检索结果-南通市图书馆

Sequential living donor liver transplantation after liver resection optimizes outcomes for patients with high-risk hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic diseases International 2025年第1期24卷 50-56页

作者： Itsuko Chih-Yi Chen Leona Bettina P Dungca Chee-Chien Yong Chao-Long Chen liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial Hospital123 Ta-Pei RoadNiao-SungKaohsiungTaiwanChina

Background:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. While liver transplantation (LT) provides the best long-term survival, it is constrained by organ scarcity and strict criteria. liver resection (LR) is often the initial treatment for patients with solitary tumors and preserved liver function. The high recurrence rates associated with LR has prompted the exploration of sequential living donor liver transplantation (seq LDLT) after LR as a strategy for HCC patients with high-risk of ***:We analyzed data from 27 adult patients who underwent seq LDLT after LR for HCC at Kaohsiung Chang Gung Memorial Hospital (KCGMH) between June 1994 and December 2023. Patients were selected based on high-risk histopathological features post-LR or as part of downstaging strategy. Outcomes measured included overall survival (OS) and disease-free survival (DFS).Results:Among 765 HCC patients who underwent LDLT, 204 received LR before LDLT, and 27 underwent seqL DLT. Five patients (19%) underwent living donor liver transplantation (LDLT) following LR as a downstaging strategy while the rest received seqL DLT as a preemptive strategy. The median age was 53.5 years with 85%males. Chronic hepatitis B was the predominant underlying disease (74%). The 1-, 3-, and 5-year OS and DFS rates were 100%, 96.0%, 96.0%and 100%, 96.2%, 96.2%, respectively, with two patients experiencing HCC recurrence. One patient died from HCC recurrence. High-risk histopathological features included microvascular invasion (52%), satellite nodules (15%), multiple tumors (26%), tumors> 5 cm(19%), and a total tumor diameter> 10 cm (7%).Conclusions:Seq LDLT offers a promising, tailored approach for managing HCC with adverse histopathologic features. Combining seq LDLT, downstaging strategies, and multidisciplinary treatments can achieve satisfactory OS and DFS in carefully selected patients, highlighting the need for refined criteria to identify the best candidates.

关键词： Living donor liver transplantation liver resection High-risk hepatocellular carcinoma Sequential living donor liver transplantation Salvage living donor liver transplantation

Current status of drug therapy for chronic hepatitis B

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第2期31卷 1-12页

作者： Chuang Jiang Zhi-Hong Zhang Jia-Xin Li Division of liver surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of General surgery Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

In this editorial,we comment on the article by Meng et *** hepatitis B(CHB)is a significant global health problem,particularly in developing *** B virus(HBV)infection is one of the most important risk factors for cirrhosis and hepatocellular *** and treatment of HBV are key measures to reduce *** present,drug therapy can effectively control virus replication and slow disease progression,but completely eliminating the virus remains a ***-HBV treatment is a long-term process,and there are many kinds of antiviral drugs with different mechanisms of action,it is essential to evaluate the safety and efficacy of these drugs to reduce side effects and improve patients’*** will summarize the current status of CHB drug treatment,hoping to provide a reference for the selection of clinical antiviral drugs.

关键词： Chronic hepatitis B Hepatitis B virus Anti virus Drug treatment Therapy

Impact of Linggui Zhugan decoction on microwave ablation outcomes and recurrence in liver cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第2期17卷 105-118页

作者： Rui Huang Jing Cui department of Acupuncture and Moxibustion Baoji Central HospitalBaoji 721000Shaanxi ProvinceChina department of liver disease Xi’an Daxing HospitalXi’an 710016Shaanxi ProvinceChina

BACKGROUND liver cancer is one of the most common malignant tumors of the digestive system,and early detection and effective treatment are crucial for improving the *** ablation(MWA)has shown promising results as a local therapeutic method for liver cancer;however,further improvement of its efficacy remains a key focus of current *** To evaluate the clinical efficacy of Linggui Zhugan decoction combined with MWA for the treatment of primary liver *** Data were collected from 164 patients with primary liver cancer who underwent MWA at our hospital between March 2019 and April *** them,79 patients(control group)received routine treatments and 85 patients(research group)received Linggui Zhugan decoction in addition to routine *** clinical efficacy,incidence of adverse reactions,and levels of serum alphafetoprotein(AFP),des-γ-carboxy prothrombin(DCP),AFP-L3,total bilirubin(TBil),alanine aminotransferase(ALT),CD4 cell count,CD8 cell count,and CD4/CD8 ratio were compared between the two groups,before and after *** three-year recurrence rates between the two groups were compared,and independent prognostic factors for recurrence were *** The study results revealed that the objective response rate(ORR)in the research group was significantly higher than that in the control group(P=0.005).After treatment,the CD4 cell count and CD4/CD8 ratio significantly increased,whereas the CD8 cell count and TBil,ALT,AFP,DCP,and AFP-L3 Levels were significantly lower in the research group than in the control group(Pdisease-free *** The combination of Linggui Zhugan decoction with MWA significantly improved the clinical efficacy and longterm pro

