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Asian Journal of Andrology 2015年第1期17卷 21-25,I0006页

作者： Piero Montorsi Paolo M Ravagnani Charalambos Vlachopoulos Department of Clinical Sciences and Community Health Cardiovascular Section University of Milan Centro Cardiologico Monzino IRCCS Milan Italy Department of Cardiology Athens Medical School Greece.

Erectile dysfunction （ED） has been found to frequently precedes the onset of coronary artery disease （CAD）, representing an early marker of subclinical vascular disease, included CAD. Its recognition is, therefore, a ＂window opportunity＂ to prevent a coronary event by aggressive treatment of cardiovascular risk factors. The artery size hypothesis （ASH） has been proposed as a putative mechanism to explain the relationship between ED and CAD. Since atherosclerosis is a systemic disorder all major vascular beds should be affected to the same extent. However, symptoms at different points in the system rarely become evident at the same time. This is likely the result of smaller vessels （i.e. the penile artery） being able to less well tolerate the same amount of plaque when compared with larger ones （i.e. the coronary artery）. If true, ED will develop before CAD. We present a case in which ED developed after a coronary event yet before a coronary recurrence potentially representing a late marker of vascular progression. Reasons for this unusual sequence are discussed as they might still fit the ASH.

关键词： artery size hypothesis coronary artery disease erectile dysfunction

Life Threatening Broad QRS Tachycardia in an Infant with Conduction Disorder and SCN5A Mutation

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Congenital Heart Disease 2022年第5期17卷 550-555页

作者： Elio Caruso Silvia Farruggio Alfredo Di Pino Paolo Guccione Mohammadrafie Khorgami Department of Pediatric Cardiology and Cardiac Surgery Bambino GesùChildren’s Hospital Centro Cardiologico Pediatrico del MediterraneoSan Vincenzo HospitalTaorminaItaly cardiovascular Surgery Department Rajaie Cardiovascular Medical and Research CenterIran University of Medical SciencesTehranIran

We present the case of an infant admitted to our department for a rapid broad complex tachycardia and cardiovascular *** patient was submitted to genetic testing because of a conduction defect at baseline ECG and family history of gene mutation.A new SCN5A gene mutation variant was found leading to diagnosis of sodium-channel dysfunction arrhythmia.

关键词： Brugada child broad QRS arrhythmias SCN5A mutation

Contrast-enhanced ultrasound in differentiating malignant from benign portal vein thrombosis in hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第32期21卷 9457-9460页

作者： Luciano Tarantino Pasquale Ambrosino Matteo Nicola Dario Di Minno Department of Surgery Interventional Hepatology Unit Andrea Tortora Hospital Department of Clinical Medicine and Surgery Federico II University Unit of Cell and Molecular Biology in cardiovascular Diseases Centro Cardiologico Monzino

Portal vein thrombosis(PVT) may occur in liver cirrhosis patients. Malignant PVT is a common complication in cirrhotic patients with concomitant hepatocellular carcinoma(HCC) and, in some cases, it may be even the initial sign of an undetected HCC. Detection of malignant PVT in a patient with liver cirrhosis heavily affects the therapeutic strategy. Gray-scale ultrasound(US) is widely unreliable for differentiating benign and malignant thrombi. Although effective for this differential diagnosis, fine-needle biopsy remains an invasive technique. Sensitivity of color-doppler US in detection of malignant thrombi is highly dependent on the size of the thrombus. Contrast-enhanced computed tomography(CT) and contrast-enhanced magnetic resonance(MRI) can be useful to assess the nature of portal thrombus, while limited data are currently available about the role of positron emission tomography(PET) and PET-CT. In contrast with CT, MRI, PET, and PET-CT, contrast-enhanced ultrasound(CEUS) is a fast, effective, well tolerated and cheap technique, that can be performed even in the same session in which the thrombus has been detected. CEUS can be performed bedside and can be available also in transplanted patients. Moreover, CT and MRI only yield a snapshot analysis during contrast diffusion, while CEUS allows for a continuous real-time imaging of the microcirculation that lasts several minutes, so that the whole arterial phase and the late parenchymal phase of the contrast diffusion can be analyzed continuously by real-time US scanning. Continuous real-time monitoring of contrast diffusion entails an easy detection of thrombus maximum enhancement. Moreover, continuous quantitative analyses of enhancement(wash in- wash out studies) by CEUS during contrast diffusion is nowadays available in most CEUS machines, thus giving a more sophisticated and accurate evaluation of the contrast distribution and an increased confidence in diagnosis in difficult cases. In conclusion, CEUS is av

关键词： Contrast-enhanced ultrasound Hepatocellular carcin

Chronic kidney disease in acute coronary syndromes

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World Journal of Nephrology 2012年第5期1卷 134-145页

