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Transmission of amyloid-βpathology in humans:a perspective on clinical evidence

Neural Regeneration Research 2024年第2期19卷 390-392页

作者： Celso S.G.Catumbela Rodrigo Morales department of Neurology McGovern Medical SchoolThe University of Texas Health Science Center at HoustonHoustonTXUSA centro integrativo de Biologia y quimica aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Transmission of misfolded amyloid-β(Aβ)aggregates between human subjects:Protein misfolding disorders are a family of diseases characterized by the accumulation of misfolded protein *** proteinaceous structures,also known as amyloids,are key drivers of fatal neurodegenerative disorders such as prion diseases,Alzheimer’s disease(AD),Parkinson’s disease,and others.

关键词： amyloid diseases Aβ

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Role of peripheral amyloid-β aggregates in Alzheimer’s disease: mechanistic, diagnostic, and therapeutic implications

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Neural Regeneration Research 2025年第4期20卷 1087-1089页

作者： Nazaret Gamez Rodrigo Morales department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA centro integrativo de Biologia y quimica aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Compelling evidence demonstrates that the levels of peripheral amyloid-β(Aβ)fluctuate in Alzheimer’s disease(AD)***,Aβdeposits have been identified in peripheral ***,the relevance of peripheral Aβ(misfolded or not)in pathological situations,and the temporal appearance of these pathological fluctuations,are not well *** presence of misfolded Aβin peripheral compartments raises concerns on potential inter-individual transmissions considering the well-reported prion-like properties of this disease-associated *** latter is supported by multiple reports demonstrating that Aβmisfolding can be transmitted between humans and experimental animals through multiple routes of *** this mini-review,we discuss the potential implications of peripheral,disease-associated Aβin disease mechanisms,as well as in diagnostic and therapeutic approaches.

关键词： therapeutic amyloid latter

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Misfolded amyloid-βstrains and their potential roles in the clinical and pathological variability of Alzheimer’s disease

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Neural Regeneration Research 2023年第1期18卷 119-120页

作者： Sara Kelley Nelson Perez-Urrutia Rodrigo Morales department of Neurology University of Texas Health Science Center at HoustonHoustonTXUSA centro integrativo de Biologia y quimica aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Potential causes for the clinical and pathological variability observed in Alzheimer’s disease(AD):AD is an age-related neurodegenerative disorder characterized by the impairment of cognitive functions such as memory,learning,and *** commonly described clinical symptoms are due to particular pathological changes in the brain,including inflammation,synaptic loss,and neuronal *** changes are a consequence of the accumulation of abnormally folded amyloid-β(Aβ)and tau proteins in specific areas of the central nervous *** the progressive aging of the world’s population,the number of people affected by AD is expected to substantially and consistently increase in the coming *** positions AD as one of the main public health challenges in the near future.

关键词： clinical Alzheimer amyloid

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A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle

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Journal of Molecular Cell Biology 2019年第1期11卷 39-52页

作者： Maria I.Calvo-Sanchez Sandra Fernandez-Martos Elisa Carrasco Gema Moreno-Bueno Carmelo Bernabeu Miguel Quintanilla Jesus Espada Instituto de Investigaciones Biomedicas'Alberto Sols' Consejo Superior de Investigaciones Cientificas(CSIC)-Departamento de BioqufmicaUniversidad Autonoma de Madrid(UAM)Madrid 28029Spain Instituto de Investigaciones Biosanitarias Facultad de Ciencias ExperimentalesUniversidad Francisco de Vitoria(UFV)Pozuelo de Alarcon 28223Spain centro de Investigacion Biomedica en Red de Cancer(CIBERONC) Spain centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas(CSIC)and Centro de Investigacion Biomedica en Red de Enfermedades Raras(CIBERER)Madrid 28040Spain centro integrativo de biologfa y quimica aplicada Universidad Bernardo O'HigginsSantiago 8370854Chile Instituto Ramon y Cajal de Investigacion Sanitaria(IRyCIS) Hospital Universitario Ramon y CajalMadridSpain

The hair follicle is a biological oscillator that alternates growth,regression,and rest phases driven by the sequential activation of the proliferation differentiation programs of resident stem cell *** activation of hair follicle stem cell niches and subsequent entry into the growing phase is mainly regulated by Wnt/β-catenin signalling,while regression and resting phases are mainly regulated by Tgf-β/Bmp/Smad activity.A major question still unresolved is the nature of the molecular switch that dictates the coordinated transition between both signalling *** we have focused on the role of Endoglin(Eng),a key co-receptor for members of the Tgf-β/Bmp family of growth *** an Eng haploinsufficient mouse model,we report that Eng is required to maintain a correct follicle cycling pattern and for an adequate stimulation of hair follicle stem cell *** further report thatβ-catenin binds to the Eng promoter depending on Bmp ***,we show thatβ-catenin interacts with Smad4 in a Bmp/Eng-dependent context and both proteins act synergistically to activate Eng promoter *** observations point to the existence of a growth/rest switching mechanism in the hair follicle that is based on an Eng-dependent feedback cross-talk between Wnt/β-catenin and Bmp/Smad signals.

