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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

Journey through the birth, growth and maturity of X-ray astronomy

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Research in Astronomy and Astrophysics 2019年第10期19卷 1-16页

作者： Prahlad Chandra Agrawal MU-DAE centre of excellence in Basic sciences Mumbai University Campus at Vidhyanagari

In this biographical account, I recall my scientific journey that began in 1961 when I joined as a Physics Trainee in the BARC Training School and after one year course was admitted in TIFR as a Research Associate. During 1962–1967, I worked on determination of the He^3 /He^4 ratio in cosmic rays using a gas Cerenkov counter and also used a scintillation + solid Cerenkov detector to measure flux of protons and helium nuclei in primary cosmic rays. I also developed a large area scintillation-Cerenkov detector with a spark chamber between them for measuring charge composition of primary cosmic rays. I joined the X-ray astronomy programme in 1967 initiated by Prof. B. V. Sreekantan and played a leading role in developing a balloon borne hard X-ray instrument for studying time variability and energy spectra of cosmic X-ray sources. We carried out a series of balloon experiments and studied temporal intensity variation and energy spectra of X-ray objects like Sco X-1, Cyg X-1, etc. Results on rapid intensity changes and spectra appeared in a series of publications based on which I obtained a Ph.D. degree in 1972. Immediately afterwards, I joined Prof. Gordon Garmire at Caltech as a Research Fellow (a post-doctoral position) to work with him on the low energy component of HEAO A-2 experiment. The instrument was developed and successfully realised. Working on this satellite experiment was a thrilling experience which exposed me to the technical complexities of space instruments. The HEAO-1 satellite was launched in 1978. During 1978–1979, Guenter Riegler and I, working at JPL, reported detection of intense soft X-rays from several classes of extragalactic and Galactic objects like new BL Lacs, a new AM Her binary, coronal X-rays from active stars, etc. After returning to TIFR, I developed a rocket experiment with K. P. Singh to map the spatial and spectral distribution of the Soft Diffuse X-ray Background. At the same time, I also designed 15 cm deep Xenon filled Proportio

关键词： TIFR-X-ray Astronomy by balloons-rockets and satellites-Indian Astronomy Satellite ASTROSAT

Time-resolved spectral analysis of prompt emission from long gamma-ray bursts with GeV emission

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Research in Astronomy and Astrophysics 2014年第1期14卷 35-46页

作者： Arikkala Raghurama Rao Rupal Basak Jishnu Bhattacharya Sarthak Chandra Nikunj Maheshwari Manojendu Choudhury Ranjeev Misra Tata Institute of Fundamental Research Indian Institute of Technology centre for excellence in Basic sciences Inter-University centre for Astronomy and Astrophysics

We performed detailed time-resolved spectroscopy of bright tong gamma- ray bursts （GRBs） which show significant GeV emissions （GRB 080916C, GRB 090902B and GRB 090926A）. In addition to the standard Band model, we also use a model consisting of a black body and a power law to fit the spectra. We find that for the latter model there are indications of an additional soft component in the spectra. While previous studies have shown that such models are required for GRB 090902B, here we find that a composite spectral model consisting of two blackbodies and a power law adequately fits the data of all the three bright GRBs. We investigate the evolution of the spectral parameters and find several interesting features that appear in all three GRBs, like （a） temperatures of the blackbodies are strongly correlated with each other, （b） fluxes in the black body components are strongly correlated with each other, （c） the temperatures of the black body trace the profile of the individual pulses of the GRBs, and （d） the characteristics of power law components like the spectral index and the delayed onset bear a close similarity to the emission characteristics in the GeV regions. We discuss the implications of these results and the possibility of identifying the radiation mechanisms during the prompt emission of GRBs.

关键词： gamma rays: bursts - gamma rays: observations - methods: data analysis

Surface Passivation of Ti/4H-SiC Schottky Barrier Diode

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Communications in Theoretical Physics 2012年第10期58卷 577-582页

作者： Muhammad Khalid Saira Riaz Shahzad Naseem Microelectronics Division/centre of excellence in Solid State Physics School of Physical SciencesUniversity of the Punjab

Surface properties of SiC power devices mostly depend on the passivation layer(PL).This layer has direct influence on electrical characteristics of devices.2D numerical simulation of forward and reverse characteristics with and without different(PLs)(SiO2,HfO2 and Si3N4) has been *** results show that the breakdown voltage increases with increasing PL thickness,and there is a lesser significant effect on forward *** maximum breakdown voltage with and without SiO2 PL is 1240 V and 276 V,***2 PL has compatibility with SiC surface providing high breakdown voltage,6 and 8% higher than that of HfO2 and Si3N4 *** leakage current is observed which then further decreases on reducing the thickness of ***,variation of forward current with dielectric constant and thickness of PLs was ***,it is suggested that matches of our results with published experimental results indicate that the Sentaurus TCAD simulator is a predictive tool for the SiC Schottky barrier diode simulation.