作者： Giancarlo Marenzi Angelo Cabiati Emilio Assanelli centro Cardiologico Monzino IRCCS Department of Cardiovascular Sciences University of Milan

Chronic kidney disease(CKD) is associated with a high burden of coronary artery disease. In patients with acute coronary syndromes(ACS), CKD is highly prevalent and associated with poor short- and long-term outcomes. Management of patients with CKD presenting with ACS is more complex than in the general population because of the lack of well-designed randomized trials assessing therapeutic strategies in such patients. The almost uniform exclusion of patients with CKD from randomized studies evaluating new targeted therapies for ACS, coupled with concerns about further deterioration of renal function and therapy-related toxic effects, may explain the less frequent use of proven medical therapies in this subgroup of high-risk patients. However, these patients potentially have much to gain from conventional revascularization strategies used in the general population. The objective of this review is to summarize the current evidence regarding the epidemiology and the clinical and prognostic relevance of CKD in ACS patients, in particular with respect to unresolved issues and uncertainties regarding recommended medical therapies and coronary revascularization strategies.

关键词： Chronic kidney disease Acute coronary syndromes Non-ST-elevation myocardial infarction STelevation myocardial infarction Percutaneous coronary intervention Renal insuffciency

Myocarditis in athletes after COVID-19 infection:The heart is not the only place to screen

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Sports Medicine and Health Science 2020年第3期2卷 172-173页

作者： Martin Ibarrola Ignacio Davolos centro cardiovascular bv Bella VistaBuenos AiresArgentina Hospital de Clínicas Jose de San Martín Ciudad Autonoma de Buenos AiresArgentina

COVID-19 patients are susceptible to *** the safe return to sports after COVID-19,athletes or individuals wanting to resume physical activity should complete screening for myocardial injury and *** addition,patients with COVID-19 are reported at prevalence of 27%–31%for venous thromboembolic *** probability of deep vein thrombosis and pulmonary embolism prior to intensive exercise after COVID-19 infection should be *** prevalence of cardiac injury is reported at 19%,and the prevalence of deep vein thrombosis and pulmonary embolism is higher than that for ***,the heart is not the only system needing *** for myocardial injury and myocarditis are ***,deep vein thrombosis,and pulmonary thromboembolism must be considered,and when possible,blood troponin values,Ddimer prothrombin time,and activated partial thromboplastin time levels are determined for COVID-19 infection athletes or any individual before returning to sporting practice or intense physical activity or exercise.

关键词： Athletes Sports medicine Myocarditis Pulmonary embolism COVID-19 Screening Coronavirus Coagulopathy

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冠状动脉CT血流储备分数失败率的决定因素

国际医学放射学杂志 2019年第6期 726-727页

作者： G.Pontone J.R.Weir-McCall A.Baggiano A.Del Torto L.Fusini M.Guglielmo 许棚棚 Department of cardiovascular Imaging Centro Cardiologico MonzinoIRCCS

摘要目的计算冠状动脉CT血流储备分数(FFRCT)的失败率并寻找技术上与FFRCT计算不成功相关的因素。材料与方法本研究纳入评估无创性FFRCT在冠状动脉诊疗中的

关键词：冠状动脉失败率 CT

The aging burden of hospitalization for heart failure in Chinese populations:evidence from the Macao Heart Failure Study

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Journal of Geriatric Cardiology 2020年第9期17卷 533-543页

作者： Zhi-Nan LU Mario Evora Edmundo Lao Man Ieng Pun Weng Hong Pun Monica Pon Kong Chu Pui I Ieong Toi-Meng Mok Yong-Jian WU Coronary Heart Disease Center Cardiology DepartmentFuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina 2Centro Hospitalar Conde de São JanuárioMacaoSARChina

Objective To assess the aging burden of hospitalization for heart failure in Chinese populations in *** The Macao Heart Failure Study consists of patients hospitalized with a diagnosis of acute heart failure(AHF)at centro Hospitalar Conde de São Januário(the only public hospital that provides medical care for the approximately 600,000 residents of Macao)from January 2014 to December ***,we investigated the relationship between socioeconomic development and epidemiological characteristics of HF in *** we assessed the patients’clinical features and outcomes according to the age *** A total of 967 patients were included in the final *** median age at admission was 82 years *** advanced age at the admission of HF in Macao was significantly associated with a high-income level and the aging population *** heterogeneity existed in the epidemiological characteristics,clinical features,utilization of evidence-based therapies,short-and long-term outcomes,and prognostic utility of clinical variables among the different age *** Rapid economic development and significantly aging populations have produced a profound impact on the epidemiological characteristics of HF in Chinese *** decompensated heart failure(ADHF)is predominantly a disease of the elderly in Macao,and a significant heterogeneity exists in the clinical features,managements,and outcomes among different age ***-based risk stratification models and multidisciplinary HF teams are urgently needed to improve the management and outcomes of hospitalized heart failure(HHF)patients.

