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Genome Analysis of Plasmodium falciparum:A Preliminary Observation-Sierra Leone,2022-2023

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China CDC weekly 2024年第17期6卷 368-373页

作者： Tianyu Wang Haimo Shen Bin Xu Wanxuan Yang Shenbo Chen Junhu Chen National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Centre for International Research on Tropical DiseasesShanghaiChina School of Basic Medical Sciences and Forensic medicine Hangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina School of Global Health Chinese Centre for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina Hainan tropical Diseases Research Center(Hainan Sub-Center Chinese Center for Tropical Diseases Research)Haikou CityHainan ProvinceChina.

What is already known about this topic?Sierra Leone,with a gross domestic product(GDP)per capita below$300 and significant poverty,ranks among the world’s least developed countries(LDCs).Despite its modest population of 8.6 million,the nation reports approximately 2.6 million malaria cases ***,there has been no reporting on the malaria genome data from this *** is added by this report?In this study,we present the first reported wholegenome sequence analysis of 19 high parasite-density Plasmodium falciparum isolates from Sierra Leone,providing insights into the genomic epidemiology of this high-prevalence *** found a high degree of relatedness among infections and substantial genetic diversity,consistent with the gradual reduction in overall case ***,our whole-genome analysis revealed that,beyond drug-resistance genes,gene families related to blood cell invasion,immune evasion,and others are undergoing directional *** suggests that the population in Sierra Leone has developed a relatively strong acquired *** are the implications for public health practice?The genomic data not only facilitate the creation of single nucleotide polymorphism barcodes for case tracking but also enable the analysis of evolving transmission dynamics and selection ***,the samples from Sierra Leone exhibited higher selective pressures on resistance genes compared to those from Asia,a trend not commonly observed in other African *** suggests that less stringent healthcare systems and inconsistent treatment strategies can subject parasites to increased drug pressure,thereby accelerating the development of resistant strains.

关键词： epidemiology invasion Observation

Metadherin-driven promotion of cancer stem cell phenotypes and its effect on immunity in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第20期30卷 2624-2628页

作者： Nevena Todorović Amedeo Amedei Department of Experimental and Clinical medicine University of FlorenceFlorence 50134Italy Clinic for Infectious and tropical Diseases University Clinical Centre of SerbiaBelgrade 11000Serbia

In this editorial we provide commentary on the article published by Wang et al,featured in the recent issue of the World Journal of Gastroenterology in *** focus on the metadherin(MTDH),also known as astrocyte elevated gene-1 or lysine rich CEACAM1,and its effects on cancer stem cells(CSCs)and immunity in hepatocellular carcinoma(HCC).HCC is the most common primary liver cancer and one of the leading causes of cancer-related deaths *** HCC cases develop in the context of liver *** the pivotal mechanisms of carcinogenesis are gene mutations,dysregulation of diverse signaling pathways,epigenetic alterations,hepatitis B virus-induced hepatocarcinogenesis,chronic inflammation,impact of tumor microenvironment,oxidative *** the years,extensive research has been conducted on the MTDH role in various tumor pathologies,such as lung,breast,ovarian,gastric,hepatocellular,colorectal,renal carcinoma,neuroblastoma,melanoma,and ***,its involvement in tumor development processes including transformation,apoptosis evasion,angiogenesis,invasion,and metastasis via multiple signaling *** has been demonstrated that knockdown or knockout of MTDH disrupt tumor development and *** addition,numerous reports have been carried out regarding the MTDH influence on HCC,demonstrating its role as a predictor of poor prognosis,aggressive tumor phenotypes prone to metastasis and recurrence,and exhibiting significant potential for therapy ***,more studies finely investigated the influence of MTDH on *** CSCs are a small subpopulation of tumor cells that sharing traits with normal stem cells like self-renewal and differentiation abilities,alongside a high plasticity that alters their *** their presumed role in tumor initiation,they can drive also disease relapse,metastasis,and resistance to chemo and radiotherapy.

关键词： Hepatocellular carcinoma Metadherin Astrocyte elevated gene-1 Lysine rich

Accelerating the Control and Elimination of Major Parasitic Diseases in China—On World NTD Day 2024

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China CDC weekly 2024年第6期6卷 95-99页

作者： Yuwan Hao Tian Tian Zelin Zhu Yijun Chen Jing Xu Shuai Han Menbao Qian Yi Zhang Shizhu Li Qiang Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)Key Laboratory on Parasite and Vector BiologyMinistry of HealthWHO Centre for Tropical Diseases National Center for International Research on tropical Diseases Ministry of Science and TechnologyShanghaiChinaSchool of Global HealthChinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of MedicineShanghaiChina

Neglected tropical diseases(NTDs)are a group of diseases associated with poverty that affect over 1 billion people worldwide(1).On May 31,2021,the World Health Assembly(WHA)officially recognized January 30 as World Neglected tropical Diseases Day through decision WHA74(18).This designation aims to raise awareness about the severe impact of NTDs on disadvantaged populations and to mobilize support for control,elimination,and eradication efforts.