关键词： Primary liver cancer Microwave ablation Linggui Zhugan decoction Clinical efficacy disease-free survival Cox regression analysis

Multicenter analysis on the correlation between the anatomical characteristics of hepatic veins and hepatic venous wedge pressure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第9期31卷 43-53页

作者： Qiu-Xia Ye Ming-Ming Meng Yi-Fan Wu Cheng-Bin Dong Yu Zhang Bo-Wen Liu Yi-Fan Lv Shao-Li You Sa Lv Hui-Guo Ding Ying Han Yong-Ping Yang Bing Zhu Fu-Quan Liu liver disease Minimally Invasive Diagnosis and Treatment Center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China liver Vascular disease Diagnosis and Treatment Center The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China department of Gastroenterology and Hepatology Beijing You’an HospitalCapital Medical UniversityBeijing 100069China

BACKGROUND Wedged hepatic venous pressure(WHVP)is a crucial variable for accurately assessing the hepatic venous pressure gradient(HVPG)and is vital for the diagnosis and prognostic evaluation of patients with portal hypertension(PH).AIM To investigate the anatomical characteristics of balloon-occluded hepatic venous angiography in patients with PH and analyze the relationship between the WHVP and portal venous pressure(PVP).METHODS This retrospective study included 877 patients with PH who met the inclusion criteria from January 2020 to June *** and innovative hepatic venous angiography was performed during transjugular intrahepatic portosystemic shunt procedures to measure hepatic venous and *** patients'angiographic images were collected for *** associations between WHVP and PVP in each group were analyzed via linear regression analysis,and a predictive model was *** The 877 patients had a mean age of 52.6±13.0 years,with 582 males and 295 *** were categorized into four groups on the basis of their anatomical *** groups showed strong correlations between WHVP and *** regression coefficient between the WHVP and PVP in the hepatic right vein-portal venous angiography group was 0.884(P<0.05);in the hepatic right vein-accessory hepatic venous angiography group,it was 0.721(P<0.05);in the hepatic right vein-middle hepatic venous angiography group,it was 0.344(P<0.05);and in the hepatic right vein-nonangiography group,it was 0.293(P<0.05).CONCLUSION The presence and anatomical classification of hepatic venous collaterals are key factors influencing the relationship between WHVP with and *** on the different anatomical classifications of hepatic veins,WHVP can be used to estimate PVP,improving the accuracy of PVP prediction.

关键词： Wedged hepatic venous pressure Portal venous pressure Portal hypertension Collateral branches of the hepatic vein Transjugular intrahepatic portosystemic shunt

Three-dimensional location approach with silk thread guided hepatectomy for liver tumor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第8期31卷 66-71页

作者： Zhi-Hong Zhang Qing-Bo Feng Chuang Jiang Ji-Wei Huang Jia-Xin Li Division of liver surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Intraoperative determination of resection margin and adequate residual liver parenchyma are the key points of hepatectomy for the treatment of liver *** ultrasound and indocyanine green fluorescence navigation are the most commonly used methods at present,but the technical barriers limit their *** To evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver *** From September 2020 to January 2022,8 patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocar-cinoma,and gastric cancer liver metastasis were included in this *** patients underwent 3D-LAST in precise resection of liver *** All patients(8/8,100%)underwent the operation successfully without any *** the mean follow-up of 8.7 months,all patients survived without tumor *** In conclusion,the 3D-LAST is a safe and effective new method for liver intraop-erative navigation,which is practical and easy to *** Tip:The aim of this study is to evaluate the value of the three-dimensional location approach with silk thread(3D-LAST)in precise resection of liver *** patients with liver tumors including hepatocellular carcinoma,intrahepatic cholangiocarcinoma,hilar cholangiocarcinoma,and gastric cancer liver metastasis underwent the operation successfully without any *** the mean follow-up of 8.7 months,all patients survived without tumor *** conclusion,the 3D-LAST is a safe and effective new method for liver intraoperative navigation,which is practical and easy to *** Hepatectomy is widely used for the treatment of liver *** recent decades,the concept and practice of hepatectomy have developed from irregular,regular and anatomical to the current precise *** assistive technologies have enabled these *** ultraso