关键词： Cardiac risk factors and prevention Heart failure The elderly

Practical update on imaging and transcatheter aortic valve implantation

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World Journal of Cardiology 2015年第4期7卷 178-186页

作者： Gisela Feltes Iván J Nú ez-Gil cardiovascular Unit Centro Médico Paris Interventional Cardiology Hospital Clínico San Carlos

After very rapid advances in the development of the technique and devices,transcatheter aortic valve implantation(named TAVI or TAVR),is today a reality that is here to *** has become the minimallyinvasive treatment option for high-risk and non-surgical patients with severe symptomatic aortic *** the participation of a multidisciplinary team for its implementation,cardiac imaging plays an important *** pre-assessment to determine the suitability of the patient,the access site,the type of device,to the guidance during the procedure,and ultimately the long term monitoring of the *** selection of the patient and device,correct placement of the stent-valve and early detection of complications are of paramount importance for procedural success and for patient *** technique has advantages and disadvantages,being the cardiologist who will determine the best approach according to the type of patient and the expertise of the center in each one of *** article summarizes the last contributions of the most common used imaging techniques,in each step of the procedure.

关键词： TAVI TAVR Echocardiography Multislice tomography Cardiac magnetic resonance Aortic stenosis

Manifold benefits of choosing a minimally fluoroscopic catheter ablation approach

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World Journal of Cardiology 2013年第2期5卷 8-11页

作者： Michela Casella Antonio Dello Russo Gaetano Fassini Daniele Andreini Pasquale De Iuliis Saima Mushtaq Stefano Bartoletti Stefania Riva Claudio Tondo Cardiac Arrhythmia Research Centre Centro Cardiologico Monzino IRCCS cardiovascular Imaging Department Centro Cardiologico Monzino IRCCS St Jude Medical Italy

We report the case of a 14-year-old boy with ventricular preexcitation. A standard, fluoroscopy guided, ablation procedure was successfully performed in a postero-midseptal region with a total fluoroscopy time of about 45 min (2430 ***2). A few hours after the procedure, preexcitation reappeared. A second ablation procedure was scheduled using the EnSite NavXTM mapping system. During mapping along the tricuspid groove, preexcitation suddenly disappeared due to mechanical "bumping" of the accessory pathway and it did not recover over the next 30 min. As per our routine practice, the phase of geometry reconstruction has been continuously recorded by the system; thus, an off-line analysis allowed to pinpoint the site of earliest activation and the site of mechanical bumping, where radiofrequency obtained the accessory pathway ablation. The second procedure was performed without using fluoroscopy at all. Thanks to the geometry reconstruction, the procedure was completely successful thus avoiding a further rehospitalization.

关键词： Supraventricular arrhythmias Accessory pathway Radiofrequency ablation Electroanatomical mapping Radiation exposure

Long-term outcomes following drug-eluting stent implantation in unprotected left main bifurcation lesions

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Chinese Medical Journal 2007年第7期120卷 545-551页

作者： GE Lei John Cosgrave Ioannis Iakovou QIAN Ju-ying Pierfrancesco Agostoni Giuseppe M. Sangiorgi Flavio Airoldi Iassen Michev Alaide Chieffo Nicola Corvaja Antonio Colombo GE Jun-bo Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai 200032 China EMO centro Cuore Columbus and San Raffaele Hospital Milan Italy

Background The safety and efficacy of drug-eluting stents （DES） implantation in unprotected left main （LM） bifurcation lesions has yet to be determined. The aim of the present report was to evaluate the long-term outcome following implantation of DES in unprotected LM bifurcation lesions.Methods We identified 70 consecutive patients treated with DES in unprotected LM bifurcation lesions from April 2003 to January 2005. Of them, 42 patients were treated with sirolimus-eluting stent （SES） and 28 patients were treated with paclitaxel-eluting stent （PES）. Results Stents to the left anterior descending and to the circumflex were implanted in 62 patients. During 1-year follow-up, 3 （4.3%） patients died of cardiac causes. One of them had myocardial infarction and adjudicated as possibly due to stent thrombosis. Angiographic follow-up was available in 80% of patients. The per lesion restenosis rate was 13.4% in the entire cohort, of which 10.7% occurred in lesions treated with SES and 16.1% in those treated with PES （P=0.58）. All restenosis was focal and occurred in the lesions treated with a stent with stent size to post-procedural reference vessel diameter ratio 〈1.0 （17.6% vs 0, P=0.04）. The per patient target lesion revascularization rate at 1 year was 17.1%. One year survival free from major adverse cardiac events was 77.1%. Conclusions Treatment of LM bifurcation lesions using DES is a safe and feasible way with a low one-year mortality. The need for revascularization in 17% of patients demands for improvement.

关键词： stents revascularization restenosis thrombosis