关键词： Diseases diseases disadvantage

Attitudes,beliefs,behaviours and perspectives on barriers and enablers of Australian general practitioners towards non-drug interventions:a national survey

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Family medicine and Community Health 2024年第1期12卷 1-8页

作者： Loai Albarqouni Hannah Greenwood Caroline Dowsett Tammy Hoffmann Rae Thomas Paul Glasziou Institute for Evidence-based Healthcare Faculty of Health Sciences&MedicineBond UniversityRobinaQueenslandAustralia tropical Australian Academic Health centre TownsvilleQueenslandAustralia

Background Many guidelines recommend non-drug interventions(NDIs)for managing common conditions in primary ***,compared with drug interventions,NDIs are less widely known,promoted and *** aim to(1)examine general practitioners’(GPs’)knowledge,attitudes and practices for NDIs,including their use of the Royal Australian College of General Practitioners(RACGP)Handbook of Non-Drug Interventions(HANDI),and(2)identify factors influencing their use of NDIs and *** We conducted a web-based cross-sectional survey of practicing GP members in Australia during October-November *** survey contained five sections:characteristics of GP;knowledge and use of NDIs;attitudes towards NDIs;barriers and enablers to using HANDI;and suggestions of NDIs and ideas to improve the uptake of NDIs in primary *** Of the 366 GPs who completed the survey,242(66%)were female,and 248(74%)were≥45 years *** in three GPs reported that they regularly(‘always’)recommend NDIs to their patients when appropriate(34%),whereas one-third of GPs were unaware of HANDI(39%).GPs identified several factors that improve the uptake of HANDI,including‘access and integration of HANDI in clinical practice’,‘content and support to use in practice’and‘awareness and training’.Conclusions While many GPs are aware of the effectiveness of NDIs and often endorse their use,obstacles still prevent widespread adoption in primary *** results of this survey can serve as a foundation for developing implementation strategies to improve the uptake of effective evidence-based NDIs in primary care.

关键词： enable survey sectional

Schistosomiasis transmission in Zimbabwe:Modelling based on machine learning

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Infectious Disease Modelling 2024年第4期9卷 1081-1094页

作者： Hong-Mei Li Jin-Xin Zheng Nicholas Midzi Masceline Jenipher Mutsaka-Makuvaza Shan Lv Shang Xia Ying-jun Qian Ning Xiao Robert Berguist Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai200025China National Institute of Health Research Ministry of Health and Child CareHarareZimbabwe University of Rwanda College of Medicine and Health SciencesSchool of Medicine and PharmacyDepartment of Microbiology and ParasitologyRwanda Ingerod 407 SE-45494BrastadSweden

Zimbabwe,located in Southern Africa,faces a significant public health challenge due to *** investigated this issue with emphasis on risk prediction of schistosomiasis for the entire *** this end,we reviewed available data on schistosomiasis in Zimbabwe from a literature search covering the 1980-2022 period considering the potential impact of 26 environmental and socioeconomic variables obtained from public *** studied the population requiring praziquantel with regard to whether or not mass drug administration(MDA)had been regularly *** machinelearning algorithms were tested for their ability to predict the prevalence of schistosomiasis in Zimbabwe based on the mean absolute error(MAE),the root mean squared error(RMSE)and the coefficient of determination(R2).The findings revealed different roles of the 26 factors with respect to transmission and there were particular variations between Schistosoma haematobium and *** *** found that the top-five correlation factors,such as the past(rather than current)time,unsettled MDA implementation,constrained economy,high rainfall during the warmest season,and high annual precipitation were closely associated with higher *** prevalence,while lower elevation,high rainfall during the warmest season,steeper slope,past(rather than current)time,and higher minimum temperature in the coldest month were rather related to higher *** *** random forest(RF)algorithm was considered as the formal best model construction method,with MAE=0.108;RMSE=0.143;and R^(2)=0.517 for ***,and with the corresponding figures for *** being 0.053;0.082;and *** on this optimal model,the current total schistosomiasis prevalence in Zimbabwe under MDA implementation was 19.8%,with that of *** at 13.8% and that of *** at 7.1%,requiring annual MDA based on a population of 3,003,*** MDA,the current total schistosomiasis prevalence would