关键词： Hepatectomy Laparoscopy liver tumor Three dimensional Silk thread

Particular Chinese contributions to extracorporeal liver surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic diseases International 2025年第1期24卷 57-66页

作者： Abudusalamu Aini Qian Lu Hao Wen Wen-Tao Wang Tuerganaili Aji Zhi-Yu Chen Lei-Da Zhang Zhan-Yu Yang Jia-Yin Yang Hai-Ning Fan Wei-Lin Wang Xiang-Cheng Li Yu Zhang Jia-Hong Dong Hepatopancreatobiliary Center Organ Transplantation CenterBeijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 102218China Key Laboratory of Digital Intelligence Hepatology(Chinese Ministry of Education) School of Clinical MedicineTsinghua UniversityBeijing 100084China Research Unit of Precision Hepatobiliary surgery Paradigm Chinese Academy of Medical SciencesBeijing 100010China Institute for Organ Transplantation and Bionics Institute for Precision MedicineSchool of Clinical MedicineTsinghua UniversityBeijing 100010China Hepatobiliary&Echinococcosis surgery Digestive&Vascular Surgery CenterThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China department of liver surgery&liver Transplantation Center West China Hospital of Sichuan UniversityChengdu 610041China department of Hepatobiliary surgery Southwest HospitalThe Army Medical UniversityChongqing 100089China Faculty of Hepato-Pancreato-Biliary surgery Chinese People’s Army General HospitalBeijing 400038China liver Transplantation Center&Organ Transplantation Center West China Hospital of Sichuan UniversityChengdu 610041China Hepatopancreatobiliary surgery School of Clinical MedicineQinghai University Affiliated HospitalXining 810006China department of Hepatobiliary surgery The Second Affiliated HospitalZhejiang Univeristy School of MedicineHangzhou 310009China department of Hepatobiliary surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China department of Hepatobiliary surgery Sichuan Provincial People’s HospitalChengdu 610072China

Extracorporeal liver surgery(ELS), also known as liver autotransplantation, is a hybrid(cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently became more embraced and popularized among leading centers. ELS could be summarized into three major categories, namely, ex-situ liver resection and autotransplantation(ELRA), ante-situm liver resection and autotransplantation(ALRA) and auxiliary partial liver autotransplantation(APLA). The successful development of ELS during the past 37 years is definitely inseparable from continuous effort s done by Chinese surgeons and researchers. Especially, the precision liver surgery paradigm has allowed to transform ELS into a modularized, more simplified, and standardized surgery, to upgrade surgical skills, to improve peri-operative outcome and long-term survival, to increase the capability of surgeons to select more complex diseases and to expand the level of medical service to the population. This review highlights the Chinese contributions to the field of ELS, focusing thereby on features of different surgical types, technical innovations, disease selection and surgical indication, patient prognosis and future perspectives.

关键词： Ex-situ ex-vivo liver resection Ex-situ in-vivo liver resection Semi-ex-vivo liver resection Ex-situ liver resection after in-situ hepatectomy liver autotransplantation Autologous liver transplantation Bench hepatectomy Back-table liver resection Precision liver surgery

mRNA vaccines for gastrointestinal malignancies:cutting-edge advances and future perspectives

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2025年第2期70卷 128-131页

作者： Gang Zhang Xing Huang Tingbo Liang Zhejiang Provincial Key Laboratory of Pancreatic disease Department of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China MOE Joint International Research Laboratory of Pancreatic diseases Hangzhou 310003China

Gastrointestinal malignancies encompass cancers of the esophagus,stomach,pancreas,liver,gallbladder,biliary tract,colon,and *** to the 2020 global cancer statistics,gastrointestinal malignancies accounted for approximately 26.4%of all new cancer cases and 36.3%of new deaths(Text S1 online)[1–3].The high incidence and mortality of gastrointestinal malignancies pose a tremendous threat to human *** significant strides in the management of advanced and metastatic gastrointestinal malignancies(Text S2 online),they frequently prove incurable,with 5-year survival rates consistently remaining<20%across various affected sites[4,5].Emerging evidence increasingly underscores the promising therapeutic potential of mRNA vaccines in the field of cancer *** vaccines offer several advantages over traditional strategies(Texts S3 and S4 online)[6–8].Here,we discuss the recent progress and future perspectives of m RNA vaccines in gastrointestinal malignancies.

