there is an important lack of wind pressure coefficients(CP)data,essential input parameters for NV *** this,there are no simple but still reliable tools to predict CP data on buildings with arbitrary shapes and surrounding conditions,which means a significant limitation to NV modeling in real *** this reason,the present contribution proposes a novel cloud-based platform to predict wind pressure coefficients on *** platform comprises a set of tools for performing fully unattended computational fluid dynamics(CFD)simulations of the atmospheric boundary layer and getting reliable CP data for actual ***-expert decisions throughout the entire workflow are implemented to automatize the generation of the computational domain,the meshing procedure the solution stage,and the post-processing of the *** evaluate the performance of the platform,an exhaustive validation against wind tunnel experimental data is carried out for a wide range of case *** include buildings with openings,balconies,irregular floor-plans,and surrounding urban *** C_(P) results are in close agreement with experimental data,reducing 60%-77% the prediction error on the openings regarding the EnergyPlus *** platform introduced shows being a reliable and practical C_(P) data source for NV modeling in real building design scenarios.

关键词： natural ventilation building simulation airflow network model EnergyPlus wind pressure coefficient computational fluid dynamics

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Dynamics of phosphorus in sediments of a naturally acidic lake

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International Journal of Sediment Research 2013年第1期28卷 90-102页

作者： Temporetti PEDRO Snodgrass KIMBERLEY Pedrozo FERNANDO centro Regional Universitario Bariloche Universidad Nacional del ComahueCONICETQuintral 12508400 BarilocheArgentina Staff Environmental Engineer Water and Environmental Technologies 480 East Park StreetSuite 200 ButteMT59701MontanaEEUU INIBIOMA Centro Regional Universitario BarilocheUniversidad Nacional del ComahueCONICETQuintral 12508400 BarilocheArgentina

The mechanisms which controls the fixation and/or release of P in sediment of an extremely acidic lake（pH = 2.0 to 3.0） and its response to the influence of eutrophic urban waste water were *** results,in the chemical composition,in the mineralogy of the sediment and in the material as obtained from sediment traps,show that the lake sediments are mainly volcanic material reflecting volcanic features of the *** sedimentation rate calculated for the lake(2.5×10;mg m;day;) was higher than that observed in other similar glacial lakes in both Andean Patagonia and also elsewhere in the *** Total Phosphorus concentration in sediments was higher than figures reported by other authors for mining acid lakes,and the main fraction of P was found associated with organic *** was no control by Fe or Al on P,because both are in solution at pH < *** was concluded that changes in the natural input of nutrients（derivatives of Copahue volcano fluid,the discharge of sewage,or basin run-off） are responsible for a high concentration of SRP and N-NH;in the *** experiments showed that sediments have no ability to retain phosphorus and a continuous release of P from the sediments into the water column was *** assays where the pH was artificially increased showed that the P still remains in solution until at least pH *** was concluded that changes in the natural input of nutrients due to:1) the volcanic fluids,2) the increase in sewage charges,or 3) surface runoff upstream,maintain a high trophic state with high concentrations of dissolved P and N-NH;,although the threshold of neutral pH in the lake is *** study will enable a better understanding about of the mechanism of release/fixation of phosphorus in acidic sediments in order to assist in making decisions regarding the conservation and management of this natural environment.

关键词： Sediments Phosphorus release Acidic lake

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Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis

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World Journal of Gastroenterology 2010年第13期16卷 1622-1630页

作者： Cecilia Rodríguez Marta Medici Fernanda Mozzi Graciela Font de Valdez centro de Referencia para Lactobacilos (CERELA)-conicet Cátedra Microbiología Superior Facultad de Bioquímica Química y Farmacia Universidad Nacional de Tucumán

AIM: To investigate the potential therapeutic effect of exopolysaccharide (EPS)-producing Streptococcus thermophilus (S. thermophilus) CRL 1190 fermented milk on chronic gastritis in Balb/c mice. METHODS: Balb/c mice were fed with the fermented milk for 7 d after inducing gastritis with acetyl-salicylic acid (ASA, 400 mg/kg body weight per day for 10 d). Omeprazole was included in this study as a positive therapeutic control. The gastric in? ammatory activity was evaluated from gastric histology and in? ammation score, number of interleukin-10 (IL-10), interferon-γ (INFγ) and tumor necrosis factor-α (TNF-α) cytokine-producing cells in the gastric mucosa, and thickness of the mucus layer. RESULTS: Animals receiving treatment with the EPS-producing S. thermophilus CRL 1190 fermented milk showed a conserved gastric mucosa structure similar to that of healthy animals. In? ammation scores of the fermented milk-treated mice were lower than those of mice in the gastritis group (0.2 ± 0.03 vs 2.0 ± 0.6, P < 0.05). A marked decrease in INFγ+ (15 ± 1.0 vs 28 ± 1.2, P < 0.05) and TNF-α+ (16 ± 3.0 vs 33 ± 3.0, P < 0.05) cells and an increase in IL-10+ (28 ± 1.5 vs 14 ± 1.3, P < 0.05) cells compared to the gastritis group, was observed. Also, an increase in the thickness of the mucus gel layer (2.2 ± 0.6 vs 1.0 ± 0.3; 5.1 ± 0.8 vs 1.5 ± 0.4 in the corpus and antrum mucosa, respectively, P < 0.05) compared with the gastritis group was noted. A milk suspension of the purif ied EPS from S. thermophilus CRL1190 was also effective as therapy for gastritis.

关键词： Lactic acid bacteria Probiotics Gastritis Streptococcus thermophilus Exopolysaccharides

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One step synthesis of high efficiency nickel/mesoporous TiO_2 hybrid catalyst for hydrogen evolution reaction

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Journal of Energy Chemistry 2019年第2期28卷 79-87页

作者： Esteban A.Franceschini Melisa J.Gomez Gabriela I.Lacconi INFIQC-conicet Dto.de Fisicoquímica – Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCiudad Universitaria Departamento de Física de la Materia Condensada Centro Atómico ConstituyentesComisión Nacional de Energía Atómica

Nickel-Ti O_2 hybrid catalysts are synthesized by electrodeposition and their catalytic activity with respect to the hydrogen evolution reaction is *** types of titanium oxide particles,which are commercial particles of dense Ti O_2 and mesoporous TiO_2 particles synthesized by an aerosol method,are incorporated into the matrix of the nickel *** nickel catalysts containing Ti O_2 particles presented higher catalytic activity than the conventional nickel Watts *** TiO_2-modified nickel catalyst showed the highest catalytic activity towards HER in alkaline *** addition,this type of nickel catalyst increases its catalytic activity after ageing treatment,which is an indication of an increase in the electro-active area of the electrode.

关键词： Co-deposition Impedance spectroscopy Titanium oxide Ageing process Raman spectroscopy

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