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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Variation of Transition Characteristics in a Wall Jet

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Journal of Thermal Science 2003年第2期12卷 167-170页

作者： Marie-Francoise Scibilia centre national de la recherche scientifique ParisFrance

The characteristics of a laminar wall jet submitted to different configurations have been experimentally explored in order to obtain a better knowledge of transition modifications,In fact different parameters can accelerate or delay the transition using a smooth or rough surface,heated or not,submitted to vibrations or not .In this study,significant effects can be *** has been possible to measure the beginning of growth rates of disturbance amplitude using a wind tunnel and comparing the results with the linear stability theory.

关键词： wall jet transition acoustic vibration heat transfer turbulence roughness.

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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

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Heat Transfer in a Forced Wall Jet on a Heated Rough Surface

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Journal of Thermal Science 2000年第1期9卷 85-92页

作者： Marie-Francoise Scibilia Lemfi - centre national de la recherche scientifique Campus Universitaire

In this paper, an experimental investigation of a Iaminar wall jet in the presence of a heated wall with stationary particles on its surface, is reported. The wall jet was submitted to external acoustic vibrations amplifying the coherent structures appearing in the laminar region. A wind tunnel was used at very low Reynolds number. Mean velocity and turbulence intensity were measured by a constant temperature anemometer. Measurements were taken in the transition and turbulent regions. Embedded particles were outside the viscous sublayer and it was observed that their presence modifies significantly the flow characteristics in particular the boundary layer is thickened. This study can bring a better understanding of the structure of a flow when it is heated and forced on a rough wall.

关键词： heat transfer turbulence boundary layer wall jet roughness acoustics.

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Variation of CH_4 concentrations recorded in Dunde ice core bubbles

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Chinese Science Bulletin 1999年第4期44卷 383-384页

作者： J. Chappellaz laboratoire de Glaciologie et Geophysique de I'Environnement centre national de la recherche scientifique

GREENHOUSE gases such as CH4 in the ancient atmospheric concentration can be reconstructed by extracting and analyzing the gases trapped in polar ice core bubbles. It is a new attempt to extract and analyze the CH4 concentration in Dunde ice core for the study of mountain glacier. Samples were taken from the about 140-m ice core drilled in 1987 in Dunde ice cap in Qilian Mountain. The ice core has been well preserved in cold room. 12 samples were taken from the upper 95 m, and cut to 15 cm in length and 5cm in diameter. CH4 concentrations were measured in CNRS laboratory of Glaciology, Grenoble, France.

关键词： core Variation of CH4 concentrations recorded in Dunde ice core bubbles CH

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Construire une question de recherche dans l’interdisciplinarité Building an Interdisciplinary Research Question

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Psycho-Oncologie 2024年第2期18卷 79-85页

作者： Elsa Bansard MSH Paris Saclay Centre national de la recherche scientifiqueGif-sur-Yvette91190France

Interdisciplinarity is strongly promoted by institutions and is the subject of abundant scientific publications on its history,definition,and typologies,as well as on its obstacles and *** article aims to provide insight into the development of an interdisciplinary research *** will present the path that led from an administrative management question to a doctorate in philosophy of medicine on supportive care,thanks to a rich collaboration between a wide range of academic,hospital,and association *** analysis of the literature will show how the long history of science underpins disciplinary issues in the development of a research *** method will make visible the long dialogue between the partners in this *** results will show how the research question evolved throughout the ***,the discussion will propose three concepts to put interdisciplinarity into perspective:collaboration,attention,and tranquility.

