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Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan

World Journal of Gastroenterology 2010年第4期16卷 474-478页

作者： Sergio A con Hiroaki Takeuchi Mitsuaki Nishioka Norihito Morimoto Tetsuro Sugiura Nobufumi Yasuda Reinaldo con-Wong centro digestivo doctores con-mediplaza 245-1200 San JoséCosta Rica Department of Clinical Laboratory Medicine Kochi Medical School Kochi UniversityNankoku-cityKochi 783-8505Japan Department of Public Health Kochi Medical SchoolKochi University Nankoku-cityKochi 783-8505Japan centro digestivo doctores con-mediplaza 245-1200 San JoséCosta Rica

AIM:To evaluate the prevalence of Helicobacter pylori(*** ) babA2 ,babB and a recombinant gene between babA2 and babB(babA2/B ),and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical ***:A total of 95 continuous ***-positive Costa Rican(41 males and 54 females;mean age,50.65 years;SD,± 13.04 years) and 95 continuous ***-positive Japanese(50 males and 45 females;mean age,63.43;SD,± 13.21 years) patients underwent upper endoscopy from October 2005 to July *** were enrolled for the polymerase chain reaction(PCR)-based genotyping of the *** babA2 ,babB and babA2/B *** analysis was performed using the χ2 test and the Fisher's exact probability test and multivariate analysis was performed by logistic regression adjusting for gender and age.P conCLUSION:These results suggest that the status of babA2 and babA2/B shows geographic differences,and that babA2 has clinical relevance in Costa Rica.

关键词： babA2 babA2/B Costa Rica Helicobacter pylori Japan

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Role of bacterial and genetic factors in gastric cancer in Costa Rica

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World Journal of Gastroenterology 2009年第2期15卷 211-218页

作者： Sergio A con Hiroaki Takeuchi Gil R con-Chin Vicky G con-Chin Nobufumi Yasuda Reinaldo con-Wong centro digestivo doctores con-mediplaza Pavas 245-1200 San José Costa Rica Department of Clinical Laboratory Medicine Kochi Medical School Kochi University Nankoku-city Kochi 783-8505 Japan Department of Public Health Kochi Medical School Kochi University Nankoku-city Kochi 783-8505 Japan

AIM： To evaluate several risk factors for gastric cancer （GC） in Costa Rican regions with contrasting GC incidence rate （GCIR）. METHODS： According to GCIR, 191 Helicobacter pylori （H pylori）-positive patients were classified into groups A （high GCIR, n = 101） and B （low GCIR, n = 90）. Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin （IL）-1β and IL-10 by PCRRFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS： Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach （mixed strain infection） were more frequently found in group A than in group B, and cagA and vacA s1b were significantly associated with high GCIR （P = 0.026 and 0.041, respectively）. IL- 1β＋3954_T/C （OR 2.1, 1.0-4.3）, IL-1RN^＊2/L （OR 3.5, 1.7-7.3） and IL-10-592_C/A （OR 3.2, 1.5-6.8） were individually associated with GC, and a combination of these cytokine polymorphisms with Hpylori vacA slb and ml further increased the risk （OR 7.2, 1.4-36.4）. conCLUSION： Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of Hpylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica.

关键词： Costa Rica Gastric cancer Helicobacterpylori Host genetic factors

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