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Large eustachian valve fostering paradoxical thromboembolism:passive bystander or serial partner in crime?

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World Journal of Cardiology 2021年第7期13卷 204-210页

作者： Eustaquio Maria Onorato invasive Cardiology Centro Cardiologico MonzinoIstituto di Ricovero e Cura a Carattere ScientificoMilan 20138Italy

Catheter-based closure of patent foramen ovale(PFO)is more effective than medical therapy in the prevention of recurrent stroke[1].it is likely that a proportion of patients evaluated for potential transcatheter PFO closure has actually different anatomical variants particularly common in the right atrium such as eustachian valve,Chiari network,Thebesian valve and Crista ***,the eustachian valve may represent an increased risk factor for left circulation thromboembolism beyond that associated with PFO size and *** patients may benefit the most from percutaneous closure procedure.

关键词： Eustachian valve Chiari’s network Patent foramen ovale Right-to-left shunt Paradoxical embolism Echocardiography

Study of the impact of the Patient Rhythm during Cryoballoon Ablation on the Acute Biophysical Parameters

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World Journal of Cardiovascular Diseases 2022年第1期12卷 65-76页

作者： Mohamed Sanhoury Gaetano Fassini Salvatore Pala Massimo Moltrasio Fabrizio Tundo Stefania Riva Antonio Dello Russo Michela Casella Claudio Tondo Cardiac Arrhythmia Research Centre Department of Cardiovascular Sciences University of Milan Centro Cardiologico Monzino IRCCS Milan Italy Electrophysiology Unit Department of Cardiology and Angiology University of Alexandria Alexandria Egypt

Background: Pulmonary vein isolation by means of cryoballoon is a well-established way of treatment of atrial fibrillation. The aim of the study was to compare the acute cryoballoon biophysical parameters attained during energy applications to the individual pulmonary vein during sinus rhythm versus atrial fibrillation. Methods: 100 Patients who underwent their first-time PVI using second-generation cryoballoon for symptomatic and drug-refractory AF, between the beginning of March to end of August 2016, were initially screened. 61 patients with paroxysmal AF were included in the present study. 39 patients with persistent AF were excluded. No pre-procedural anatomical imaging was reported. Results: A total of 61 patients (male 80%, age 59.3 ± 13.4 years) were included in the present analysis. ite-space:normal;font-family:Verdana;

关键词： Pulmonary Vein isolation Cryoballoon Paroxysmal Atrial Fibrillation Biophysical Parameters

Vitamin D and acute myocardial infarction

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World Journal of Cardiology 2017年第1期9卷 14-20页

作者： Valentina Milazzo Monica De Metrio Nicola Cosentino Giancarlo Marenzi Elena Tremoli centro cardiologico monzino I.R.C.C.S.20138 MilanItaly

Vitamin D deficiency is a prevalent condition,cutting across all ethnicities and among all age groups,and occurring in about 30%-50% of the population. Besides vitamin D established role in calcium homeostasis,its deficiency is emerging as a new risk factor for coronary artery disease. Notably,clinical investigations have suggested that there is an association between hypovitaminosis D and acute myocardial infarction(AMi). Not only has it been linked to incident AMi,but also to increased morbidity and mortality in this clinical setting. Moreover,vitamin D deficiency seems to predispose to recurrent adverse cardiovascular events,as it is associated with post-infarction complications and cardiac remodeling in patients with AMi. Several mechanisms underlying the association between vitamin D and AMi risk can be involved. Despite these observational and mechanistic data,interventional trials with supplementation of vitamin D are controversial. in this review,we will discuss the evidence on the association between vitamin D deficiency and AMi,in terms of prevalence and prognostic impact,and the possible mechanisms mediating it. Further research in this direction is warranted and it is likely to open up new avenues for reducing the risk of AMi.

关键词：维生素 D 尖锐心肌的梗塞发生预后

Manifold benefits of choosing a minimally fluoroscopic catheter ablation approach

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World Journal of Cardiology 2013年第2期5卷 8-11页

作者： Michela Casella Antonio Dello Russo Gaetano Fassini Daniele Andreini Pasquale De iuliis Saima Mushtaq Stefano Bartoletti Stefania Riva Claudio Tondo Cardiac Arrhythmia Research Centre Centro Cardiologico Monzino IRCCS Cardiovascular imaging Department Centro Cardiologico Monzino IRCCS St Jude Medical italy

We report the case of a 14-year-old boy with ventricular preexcitation. A standard, fluoroscopy guided, ablation procedure was successfully performed in a postero-midseptal region with a total fluoroscopy time of about 45 min (2430 ***2). A few hours after the procedure, preexcitation reappeared. A second ablation procedure was scheduled using the EnSite NavXTM mapping system. During mapping along the tricuspid groove, preexcitation suddenly disappeared due to mechanical "bumping" of the accessory pathway and it did not recover over the next 30 min. As per our routine practice, the phase of geometry reconstruction has been continuously recorded by the system; thus, an off-line analysis allowed to pinpoint the site of earliest activation and the site of mechanical bumping, where radiofrequency obtained the accessory pathway ablation. The second procedure was performed without using fluoroscopy at all. Thanks to the geometry reconstruction, the procedure was completely successful thus avoiding a further rehospitalization.