关键词： Interdisciplinarity humanities and social sciences supportive care oncology

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4.2K直流背景场下Bi2223超导带材的交流损耗

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稀有金属材料与工程 2003年第9期32卷 769-772页

作者：胡立发 A.Sulpice E.Mossang 李成山纪平吴怡芳冯勇张平祥周廉西北有色金属研究院 CRTBT of centre national de la recherche scientifique Grenoble France CRTBT of centre national de la recherche scientifique LCMI of centre national la recherche scientifique

研究了Bi2223高温超导带材在4.2K和外加直流背景场条件下的交流损耗。讨论了磁场、电流、基体电阻率、超导芯的数目等因素对交流损耗的影响。所有的测量都在4.2K下进行,外加磁场的幅值最大是5T,损耗的测量采用传输电流法。

关键词： Bi2223 交流损耗临界电流直流磁场

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The High Light Response and Redox Control of Thylakoid FtsH Protease in Chlamydomonas reinhardtii

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Molecular Plant 2017年第1期10卷 99-114页

作者： Fei Wang Yafei Qi Alizee Malnoe Yves Choquet Francis-Andre Wollman Institut de Biologie Physico-Chimique Unite Mixte de Recherche 7141 Centre National de la Recherche Scientifique/Universite Pierre et Marie Curie Paris 75005 France

In Chlamydomonas reinhardtii, the major protease involved in the maintenance of photosynthetic machinery in thylakoid membranes, the FtsH protease, mostly forms large hetero-oligomers （-1 MDa） comprising FtsH1 and FtsH2 subunits, whatever the light intensity for growth. Upon high light exposure, the FtsH subunits display a shorter half-life, which is counterbalanced by an increase in FTSH1/2 mRNA levels, resulting in the modest upregulation of FtsH1/2 proteins. Furthermore, we found that high light increases the protease activity through a hitherto unnoticed redox-controlled reduction of intermolecular disulfide bridges. We iso- lated a Chlamydomonas FTSH1 promoter-deficient mutant, ftsh1-3, resulting from the insertion of a TOC1 transposon, in which the high light-induced upregulation of FTSH1 gene expression is largely lost. In ftsh1- 3, the abundance of FtsH1 and FtsH2 proteins are loosely coupled （decreased by 70% and 30%, respectively） with no formation of large and stable homo-oligomers. Using strains exhibiting different accumulation levels of the FtsH1 subunit after complementation of ftsh1-3, we demonstrate that high light tolerance is tightly correlated with the abundance of the FtsH protease. Thus, the response of Chlamydomonas to light stress involves higher levels of FtsH 1/2 subunits associated into large complexes with increased proteolytic activity.

关键词： chloroplast protease regulation of gene expression photoinhibition Chlamydomonas reinhardtii

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Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

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Neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian Philippe Rondeau laura Gence Nicolas Diotel Universitéde la Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

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DIFFUSIVE-DISPERSIVE TRAVELING WAVES AND KINETIC RElaTIONS IV. COMPRESSIBLE EULER EQUATIONS

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Chinese Annals of Mathematics,Series B 2003年第1期24卷 17-34页

作者： N. BEDJAOUI P.G.LEFLOCH centre de Mathematiques Appliquees & centre national de la recherche scientifique UMR 7641 Ecole Polytechnique 91128 Palaiseau Cedex France. INSSET Universite de Picardie 48 rue Raspail 02109 Saint-Quentin France.Centre de Mathematiques Appliquees & Centre National de la Recherche Scientifique UMR 7641 Ecole Polytechnique 91128 Palaiseau Cedex France.

The authors consider the Euler equations for a compressible fluid in one space dimensionwhen the equation of state of the fluid does not fulfill standard convexity assumptions andviscosity and capillarity effects are taken into account. A typical example of nonconvex con-stitutive equation for fluids is Van der Waals' equation. The first order terms of these partialdifferential equations form a nonlinear system of mixed (hyperbolic-elliptic) type. For a class ofnonconvex equations of state, an existence theorem of traveling waves solutions with arbitrarylarge amplitude is established here. The authors distinguish between classical (compressive) andnonclassical (undercompressive) traveling waves. The latter do not fulfill lax shock inequali-ties, and are characterized by the so-called kinetic relation, whose properties are investigatedin this paper.

关键词： Elasto dynamics Phase transitions Hyperbolic conservation law Diffusion Dispersion Shock wave Undercompressive Entropy inequality Kinetic relation

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