关键词： gastrointestinal vaccines stomach

Internal biliary diversion using appendix during liver transplantation for progressive familial intrahepatic cholestasis type 1:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal surgery 2025年第2期17卷 279-284页

作者： Jia-Qi Song Tao Zhou Yi Luo Yuan Liu department of liver surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China

BACKGROUND Progressive familial intrahepatic cholestasis type 1(PFIC-1)is a genetic cholestatic disease causing end-stage liver disease,which needs liver transplantation(LT).Simultaneous biliary diversion(BD)was recommended to prevent allograft steatosis after transplantation,while increasing the risk of ***,an attempt was made to perform BD using appendix to prevent bacterial translocation after *** SUMMARY An 11-month-old boy diagnosed with PFIC-1 received ABO compatible living donor LT due to refractory jaundice and *** mother donated her left lateral segment with a graft-to-recipient weight ratio of 2.9%.Internal BD was constructed during LT using the appendix by connecting its proximal end with the intrahepatic biliary duct and the distal end with *** leakage was suspected on the 5th day after transplantation and exploratory laparotomy indicated biliary leakage at the cutting surface of *** liver function returned to normal on the 9th day post-operation and maintained normal during the 15-month *** at 10 months after transplantation confirmed the direct secretion of bile into *** tomography scan(4 months and 10 months)and liver biopsy(10 months)indicated no steatosis in the *** complaint of recurrent diarrhea,infection or growth retardation was reported during *** Internal BD using appendix during LT is effective in preventing allograft steatosis and post-transplant infection in PFIC-1 recipients.

关键词： liver transplantation Progressive familial intrahepatic cholestasis type 1 Biliary diversion Appendix Case report

Serum ECM1 is a promising biomarker for staging and monitoring fibrosis in patients with chronic hepatitis B

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第2期68卷 431-440页

作者： Lian Liu Danyan Zhang Rong Fan Shipeng Cheng Jichao Yang Liyan Ma Zhiyang Ling Yaguang Zhang Jinlin Hou Xiaomei Wang Bing Sun Junqi Niu Shanghai Institute of Biochemistry and Cell Biology Centre for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China department of Infectious disease Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Med-X Institute Centre for Immunological and Metabolic DiseasesThe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an Jiaotong UniversityXi’an 710061China Hepatology department Centre of Infectious Diseases and Pathogen BiologyFirst Hospital of Jilin UniversityChangchun 130021China

It is critical to assess the extent and progression of liver fibrosis for patients to receive suitable treatments,but its diagnostic methods remain *** matrix protein 1(ECM1)has previously been reported to be a key factor in the induction and progression of liver ***,little is known about the use of ECM1 as a biomarker to evaluate *** a CCl_(4)-induced mouse model of liver fibrosis,the present study demonstrated that ECM1 decreased with gradually increasing *** biopsy as a reference,the serum ECM1 levels decreased with increasing fibrosis stage in 247 patients with liver fibrosis,but there were no significant changes between fibrosis stage 2 and stage 0–*** improve the performance of ECM1,age,platelet count,and ECM1 concentration were combined to calculate an EPA(ECM1-platelet-age)score(ranging from 0 to 10).The areas under the receiver operating characteristic curve of the EPA scores for the detection of F≥2,F≥3,and F4 were 0.6801,0.7377,and 0.8083,respectively,which showed a comparable or significantly greater diagnostic performance for assessing fibrosis than that of the AST/ALT ratio,APRI score,or FIB-4 *** HBV patients following antiviral treatment,the dynamics of the EPA score depended on the status of liver fibrosis *** accuracy of the EPA score in predicting fibrosis regression and progression was 66.00%and 71.43%,respectively,while that of the LSM,another useful method for monitoring hepatic fibrosis changes during treatment,was only 52.00%and 7.14%,*** with healthy controls,there were lower levels of serum ECM1 in HBV patients and individuals with HCV infection,MAFLD,ALD,PBC,and *** findings suggested that individuals with reduced ECM1 levels may have a risk of developing liver injury,and further examinations or medical care are *** conclusion,the ECM1-containing EPA score is a valuable noninvasive test for staging fibrosis and predicting the progression of liv

关键词： ECM1 EPA score noninvasive biomarker dynamic liver fibrosis injury