关键词： Passivation breakdown voltage leakage current electric field on-resistance

Classical Ethylene Insensitive Mutants of the Arabidopsis EIN2 Orthologue Lack the Expected‘hypernodulation’ Response in Lotus japonicus

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Journal of Integrative Plant Biology 2013年第4期55卷 395-408页

作者： Pick Kuen Chan Bandana Biswas Peter M. Gresshoff Australian Research Council (ARC) centre of excellence for Integrative Legume Research The University of Queensland ARC centre of excellence for Integrative Legume Research and School of Agriculture and Food sciences The University of Queensland

Three independent ethylene insensitive mutants were selected from an EMS- mutagenized population of Lotus japonicus MG-20 （Miyakojima）. The mutants, called ＇Enigma＇, were mutated in the LjEIN2a gene from Lotus chromosome 1, sharing significant homology with Arabidopsis EIN2 （ethylene-insensitive2）. All three alleles showed classical ethylene insensitivity phenotypes （e.g., Triple Response）, but lacked the increased nodulation phenotype commonly associated with ethylene insensitivity. Indeed, all showed a marginal reduction in nodule number per plant, a phenotype that is enigmatic to sickle, an ethylene- insensitive EIN2 mutant in Medicago truncatula. In contrast to wild type, but similar to an ETRI-1 ethylene ethylene-insensitive transgenic of L. japonicus, enigma mutants formed nodules in between the protoxylem poles, demonstrating the influence of ethylene on radial positioning. Suppression of nodule numbers by nitrate and colonisation by mycorrhizal fungi in the enigma-1 mutant were indistin- guishable from the wild-type MG-20. However, reflecting endogenous ethylene feedback, the enigma-1 mutant released more than twice the wild-type amount of ethylene, enigma-1 had a moderate reduction in growth, greater root mass （and lateral root formation）, delayed flowering and ripening, smaller pods and seeds. Expression analysis of ethylene-regulated genes, such as ETR1, NRL1 （neverripe-like 1）, and ElL3 in shoots and roots of enigma-1 and MG-20 illustrated that the ethylene-insensitive mutation strongly affected transcriptional responses in the root. These mutants open the possibility that EIN2 in L. japonicus, a determinate nodulating legume, acts in a more complex fashion possibly through the presence of a duplicated copy of LjEIN2.

关键词： ABA development ethylene legume nodulation symbiosis.

Lead isotope signatures of Pb-Zn sulfide mineralization in the Reshian-Lamnian area of Azad Jammu and Kashmir,Pakistan

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Chinese Journal Of Geochemistry 2010年第1期29卷 65-74页

作者： Mohammad Tahir Shah Tazeem Khan Ahmad Khan National centre of excellence in Geology University of Peshawar Department of Earth sciences University of Sargodha

The Reshian-Lamnian area within the Hazara-Kashmir syntaxis in Pakistan is composed mainly of the rocks of the Salkhala,Panjal and Murree *** metal sulfide mineralization in the form of sphalerite and galena with lesser amounts of chalcopyrite and pyrite is present within the Salkhala Formation of the study *** all these ore phases are homogeneous in *** Pb isotopic composition of galena from the area suggests that there is very little or negligible variation in the ratios of 206Pb/204Pb,207Pb/204Pb and 208Pb/*** ages ranging from 509 to 562 Ma and the μ values of 10.71 to 10.93 have been calculated for the studied Pb-Zn *** the basis of field features,mineralogy and Pb-isotope signatures,it is concluded that the Pb-Zn sulfide mineralization in the Reshian-Lamnia area is pre-Himalayan in age and can be correlated with the Cambro-Ordovician(Pan-African) orogenic event.

关键词：铅同位素组成铅锌硫化矿克什米尔巴基斯坦签名边境地区化学成分喜马拉雅

Transfer of Heavy Metals from Soils to Vegetables and Associated Human Health Risks at Selected Sites in Pakistan

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Pedosphere 2018年第4期28卷 666-679页

作者： Zahir Ur REHMAN Sardar KHAN Mohammad Tahir SHAH Mark L.BRUSSEAU Said Akbar KHAN Jon MAINHAGU Department of Environmental sciences University of Peshawar School of Earth and Environmental sciences University of Arizona National centre of excellence in Geology University of Peshawar

Contamination of the food chain with heavy metals is considered as one of the major environmental pathways of human exposure to metals leading to potential health risks. This study aimed to investigate the concentrations of heavy metals such as copper （Cu）, zinc （Zn）, chromium （Cr）, nickel （Ni）, and manganese （Mn） in agricultural soils and food crops （fruit, leaf, and root vegetables）, and their associated health risks to the local population in selected southern districts of Khyber Pakhtunkhwa Province, Pakistan. The concentrations of the selected metals in soil varied over a wide range, in the following decreasing order： Mn 〉 Zn 〉 Cr 〉 Ni 〉 Cu. The bioaccunmlation of metals in vegetables was within the permissible risk limits, except for Cr which showed higher contamination in all the tested food crops. The trend of metal transfer factors for different vegetables was in the order of Cu 〉 Ni 〉 Cr 〉 Mn 〉 Zn, while the calculated daily intake of metals （DIM） in adults and children through consumption of food crops was in the decreasing order of Mn 〉 Zn 〉 Ni 〉 Cr 〉 Cu. The health risk index （HRI） values for the heavy metals for both adults and children were less than 1. Therefore, no significant health risk is anticipated for the local consumers through ingestion of these food crops.

关键词： contamination daily intake food crops metal accumulation metal pollution metal transfer factor risk index

Long Lifetime Ultracold Plasma Produced by a Nanosecond Laser in a Supersonic Nitric Oxide Molecular Beam Environment

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Plasma Science and Technology 2014年第4期16卷 305-310页

作者：刘金波陆荣华郭丽金玉奇郭敬为 Key Laboratory of Chemical lasers Dalian Institute of Chemical PhysicsChinese Academy of Sciences Key Laboratory for Quantum Optics and centre for Cold Atom Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences

Ultracold plasma provides a possible route to approach the strongly-coupled regime under laboratory conditions. Normally, the lifetime of ultracold plasma is very limited due to plasma heating and expansion mechanisms. We present a new method to generate long lifetime ultracold plasmas consisting mainly of cations and anions. This plasma demonstrates a capability of traversing a DC barrier of up to 5 （or -3） V. The lifetime of this plasma is expected to be more than 250us. Finally, molecular dynamics （MD） simulation is used to explain how anions slow the expansion rate and prolong the lifetime of this plasma.

关键词： ultracold plasma nitric oxide long lifetime