关键词： Machine-learning Transmission risk model Schistosomiasis Zimbabwe

Prevalence estimates of Opisthorchis viverrini and Clonorchis sinensis infection in the Greater Mekong subregion:a systematic review and meta-analysis

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Infectious Diseases of Poverty 2024年第3期13卷 11-25页

作者： Pornphutthachat Sota Morsid Andityas Manas Kotepui Banchob Sripa WHO Collaborating centre for Research and Control of Opisthorchiasis(Southeast Asian Liver Fluke Disease) Tropical Disease Research CenterKhon Kaen UniversityKhon KaenThailand Faculty of veterinary medicine Khon Kaen UniversityKhon KaenThailand Department of Bioresources Technology and veterinary Veterinary Technology Study ProgramVocational CollegeUniversitas Gadjah MadaDepokIndonesia School of Allied Health Sciences Walailak UniversityNakhon Si ThammaratThailand Department of tropical medicine Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Medical Technology Program Faculty of ScienceNakhon Phanom UniversityNakhon PhanomThailand

Background Opisthorchiasis and clonorchiasis,caused by Opisthorchis viverrini and Clonorchis sinensis,respectively,are significant yet neglected foodborne trematodiases in the Great Mekong Subregion(GMS).Despite the reporting of the prevalence of these human liver flukes in the region over the past decades,there has been a lack of a comprehensive and systematic consolidation of this ***,we aimed to conduct a thorough systematic review and meta-analysis to synthesize and analyze time-trend prevalence estimates of both *** and *** across the GMS for the past 30 *** This study undertakes a systematic review using a comprehensive search for published articles in PubMed,EMBASE,Scopus,Cochrane and Thai Journal Online databases until early *** pooled prevalence of *** and *** infection was analyzed through a random-effects meta-analysis,with meta-regression analysis used to quantify associations with study ***-group analysis was conducted,whenever comparison data were available,to assess the risk of *** and *** infection in each GMS *** among studies was assessed using the Q statistic and quantified by using the I^(2)*** From a total of 2997 articles,155 articles comprising 218 datasets and 751,108 participants were included for *** GMS prevalence of *** was 21.11%[45,083/260,237;95%confidence interval(CI):17.74-24.47%].Pooled prevalence estimates were highly observed in Laos(34.06%,95%CI:26.85-41.26%),followed by Thailand(18.19%,95%CI:13.86-22.51%),and Cambodia(10.48%,95%CI:5.52-15.45%).Myanmar and Vietnam had limited data sources for *** sinensis infection in GMS was 25.33%(95%CI:18.32-32.34%),with Guangxi,China,exhibiting the highest prevalence rates at 26.89%(95%CI:18.34-35.43%),while Vietnam had a prevalence rate of 20.30%(95%CI:9.13-31.47%).*** prevalence decreased significantly over time,whereas *** infec

关键词： Great Mekong subregion Human Meta-analysis

Natural variables separate the endemic areas of Clonorchis sinensis and Opisthorchis viverrini along a continuous, straight zone in Southeast Asia

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贫困所致传染病(英文) 2024年第2期13卷 1-13页

作者： Zheng Jin-Xin Zhu Hui-Hui Xia Shang Qian Men-Bao Nguyen Hung Manh Sripa Banchob Sayasone Somphou Khieu Virak Bergquist Robert Zhou Xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China One Health Center Shanghai Jiao Tong University The University of Edinburgh Shanghai China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for tropical Diseases Research) NHC Key Laboratory of Parasites and Vectors Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases Shanghai China Institute of Ecology and Biological Resources Graduate University of Science and Technology Vietnam Academy of Science and Technology Hoang Quoc Viet Street Hanoi Vietnam WHO Collaborating centre for Research and Control of Opisthorchiasis (Southeast Asian Liver Fluke Disease) Tropical Disease Research Laboratory Department of Tropical Medicine Faculty of Medicine Khon Kaen University Mittraparb Road Khon Kaen Thailand Lao tropical and Public Health Institute Ministry of Health Vientiane Lao PDR National centre for Parasitology Entomology and Malaria Control Ministry of Health Phnom Penh Cambodia Ingerod Brastad Sweden (formerly at the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases) World Health Organization Geneva Switzerland