关键词： Supraventricular arrhythmias Accessory pathway Radiofrequency ablation Electroanatomical mapping Radiation exposure

Life Threatening Broad QRS Tachycardia in an infant with Conduction Disorder and SCN5A Mutation

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Congenital Heart Disease 2022年第5期17卷 550-555页

作者： Elio Caruso Silvia Farruggio Alfredo Di Pino Paolo Guccione Mohammadrafie Khorgami Department of Pediatric Cardiology and Cardiac Surgery Bambino GesùChildren’s Hospital Centro Cardiologico Pediatrico del MediterraneoSan Vincenzo HospitalTaorminaItaly Cardiovascular Surgery Department Rajaie Cardiovascular Medical and Research CenterIran University of Medical SciencesTehranIran

We present the case of an infant admitted to our department for a rapid broad complex tachycardia and cardiovascular *** patient was submitted to genetic testing because of a conduction defect at baseline ECG and family history of gene mutation.A new SCN5A gene mutation variant was found leading to diagnosis of sodium-channel dysfunction arrhythmia.

关键词： Brugada child broad QRS arrhythmias SCN5A mutation

Partial closure with a self-made fenestrated device of secundum atrial septal defect with severe pulmonary artery hypertension in adults

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Journal of Geriatric Cardiology 2021年第6期18卷 498-504页

作者： Tullio Tesorio Luigi Salemme Sebastiano Verdoliva Marco Ferrone Paola Tesorio Eustaquio Maria Onorato Unitàdi Cardiologia interventistica Emodinamica Casa di Cura MontevergineVia Mario MalzoniMercoglianoItaly centro cardiologico monzino Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)University School of MilanMilanItaly

Secundum atrial septal defect(ASD)repres-ents one of the most common congenital heart diseases,accounting for up to 10%of all congenital heart *** is often diagnosed in adulthood due to the absence of clinical symptoms.[1]By the age of 40 years,90%of untreated patients have symptoms of exertional dyspnea,fatigue,pal-pitation,sustained arrhythmia,or even evidence of heart failure.

关键词： septal sustained atrial

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冠状动脉CT血流储备分数失败率的决定因素

国际医学放射学杂志 2019年第6期 726-727页

作者： G.Pontone J.R.Weir-McCall A.Baggiano A.Del Torto L.Fusini M.Guglielmo 许棚棚 Department of Cardiovascular imaging Centro Cardiologico MonzinoIRCCS

摘要目的计算冠状动脉CT血流储备分数(FFRCT)的失败率并寻找技术上与FFRCT计算不成功相关的因素。材料与方法本研究纳入评估无创性FFRCT在冠状动脉诊疗中的

关键词：冠状动脉失败率 CT

Relevance of Spike/Estrogen Receptor-αinteraction for endothelial-based coagulopathy induced by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2459-2462页

作者： Silvia Stella Barbieri Franca Cattani Leonardo Sandrini Magda Maria Grillo Alessandra Amendola Carmen Valente Carmine Talarico Daniela iaconis Gabriele Turacchio Miriam Lucariello Lucia Lione Erika Salvatori Patrizia Amadio Gloria Garoffolo Mariano Maffei Francesca Galli Andrea Rosario Beccari Giuseppe Sberna Emanuele Marra Marica Zoppi Michael Michaelides Giuseppe Roscilli Luigi Aurisicchio Riccardo Bertini Marcello Allegretti Maurizio Pesce centro cardiologico monzino IRCCSMilanoItaly Dompéfarmaceutici S.p.A. L’AquilaItaly istituto Nazionale per le Malattie infettive Lazzaro Spallanzani RomaItaly institute of Experimental Endocrinology and Oncology“G.Salvatore”(iEOS) National Research CouncilNaplesItaly EXSCALATE DompéFarmaceutici S.p.ANapoliItaly Takis S.r.l. RomeItaly National institute on Drug Abuse intramural Research Program Baltimore21224MDUSA Johns Hopkins School of Medicine BaltimoreMDUSA Atreius S.a.s. L’AquilaItaly

Dear Editor,The severe coagulation syndrome in numerous organs is the major life-threatening conditions characterizing the acute infection by *** inflammation/dysfunction,platelet hyper-reactivity,generation of neutro... 详细信息

关键词： organs infection acute

冠状动脉疾病后勃起功能障碍的临床意义：符合动脉尺寸的假说吗？

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Asian Journal of Andrology 2015年第1期17卷 21-25,I0006页

作者： Piero Montorsi Paolo M Ravagnani Charalambos Vlachopoulos Department of Clinical Sciences and Community Health Cardiovascular Section University of Milan Centro Cardiologico Monzino IRCCS Milan Italy Department of Cardiology Athens Medical School Greece.

Erectile dysfunction （ED） has been found to frequently precedes the onset of coronary artery disease （CAD）, representing an early marker of subclinical vascular disease, included CAD. its recognition is, therefore, a ＂window opportunity＂ to prevent a coronary event by aggressive treatment of cardiovascular risk factors. The artery size hypothesis （ASH） has been proposed as a putative mechanism to explain the relationship between ED and CAD. Since atherosclerosis is a systemic disorder all major vascular beds should be affected to the same extent. However, symptoms at different points in the system rarely become evident at the same time. This is likely the result of smaller vessels （i.e. the penile artery） being able to less well tolerate the same amount of plaque when compared with larger ones （i.e. the coronary artery）. if true, ED will develop before CAD. We present a case in which ED developed after a coronary event yet before a coronary recurrence potentially representing a late marker of vascular progression. Reasons for this unusual sequence are discussed as they might still fit the ASH.

关键词： artery size hypothesis coronary artery disease erectile dysfunction