关键词： Endoglin hair follicle skin stem cells Wnt/β-catenin Tgf-β/Bmp/Smad

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Gut passage of epigeous ectomycorrhizal fungi by two opportunistic mycophagous rodents

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Current Zoology 2011年第3期57卷 293-299页

作者： Citlalli CASTILLO-GUEVARAl Josette SIERRA Gema GALINDO-FLORES Mariana CUAUTLE Carlos LARA centro de Investigacion en Ciencias Biologicas Universidad Autonoma de Tlaxcala Km 10.5 Autopista Tlaxcala-San Martin Texmelucan San Felipe Ixtacuixtla Tlaxcala 90120 Mexico departamento de quimica y biologfa Universidad de las Americas-Puebla Ex-hacienda Sta Catarina Martir s/n Cholula Puebla 72810 Mexico centro Tlaxcala de Biologia de la Conducta Universidad Autdnoma de Tlaxcala-UNAM Carretera Tlaxcala-Puebla Km 1.5 s/n Tlaxcala Tlaxcala 90070 Mexico

Mycophagists can influence fungal diversity within their home ranges by ensuring the continued and effective dispersal of spores from one site to another. However, the passage of spores through the digestive tract of vertebrates can affect the activity and viability of the spores ingested. This phenomenon has been rarely documented in opportunistic mycophagists consuming epigeous fungi. Using laboratory experiments, we investigated the activity and viability of spores of two epigeous ectomycorrhizal fungal species (Laccaria trichodermophoraandSuillus tomentosus) after passage through the digestive tract of two opportunistic mycophagous small rodents, the volcano mousePeromyscus alstoniand the deer mouseP. maniculatus. We found that passage through the gut of either species of rodent had a significant effect on spore activity and viability for both fungal species. The proportion of active spores (0.37–0.40) ofL. trichodermophorain the feces of both species of rodents was less than that recorded for the control (0.82). However, the proportion of active spores (0.64–0.73) ofS. tomentosusin the feces of each species of rodent was higher than in the control (0.40). On the other hand, the viability of spores was lower (0.26–0.30 inL. trichodermophoraand 0.60–0.69 inS. tomentosus) for both fungi when consumed by either rodent relative to the controls (0.90 inL. trichodermophoraand 0.82 inS. tomentosus). These findings suggest that these rodent species may be effective dispersers of both epigeous fungi.

关键词：外生菌根真菌啮齿类动物主义肠道动物物种实验室实验活动范围脊椎动物

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Temporal-spatial segregation among hummingbirds foraging on honeydew in a temperate forest in Mexico

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Current Zoology 2011年第1期57卷 56-62页

作者： Carlos LARA Vanessa MARTINEZ-GARCIA Raul ORTIZ-PULIDO Jessica BRAVO-CAdeNA Salvador LORANCA Alex CORDOBA-AGUILAR Laboratorio de Ecologfa de la Conducta Centro Tlaxcala de Biologfa de la Conducta UAT-UNAM Km 1.5 carretera Tlaxcala- Puebla s/n Colonia Xicohtencatl Apdo. Postal 262 Tlaxcala Tlaxcala 90070 Mexico Laboratorio de Ecologfa de Poblaciones. centro de Investigaciones Biologicas. Universidad Autonoma del Estado de Hidalgo Mexico departamento de quimica y Biologia. Universidad de las Ameficas-Puebla. Cholula Puebla Mexico departamento de Ecologfa Evolutiva. lnstituto de Ecologfa Universidad Nacional Autonoma de Mexico Distrito Federal Mexico

Spatial and temporal variation in interactions between hummingbirds and plants have often been examined, and hummingbirds and insects are known to indirectly interact in networks of nectar plants. In a highland temperate forest in Hidalgo, Mexico some oak trees were heavily infested by honeydew-producing insects (family Margarodidae, tribe Xylococcini, genusStrigmacoccus) and the honeydew was consumed by hummingbirds. Here using survival analysis we investigate how the honeydew produced by dense populations of these margarodids is temporally and spatially partitioned by hummingbirds. We also measured the availability and quality of honeydew exudates, and then we recorded the time until a bird visited and used such resources. Four hummingbird species consumed this resource (Atthis eloisa, Hylocharis leucotis, Colibri thalassinusandeugenes fulgens). Data from 294 hours of observation on seven focal trees suggested temporal and spatial segregation among visiting birds according to body size and territorial behavior during the most honeydew-limited time. Hummingbird species differed in the daily times they foraged, as well as in the location where honeydew-producing insects were visited on the trees. Temporal and spatial segregation among hummingbird species is interpreted as an adaptation to reduce the risk of aggressive encounters. This may facilitate multispecies coexistence and allow these birds to exploit honeydew more effectively.

关键词：温带森林墨西哥蜂鸟蜜露觅食时空蜜源植物和空间

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