Background Clonorchiasis and opisthorchiasis, caused by the liver flukesClonorchis sinensis andOpisthorchis viverrini respectively, represent significant neglected tropical diseases (NTDs) in Asia. The co-existence of these pathogens in overlapping regions complicates effective disease control strategies. This study aimed to clarify the distribution and interaction of these diseases within Southeast *** We systematically collated occurrence records of human clonorchiasis (n = 1809) and opisthorchiasis (n = 731) across the Southeast Asia countries. Utilizing species distribution models incorporating environmental and climatic data, coupled machine learning algorithms with boosted regression trees, we predicted and distinguished endemic areas for each fluke species. Machine learning techniques, including geospatial analysis, were employed to delineate the boundaries between these *** Our analysis revealed that the endemic range ofC. sinensis andO. viverrini in Southeast Asia primarily spans across part of China, Vietnam, Thailand, Laos, and Cambodia. During the period from 2000 to 2018, we identifiedC. sinensis infections in 84 distinct locations, predominantly in southern China (Guangxi Zhuang Autonomous Region) and northern Vietnam. In a stark contrast,O. viverrini was more widely distributed, with infections documented in 721 locations across Thailand, Laos, Cambodia, and Vietnam. Critical environmental determinants were quantitatively analyzed, revealing annual mean temperatures ranging between 14 and 20 °C in clonorchiasis-endemic areas and 24–30 °C in opisthorchiasis regions (P < 0.05). The machine learning model effectively mapped a distinct demarcation zone, demonstrating a clear separation between the endemic areas of these two liver flukes with AUC from 0.9 to1. The study in Vietnam delineates the coexistence and geographical boundaries ofC. sinensis andO. viverrini, revealing distinct endemic zones and a transitional area where both live

关键词： Liver fluke Clonorchiasis Opisthorchiasis Clonorchis sinensis Opisthorchis viverrine Southeast Asia Machine learning Ecological study

Metabolomics for quality assessment of poultry meat and eggs

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Food Quality and Safety 2024年第1期8卷 27-40页

作者： M.S.Yogeswari Jinap Selamat Nuzul Noorahya Jambari Alf Khatib Mohd Hishammfariz Mohd Amin Suganya Murugesu Laboratory of Food Safety and Food Integrity Institute of Tropical Agriculture and Food SecurityUniversiti Putra MalaysiaSerdangSelangor Darul EhsanMalaysia Department of Food Science Faculty of Food Science and TechnologyUniversiti Putra MalaysiaSerdangSelangor Darul EhsanMalaysia Department of Pharmaceutical Chemistry Kulliyyah of PharmacyInternational Islamic University MalaysiaKuantanPahang Darul MakmurMalaysia Faculty of Pharmacy Airlangga UniversitySurabayaIndonesia Department of veterinary Service Malaysia Federal Government Administration CentrePutrajayaMalaysia

The poultry industry is experiencing rapid growth *** accelerated growth has led to multiple food fraud incidents across the food supply chain,which consequently created a demand for precise determination of quality poultry *** increase in demand for precise poultry production quality has necessitated advanced *** has emerged as a viable solution by offering detailed differentiation of biochemical indicators throughout the poultry supply ***,this study provides a means to address risk factors affecting the poultry industry without compromising animal welfare,which is a critical *** review focuses on important issues related to poultry product quality *** adulteration has escalated in recent years as it is driven by the increasing focus on consuming high-quality and nutritious ***,there is no specifc guideline for such determinations,especially when appearance,texture,and taste can be manipulated by substituting for food *** can pave the way for a deeper understanding of existing and novel biochemical indicators responsible for determining the quality of poultry meat and *** approach holds the potential to enhance the overall quality of poultry meat and egg products while also preventing food fraud.

关键词： Poultry metabolomics welfare application authentication.

Transplantation of a pectoralis major flap for the repair of myiasis wounds

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World Journal of Emergency medicine 2024年第3期15卷 238-240页

作者： Yongkang Cai Yilin He Xiaoxing Tan Tangchun Liu Qingdeng Feng Dongjing Zhang Zhengfei Yang Department of Oral and Maxillofacial Surgery Sun Yat-sen Memorial HospitalGuangzhou 510120China Department of Emergency medicine Sun Yat-sen Memorial HospitalGuangzhou 510120China Chinese Atomic Energy Agency centre of Excellence on Nuclear Technology Applications for Insect Control Key Laboratory of Tropical Disease Control of the Ministry of EducationSun Yat-sen UniversityGuangzhou 510080China International Atomic Energy Agency Collaborating centre Sun Yat-sen UniversityGuangzhou 510080China

Myiasis is a disease caused by the invasion and colonization of human tissues and organs by the larvae of *** is manifested by the formation of necrotic tissue in the lesion,the colonization of fly eggs and the spread of fly *** disease is mostly found in areas with poor sanitary *** wound care,necrotic tissue formation,reduced immunity,and frequent contact with flies are risk factors for this *** can be divided into obligate and facultative parasitism,^([1])while some scholars have classified myiasis according to its location.^([2])In addition,some cases of myiasis are secondary to wound infection or poor surgical maintenance.^([3,4]).

关键词： wound immunity myiasis